|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Survival outcome of patients with spontaneously ruptured hepatocellular carcinoma treated surgically or by transarterial embolization显示文摘AIM: To evaluate clinical outcomes of patients that underwent surgery, transarterial embolization (TAE), or supportive care for spontaneously ruptured hepatocellular carcinoma (HCC). METHODS: A consecutive 54 patients who diagnosed as spontaneously ruptured HCC at our institution between 2003 and 2012 were retrospectively enrolled. HCC was diagnosed based on the diagnostic guidelines issued by the 2005 American Association for the Study of Liver Diseases. HCC rupture was defined as disruption of the peritumoral liver capsule with enhanced fluid collection in the perihepatic area adjacent to the HCC by dynamic liver computed tomography, and when abdominal paracentesis showed an ascitic red blood cell count of > 50000 mm 3 /mL in bloody fluid. RESULTS: Of the 54 patients, 6 (11.1%) underwent surgery, 25 (46.3%) TAE, and 23 (42.6%) supportive care. The 2-, 4and 6-mo cumulative survival rates at 2, 4 and 6 mo were significantly higher in the surgery (60%, 60% and 60%) or TAE (36%, 20% and 20%) groups than in the supportive care group (8.7%, 0% and 0%), respectively (each, P < 0.01), and tended to be higher in the surgical group than in the TAE group. Multivariate analysis showed that serum bilirubin (HR = 1.09, P < 0.01), creatinine (HR = 1.46, P = 0.04), and vasopressor requirement (HR = 2.37, P = 0.02) were significantly associated with post-treatment mortality, whereas surgery (HR = 0.41, P < 0.01), and TAE (HR = 0.13, P = 0.01) were inversely associated with posttreatment mortality. CONCLUSION: Post-treatment survival after surgery or TAE was found to be better than after supportive care, and surgery tended to provide better survival benefit than TAE. | Young-Joo Jin Jin-Woo Lee Seoung-Wook Park Jung Il Lee Don Haeng Lee Young Soo Kim Soon Gu Cho Yong Sun Jeon Kun Young Lee Seung-Ik Ahn | 2013 | World Journal of Gastroenterology2013，19，28： | 23 |
| 2 | Current Challenges for the Practical Application of Electroencephalography-Based Brain-Computer Interfaces显示文摘It has been almost 50 years since the term“brain–computer interface”(BCI)was first proposed by Jacques J.Vidal in 1973[1].Unlike traditional electronic interfaces that transmit nonliving information between devices,BCIs set up a communication bridge between a living brain and nonliving devices.Technically speaking,a BCI is a system that measures brain activity and converts it into the artificial outputs that replace,restore,enhance,supplement,or improve the natural central nervous system outputs[2].At present,electroencephalography(EEG)is the most commonly used brain signal for BCIs. | Minpeng Xu Feng He Tzyy-Ping Jung Xiaosong Gu Dong Ming | 2021 | Engineering2021，7，12： | 15 |
| 3 | Effect of focal laser photocoagulation in eyes with mild to moderate non-proliferative diabetic retinopathy显示文摘AIM:To report the effect of focal laser photocoagulation on both the severity of hard exudates(HEs) and the rate of disease progression in eyes with mild to moderate non-proliferative diabetic retinopathy(NPDR).METHODS: We retrospectively reviewed the medical records of 33 patients(60 eyes) who had been diagnosed with mild to moderate NPDR between January 2006 and December 2012.The patients were divided into 2 groups:Group A(38 eyes in 20 patients treated using focal laser photocoagulation) and Group B(treated without laser photocoagulation).We also reviewed the best corrected visual acuity measurements,and the fundus photographs taken at both baseline and follow-up visits. RESULTS: In Group A,HE severity grade had decreased significantly from baseline to the final visit(P <0.05),but this was not the case in Group B(P =0.662).The cumulative probabilities of retinopathy progression at 5y were 26% in Group A and 30% in Group B.KaplanMeier survival curves showed no significant difference between the groups with regard to retinopathy progression(P =0.805).CONCLUSION: Focal laser photocoagulation reduced the levels of HEs in eyes with mild to moderate NPDR.However,the treatment was not able to decelerate the progression of DR. | Seong Hun Jeong Jung Il Han Sung Won Cho Dong Won Lee Chul Gu Kim Tae Gon Lee Jong Woo Kim | 2016 | International Journal of Ophthalmology(English edition)2016，9，10： | 10 |
| 4 | Microstructure and corrosion resistance of a Mg2Sn-dispersed Mg alloy subjected to pulsed electron beam treatment显示文摘We report that the corrosion resistance of a Mg-Sn-based alloy with MgzSn precipitates can be considerably improved by surface modification using pulsed electron beam treatment.The alloy subjected to a pulse electron beam treatment showed a modified surface layer with a thickness of〜12 μm,appearing more resistant to corrosion attack than the bare surface of the alloy.In 0.6 M NaCl solution,the alloys with and without the surface modification exhibited average corrosion rates of 4.3 and 8.1 mm y^-1,respectively.The improved corrosion resistance was attributed to reduced cathodic activation,resulting from the surficial reduction of relatively noble Mg2Sn precipitates. | Daseul Lee Beomcheol Kim Soo-Min Baek Jisoo Kim Hyung Wook Park Jung Gu Lee Sung Soo Park | 2020 | Journal of Magnesium and Alloys2020，8，2： | 4 |
| 5 | Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization显示文摘NF-κB, a family of transcription factors regulating diverse biological processes including immune responses, is activated by canonical and noncanonical pathways based on degradation of IκBα and processing of the IκB-like protein p100, respectively. Although p100 responds to noncanonical NF-κB stimuli for processing, it does not undergo degradation, but rather becomes accumulated, along with canonical NF-κB activation. We show here that the stability of p100 is tightly controlled by a deubiquitinase, Otub1. Otub1 deficiency not only promotes signal-induced p100 processing and noncanonical NF-κB activation but also causes steady-state p100 degradation, leading to aberrant NF-κB activation in the canonical pathway. B-cell-conditional deletion of Otub1 results in B-cell hyperplasia, antibody hyper-production, and lupus-like autoimmunity. Otub1-deficient B cells display aberrantly activated phenotypes and overproduce the cytokine IL-6, contributing to autoimmunity induction. Thus, maintenance of p100 stability by Otub1 serves as an unusual mechanism of NF-κB regulation that prevents autoimmunity. | Yanchuan Li Jin-Young Yang Xiaoping Xie Zuliang Jie Lingyun Zhang Jianhong Shi Daniel Lin Meidi Gu Xiaofei Zhou Haiyan S. Li Stephanie S. Watowich Antrix Jain Sung Yun Jung Jun Qin Xuhong Cheng Shao-Cong Sun | 2019 | Cell Research2019，29，6： | 3 |
| 6 | Bispectral index monitoring as an adjunct to nurse-administered combined sedation during endoscopic retrograde cholangiopancreatography显示文摘AIM:To determine whether bispectral index (BIS) monitoring is useful for propofol administration for deep sedation during endoscopic retrograde cholangiopancreatography (ERCP). METHODS:Fifty-nine consecutive patients with a variety of reasons for ERCP who underwent the procedure at least twice between 1 July 2010 and 30 November 2010. This was a randomized cross-over study, in which each patient underwent ERCP twice, once with BIS monitoring and once with control monitoring. Whether BIS monitoring was done during the first or second ERCP procedure was random. Patients were intermittently administered a mixed regimen including midazolam, pethidine, and propofol by trained nurses. The nurse used a routine practice to monitor sedation using the Modified Observer's Assessment of Alertness/Sedation (MOAA/S) scale or the BIS monitoring. The total amount of midazolam and propofol used and serious side effects were compared between the BIS and control groups. RESULTS:The mean total propofol dose administered was 53.1 ± 32.2 mg in the BIS group and 54.9 ± 30.8 mg in the control group (P = 0.673). The individual propofol dose received per minute during the ERCP procedure was 2.90 ± 1.83 mg/min in the BIS group and 3.44 ± 2.04 mg in the control group (P = 0.103). The median value of the MOAA/S score during the maintenance phase of sedation was comparable for the two groups. The mean BIS values throughout the procedure (from insertion to removal of the endoscope) were 76.5 ± 8.7 for all 59 patients in using the BIS monitor. No significant differences in the frequency of < 80% oxygen saturation, hypotension (< 80 mmHg), or bradycardia (< 50 beats/min) were observed between the two study groups. Four cases of poor cooperation occurred, in which the procedure should be stopped to add the propofol dose. After adding the propofol, the procedure could be conducted successfully (one case in the BIS group, three cases in the control group). The endoscopist rated patient sedation as excellent for all patients in both groups. All patients in both groups rated their level of satisfaction as high (no discomfort). During the post-procedural follow-up in the recovery area, no cases of clinically significant hypoxic episodes were recorded in either group. No other postoperative side effects related to sedation were observed in either group. CONCLUSION:BIS monitoring trend to slighlty reduce the mean propofol dose. Nurse-administered propofol sedation under the supervision of a gastroenterologist may be considered an alternative under anesthesiologist. | Se Young Jang Hyun Gu Park Min Kyu Jung Chang Min Cho Soo Young Park Seong Woo Jeon Won Young Tak Young Oh Kweon Sung Kook Kim Young Hoon Jeon | 2012 | World Journal of Gastroenterology2012，18，43： | 3 |
| 7 | Light Triggers the miRNA-Biogenetic Inconsistency for De-etiolated Seedling Survivability in Arabidopsis thaliana显示文摘The shift of dark-grown seedlings into light causes enormous transcriptome changes followed by a dramatic developmental transition.Here,we show that microRNA(miRNA)biogenesis also undergoes regulatory changes during de-etiolation.Etiolated seedlings maintain low levels of primary miRNAs(pri-miRNAs)and miRNA processing core proteins,such as Dicer-like 1,SERRATE,and HYPONASTIC LEAVES 1,whereas during de-etiolation both pri-miRNAs and the processing components accumulate to high levels.However,the levels of most miRNAs do not notably increase in response to light.To reconcile this inconsistency,we demonstrated that an unknown suppressor decreases miRNA-processing activity and light-induced SMALL RNA DEGRADING NUCLEASE 1 shortens the half-life of several miRNAs in de-etiolated seedlings.Taken together,these data suggest a novel mechanism,miRNA-biogenetic inconsistency,which accounts for the intricacy of miRNA biogenesis during de-etiolation.This mechanism is essential for the survival of de-etiolated seedlings after long-term skotomorphogenesis and their optimal adaptation to ever-changing light conditions. | Suk Won Choi Moon Young Ryu Andras Viczian Hyun Ju Jung Gu Min Kim Agustin LArce Natalia PAchkar Pablo Manavella Ulla Dolde Stephan Wenke Attila Molnar Ferenc Nagy Seok Keun Cho Seong Wook Yang | 2020 | Molecular Plant2020，13，3： | 3 |
| 8 | Perovskite synthesizability using graph neural networks显示文摘Perovskite is an important material type in geophysics and for technologically important applications.However,the number of synthetic perovskites remains relatively small.To accelerate the high-throughput discovery of perovskites,we propose a graph neural network model to assess their synthesizability.Our trained model shows a promising 0.957 out-of-sample true positive rate,significantly improving over empirical rule-based methods.Further validation is established by demonstrating that a significant portion of the virtual crystals that are predicted to be synthesizable have already been indeed synthesized in literature,and those with the lowest synthesizability scores have not been reported.While previous empirical strategies are mainly applicable to metal oxides,our model is general and capable of predicting the synthesizability across all classes of perovskites,including chalcogenide,halide,and hydride perovskites,as well as anti-perovskites.We apply the method to identify synthesizable perovskite candidates for two potential applications,the Li-rich ion conductors and metal halide optical materials that can be tested experimentally. | Geun Ho Gu Jidon Jang Juhwan Noh Aron Walsh Yousung Jung | 2022 | npj Computational Materials2022，，1： | 2 |
| 9 | A real maximum power point tracking method for mismatching compensation in PV array under partially shaded conditions 显示文摘 | YOUNG HYOK JI DO0 YONG JUNG JUN GU K | 2011 | IEEE Transactions on Power Electronics2011，26，4： | 1 |
| 10 | Robotic gastrectomy for gastric cancer: surgical techniques and clinical merits显示文摘 | Kim MC Heo GU Jung GJ | 2010 | Surg Endosc2010，24，3： | 1 |
| 11 | Improved control for high power static var compensator using novel vector product phase locked loop (VP-PLL)显示文摘 | Gu H. Jung Guk C. Cho Gyu H. Cho | 1999 | International Journal of Electronics1999，，： | 1 |
| 12 | Rubotic gastrectomy for gastric canc-er :Surgical techniques and clinical merits 显示文摘 | Kim MC Heo GU Jung GJ | 2010 | Surg Endosc2010，24，3： | 1 |
| 13 | Subnasale flap for correction of columella base deviation secondary unilateral cleft lip nasal deformity显示文摘 | Jung DH Chang GU Back SH | 2010 | J Craniofac Surg2010，，1： | 1 |
| 14 | Robotic gastrectomy for gastric cancer:surgical techniques and clinical merits 显示文摘 | Kim MC Heo GU Jung GT | 2010 | Surg Endosc2010，24，3： | 1 |
| 15 | Aerosol chemistry and the effect of aerosol water content on visibility impairment and radiative forcing in Guangzhou during the 2006 Pearl River Delta campaign显示文摘 | Jinsang Jung Hanlim Lee Young J. Kim Xingang Liu Yuanhang Zhang Jianwei Gu Shaojia Fan | 2009 | Journal of Environmental Management2009，，11： | 1 |
| 16 | A real maximum power point tracking method for mismatching compensation in PV array under partially shaded conditions 显示文摘 | Ji Y H Jung D Y Kim Jun Gu | 2011 | IEEE Transactions on Power Electronics2011，26，4： | 1 |
| 17 | Metformin induces osteoblast differentiation via orphan nuclear receptor SHP-mediated transactivation of Runx2显示文摘 | Won Gu Jang Eun Jung Kim In-Ho Bae Kkot-Nim Lee Yong Deuk Kim Don-Kyu Kim Sun-Hun Kim Chul-Ho Lee Renny T Franceschi Hueng-Sik Choi Jeong-Tae Koh | 2010 | Bone2010，，4： | 1 |
| 18 | Cathodic protection criteria of thermally insulated pipeline in soil显示文摘 | Yong Wook Kim | 2001 | Corrosion Science2001，43，10： | 1 |
| 19 | Effect of chloride ions on 4-chlorophenol photodegradation in the absence and presence of titanium silicalite-2 显示文摘 | Gu Kang Man Sun Jung Hyea Jin Kim Kang | 2000 | Janrnal of Photochemistry and Photobiology A : Chemistry2000，136，12： | 1 |
| 20 | Inactivating mutations of caspase-8 gene in colorectal carcinomas显示文摘 | Hong Sug Kim Jong Woo Lee Young Hwa Soung Won Sang Park Su Young Kim Jong Heun Lee Jik Young Park Youg Gu Cho Chang Jae Kim Seong Whan Jeong Suk Woo Nam Sang Ho Kim Jung Young Lee Nam Jin Yoo Sug Hyung Lee | 2003 | Gastroenterology2003，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员