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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 3 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 4 | The prevalence and risk factors of retinal microvascular abnormalities in older persons显示文摘 | Tien Yin Wong Ronald Klein A.Richey Sharrett Teri A Manolio Larry D Hubbard Emily K Marino Lewis Kuller Gregory Burke Russell P Tracy Joseph F Polak John S Gottdiener David S Siscovick | 2003 | Ophthalmology2003，，4： | 1 |
| 5 | The Impact of Ice Phase Cloud Parameterizations on Tropical Cyclone Prediction显示文摘 | Jin Yi Wang Shouping Nachamkin Jason Doyle James D Thompson Gregory Grasso Lewis Holt Teddy Moskaitis Jon Jin Hao Hodur Richard M Zhao Qingyun Liu Ming DeMaria Mark | 2014 | Monthly Weather Review2014，，2： | 1 |
| 6 | Low-phase-noise, single- frequency, single-mode 608 W thulium fiber amplifier 显示文摘 | Gregory D Goodno Lewis D | 2009 | Optics Letters2009，34，： | 1 |
| 7 | Sildenafil Improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure 显示文摘 | Gregory D Lewis M D Justine lachmann M D | 2007 | Circulation2007，115，1： | 1 |
| 8 | Long term survival after pancreatic resection for pancreatic adenocarcinoma显示文摘 | Nuzhat A Ahmad James D Lewis Gregory G Ginsberg Daniel G Haller Jon B Morris Noel N Williams Ernest F Rosato Michael L Kochman | 2001 | The American Journal of Gastroenterology2001，，9： | 1 |
| 9 | Lipopro-tein particles,insulin,adiponectin,C-reactive proteinand risk ofcoronary heart diseas e am on g m en with met abolicsyndrome显示文摘 | Lewis H Kuller Gregory Grandts Jerome D Cohen | 2007 | Atherosclerosis2007，195，1： | 1 |
| 10 | Exercise oscillatory ventilation:Mechanisms and prognostic significance显示文摘Alteration in breathing patterns characterized by cyclic variation of ventilation during rest and during exercise has been recognized in patients with advanced heart failure(HF) for nearly two centuries. Periodic breathing(PB) during exercise is known as exercise oscillatory ventilation(EOV) and is characterized by the periods of hyperpnea and hypopnea without interposed apnea. EOV is a non-invasive parameter detected during submaximal cardiopulmonary exercise testing. Presence of EOV during exercise in HF patients indicates significant impairment in resting and exercise hemodynamic parameters. EOV is also an independent risk factor for poor prognosis in HF patients both with reduced and preserved ejection fraction irrespective of other gas exchange variables. Circulatory delay, increased chemosensitivity, pulmonary congestion and increased ergoreflex signaling have been proposed as the mechanisms underlying the generation of EOV in HF patients. There is no proven treatment of EOV but its reversal has been noted with phosphodiesterase inhibitors, exercise training and acetazolamide in relatively small studies. In this review, we discuss the mechanistic basis of PB during exercise and the clinical implications of recognizing PB patterns in patients with HF. | Bishnu P Dhakal Gregory D Lewis | 2016 | World Journal of Cardiology2016，8，3： | 0 |
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