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| 1 | Endoscopic findings in patients with Schatzki rings:Evidence for an association with eosinophilic esophagitis显示文摘AIM:To investigate endoscopic findings in patients with Schatzki rings(SRs) with a focus on evidence for eosinophilic esophagitis(EoE).METHODS:We consecutively approached all adult patients scheduled for elective outpatient upper endoscopy for a variety of indications at the German Diagnostic Clinic,Wiesbaden,Germany between July 2007 and July 2010.All patients with endoscopically diagnosed SRs,defined as thin,symmetrical,mucosal structures located at the esophagogastric junction,were prospectively registered.Additional endoscopic findings,clinical information and histopathological findings with a focus on esophageal eosinophilia(≥ 20 eosinophils/high power field) were recorded.The criteria for active EoE were defined as:(1) eosinophilic tissue infiltration ≥ 20 eosinophils/hpf;(2) symptoms of esophageal dysfunction;and(3) exclusion of other causes of esophageal eosinophilia.Gastroesophageal reflux disease was excluded by proton pump inhibitor treatment prior to endoscopy.The presence of ≥ 20 eosinophils/hpf in esophageal biopsies in patients that did not fulfil the criteria of EoE was defined as esophageal hypereosinophilia.RESULTS:A SR was diagnosed in 171(3.3%;128 males,43 females,mean age 66 ± 12.9 years) of the 5163 patients that underwent upper gastrointestinalendoscopy.Twenty of the 116 patients(17%) from whom esophageal biopsies were obtained showed histological hypereosinophilia(≥ 20 eosinophils/hpf).Nine of these patients(8 males,1 female,mean age 49 ± 10 years) did not fulfill all diagnostic criteria of EoE,whereas in 11(9%) patients with ≥ 20 eosinophils/hpf,a definite diagnosis of EoE was made.Three of the 11 patients(27%) with definite EoE had no suspicious endoscopic features of EoE.In contrast,in the 25 patients in whom EoE was suspected by endoscopic features,EoE was only confirmed in 7(28%) patients.Patients with EoE were younger(mean age 41.5 ± 6.5 vs 50.5 ± 11.5 years,P = 0.012),were more likely to have a history of allergies(73% vs 29%,P = 0.007) and complained more often of dysphagia(91% vs 34%,P = 0.004) and food impaction(36% vs 6%,P = 0.007) than patients without EoE.Endoscopically,additional webs were found significantly more often in patients with EoE than in patients without EoE(36% vs 11%,P = 0.04).Furthermore,the SR had a tendency to be narrower in patients with EoE than in those without EoE(36% vs 18%,P = 0.22).The percentage of males(73% vs 72%,P = 1.0) and frequency of heartburn(27% vs 27%,P = 1.0) were not significantly different in both groups.The 9 patients with esophageal hypereosinophilia that did not fulfil the diagnostic criteria of EoE were younger(mean age 49 ± 10 years vs 58 ± 6 years,P = 0.0008) and were more likely to have a history of allergies(78% vs 24%,P = 0.003) than patients with < 20 eosinophils/hpf.Predictors of EoE were younger age,presence of dysphagia or food impaction and a history of allergies.CONCLUSION:A significant proportion of patients with SRs also have EoE,which may not always be suspected according to other endoscopic features. | Michaela Müller Alexander J Eckardt Annette Fisseler-Eckhoff Susanne Haas Ines Gockel Till Wehrmann | 2012 | World Journal of Gastroenterology2012，18，47： | 2 |
| 2 | Is the schatzki ring a unique esophageal entity?显示文摘AIM:To study,whether the association of Schatzki rings with other esophageal disorders support one of the theories about its etiology.METHODS:From 1987 until 2007,all patients with newly diagnosed symptomatic Schatzki rings (SRs) were prospectively registered and followed.All of them underwent structured interviews with regards to clinical symptoms,as well as endoscopic and/or radiographic examinations.Endoscopic and radiographic studies determined the presence of an SR and additional morphological abnormalities.RESULTS:One hundred and sixty-seven patients (125 male,42 female) with a mean age of 57.1±14.6 years were studied.All patients complained of intermittent dysphagia for solid food and 113 (79.6%) patients had a history of food impaction.Patients experienced symptoms for a mean of 4.7±5.2 years before diagnosis.Only in 23.4% of the 64 patients who had endoscopic and/or radiological examinations before their first presentation to our clinic,was the SR previously diagnosed.At presentation,the mean ring diameter was 13.9±4.97 mm.One hundred and sixty-two (97%) patients showed a sliding hiatal hernia.Erosive reflux esophagitis was found in 47 (28.1%) patients.Twenty-six (15.6%) of 167 patients showed single or multiple esophageal webs;five (3.0%) patients exhibited eosinophilic esophagitis;and four (2.4%) had esophageal diverticula.Four (7%) of 57 patients undergoing esophageal manometry had nonspecific esophageal motility disorders.CONCLUSION:Schatzki rings are frequently associated with additional esophageal disorders,which support the assumption of a multifactorial etiology.Despite typical symptoms,SRs might be overlooked. | Michaela Müller Ines Gockel Philip Hedwig Alexander J Eckardt Kathrin Kuhr Jochem Knig Volker F Eckardt | 2011 | World Journal of Gastroenterology2011，17，23： | 2 |
| 3 | Retinoic acid receptor beta silences human papillomavirus-18 oncogene expression by induction of de novo methylation and heterochromatinization of the viral control region显示文摘 | De-Castro Arce J Gockel KE Rosl F | 2007 | J Biol Chem2007，282，28： | 1 |
| 4 | Thalidomide induces apoptosis in human monocytes by using a cytochrome c-dependent pathway显示文摘 | Gockel HR Lugering A Heidemann J | 2004 | Immunol2004，172，8： | 1 |
| 5 | Achalasia: will genetic studies provide insights? 显示文摘 | Gockel HR Schumacher J Gockel I | 2010 | Hum Genet2010，128，4： | 1 |
| 6 | Expression of chomokine receptor CXCR4 in esophageal squamous cell and adenocarcinoma 显示文摘 | Gockel J Schimanski CC Heinrich C | 2006 | BMC Cancer2006，6，： | 1 |
| 7 | Dissatisfaction with post-opera- tive pain management-A prospective analysis of 1071 patients 显示文摘 | Roth W Kling J Gockel I | 2005 | Acute Pain2005，7，2： | 1 |
| 8 | Transoral thyroid and parathyroid surgery—Development of a new transoral technique显示文摘 | Elias Karakas Thorsten Steinfeldt Andreas Gockel Thorsten Schlosshauer Carsten Dietz Jens J?ger Reiner Westermann Frank Sommer Hans Rudolf Richard Cornelia Exner Andreas M. Sesterhenn Detlef K. Bartsch | 2011 | Surgery2011，，1： | 1 |
| 9 | Application,feasibility,and efficacy of a combined intravascular ultrasound and stent delivery system:results from a prospective multicenter trial显示文摘 | Gockel K Koschyk D | 2005 | J Interv Cardiol2005，18，5： | 1 |
| 10 | Thalidomide induces apoptosis in human monocytes by using a cytochrome c-dependent pathway显示文摘 | Gockel HR Lügering A Heidemann J | 2004 | J Immunol2004，172，： | 1 |
| 11 | Thalidomideinduces apoptosis in human monocytes by using a cytochromec-dependent pathway显示文摘 | Gockel HR Lügering A Heidemann J | 2004 | J Immunol2004，172，8： | 1 |
| 12 | Application,feasibility,and efficacy of a combined intravascular ultrasound and stent delivery system:results from a prospective multicenter trial显示文摘 | Rieber J Gockel K Koschyk D | 2005 | J Interv Cardiol2005，18，5： | 1 |
| 13 | Achalasia:will genetic studies provide insights显示文摘 | Gockel HR Schumacher J Gockel I | 2010 | Hum Genet2010，128，4： | 1 |
| 14 | Quality of life after subtotal resection and gastrectomy for gastric cancer显示文摘 | Gockel I Pietzka S J unginger T | 2005 | Chirurg2005，76，3： | 1 |
| 15 | Quantitative genetic analysis of natural variation in body size in Droso- phila melanogaster 显示文摘 | Gockel J Robinson S J Kennington W J | 2002 | Heredity2002，89，2： | 1 |
| 16 | Image cytometric DNA analysis of mucosal biopsies in patients with primary achalasia显示文摘瞄准:为随后的快速的诊断在弛缓不能病人的粘膜活体检视决定 DNA 非整倍性。方法:从中间的活体检视第三根食管与弛缓不能在 15 个病人被获得。染色的 Immunohistochemical 为 p53 为 Ki67 和 PAb 1801 与单音的同种细胞的抗体 MIB-1 被执行,除了为发育异常的常规 histologic 考试。新鲜活体检视材料的原子核是酶的联盟者并且机械地孤立,并且 DNA 内容在福尔根的染色以后与图象血细胞计数被决定。恶意分级的 DNA 根据 Boecking 被估计决定在正常双山峰附近注意的 DNA 价值的可变性。测量的进一步的索引包括了整倍体的率,和 5c- , 7c-exceeding 和 9c-exceeding 评价。结果:组织学的考试没表明发育异常;当时 MIB-1 (基础) 在 8/15 弛缓不能标本显示出阳性反应, p53 在所有标本是否定的。图象 cytometric DNA 分析在 4/15 (26.7%) 检测了非整倍性标本。从有象标本一样的有鳞的房间癌的 15 个病人的样品只获得了 2 对作为参考测试服务的肿瘤厘米近似。象 9 件 peritumoral 样品(9/15 ) 一样的所有癌(15/15 ) 是一整倍体。从有 peritumoral 和癌标本的弛缓不能病人的活体检视的比较统计上揭示了有效差量考虑整倍体的率(双:P <
0.0001;四倍的:P = 0.001 ) ,根据 Boecking 恶意分级(P <
0.0001 ) 并且 5c-(P <
0.0001 ) , 7c-(P <
0.0001 ) ,并且 9c-(P = 0.0001 ) 在各自的顺序与 progredient DNA 改变超过率。结论:发现那 DNA 非整倍性被图象血细胞计数与弛缓不能在病人的食道的标本识别,它可能由于在 27% 病人作为癌前期损害介绍的特定的染色体改变,导致我们断定图象血细胞计数代表一个珍贵屏蔽工具。 | I Gockel P K(a|¨)mmerer J Brieger UR Heinrich WJ Mann F Bittinger VF Eckardt T Junginger | 2006 | World Journal of Gastroenterology2006，12，19： | 0 |
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