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| 1 | Doublecortin and CaM kinase-like-1 as an independent prognostic factor in patients with resected pancreatic carcinoma显示文摘AIM To elucidate the effect of expression of doublecortin and Ca M kinase-like-1(DCLK1) in patients with pancreatic ductal adenocarcinoma(PDAC). METHODS Tumor specimens were obtained from 136 patients with pancreatic cancer who had undergone resection without preoperative therapy between January 2000 and December 2013 at the Department of Surgical Oncology, Osaka City University. The resected specimens were analyzed for associations with clinicopathological data, including DCLK1 expression, epithelial mesenchymal transition(EMT) marker expression, and cancer stem cell(CSC) marker expression. Univariate and multivariate survival analyses were performed and we assessed the association between DCLK1 expression and clinicopathological factors, including the EMT marker and CSC marker.RESULTS In total, 48.5%(66/136) of the pancreatic cancer samples were positive for DCLK1. Patients with DCLK1-positive tumors had significantly shorter survival times than those with DCLK1-negative tumors(median, 18.7 mo vs 49.5 mo, respectively; P < 0.0001). Positive DCLK1 expression correlated with histological grade(P = 0.0290), preoperative CA19-9 level(P = 0.0060), epithelial cell adhesion molecule(Ep CAM) expression(P = 0.0235), and the triple-positive expression of CD44/CD24/Ep CAM(P = 0.0139). On univariate survival analysis, five factors were significantly associated with worse overall survival: histological grade of G2 to G4(P = 0.0091), high preoperative serum SPan-1 level(P = 0.0034), R1/2(P < 0.0001), positive expression of DCLK1(P < 0.0001) or CD44(P = 0.0245). On multivariate survival analysis, R1/2 [odds ratio(OR) = 2.019, 95% confidence interval(CI): 1.380-2.933; P = 0.0004] and positive DCLK1 expression(OR = 1.848, 95%CI: 1.2854-2.661; P = 0.0009) were independent prognostic factors. CONCLUSION DCLK1 expression was found to be an independent prognostic factor and it may play a crucial prognostic role by promoting acquisition of stemness. | Kohei Nishio Kenjiro Kimura Ryosuke Amano Bunzo Nakata Sadaaki Yamazoe Go Ohira Kotaro Miura Naoki Kametani Hiroaki Tanaka Kazuya Muguruma Kosei Hirakawa Masaichi Ohira | 2017 | World Journal of Gastroenterology2017，23，31： | 3 |
| 2 | Sm-doped CsBr crystal as a new radio-photoluminescence (RPL) material显示文摘Radio-photoluminescence(RPL) is a phenomenon seen in luminescent materials in which the appearance of new photoluminescence(PL) emission is induced by an incident ionizing radiation such as X-rays; and the signal is stable even after the irradiation and during the PL measurement. Since the induced PL intensity is proportional to the irradiation dose, the RPL can be used in radiation measurements. The distinct advantage of RPL over the conventional thermally- or photo-stimulated luminescence(abbreviated as TSL or PSL) dosimeters is the stability of response signal. With an RPL detector, it allows us to readout the signal multiple time without signal fading. In this work, we discovered that CsB r:Sm showed an RPL phenomenon by X-ray irradiation, and we characterized this new material as an RPL detector. While the sample showed PL emissions mainly in the visible range, after an X-ray irradiation additional emissions could be observed in the red to near-infrared range around 650–850 nm and 900–1000 nm and longer. The RPL response was fairly stable overall, but very interestingly the 650–850 nm signal slightly increased while the 900–1000 nm decreased during PL readout. The dynamic range was confirmed over 1–10~4 mG y with linear response. | Go Okada Yutaka Fujimoto Hironori Tanaka Safa Kasap Takayuki Yanagida | 2016 | Journal of Rare Earths2016，34，8： | 2 |
| 3 | Intracorporeal esophagojejunal anastomosis after laparoscopic total gastrectomy for patients with gastric cancer显示文摘 | Hiroshi Okabe Kazutaka Obama Eiji Tanaka Akinari Nomura Jun-ichiro Kawamura Satoshi Nagayama Atsushi Itami Go Watanabe Seiichiro Kanaya Yoshiharu Sakai | 2009 | Surgical Endoscopy2009，，9： | 2 |
| 4 | Intracorporeal esophagojejunal anastomosis after laparoscopic total gastrectomy for patients with gastric cancer显示文摘 | Hiroshi Okabe Kazutaka Obama Eiji Tanaka Akinari Nomura Jun-ichiro Kawamura Satoshi Nagayama Atsushi Itami Go Watanabe Seiichiro Kanaya Yoshiharu Sakai | 2009 | Surgical Endoscopy2009，，9： | 1 |
| 5 | Lightness modification of color image for protanopia and deuteranopia显示文摘 | Go Tanaka Noriaki Suetake Eiji Uchino | 2010 | Optical Review2010，，1： | 1 |
| 6 | Simple lightness modification for color vision impaired based on Craik–O’Brien effect显示文摘 | Noriaki Suetake Go Tanaka Hayato Hashii Eiji Uchino | 2012 | Journal of the Franklin Institute2012，，6： | 1 |
| 7 | Mutations in 23S rRNA are associated with Clarithromyein resistance in Helicobacter pylori 显示文摘 | Versalovie J Shortridge D Kibler K Griffy MV Beyer J Flamm RK Tanaka SK Graham DY Go ME | 1996 | Antimierob Agents Chemotherapy1996，40，2： | 1 |
| 8 | Effect of Diesel Exhaust Particles on House Dust Mite-Induced Airway Eosinophilic Inflammation and Remodeling in Mice显示文摘 | Go Takahashi Hiroyuki Tanaka | 2010 | J Pharmacol Sci2010，112，2： | 1 |
| 9 | Motion reconstruction of the small carry-on impactor aboard Hayabusa2显示文摘Subsurface exploration is one of the most ambitious scientific objectives of the Hayabusa2 mission.A small device called small carry-on impactor(SCI)was developed to create an artificial crater on the surface of asteroid Ryugu.This enables us to sample subsurface materials,which will provide a window to the past.The physical properties of the resulting crater are also useful for understanding the internal structure of Ryugu.Accurate understanding of the crater and ejecta properties,including the depth of excavation of subsurface materials,requires accurate information on impact conditions.In particular,the impact angle is a critical factor because it greatly influences the size and shape of the crater.On April 5,2019,the Hayabusa2 spacecraft deployed the SCI at 500 m of altitude above the asteroid surface.The SCI gradually reduced its altitude,and it shot a 2 kg copper projectile into the asteroid 40 min after separation.Estimating the position of the released SCI is essential for determining the impact angle.This study describes the motion reconstruction of the SCI based on the actual operation data.The results indicate that the SCI was released with high accuracy. | Takanao Saiki Yuya Mimasu Yuto Takei Manabu Yamada Hirotaka Sawada K azunori Ogawa Naoko Ogawa Hiroshi Takeuchi Akira Miura Yuri Shimaki Koji Wada Rie Honda Yasuhiro Yokota Kei Shirai Naruhisa Sano Hirohito Ohtsuka Go Ono Kent Yoshikawa Shota Kikuchi Chikako Hirose Yukio Yamamoto Takahiro Iwata Masahiko Arakawa Seiji Sugita Satoshi Tanaka Fuyuto Terui Makoto Yoshikawa Satoru Nakazawa Sei-ichiro Watanabe Yuichi Tsuda | 2020 | Astrodynamics2020，4，4： | 0 |
| 10 | Hayabusa2’s station-keeping operation in the proximity of the asteroid Ryugu显示文摘The Japanese interplanetary probe Hayabusa2 was launched on December 3,2014 and the probe arrived at the vicinity of asteroid 162173 Ryugu on June 27,2018.During its 1.4 years of asteroid proximity phase,the probe successfully accomplished numbers of record-breaking achievements including two touchdowns and one artificial cratering experiment,which are highly expected to have secured surface and subsurface samples from the asteroid inside its sample container for the first time in history.The Hayabusa2 spacecraft was designed not to orbit but to hover above the asteroid along the sub Earth line.This orbital and geometrical configuration allows the spacecraft to utilize its high-gain antennas for telecommunication with the ground station on Earth while pointing its scientific observation and navigation sensors at the asteroid.This paper focuses on the regular station-keeping operation of Hayabusa2,which is called“home position”(HP)-keeping operation.First,together with the spacecraft design,an operation scheme called HP navigation(HPNAV),which includes a daily trajectory control and scientific observations as regular activities,is introduced.Following the description on the guidance,navigation,and control design as well as the framework of optical and radiometric navigation,the results of the HP-keeping operation including trajectory estimation and delta-V planning during the entire asteroid proximity phase are summarized and evaluated as a first report.Consequently,this paper states that the HP.keeping operation in the framework of HPNAV had succeeded without critical incidents,and the number of trajectory control delta-V was planned fficiently throughout the period. | Yuto Takei Takanao Saiki Yukio Yamamoto Yuya Mimasu Hiroshi Takeuchi Hitoshi Ikeda Naoko Ogawa Fuyuto Terui Go Ono Kent Yoshikawa Tadateru Takahashi Hirotaka Sawada Chikako Hirose Shota Kikuchi Atsushi Fuji Takahiro Iwata Satoru Nakazawa Masahiko Hayakawa Ryudo Tsukizaki Satoshi Tanaka Masanori Matsushita Osamu Mori Daiki Koda Takanobu Shimada Masanobu Ozaki Masanao Abe Satoshi Hosoda Tatsuaki Okada Hajime Yano Takaaki Kato Seiji Yasuda Kota Matsushima Tetsuya Masuda Makoto Yoshikawa Yuichi Tsuda | 2020 | Astrodynamics2020，4，4： | 0 |
| 11 | Development of a Topic Providing System with Inferences of Behaviors from Daily Life显示文摘 | Seiji Suzuki Go Tanaka Chiaki Doi Tomohiro Nakagawa Hiroshi Inamura Ken Ohta Tadanori Mizuno Hiroshi Mineno | 2013 | Computer Technology and Application2013，4，3： | 0 |
| 12 | Comparison of clinicopathological characteristics between resected ampullary carcinoma and carcinoma of the second portion of the duodenum显示文摘BACKGROUND Few studies compared the oncological and biological characteristics between ampullary carcinoma(AC) and cancer of the second portion of the duodenum(DC-Ⅱ), although both tumors arise from anatomically close locations.AIM To elucidate differences in clinicopathological characteristics, especially the patterns of lymph node metastasis(LNM), between AC and DC-Ⅱ.METHODS This was a retrospective cohort study of 80 patients with AC and 27 patients with DC-Ⅱ who underwent pancreaticoduodenectomy between January 1998 and December 2018 in two institutions. Clinicopathological factors, LNM patterns, and prognosis were compared between the two groups.RESULTS The patients with AC and DC-Ⅱ did not exhibit significant differences in 5-year overall survival(66.0% and 67.1%, respectively) and 5-year relapse-free survival(63.5% and 62.2%, respectively). Compared to the patients with DC-Ⅱ, the rate of preoperative biliary drainage was higher(P = 0.042) and the rates of digestive symptoms(P = 0.0158), ulcerative-type cancer(P < 0.0001), large tumor diameter(P < 0.0001), and advanced tumor stage(P = 0.0019) were lower in the patients with AC. The LNM rates were 27.5% and 40.7% in patients with AC and DC-Ⅱ,respectively, without significant difference(P = 0.23). The rates of LNM to hepatic nodes(N-He)and pyloric nodes(N-Py) were significantly higher in patients with DC-Ⅱ than in those with AC(metastasis to N-HE: 18.5% and 5% in patients with DC-Ⅱ and AC, respectively;P = 0.0432;metastasis to N-Py: 11.1% and 0% in patients with DC-Ⅱ and AC, respectively;P = 0.0186)CONCLUSION Although there were no significant differences in the prognosis and recurrence rates between the two groups, metastases to N-He and N-Py were more frequent in patients with DC-Ⅱ than in those with AC. | Kohei Nishio Kenjiro Kimura Akihiro Murata Go Ohira Hiroji Shinkawa Shintaro Kodai Ryosuke Amano Shogo Tanaka Sadatoshi Shimizu Shigekazu Takemura Akishige Kanazawa Shoji Kubo Takeaki Ishizawa | 2022 | World Journal of Gastrointestinal Surgery2022，14，11： | 0 |
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