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| 1 | Regulation of TH17 cell differentiation by innate immune signals显示文摘在抗原刺激之上,天真的 T 助手房间区分进不同的系达到专业化性质和受动器功能。T H 17 房间, CD4 + 受动器 T 房间的一个最近识别的系,对真菌和细胞外的细菌在有免疫力的防卫起一个关键作用,而且贡献许多自体免疫的条件的致病。T H 17 房间被在 T 房间表明小径和 transcriptional 管理者的一个复杂网络安排。当 T 房间内在的小径的参与广泛地被描述了时,我们开始就正在欣赏怎么 T H 17 房间开发被外来的小径塑造,特别天生的有免疫力的信号。树枝状的房间(DC ) ,到天生的桥牌的最重要的房间类型和适应免疫,驱动器 T 由提供 antigenic, costimulatory 和 cytokine 的 H 17 房间区别发信号。这被 DC 被天生、煽动性的信号的识别经由模式识别受体, cytokine 受体和接着激活细胞内部的发信号网络的另外的 immunomodulatory 受体调停。特别地, p38α地图 kinase 作为一条批评小径出现了编程序 DC 依赖的 T 由在 DC 集成多重有启发性的信号的 H 17 房间区别。这里,我们在导出 DC 的天生的有免疫力的信号由驾驶 T H 17 房间区别。 | Gonghua Huang Yanyan Wang Hongbo Chi | 2012 | Cellular & Molecular Immunology2012，9，4： | 24 |
| 2 | Molecular identification of Echinococcus species from eastern and southern Qinghai, China, based on the mitochondrial cox1 gene显示文摘 | Junying Ma Hu Wang Gonghua Lin Philip S. Craig Akira Ito Zhenyuan Cai Tongzuo Zhang Xiumin Han Xiao Ma Jingxiao Zhang Yufang Liu Yanmei Zhao Yongshun Wang | 2012 | Parasitology Research2012，，1： | 2 |
| 3 | Synthesis and nematicidal activity of piperazinedione derivatives based on the natural product Barettin显示文摘Nematodes are serious constraints of crop production worldwide. However, the traditional nematicides suffer from the side-effects, including environmental and human toxicity. Herein, more than 70 novel piperazinedione derivatives based on the natural product Barettin were synthesized and evaluated against the root-knot nematode Meloidogyne incognita(M. incognita). While most of synthesized compounds exhibited certain nematicidal activity at high concentration, the best one showed a nematicidal activity of 75% at 2.4 mmol/L. | Haiyang Sun Hui Li Jiayi Wang Gonghua Song | 2018 | Chinese Chemical Letters2018，29，6： | 2 |
| 4 | A review on COVID-19 transmission,epidemiological features,prevention and vaccination显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused hundreds of millions of infections and millions of deaths over past two years.Currently,many countries have still not been able to take the pandemic under control.In this review,we systematically summarized what we have done to mitigate the COVID-19 pandemic,from the perspectives of virus transmission,public health control measures,to the development and vaccination of COVID-19 vaccines.As a virus most likely coming from bats,the SARS-CoV-2 may transmit among people via airborne,faecal-oral,vertical or foodborne routes.Ourmeta-analysis suggested that the R0 of COVID-19 was 2.9(95%CI:2.7–3.1),and the estimates in Africa and Europe could be higher.The median Rt could decrease by 23–96%following the nonpharmacological interventions,including lockdown,isolation,social distance,and face mask,etc.Comprehensive intervention and lockdown were the most effective measures to control the pandemic.According to the pooled R0 in our meta-analysis,there should be at least 93.3%(95%CI:89.9–96.2%)people being vaccinated around the world.Limited amount of vaccines and the inequity issues in vaccine allocation call for more international cooperation to achieve the antiepidemic goals and vaccination fairness. | Yuqin Zhang Gonghua Wu Shirui Chen Xu Ju Wumitijiang Yimaer Wangjian Zhang Shao Lin Yuantao Hao Jing Gu Jinghua Li | 2022 | Medical Review2022，2，1： | 2 |
| 5 | Application of ultrasound irradiation for reactions of N-hydroxymethylation显示文摘 | Zhong Wujun Song Gonghua Peng Yanqing | 2000 | Synthetic Communications2000，30，20： | 1 |
| 6 | Palladium nanoparticles supported on functional ionic liquid modified magnetic nanoparticles as recyclable catalyst for room temperature Suzuki reaction显示文摘 | Jiayi W Beiling X Haiyang S Gonghua S | 2013 | Tetrahedron Letters2013，54，： | 1 |
| 7 | Synthesis and antifeedant activity of new oxadiazolyl 3 (2H) -pyridazinones 显示文摘 | Song C Xuhong Q Gonghua S | 2003 | J Agric Food Chem2003，51，1： | 1 |
| 8 | Aqueous-Phase, Palladium-Catalyzed Heck Reaction: The Significant Role of CN-containing Counter Anion显示文摘水溶性的 diol-functionalized imidazolium 离子的液体 1,从 2,2 二度(1-methyl-methyl-imidazolium ) 准备了 propane-1,3-diol 溴化物,钾氢氧化物,和 malononitrile,在温和条件下面在水的阶段与 acrylates 为芳基卤化物的催化钯的 arylation 被用作有效没有磷化氢的 ligand。与包含 CN 阴离子协调 diol-functionalized imidazolium 阳离子的行动的 synergistic 在改进催化剂的活动和稳定性起了关键作用,这被发现。 | Cai Yueqin Song Gonghua Zhou Xiaoying | 2012 | Chinese Journal of Chemistry2012，30，12： | 1 |
| 9 | The effects of aB-crystallin on mitochondrial death pathway during hydrogen peroxide induced apoptosis显示文摘 | Shuang Liu Gonghua Deng Zizhi Tu | 2005 | EXCLI Journal2005，4，： | 1 |
| 10 | Regulation of JNK and p38MAPK in the immune system:Signal integration,propagation and ter- mination显示文摘 | Gonghua Huang Lewis Zhichang Shi Hongbo Chi | 2009 | Cytokine2009，48，3： | 1 |
| 11 | Solution phase parallel synthesis of 4-aminophenyl ethers using a carboxyl-functionalized ionic liquid as support 显示文摘 | Peng Yanqing Yi Fengping Song Gonghua | 2005 | Monatshefte fur Chemie2005，136，： | 1 |
| 12 | Amino-functionalized Ionic Liquid as an Efficient and Recyclable Catalyst for Knoevenagel Reactions in Water显示文摘 | Yueqin Cai Yanqing Peng Gonghua Song | 2006 | Catalysis Letters (-)2006，，1： | 1 |
| 13 | The role of reactive oxygen species in silicon dioxide nanoparticle- induced cytotoxicity and DNA damage in HaCaT cells显示文摘 | GONG Chunmei TAO Gonghua YANG Linqing | 2012 | Molecular Biology Reports2012，39，4： | 1 |
| 14 | Investigation on the Coordination Mode of IL-Supported Diols Used as Phosphine-Free Ligands for Palladium Catalyzed Heck Reaction显示文摘为钯用作没有磷化氢的 ligands 的支持 IL 的 diols 的协作模式催化哎呀反应被调节他们的作文调查了。在有金属 Pd 在的这些支持 IL 的 diols 的协作的差别哎呀反应与阳离子戒指的变化有关,在反应导致 Pd 催化剂的不同活动。试验性的结果显示 Pd 催化剂的活动主要被阳离子戒指的电子密度影响。比作 pyridinium 和 piperidinium 阳离子, imidazolium 阳离子显示出最好的协作到金属 Pd。同时, C-2 氢和烷基方面链的长度也在协作上有影响。 | Yueqin Cai Gonghua Song Xiao Chen | 2013 | Chinese Journal of Chemistry2013，31，10： | 1 |
| 15 | Dramatically accelerated synthesis of β-aminoketones via aqueous Mannich reaction under combined microwave and ultrasound irradiation 显示文摘 | Yanqing Peng Ruiling Dou Gonghua Song | 2005 | Syrdett2005，14，： | 1 |
| 16 | Reusable Pd nanoparticles immobilized on functional ionic liquid co-poly- merized with styrene for Suzuki reactions in water-ethanol solu- tion显示文摘 | JIAYI WANG GONGHUA SONG YANQING PENG | 2011 | Tetrahedron Letters2011，52，13： | 1 |
| 17 | The kinase p38αfunctions in dendritic cells to regulate Th2-cell differentiation and allergic inflammation显示文摘Dendritic cells(DCs)play a critical role in controlling T helper 2(Th2)cell-dependent diseases,but the signaling mechanism that triggers this function is not fully understood.We showed that p38αactivity in DCs was decreased upon HDM stimulation and dynamically regulated by both extrinsic signals and Th2-instructive cytokines.p38α-specific deletion in cDC1s but not in cDC2s or macrophages promoted Th2 responses under HDM stimulation.Further study showed that p38αin cDC1s regulated Th2-cell differentiation by modulating the MK2−c-FOS−IL-12 axis.Importantly,crosstalk between p38α-dependent DCs and Th2 cells occurred during the sensitization phase,not the effector phase,and was conserved between mice and humans.Our results identify p38αsignaling as a central pathway in DCs that integrates allergic and parasitic instructive signals with Th2-instructive cytokines from the microenvironment to regulate Th2-cell differentiation and function,and this finding may offer a novel strategy for the treatment of allergic diseases and parasitic infection. | Miaomiao Han Jingyu Ma Suidong Ouyang Yanyan Wang Tingting Zheng Peishan Lu Zihan Zheng Weiheng Zhao Hongjin Li Yun Wu Baohua Zhang Ran Hu Kinya Otsu Xinguang Liu Ying Wan Huabin Li Gonghua Huang | 2022 | Cellular & Molecular Immunology2022，19，7： | 1 |
| 18 | SiO 2nanoparticles induce global genomic hypomethylation in HaC aT cells显示文摘 | GONG Chunmei TAO Gonghua YANG Linqing | 2010 | Biochem Biophys Res Commun2010，397，3： | 1 |
| 19 | Microwave-assisted clean synthesis of 6-aryl-2, 4-diamino-1,3, 5-triazines in 显示文摘 | PENG Yanqing SONG Gonghua | 2004 | Tetrahedeon Letters2004，45，27： | 1 |
| 20 | Methylation of PARP-1 promoter involved in the regulation of nano-SiO 2-induced decrease of PARP-1mRNA expression显示文摘 | GONG Chunmei TAO Gonghua YANG Linqing | 2012 | Toxicol Lett2012，209，3： | 1 |
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