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| 1 | Biliary phosphatidylcholine and lysophosphatidylcholine profiles in sclerosing cholangitis显示文摘AIM:To analyze phospholipid profiles in intrahepatic bile from patients with primary sclerosing cholangitis(PSC)and secondary sclerosing cholangitis(SSC).METHODS:Intrahepatic bile specimens collected via endoscopic retrograde cholangiography from 41 patients were analyzed.Fourteen of these patients were diagnosed with PSC,10 with SSC,11 with choledocholithiasis or no identifiable biliary disease,and 6 with cholangiocellular carcinoma(CCC).Bile acid,cholesterol,protein,and bilirubin contents as well as pancreas lipase activity in bile were determined by biochemical methods.Phosphatidylcholine(PC)and lysophosphatidylcholine(LPC)species were quantified using nanoelectrospray ionization tandem mass spectrometry.RESULTS:Bile from all the examined patient groups showed a remarkably similar PC and LPC species composition,with only minor statistical differences.Total biliary PC concentrations were highest in controls(8030±1843 mol/L)and lowest in patients with CCC(1969±981 mol/L)(P=0.005,controls vs SSC and CCC,respectively,P<0.05).LPC contents in bile were overall low(4.2%±1.8%).Biliary LPC/PC ratios and ratios of biliary PC to bilirubin,PC to cholesterol,PC to protein,and PC to bile acids showed no intergroup differences.CONCLUSION:PC and LPC profiles being similar in patients with or without sclerosing cholangitis,these phospholipids are likely not of major pathogenetic importance in this disease group. | Annika Gauss Robert Ehehalt Wolf-Dieter Lehmann Gerhard Erben Karl-Heinz Weiss Yvonne Schaefer Petra Kloeters-Plachky Adolf Stiehl Wolfgang Stremmel Peter Sauer Daniel Nils Gotthardt | 2013 | World Journal of Gastroenterology2013，19，33： | 3 |
| 2 | Is stenting necessary after balloon dilation of post-transplantation biliary strictures? Results of a prospective comparative study显示文摘 | H. Kulaksiz K. Weiss D. Gotthardt G. Adler W. Stremmel A. Schaible A. Dogan A. Stiehl P. Sauer | 2008 | Endoscopy2008，，09： | 2 |
| 3 | Endoscopic Retrograde Cholangiopancreatography in Diagnosis and Treatment of Primary Sclerosing Cholangitis显示文摘 | Daniel Gotthardt Adolf Stiehl | 2010 | Clinics in Liver Disease2010，，2： | 1 |
| 4 | Genotype-Dependent Brown Adipose Tissue Activation in Patients With Pheochromocytoma and Paraganglioma显示文摘 | Puar T van Berkel A Gotthardt M | 2016 | J Clin Endocrinol Metab2016，101，1： | 1 |
| 5 | The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase显示文摘 | Schmutzler C Bacinski A Gotthardt I | 2008 | Endocrinology2008，148，6： | 1 |
| 6 | Nuclear magnetic resonance studies of martensific phase transformation in NiTi shape memory alloys显示文摘 | Dintitropoulosc Gotthardt C R | 2002 | Materials Transactions2002，43，5： | 1 |
| 7 | Endocrine disruptors and the thyroid gland: a combined in vitro and in vivo analysis of potential new biomarkers 显示文摘 | SCHMUTZLER C GOTTHARDT I HOFMAN P J | 2007 | Environ Health Perspect2007，1151，： | 1 |
| 8 | Interaction between microstructure and multiple-step transformation in binary NiTi alloys using in-situ transmission electron microscopy observations显示文摘 | BATAILLARD L BIDAUX J E GOTTHARDT R | 1998 | Philosophical Magazine A1998，78，： | 1 |
| 9 | Endoplasmic reliculum stress sensing in the unfolded protein eespense 显示文摘 | Gardner BM Pincus D Gotthardt K | 2013 | Cold Spring Harb Perspect Biol2013，5，01： | 1 |
| 10 | German Randomized Acupuncture Trial for chronic shoulder pain ( GRASP)-a pragmatic, controIled, patient- blinded,multi-centre trial in an outpatient care environment 显示文摘 | MOLSBERGER A F SCHNEIDER T GOTTHARDT H | 2010 | Pain2010，151，1： | 1 |
| 11 | Endoplasmic retieulum stress sensing in the unfolded protein response 显示文摘 | Gardner B M Pineus D Gotthardt K | 2013 | Cold Spring Harb Perspect B/o/2013，5，01： | 1 |
| 12 | Endoplasmic reticulum stress sensing in the unfolded protein response 显示文摘 | Gardner BM Pincus D Gotthardt K | 2013 | Cold Spring Harb Perspect Biol2013，5，01： | 1 |
| 13 | Endoplasmic reticu- lum stress sensing in the unfolded protein response 显示文摘 | Gardner B M Pincus D Gotthardt K | 2013 | Cold Spring Harb Perspect Biol2013，5，01： | 1 |
| 14 | Localization of the Wilson disease protein in murine intestine 显示文摘 | Weiss KH Wurz J Gotthardt D | 2008 | J Anat2008，213，3： | 1 |
| 15 | Reeler/Disa-bled-like disruption of neuronal migration in knockout mice lackingthe VLDL receptor and ApoE receptor 2显示文摘 | Trommsdorff M Gotthardt M Hiesbei-er T | 1999 | Cell1999，97，6： | 1 |
| 16 | Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci显示文摘 | Trine Folseraas Espen Melum Philipp Rausch Brian D. Juran Eva Ellinghaus Alexey Shiryaev Jon K. Laerdahl David Ellinghaus Christoph Schramm Tobias J. Weismüller Daniel Nils Gotthardt Johannes Roksund Hov Ole Petter Clausen Rinse K. Weersma Marcel Janse Ki | 2012 | Journal of Hepatology2012，，2： | 1 |
| 17 | Intestinal transplantation: review of operative techniques显示文摘 | Arash Nickkholgh Pietro Contin Kareem Abu‐Elmagd Mohammad Golriz Daniel Gotthardt Christian Morath Peter Schemmer Arianeb Mehrabi | 2013 | Clin Transplant2013，，： | 1 |
| 18 | Endocrine disruptors and the thyroid gland-a combined in vitro and in vivo analysis of potential new biomarkers显示文摘 | Schmutzler C Gotthardt I Hofmann P J | | 0，，1： | 1 |
| 19 | The role of bone scintigraphy in patients with Erdheim-Chester disease 显示文摘 | Gotthardt M Weleke U Brandt D | 2000 | Clin Nucl Med2000，25，6： | 1 |
| 20 | Nuclear medicine imaging and therapy of neuroendoerine tumours 显示文摘 | Gotthardt M Dijkgraaf I Boerman OC | 2006 | Cancer Ima- ging2006，6，： | 1 |
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