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| 1 | A single administration of fish oil inhibits the acute inflammatory response in rats显示文摘Objective: To investigate the antiinflammatory effects of a single administration of fish oil(FO) on the acute inflammatory response. Methods: The paw edema and pleurisy models were used to evaluate the effects of FO dissolved in olive oil(FOP) orally administered in a single dose in rats. Nitric oxide(NO) concentrations in the pleural exudate were performed according to the Griess method and the cytokine concentrations were determined by Luminex bead-based multiplex assay. Results: FOP treatment(30 and 300 mg/kg) significantly reduced paw edema. FOP treatment at 18.75, 37.5, 75.0, 150.0, and 300 mg/kg decreased both the volume of pleural exudate and cellular migration into the pleural cavity and each of these doses presented the same effectiveness. Treatment with FOP(300 mg/kg) reduced NO, TNF-α, IL-1β, and IL-6 concentrations in the pleural exudate. Conclusions: The present data provide evidence that FO has inhibitory effects on the acute inflammatory response when administered in a single dose in rats. This effect might be attributable to a direct inhibitory effect of FO on the production or release of inflammatory mediators that are involved in the pathological processes evaluated herein. | Laura Licia Milani de Arruda Franciele Queiroz Ames Damila Rodrigues de Morais Renata Grespan Ana Paula Maziero Gil Maria Angelica Raffaini Covas Pereira Silva Jesui Vergilio Visentainer Roberto Kenji Nakamura Cuman Ciomar Aparecida Bersani-Amado | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，8： | 2 |
| 2 | Posture control in Pusher syndrome:influence of lateral semicircular canals显示文摘 | Taiza Elaine Grespan dos Santos Pontelli Octavio Marques Pontes-Neto José Fernando Colafemina | 2005 | Rev Bras Otorrinolaringol2005，71，： | 1 |
| 3 | A crucial role for TNFalphain mediating neutrophil influx induced by endogenouslygenerated or exogenous chemokines,KC/CXCL1 and LIX/CXCL5显示文摘 | Vieira SM Lemos HP Grespan R | 2009 | Br J Pharmacol2009，158，3： | 1 |
| 4 | Robot-assisted la- paroscopic hysterectomy vs traditional laparoscopic hysterectomy:five metaanalyses显示文摘 | Scandola M Grespan L Vicentini M | 2011 | Journal of minimally invasive gynecology2011，18，6： | 1 |
| 5 | Prostaglan?din mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma pro?duction显示文摘 | Lemos H P Grespan R Vieira S M et aI | 2009 | Proc Nat! Acad Sci USA2009，106，14： | 1 |
| 6 | A crucial role for TNF- alpha in mediating neutrophil influx induced by endogenously gen- erated or exogenous chemokines, KC/CXCL1 and LIX/CXCL5显示文摘 | Vieira SM Lemos HP Grespan R | 2009 | Br J Pharmacol2009，158，3： | 1 |
| 7 | Interleukin-17 and kidney allograft outcome显示文摘 | Crispim J C Grespan R Martelli-Palomino G | 2009 | Transplant Proc2009，41，5： | 1 |
| 8 | Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in imqarmnation by inhibi- ting IL-12 and IFN'y production显示文摘 | Lemos HP Grespan R Vieira SM | 2009 | PNAS2009，106，15： | 1 |
| 9 | Effect of Zingiber officinale essential oil on Fusarium verti- cillioides and fumonisin production 显示文摘 | Yamamoto-Ribeiro MM Grespan R Kohiyama CY | 2013 | Food Chem2013，141，3： | 1 |
| 10 | Venice Channel side-wall assessment with GPR technique-a case study显示文摘 | Francese R G Galgaro A Grespan A | 2004 | Journal of Applied Geophysics2004，56，1： | 1 |
| 11 | Anti-arthritic effect of eugenol on collagen-induced arthritis experimental model显示文摘 | Grespan R Paludo M Lemos H | 2012 | Biol Pharm Bull2012，35，10： | 1 |
| 12 | Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFN-gamma production显示文摘 | Lemos H P Grespan R Vieira S M | 2009 | Proc Natl Acad Sci USA2009，106，14： | 1 |
| 13 | Protective effect of RC-3095,an antagonist of the gastrin-releasing peptide receptor,in experimental arthritis显示文摘 | Oliveira PG Grespan R Pinto LG | 2011 | Arthritis Rheum2011，63，10： | 1 |
| 14 | Immunomodulatory effect of Canova medication on experimental Leishmania amazonensis infection显示文摘 | W.K.V. Pereira M.V.C. Lonardoni R. Grespan S.M. Caparroz-Assef R.K.N. Cuman C.A. Bersani-Amado | 2004 | Journal of Infection2004，，： | 1 |
| 15 | Inter- leukin-17 and kidney allograft outcome 显示文摘 | Crispim JC Grespan R Martelli-Palomino G | 2009 | Transplant Proc2009，41，5： | 1 |
| 16 | Measurement of Economic Result in Public Organizations: A Departmental Analysis显示文摘 | Carlos Alberto Grespan Bonacim Adriana Maria Procopio de Araujo | 2014 | Journal of Modern Accounting and Auditing2014，10，2： | 0 |
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