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| 1 | Sustained low diffusing capacity in hepatopulmonary syndrome after liver transplantation显示文摘AIM: To study the presence of sustained low diffusing capacity (DLCO) after liver transplantation (LT) in patients with hepatopulmonary syndrome (HPS).METHODS: Six patients with mild-to-severe HPS and 24 without HPS who underwent LT were prospectively followed before and after LT at mid-term (median, 15 mo). HPS patients were also assessed at long-tem (median, 86 mo).RESULTS: Before LT, HPS patients showed lower PaO2 (71 ± 8 mmHg), higher AaPO2 (43 ± 10 mmHg) and lower DLCO (54% ± 9% predicted), due to a combination of moderate-to-severe ventilation-perfusion (VA/Q) imbalance, mild shunt and diffusion limitation, than non-HPS patients (94 ± 4 mmHg and 19 ± 3 mmHg, and 85% ± 3% predicted, respectively) (P < 0.05 each). Seven non-HPS patients had also reduced DLCO (70% ± 4% predicted).At mid- and long-term after LT, compared to pre-LT, HPS patients normalized PaO2 (91 ± 3 mmHg and 87 ± 5 mmHg), AaPO2 (14 ± 3 mmHg and 23 ± 5 mmHg) and all VA/Q descriptors (P < 0.05 each) without changes in DLCO (53% ± 8% and 56% ± 7% predicted, respectively). Post-LT DLCO in non-HPS patients with pre-LT low DLCO was unchanged (75% ± 6% predicted).CONCLUSION: While complete VA/Q resolution in HPS indicates a reversible functional disturbance, sustained low DLCO after LT also present in some non-HPS patients, points to persistence of sub-clinical liver-induced pulmonary vascular changes. | Graciela Martínez-Pallí Federico P Gómez Joan A Barberà Miquel Navasa Josep Roca Robert Rodríguez-Roisin Felip Burgos Conchi Gistau | 2006 | World Journal of Gastroenterology2006，12，36： | 6 |
| 2 | Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice显示文摘AIM:To study the action of aminoguanidine on pancreatic cancer xenografts in relation to cell proliferation,apoptosis,redox status and vascularization.METHODS:Xenografts of PANC-1 cells were developed in nude mice. The animals were separated into two groups:control and aminoguanidine treated. Tumor growth,survival and appearance of metastases were determined in vivo in both groups. Tumors were excised and ex vivo histochemical studies were performed. Cell growth was assessed by Ki-67 expression. Apoptosis was studied by intratumoral expression of B cell lymphoma-2 protein (Bcl-2) family proteins and Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (Tunel). Redox status was evaluated by the expression of endothelial nitric oxide synthase (eNOS),catalase,copper-zinc superoxide dismutase (CuZnSOD),manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). Finally,vascularization was determined by Massons trichromic staining,and by VEGF and CD34 expression.RESULTS:Tumor volumes after 32 d of treatment by aminoguanidine (AG) were significantly lower than in control mice (P < 0.01). Median survival of AG mice was significantly greater than control animals (P < 0.01). The appearance of both homolateral and contralateral palpable metastases was significantly delayed in AG group. Apoptotic cells,intratumoral vascularization (trichromic stain) and the expression of Ki-67,Bax,eNOS,CD34,VEGF,catalase,CuZnSOD and MnSOD were diminished in AG treated mice (P < 0.01),while the expression of Bcl-2 and GPx did not change.CONCLUSION:The antitumoral action of aminoguanidine is associated with decreased cell proliferation,reduced angiogenesis,and reduced expression of antioxidant enzymes. | Nora A Mohamad Graciela P Cricco Lorena A Sambuco Máximo Croci Vanina A Medina Alicia S Gutiérrez Rosa M Bergoc Elena S Rivera Gabriela A Martín | 2009 | World Journal of Gastroenterology2009，15，9： | 3 |
| 3 | Performance evaluation of discharge plasma process for gaseous pollutant removal显示文摘 | Hyun H K Graciela P Kazunori T | 2002 | Journal of Electrostatics2002，55，1： | 1 |
| 4 | Combined effect of bacteriocins on the survival of various Listeria species in broth and meat system显示文摘 | GRACIELA V JORGE P FERNANDO S | 2000 | Curt Microbiol2000，41，6： | 1 |
| 5 | Solvent - free catalytic preparation of 1,1 - diacetates from aldehydes using a wells - dawson acid (H6P2W18 O62 · 24H2O) 显示文摘 | GUSTAVO P R HORACIO J T GRACIELA T B | 2003 | Tetrahedrom Letters2003，44，1： | 1 |
| 6 | Performance evaluation of discharge plasma process for gaseous pollutant removal显示文摘 | Hyun H K Graciela P Kazunori T | 2002 | Journal of Electrostatics2002，55，3： | 1 |
| 7 | Solvent-free catalytic preparation of 1,1-diacetates from aldehydes using a Wells-Dawson acid (H6P2W18 O62· 24H2O) 显示文摘 | Gustavo P Romanelli Horacio J Thomas Graciela T | 2003 | Tetrahedron Lett2003，44，3： | 1 |
| 8 | IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1显示文摘 | Suzuki Hitoshi Moldoveanu Zina Hall Stacy Brown Rhubell Vu Huong L Novak Lea Julian Bruce A Tomana Milan Wyatt Robert J Edberg Jeffrey C Alarcón Graciela S Kimberly Robert P Tomino Yasuhiko Mestecky Jiri Novak Jan | 2008 | Journal of Clinical Investigation2008，，2： | 1 |
| 9 | Interference of aluminum on iron metabolism in erythroleukaemia K562 cells显示文摘 | Gladys P A Graciela G A Beatriz S A | 1999 | Journal of Inorganic Biochemistry1999，76，： | 1 |
| 10 | Removal of metal ions by modified pinus radiata bark and tannins from water solutions 显示文摘 | Graciela P Juanita F Jaime B | 2003 | Water Research2003，37，： | 1 |
| 11 | An assessment of the determinants of university technology transfer 显示文摘 | Jose' L G P Graciela K Inaki P L | 2013 | E- conomic Development Quarterly2013，27，1： | 1 |
| 12 | Antioxidant effects of water-and lipid-soluble nitroxide radicals in liposomes显示文摘 | Alejandra N C Lidia L P Graciela B | 2004 | Free Radical Biology and Medicine2004，37，12： | 1 |
| 13 | Performance evaluation of discharge plasma process for gaseous pollutant removal 显示文摘 | Hyun H K Graciela P Kazunori T | 2002 | Journal of Electrostatics2002，55，1： | 1 |
| 14 | Salt tolerant tomato plants show increased levels of jasmonic acid 显示文摘 | Hilda P Graciela R Sergio A | 2003 | Plant Growth Regul2003，41，： | 1 |
| 15 | Fermentation of quinoa and wheat slurries by Lactobacillus plantarum CRL778:proteolytic activity显示文摘 | ANDREA M D MICAELA P GRACIELA F DV | 2013 | Applied Microbiology and Biotechnology2013，97，7： | 1 |
| 16 | Biosynthesis and ultrasonic degradation of bacterial poly(γ-glutamic acid) 显示文摘 | Graciela P C Francisco C Jordi J B | 1999 | Biotech Bioeng1999，63，1： | 1 |
| 17 | Antioxidant effects of water-and lipid-soluble nitroxide radicals in liposomes 显示文摘 | Alejandra N C Lidia L P Graciela B | 2004 | Free Radical Biology and Medicine2004，37，12： | 1 |
| 18 | Properties and Microsstruc- ture of Plasticized Zein Films显示文摘 | Lai Huey-Min Graciela W P | 1997 | Cereal Chemistry1997，74，6： | 1 |
| 19 | Properties and mi crostructure of plasticized zein films显示文摘 | Huey-min L Graciela W P | 1997 | Cereal Chem1997，74，6： | 1 |
| 20 | Performance evaluation of discharge plasma process for gaseous pollutant removal 显示文摘 | Hyun H Graciela P Kasunori T | 2002 | Journal of Electrostatics2002，55，1： | 1 |
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