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| 1 | Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples显示文摘AIM To compare(1) demographics in urea breath test(UBT) vs endoscopy patients; and(2) the molecular detection of antibiotic resistance in stool vs biopsy samples.METHODS Six hundred and sixteen adult patients undergoing endoscopy or a UBT were prospectively recruited to the study. The Geno Type Helico DR assay was used to detect Helicobacter pylori(H. pylori) and antibiotic resistance using biopsy and/or stool samples from CLOpositive endoscopy patients and stool samples from UBT-positive patients. RESULTS Infection rates were significantly higher in patients referred for a UBT than endoscopy(overall rates: 33% vs 19%; treatment-na?ve patients: 33% vs 14.7%, respectively). H. pylori-infected UBT patients were younger than H. pylori-infected endoscopy patients(41.4 vs 48.4 years, respectively, P < 0.005), with a higher percentage of H. pylori-infected males in the endoscopy-compared to the UBT-cohort(52.6% vs 33.3%, P = 0.03). The Geno Type Helico DR assay was more accurate at detecting H. pylori infection using biopsy samples than stool samples [98.2%(n = 54/55) vs 80.3%(n =53/66), P < 0.005]. Subset analysis using stool and biopsy samples from CLO-positive endoscopy patients revealed a higher detection rate ofresistance-associated mutations using stool samples compared to biopsies. The concordance rates between stool and biopsy samples for the detection of H. pylori DNA, clarithromycin and fluoroquinolone resistance were just 85%, 53% and 35%, respectively. CONCLUSION Differences between endoscopy and UBT patients provide a rationale for non-invasive detection of H. pylori antibiotic resistance. However, the Geno Type Helico DR assay is an unsuitable approach. | Denise E Brennan Joseph Omorogbe Mary Hussey Donal Tighe Grainne Holleran Colm O'Morain Sinéad M Smith Deirdre McNamara | 2016 | World Journal of Gastroenterology2016，22，41： | 6 |
| 2 | Assessment of serum angiogenic factors as a diagnostic aid for small bowel angiodysplasia in patients with obscure gastrointestinal bleeding and anaemia显示文摘AIM To assess the use of serum levels of angiopoietin-1(Ang1), Ang2 and tumor necrosis factor-α(TNFα) as predictive factors for small bowel angiodysplasia(SBA).METHODS Serum samples were collected from patients undergoing capsule endoscopy for any cause of obscure gastrointestinal bleeding(OGIB) or anaemia. Based on small bowel findings patients were divided into 3 groups:(1) SBA;(2) other bleeding causes; and(3) normal, according to diagnosis. Using ELISA technique we measured serum levels of Ang1, Ang2 and TNFα and compared mean and median levels between the groups based on small bowel diagnosis. Using receiver operator curve analysis we determined whether any of the factors were predictive of SBA.RESULTS Serum samples were collected from a total of 120 patients undergoing capsule endoscopy for OGIB or anaemia: 40 with SBA, 40 with other causes of small bowel bleeding, and 40 with normal small bowel findings. Mean and median serum levels were measured and compared between groups; patients with SBA had significantly higher median serum levels of Ang2(3759 pg/mL) compared to both other groups, with no significant differences in levels of Ang1 or TNFα based on diagnosis. There were no differences in Ang2 levels between the other bleeding causes(2261 pg/mL) and normal(2620pg/mL) groups. Using Receiver Operator Curve analysis, an Ang2 level of > 2600 pg/mL was found to be predictive of SBA, with an area under the curve of 0.7. Neither Ang1 or TNFα were useful as predictive markers.CONCLUSION Elevations in serum Ang2 are specific for SBA and not driven by other causes of bleeding and anaemia. Further work will determine whether Ang2 is useful as a diagnostic or prognostic marker for SBA. | Grainne Holleran Mary Hussey Sinead Smith Deirdre McNamara | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，3： | 3 |
| 3 | 小P值并不能保证可靠结果:以帕金森病的静息态脑功能成像元分析为例显示文摘Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain disorders.For precise localization of abnormal brain activity,a voxel-level comparison is needed.Because of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1]. | 贾熙泽 赵娜 董昊铭 孙家伟 Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa 陈博宇 陈俊 Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito 范国光 Federica Di Nardo 冯怡萱 Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay B.Horak 胡晓 胡晓飞 黄飚 黄沛钰 贾泽娟 Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani 李静 李晴 刘爱萍 刘波 刘虎 刘卫国 Renaud Lopes 娄毓婷 罗巍 Tara Madhyastha 毛妮妮 Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica 商慧芳 James M.Shine Priyank Shukla Tomas Slavicek 宋潇鹏 Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt 王健 王珏 Z.Jane Wang 魏鲁庆 邬霞 徐晓俊 闫磊 杨靓 杨万群 姚乃琳 张得龙 张久权 张敏鸣 张艳玲 周彩红 严超赣 左西年 Mark Hallett 吴涛 臧玉峰 | 2021 | Science Bulletin2021，66，21： | 3 |
| 4 | A prospective 52week mucosal healing assessment of small bowel Crohn’s disease as detected by capsule endoscopy显示文摘 | Barry Hall Grainne Holleran Jun-Liong Chin Sinead Smith Barbara Ryan Nasir Mahmud Deirdre McNamara | 2014 | Journal of Crohn’s and Colitis2014，，： | 3 |
| 5 | BRAF inhibitor treatment of melanoma causing colonic polyps:An alternative hypothesis显示文摘Colonic polyps may arise from BRAF inhibitor treatment of melanoma, possibly due paradoxical activation of the mitogen-activated protein(MAP)-kinase pathway. In an alternative evidence based scenario, tubular colonic adenomas with APC gene mutations have also been identified in the context of BRAF inhibitor treatment, in the absence of mutations of MAPK genes. A minority of colorectal cancers develop by an alternative 'serrated polyp pathway'. This article postulates a novel hypothesis, that the established phenotypic and molecular characteristics of serrated colonic polyps/CRC offer an intriguing insight into the pathobiology of BRAF inhibitor induced colonic polyps. Serrated polyps are characterized by a Cp G island methylation phenotype, MLH1 silencing and cellular senescence. They also have BRAF mutations. The contention is that BRAF inhibitor induced polyps mimic the afore-described histology and molecular features of serrated polyps with the exception that instead of the presence of BRAF mutations they induce C-RAF homodimers and B-RAF: C-RAF heterodimers. | Fergal C Kelleher Grainne Callaghan Catriona Gallagher Hazel O'Sullivan | 2017 | World Journal of Gastroenterology2017，23，17： | 2 |
| 6 | Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes显示文摘The term 'neurodevelopmental disorder' broadly encompasses conditions thought to arise early in development and includes schizophrenia, bipolar disorder and autism among others. These conditions share a number of genetic and environmental risk factors postulated to lead to common difficulties in socio-emotional processing, communication and cognitive function. The alternative position is that, while the same traits are affected across these conditions, the nature or direction in which they are modified may be distinct. MRI studies provide a rapidly expanding and rich database which we propose can be used to contribute to this debate. Anatomical likelihood estimation (ALE) is a method of meta-analysis applied to voxel-based MRI studies. We have adapted this method to explore the extent to which schizophrenia and bipolar disorder and schizophrenia and autism share a common brain structural phenotype. We will review this work here and discuss whether there is sufficient other evidence to justify a common framework for further research into the inter-relatedness of such conditions. | MCALONAN Grainne M YU Kevin K CHAN Raymond C K CHUA Siew E CHEUNG Charlton | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 7 | E-CRISP: fast CRISPR target site identification 显示文摘 | Florian H Grainne K Michael B | 2014 | Nat Methods2014，11，2： | 1 |
| 8 | Small bowel angiodysplasia and novel disease associations: a cohort study显示文摘 | Grainne Holleran Barry Hall Mary Hussey Deirdre McNamara | 2013 | Scandinavian Journal of Gastroenterology2013，，4： | 1 |
| 9 | Screening for testosterone, methyltestosterone, 19-nortestosterone residues and their metabolites in bovine urine with enzyme-linked immunosorbent assay (ELISA)显示文摘 | Huihui Lu Grainne Conneely Mark A. Crowe Margaret Aherne Miloslav Pravda George G. Guilbault | 2006 | Analytica Chimica Acta2006，，1： | 1 |
| 10 | Identifying theage cohort responsible for transmission in a natural outbreak of Bor-detella bronchiseptica显示文摘 | GRAINNE H L DIVYA S ANDREW F R | 2010 | PLoS Pathogens2010，6，12： | 1 |
| 11 | A comparison of ITS nuclear rDNA sequence data and AFLP markers for phylogenetic studies in phyllostachys (bambusoideae,poaceae)显示文摘 | Stephen A R Grainne N C | 2000 | Journal of Plant Reasearch2000，，113： | 1 |
| 12 | Colon capsule endoscopy as possible filter test for colonoscopy selection in a screening population with positive fecal immunology显示文摘 | Grainne Holleran Ronan Leen Colm O’Morain Deirdre McNamara | 2014 | Endoscopy2014，，07： | 1 |
| 13 | Objective and subjective assessment of sleep in chronic low back pain patients compared with healthy age and gender matched controls:a pilot study 显示文摘 | Grainne M O'Donoghur NiaU Fox Conor Heneghan | 2009 | BMC Musculoskeletal Disorder2009，10，2： | 1 |
| 14 | Iodine Intake in Somalia Is Excessive and Associated with the Source of Household Drinking Water1-3显示文摘 | Kassim Ismail A R Moloney Grainne Busili Ahono Nur Abukar Yusuf Paron Paolo Jooste Pieter Gadain Hussein Seal Andrew J | 2014 | The Journal of Nutrition2014，，： | 1 |
| 15 | Can you see the real me? Activation and expression of the 'true self'on the internet显示文摘 | John A Bargh Katelyn Y A McKenna Grainne M Fitzsimons | 2002 | Jour-nal of Social Issues2002，，1： | 1 |
| 16 | Array based detection of antibiotic resistance genes in Gram negative bacteria isolated from retail poultry meat in the UK and Ireland 显示文摘 | Grainne N Violetta N Martin J W | 2014 | International Journal of Food Microbiology2014，179，： | 1 |
| 17 | Systemic lupus erythematosus显示文摘 | Larissa Lisnevskaia Grainne Murphy David Isenberg | 2014 | The Lancet2014，，： | 1 |
| 18 | Pill Cam COLON 2~? as a pan-enteroscopic test in Crohn's disease显示文摘A recent paper by Boal Carvalho et al demonstrates the potential of Pill Cam COLON 2?(PCC2) as a panenteric investigation in Crohn's disease(CD). Our own prospective data in patients with known CD also shows good correlation between PCC2 and small/large bowel investigations(R = 0.896,P < 0.0004/R = 0.6667,P <0.035). Larger studies are warranted to prospectively validate the use of PCC2 in the investigation and monitoring of both small and large bowel CD. | Barry Hall Grainne Holleran Deirdre McNamara | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，16： | 1 |
| 19 | Small bowel Dieulafoy lesions: An uncommon cause of obscure bleeding in cirrhosis显示文摘Dieulafoy lesions(DLs) are an uncommon cause of gastrointestinal bleeding, accounting for up to 2% of cases overall. They are largely under recognised and difficult to treat. Up to 95% occur in the stomach, and only case reports document their occurrence in the small bowel(SB). Little is known about their pathophysiology, although there have been associations made previously with chronic liver disease, thought to be due to the erosive effects of alcohol on the mucosa overlying the abnormally dilated vessels. We present a case series of 4 patients with a long duration of obscure gastrointestinal bleeding, who were diagnosed with small intestinal DLs and incidentally diagnosed with chronic liver disease. The histories describe the challenges in both diagnosis and treatment of small intestinal DLs. Our case series suggest a previously unreported link between chronic liver disease and SB DLs which may be due to anatomical vasculature changes or a shift in angiogenic factors as a consequence of portal hypertension or liver cirrhosis. | Grainne Holleran Mary Hussey Deirdre Mc Namara | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，16： | 1 |
| 20 | Does EUS‐FNA molecular analysis carry additional value when compared to cytology in the diagnosis of pancreatic cystic neoplasm? A systematic review显示文摘 | Amy Gillis Ilaria Cipollone Grainne Cousins Kevin Conlon | 2015 | HPB2015，，5： | 1 |
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