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| 1 | Activins and activin antagonists in hepatocellular carcinoma显示文摘In many parts of the world hepatocellular carcinoma (HCC)is among the leading causes of cancer-related mortality but the underlying molecular pathology is still insufficiently understood.There is increasing evidence that activins,which are members of the transforming growth factorβ(TGFβ)superfamily of growth and differentiation factors,could play important roles in liver carcinogenesis.Activins are disulphide-linked homo- or heterodimers formed from four differentβsubunits termedβA,βB,βC,andβE,respectively.Activin A, the dimer of twoβA subunits,is critically involved in the regulation of cell growth,apoptosis,and tissue architecture in the liver,while the hepatic function of other activins is largely unexplored so far.Negative regulators of activin signals include antagonists in the extracellular space like the binding proteins follistatin and FLRG,and at the cell membrane antagonistic coreceptors like Cripto or BAMBI.Additionally,in the intracellular space inhibitory Smads can modulate and control activin activity.Accumulating data suggest that deregulation of activin signals contributes to pathologic conditions such as chronic inflammation,fibrosis and development of cancer.The current article reviews the alterations in components of the activin signaling pathway that have been observed in HCC and discusses their potential significance for liver tumorigenesis. | Alev Deli Emanuel Kreidl Stefan Santifaller Barbara Trotter Katja Seir Walter Berger Rolf Schulte-Hermann Chantal Rodgarkia-Dara Michael Grusch | 2008 | World Journal of Gastroenterology2008，14，11： | 8 |
| 2 | Digalloylresveratrol,a new phenolic acid derivative induces apoptosis and cell cycle arrest in human HT-29 colon cancer cells显示文摘 | BERHAUS A FRITZER-SZEKERES M GRUSCH M | 2009 | Cancer Letters2009，274，： | 1 |
| 3 | Digalloylresveratrol,a new phenolic acid derivative induces apoptosis and cell cycle arrest in human HT-29 colon cancer cells显示文摘 | Bernhaus A Fritzer-Szekeres M Grusch M | 2009 | Cancer Lett2009，274，2： | 1 |
| 4 | Fas ligand is expressed in normal brcast epithelial cells and is frequently up-regulated in breast cancer显示文摘 | Müllauer L Mosberger I Grusch M | | 0，，： | 1 |
| 5 | Digalloylresveratrol, a novel resveratrol analog inhibits the growth of human pancreatic cancer cells显示文摘 | Philipp Saiko Geraldine Graser Benedikt Giessrigl Marie-Thérèse Steinmann Heike Schuster Andreas Lackner Michael Grusch Georg Krupitza Walter Jaeger Venkateswarlu Somepalli Trimurtulu Golakoti Monika Fritzer-Szekeres Thomas Szekeres | 2013 | Investigational New Drugs2013，，5： | 1 |
| 6 | Interaction between fatty acid synthase-and ErbB-systems in ovarian cancer cells显示文摘 | Grunt TW Wagner R Grusch M | 2009 | Biochem Biophys Res Commun2009，385，3： | 1 |
| 7 | Vaults and the ma- jor vault protein:novel roles in signal pathway regulation and immunity显示文摘 | Berger W Steiner E Grusch M | 2009 | Cell Mol Life Sci2009，66，1： | 1 |
| 8 | The MYC dualism in growth and death显示文摘 | FUHRMANN G ROSENBERGER G GRUSCH M | 1999 | Mut Res1999，43，： | 1 |
| 9 | Interac- tion between fatty acid synthase-and ErbB-systems in ovarian cancer cells显示文摘 | Grunt TW Wagner R Grusch M | 2009 | Biochem Biophys Res Commun2009，385，3： | 1 |
| 10 | Interaction between fatty acid synthase and ErbB systems in ovarian cancer cells 显示文摘 | Grunt TW Wagner R Grusch M | 2009 | Bio- chem Biophys Res Commun2009，385，3： | 1 |
| 11 | The MYC dualism in growth and death显示文摘 | Rosenberger G Grusch M | 1999 | Mutat Res1999，437，3： | 1 |
| 12 | Interaction between fatty acid synthase-and erbb-systems in ovarian cancer cells显示文摘 | Grunt TW Wagner R Grusch M | | 0，，03： | 1 |
| 13 | The MYC dualism in growth and death显示文摘 | Fuhrmann G Rosenberger G Grusch M | 1999 | Mutat Res1999，437，3： | 1 |
| 14 | Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells显示文摘 | Thomas W. Grunt Renate Wagner Michael Grusch Walter Berger Christian F. Singer Brigitte Marian Christoph C. Zielinski Ruth Lupu | 2009 | Biochemical and Biophysical Research Communications2009，，3： | 1 |
| 15 | Hydrogen peroxide mediates EGCG-induced antioxidant protection in human keratinocytes显示文摘 | Leonilla Elbling Irene Herbacek Rosa-Maria Weiss Christian Jantschitsch Michael Micksche Christopher Gerner Heinrich Pangratz Michael Grusch Siegfried Knasmüller Walter Berger | 2010 | Free Radical Biology and Medicine2010，，9： | 1 |
| 16 | Targeting fibroblast - growth - factor - receptor - dependent signaling for cancer therapy 显示文摘 | Heinzle C Sutterluty H Grusch M | 2011 | Expert Opin Ther Targets2011，7，： | 1 |
| 17 | Interaction be- tween fatty acid synthase - and ErbB - systems in ovarian cancer cells显示文摘 | GRUNT T W WAGNER R GRUSCH M | 2009 | Biochem Biophys Res Commun2009，385，3： | 1 |
| 18 | Consequences of IMP dehydrogenase inhibition, and its relationship to cancer and apoptnsis 显示文摘 | Jayaram HN Cooney DA Grusch M | 1999 | Curr Med Chem1999，6，7： | 1 |
| 19 | Fas ligand is expressed in normai breast epithelial cells and is frequently up-regulated in breast cancer显示文摘 | Mullauer L Mosberger I Grusch M | 2000 | J Pathol2000，190，1： | 1 |
| 20 | Tfimidox, an inhibitor of ribonucleotide reductase, synergistically enhances the inhibition of colony formation by Ara-Cin HL-60 human promyelocytic leukemia cells显示文摘 | Fritzer-Szekeres M Salamon A Grusch M | 2002 | Biochem Pharmacol2002，64，3： | 1 |
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