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| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | Distributions that are both subexponential and in the domain of an extreme-value distribution显示文摘 | Goldie C M Resnick S | 1988 | Adv Appl Probab1988，20，： | 1 |
| 3 | Withholding of drip irriga- tion between transplanting and flowering increases the yield of field- grown tomato under plastic mulch 显示文摘 | Ngouajio M Wang Guangyao Goldy R | 2007 | Agricultural Water Manage- ment2007，87，3： | 1 |
| 4 | Second trimester screening for Down's syndrome :7 years experience 显示文摘 | Beaman J M Goldie DJ | 2001 | J Med Sereen2001，8，3： | 1 |
| 5 | Force platform measures for evaluating postural control: reliability and validity 显示文摘 | Goldie P A Bach T M Evans O M | 1989 | Arch Phys Med Rehabil1989，70，： | 1 |
| 6 | A new family of cin-chona-derived bifunctional asymmetric phase-trans-fer catalysts: application to the enantio-and diastere-oselective nitro-mannich reaction of amidosulfones显示文摘 | Johnson M Rattley S Sladoj evich F Barber M Nunez G Goldys M Dixon J | 2012 | Org Lett2012，14，： | 1 |
| 7 | Catalytic Antibodies Generated By in Vitro Immunization 显示文摘 | Stahl M Goldie B Bourne S P | 1995 | J Am Chem Soc1995，117，18： | 1 |
| 8 | Withholding of drip irrigation between transplanting and flowering increases the yield of field-grown tomato under plastic mulch显示文摘 | NGOUAJIO M WANG G GOLDY R | 2007 | Agricultural water management2007，87，3： | 1 |
| 9 | Subexponentiality and infinite divisibility显示文摘 | Embrechts P Goldie C M Veraverbeke N | 1979 | Z Wahrscheinlichkeitsth1979，49，： | 1 |
| 10 | Second trimester screening for Down's syndrome:7 years experience显示文摘 | Beaman J M Goldie D J | 2001 | J Med Screen2001，8，3： | 1 |
| 11 | Introducing HPV Vaccine in Developing Countries Key Challenges and Issues显示文摘 | Agosti J M Goldie S J | 2007 | N Engl J Med2007，356，19： | 1 |
| 12 | Bilobalide,a unique constituent of Ginkgo biloba,inhibits inflammatory pain in rats显示文摘 | Goldie M Dolan S | 2013 | Behavioural Pharmacology2013，24，4： | 1 |
| 13 | Distributions that are both subexponential and in the domain of attraction of an extreme value distri- butionP显示文摘 | Goldie C M Resbick S | 1988 | Advance in Applied Probability1988，20，： | 1 |
| 14 | Withholding of drip irrigation between transplanting and flowering increases the yield of field grown tomato under plastic mulch显示文摘 | Ngouajio M Wang G Goldy R | 2007 | Agricultural Water Man agement2007，87，3： | 1 |
| 15 | Extend- ed-range linear magnetostrictive motor with double- sided three-phase stators 显示文摘 | KIM W J GOLDIE J H GERVER M J | 2002 | IEEE Trans Industry Applications2002，38，3： | 1 |
| 16 | A critical assessment of the factors affecting reporter gene assays for promoter SNP function: a reassessment of - 308 TNF polymorphism function using a novel integrated reporter system 显示文摘 | Karimi M Goldie LC Cruickshank MN | 2009 | Eur J Hum Genet2009，17，11： | 1 |
| 17 | Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons显示文摘 | Goldie BJ Dun MD Lin M | 2014 | Nucleic Acids Res2014，42，14： | 1 |
| 18 | Activity-associated miRNA are packaged in Maplb-enriched exosomes released from depolarized neurons显示文摘 | Goldie B J Dun MD Lin M | 2014 | Nucleic Acids Res2014，42，14： | 1 |
| 19 | Force platform measures for evaluating postural control:Reliability and validi- ty显示文摘 | GOLDIE P A BACH T M EVANS O M | 1989 | Arch Phys Med Rehabil1989，70，7： | 1 |
| 20 | On convolution tails 显示文摘 | EMBRECHTS P GOLDIE C M | 1982 | Stochastic Process Appl1982，13，： | 1 |
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