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| 1 | Long-term safety of lamivudine treatment in patients with chronic hepatitis B显示文摘 | Anna S.F Lok Ching-Lung Lai Nancy Leung Guang-Bi Yao Zhen-Yu Cui Eugene R Schiff Jules L Dienstag E.Jenny Heathcote Nancy R Little Dorothea A Griffiths Stephen D Gardner Mary Castiglia | 2003 | Gastroenterology2003，，6： | 3 |
| 2 | Conduit necrosis following esophagectomy: An up-to-date literature review显示文摘Esophageal conduit ischaemia and necrosis is an uncommon but devastating complication of esophagectomy and remains one of the most challenging issues in surgical practice. The incidence, time interval to develop symptoms, and clinical presentation are highly variable with no predictable pattern. Evidence comes from case reports and case series rather than randomized controlled trials.We describe the issues surrounding conduit necrosis affecting the stomach,jejunum and colon as an esophageal replacement and the advantages,disadvantages and challenges of each type of reconstruction. Diagnosis is challenging for the most experienced surgeon. Upper gastrointestinal endoscopy and computed tomography thorax with both oral and intravenous contrast is the gold standard. Management, either conservative or interventional is also a difficult decision. Management options include conservative treatment and more aggressive treatments such as stent insertion, surgical debridement and repair of the esophagus using jejunum, colon or a musculocutaneous flap. In spite of recent advances in surgical techniques, there is no reliable strategy to manage esophageal conduit necrosis. Our review covers the pathophysiology and clinical significance of esophageal necrosis while highlighting current techniques of prevention, diagnosis and treatment of this life-threatening condition. | Antonios Athanasiou Mairead Hennessy Eleftherios Spartalis Benjamin H L Tan Ewen A Griffiths | 2019 | World Journal of Gastrointestinal Surgery2019，11，3： | 2 |
| 3 | Long-term safety of lamivudine treatment in patients with chronic hepatitis B显示文摘 | Anna S.F Lok Ching-Lung Lai Nancy Leung Guang-Bi Yao Zhen-Yu Cui Eugene R Schiff Jules L Dienstag E.Jenny Heathcote Nancy R Little Dorothea A Griffiths Stephen D Gardner Mary Castiglia | 2003 | Gastroenterology2003，，6： | 2 |
| 4 | SLC26A4 mutation testing for hearing loss associated with enlargement of the vestibular aqueduct显示文摘Pendred syndrome(PS) is characterized by autosomal recessive inheritance of goiter associated with a defect of iodide organification, hearing loss, enlargement of the vestibular aqueduct(EVA), and mutations of the SLC26A4 gene. However, not all EVA patients have PSor SLC26A4 mutations. Two mutant alleles of SLC26A4 are detected in 1/4 of North American or European EVA populations, one mutant allele is detected in another 1/4 of patient populations, and no mutations are detected in the other 1/2. The presence of two mutant alleles of SLC26A4 is associated with abnormal iodide organification, increased thyroid gland volume, increased severity of hearing loss, and bilateral EVA. The presence of a single mutant allele of SLC26A4 is associated with normal iodide organification, normal thyroid gland volume, less severe hearing loss and either bilateral or unilateral EVA. When other underlying correlations are accounted for, the presence of a cochlear malformation or the size of EVA does not have an effect on hearing thresholds. This is consistent with observations of an Slc26a4 mutant mouse model of EVA in which hearing loss is independent of endolymphatic hydrops or inner ear malformations. Segregation analyses of EVA in families suggest that the patients carrying one mutant allele of SLC26A4 have a second, undetected mutant allele of SLC26A4, and the probability of a sibling having EVA is consistent with its segregation as an autosomal recessive trait. Patients without any mutations are an etiologically heterogeneous group in which siblings have a lower probability of having EVA. SLC26A4 mutation testing can provide prognostic information to guide clinical surveillance and management, as well as the probability of EVA affecting a sibling. | Taku Ito Julie Muskett Parna Chattaraj Byung Yoon Choi Kyu Yup Lee Christopher K Zalewski Kelly A King Xiangming Li Philine Wangemann Thomas Shawker Carmen C Brewer Seth L Alper Andrew J Griffith | 2013 | World Journal of Otorhinolaryngology2013，3，2： | 2 |
| 5 | Virtu-alness and Knowledge in Teams:Managing the Love Triangle of Organizations,Individuals,And Information Technology 显示文摘 | GRIFFITH T L SAWYER J E NEALE M A | 2003 | MIS Quarterly2003，，2： | 1 |
| 6 | Characterization of antifreeze activity in antarctic plants显示文摘 | BRAVO L A GRIFFITH M | 2005 | Journal of Experimental Botany2005，56，414： | 1 |
| 7 | The interaction of HzO2 with exchanged titanium oxide systems(TS-l, TiO2, -APO-5, Ti-ZSM-5) 显示文摘 | Karen L A Damien M M Griffiths E | 2003 | Physical Chemistry Chemical Physics2003，5，： | 1 |
| 8 | Un-drained failure mechanisms of slopes in random soil显示文摘 | Zhu H Griffiths D V Fenton G A Zhang L M | 2015 | Engineering Geology2015，191，： | 1 |
| 9 | Preliminary comparison of landscape pattern-Normalized difference vegetation index (NDVI) relationships to central plains stream conditions 显示文摘 | Griffith J A Martinko E A Whistler J L | 2002 | Journal of Environmental Quality2002，31，： | 1 |
| 10 | Completely automated open- path FT-IR spectrometry 显示文摘 | Griffiths P R Shao L Leytem A B | 2009 | Analytical and Bioanalytical Chemistry2009，393，1： | 1 |
| 11 | Uncovering mental representations with Markov chain Monte Carlo显示文摘 | Sanborn A N Griffiths T L Shiffrin R M | | 0，，60： | 1 |
| 12 | Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding显示文摘 | Joseph L Kim Kurt A Morgenstern James P Griffith Maureen D Dwyer John A Thomson Mark A Murcko Chao Lin Paul R Caron | 1998 | Structure1998，，1： | 1 |
| 13 | Vascular calcification does not predict anastomotic leak or conduit necrosis following oesophagectomy显示文摘BACKGROUND Anastomotic leaks(AL)and gastric conduit necrosis(CN)are serious complications following oesophagectomy.Some studies have suggested that vascular calcification may be associated with an increased AL rate,but this has not been validated in a United Kingdom population.AIM To investigate whether vascular calcification identified on the pre-operative computed tomography(CT)scan is predictive of AL or CN.METHODS Routine pre-operative CT scans of 414 patients who underwent oesophagectomy for malignancy with oesophagogastric anastomosis at the Queen Elizabeth Hospital Birmingham between 2006 and 2018 were retrospectively analysed.Calcification of the proximal aorta,distal aorta,coeliac trunk and branches of the coeliac trunk was scored by two reviewers.The relationship between these calcification scores and occurrence of AL and CN was then analysed.The Esophagectomy Complications Consensus Group definition of AL and CN was used.RESULTS Complication data were available in n=411 patients,of whom 16.7%developed either AL(15.8%)or CN(3.4%).Rates of AL were significantly higher in female patients,at 23.0%,compared to 13.9%in males(P=0.047).CN was significantly more common in females,(8.0%vs 2.2%,P=0.014),patients with diabetes(10.6%vs 2.5%,P=0.014),a history of smoking(10.3%vs 2.3%,P=0.008),and a higher American Society of Anaesthesiologists grade(P=0.024).Out of the 14 conduit necroses,only 4 occurred without a concomitant AL.No statistically significant association was found between calcification of any of the vessels studied and either of these outcomes.Multivariable analyses were then performed to identify whether a combination of the calcification scores could be identified that would be significantly predictive of any of the outcomes.However,the stepwise approach did not select any factors for inclusion in the final models.The analysis was repeated for composite outcomes of those patients with either AL or CN(n=69,16.7%)and for those with both AL and CN(n=10,2.4%)and again,no significant associations were detected.In the subset of patients that developed these outcomes,no significant associations were detected between calcification and the severity of the complication.CONCLUSION Calcification scoring was not significantly associated with Anastomotic Leak or CN in our study,therefore should not be used to identify patients who are high risk for these complications. | Benjamin J Jefferies Emily Evans James Bundred James Hodson John L Whiting Colm Forde Ewen A Griffiths | 2019 | World Journal of Gastrointestinal Surgery2019，11，7： | 1 |
| 14 | Carotenogenesis during tuber development and storage in potato显示文摘 | Morris W L Ducreux D Griffiths W Stewart D Davies H V Taylor M A | 2004 | Journal of Experimental Botany2004，55，： | 1 |
| 15 | Information processing in tradition- al, hybrid, and virtual teams: from nascent knowledge to transactive memory 显示文摘 | GRIFFITH T L Neale M A | 2001 | Research in Organizational Behavior2001，213，： | 1 |
| 16 | Do spatial effecfs really matter in regression analysis 显示文摘 | Anselin L Griffith D A | 2005 | Papers in Regional Science2005，65，1： | 1 |
| 17 | Do spatial effects really matter in regression analysis? 显示文摘 | Anselin L Griffith D A | 1988 | Papers Regional Science Associa- tion1988，65，1： | 1 |
| 18 | Integration of surface modification and 3-D fabrication techniques to prepare patterned poly (L-lactide) substrates allowing regionally selective cell adhesion 显示文摘 | Park A Wu B Griffith L G | 1998 | J Biomater Sci Polym Ed1998，9，2： | 1 |
| 19 | Preliminary performance measurements for a streak camera with a large-format direct coupled charged-coupled device readout显示文摘 | LERCHE R A MCDONALD J W GRIFFITH R L | 2004 | Rev Sei Instrum2004，75，10： | 1 |
| 20 | Macrokinetic analysis of blockade of NMDA-gated currents by substituted alcohols, alkanes and ethers显示文摘 | Hugh E Criswell Zhen Ming Nathanial Pleasant Benjamin L Griffith Robert A Mueller George R Breese | 2004 | Brain Research2004，，1： | 1 |
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