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| 1 | Oral pharmacological treatment for patent ductus arteriosus in premature neonates with hemodynamic repercussions显示文摘Objective: To evaluate the efficacy of oral indomethacin, ibuprofen, and paracetamol in oral dosage form on patent ductus arteriosus(PDA) in premature neonates with significant clinical and hemodynamic repercussions(CHRs) and to determine the effect of these respective treatments on renal function.Methods: A retrospective study of cases of PDA in premature neonates in the Neonatal Intensive Care Unit was conducted. The treatments consisted of indomethacin[0.2 mg/(kg$d), 3-day cycle], ibuprofen [10 mg/(kg$d) followed by 5 mg/(kg$d), 3-day cycle], and paracetamol(15 mg/kg every 6 h, 5-day cycle). The drugs were administered as an oral solution. The following variables were considered: gestational age,newborn weight at birth, Apgar score, diuresis, serum creatinine and urea levels, and serum electrolyte levels(sodium and potassium).Results: Treatment with indomethacin presented efficacy of 87.5% in closure of the ductus with a mean outcome period of 3.5 d. In premature neonates with CHRs and contraindications for indomethacin, the initial treatment with either ibuprofen or paracetamol failed to close the ductus. However, when this treatment was followed by indomethacin, closure occurred in 66.7% of the neonates, with an outcome period of9.66 d. The initial treatment with one cycle of ibuprofen followed by one or two cycles of paracetamol failed to close the ductus.Conclusions: Oral indomethacin was effective for closure of the PDA in premature neonates with severe CHRs. Oral paracetamol or ibuprofen for PDA closure in premature neonates with severe CHRs and contraindications for indomethacin was ineffective.However, results in clinical improvements of neonates allowed the subsequent use of indomethacin and successful closure of the ductus. A significant reduction of diuresis occurred in neonates who were treated with indomethacin, either as a first-line treatment or after the failure of ibuprofen or paracetamol. | Clarissa de Albuquerque Botura Bruno Ambrósio da Rocha Thiely Balensiefer Franciele Queiroz Ames Ciomar Aparecida Bersani-Amado Roberto Kenji Nakamura Cuman | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，11： | 4 |
| 2 | A single administration of fish oil inhibits the acute inflammatory response in rats显示文摘Objective: To investigate the antiinflammatory effects of a single administration of fish oil(FO) on the acute inflammatory response. Methods: The paw edema and pleurisy models were used to evaluate the effects of FO dissolved in olive oil(FOP) orally administered in a single dose in rats. Nitric oxide(NO) concentrations in the pleural exudate were performed according to the Griess method and the cytokine concentrations were determined by Luminex bead-based multiplex assay. Results: FOP treatment(30 and 300 mg/kg) significantly reduced paw edema. FOP treatment at 18.75, 37.5, 75.0, 150.0, and 300 mg/kg decreased both the volume of pleural exudate and cellular migration into the pleural cavity and each of these doses presented the same effectiveness. Treatment with FOP(300 mg/kg) reduced NO, TNF-α, IL-1β, and IL-6 concentrations in the pleural exudate. Conclusions: The present data provide evidence that FO has inhibitory effects on the acute inflammatory response when administered in a single dose in rats. This effect might be attributable to a direct inhibitory effect of FO on the production or release of inflammatory mediators that are involved in the pathological processes evaluated herein. | Laura Licia Milani de Arruda Franciele Queiroz Ames Damila Rodrigues de Morais Renata Grespan Ana Paula Maziero Gil Maria Angelica Raffaini Covas Pereira Silva Jesui Vergilio Visentainer Roberto Kenji Nakamura Cuman Ciomar Aparecida Bersani-Amado | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，8： | 2 |
| 3 | The chrondroitin sulfate proteoglycan (CSPG4) regulates human trophoblast function 显示文摘 | Van Sinderen M Cuman C Winship A | 2013 | Placenta2013，34，10： | 1 |
| 4 | The allergic inflammatory reaction in neonatal streptozotocininduced diabetic rats:evidence of insulin resistance and microvascular dysfunction显示文摘 | Cavalher SC Cuman KN Sartoretto JL | 2008 | Inflammation Research2008，57，11： | 1 |
| 5 | Anti-inflammatory and antinociceptive activities of eugenol essential oil in experimental animal models显示文摘 | Daniel AN Sartoretto SM Schmidt G Caparroz-Assef SM Bersani-Amado CA Cuman RKN | 2009 | Rev Bras Farmacogn2009，19，1： | 1 |
| 6 | Preimplantation human blastocysts release factors that differentially alter human endometrial epithelial cell adhesion and gene expression relative to IVF success显示文摘 | Cuman C Menkhorst EM Rombauts U | 2013 | Hum Reprod2013，28，5： | 1 |
| 7 | Inhibitory effect of anethole in nonimmune acute inflammation显示文摘 | Talita Perdig?o Domiciano Márcia Machado de Oliveira Dalalio Expedito Leite Silva Alessandra Mileni Versuti Ritter Camila Fernanda Estev?o-Silva Fernando Seara Ramos Silvana Martins Caparroz-Assef Roberto Kenji Nakamura Cuman Ciomar Aparecida Bersani-Amad | 2013 | Naunyn-Schmiedeberg’s Archives of Pharmacology2013，，4： | 1 |
| 8 | Immunomodulatory effect of Canova medication on experimental Leishmania amazonensis infection显示文摘 | W.K.V. Pereira M.V.C. Lonardoni R. Grespan S.M. Caparroz-Assef R.K.N. Cuman C.A. Bersani-Amado | 2004 | Journal of Infection2004，，： | 1 |
| 9 | Canova medication changes TNF-α and IL-10 serum levels in mice infected with Trypanosoma cruzi Y strain显示文摘Objective:To identify whether Canova medication changes TNF-α and IL-10 serum levels in mice infected with Trypanosoma cruzi Y strain.Methods:Animals were divided into five groups:non-treated infected animals(I); benznidazole-treated infected animals(Bz; 100 mg/kg body weight,single daily dose by gavage); Canova medication(CM) treated infected animals(CM;0.2 mL/animal,single daily dose by gavage); benznidazole- and Canova medication–treated infected animals with the above-mentioned dose(Bz+CM);and non-infected animals(C).TNF-α and IL-10 levels were determined in serum aliquots after 4,7,10,13,and 29 days of infection.An ELISA technique was employed with R&D System Inc.antibody pairs.Results:A high increase in TNF-α and IL-10 levels occurred in the infected and CM-treated groups within the treatment employed on the 10 th day after infection,coupled with a IL-10 decrease on the 13 th day after infection when compared with the other experimental groups.Conclusions:CM may change the balance between plasma cytokine levels(TNF-α and IL-10) in mice infected with Y strain T.cruzi,with important consequences leading towards a more severe infection. | áurea Regina Telles Pupulin Lívia Bracht Márcia Machado de Oliveira Dalalio Francielli Maria de Souza Silva-Comar Bruno Ambrósio da Rocha Franciele Queiroz Ames Roberto Kenji Nakamura Cuman Ciomar Aparecida Bersani-Amado | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，9： | 0 |
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