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| 1 | Expression changes and bioinformatic analysis of Wallerian degeneration after sciatic nerve injury in rat显示文摘Wallerian degeneration (WD) remains an important research topic. Many genes are differentially expressed during the process of WD, but the precise mechanisms responsible for these differentiations are not completely understood. In this study, we used microarrays to analyze the expression changes of the distal nerve stump at 0, 1, 4, 7, 14, 21 and 28 days after sciatic nerve injury in rats. The data revealed 6 076 differentially-expressed genes, with 23 types of expression, specifically enriched in genes associated with nerve development and axonogenesis, cytokine biosynthesis, cell differentiation, cytokine/chemokine production, neuron differentiation, cytokinesis, phosphorylation and axon regeneration. Kyoto Encyclopedia of Genes and Genomes pathway analysis gave findings related mainly to the MAPK signaling pathway, the Jak-STAT signaling pathway, the cell cycle, cytokine-cytokine receptor interaction, the p53 signaling pathway and the Wnt signaling pathway. Some key factors were NGF, MAG, CNTF, CTNNA2, p53, JAK2, PLCB1, STAT3, BDNF, PRKC, collagen II, FGF, THBS4, TNC and c-Src, which were further validated by real-time quantitative PCR, Western blot, and immunohistochemistry. Our findings contribute to a better understanding of the functional analysis of differentially-expressed genes in WD and may shed light on the molecular mechanisms of nerve degeneration and regeneration. | Dengbing Yao Meiyuan Li Dingding Shen Fei Ding Shibi Lu Qing Zhao Xiaosong Gu | 2013 | Neuroscience Bulletin2013，29，3： | 18 |
| 2 | Identification and functional annotation of novel microRNAs in the proximal sciatic nerve after sciatic nerve transection显示文摘The peripheral nervous system is able to regenerate after injury, and regeneration is associated with the expression of many genes and proteins. MicroRNAs are evolutionarily conserved, small, non-coding RNA molecules that regulate gene expression at the level of translation. In this paper, we focus on the identification and functional annotation of novel microRNAs in the proximal sciatic nerve after rat sciatic nerve transection. Using Solexa sequencing, computational analysis, and quantitative reverse transcription PCR verification, we identified 98 novel microRNAs expressed on days 0, 1, 4, 7, and 14 after nerve transection. Furthermore, we predicted the target genes of these microRNAs and analyzed the biological processes in which they were involved. The identified biological processes were consistent with the known time-frame of peripheral nerve injury and repair. Our data provide an important resource for further study of the role and regulation of microRNAs in peripheral nerve injury and regeneration. | LI ShiYing YU Bin WANG YongJun YAO DengBing ZHANG ZhanHu GU XiaoSong | 2011 | Science China(Life Sciences)2011，54，9： | 16 |
| 3 | Current Challenges for the Practical Application of Electroencephalography-Based Brain-Computer Interfaces显示文摘It has been almost 50 years since the term“brain–computer interface”(BCI)was first proposed by Jacques J.Vidal in 1973[1].Unlike traditional electronic interfaces that transmit nonliving information between devices,BCIs set up a communication bridge between a living brain and nonliving devices.Technically speaking,a BCI is a system that measures brain activity and converts it into the artificial outputs that replace,restore,enhance,supplement,or improve the natural central nervous system outputs[2].At present,electroencephalography(EEG)is the most commonly used brain signal for BCIs. | Minpeng Xu Feng He Tzyy-Ping Jung Xiaosong Gu Dong Ming | 2021 | Engineering2021，7，12： | 15 |
| 4 | Non-coding RNAs as Emerging Regulators of Neural Injury Responses and Regeneration显示文摘Non-coding RNAs(ncRNAs) are a large cluster of RNAs that do not encode proteins,but have multiple functions in diverse cellular processes.Mounting evidence indicates the involvement of nc RNAs in the physiology and pathophysiology of the central and peripheral nervous systems.It has been shown that numerous ncRNAs,especially micro RNAs and long non-coding RNAs,are differentially expressed after insults such as acquired brain injury,spinal cord injury,and peripheral nerve injury.These ncRNAs affect neuronal survival,neurite regrowth,and glial phenotype primarily by targeting specific mRNAs,resulting in translation repression or degradation of the mRNAs.An increasing number of studies have investigated the regulatory roles of micro RNAs and long non-coding RNAs in neural injury and regeneration,and thus a new research field is emerging.In this review,we highlight current progress in the field in an attempt to provide further insight into post-transcriptional changes occurring after neural injury,and to facilitate the potential use of ncRNAs for improving neural regeneration.We also suggest potential directions for future studies. | Songlin Zhou Fei Ding Xiaosong Gu | 2016 | Neuroscience Bulletin2016，32，3： | 12 |
| 5 | Altered microRNA expression following sciatic nerve resection in dorsal root ganglia of rats显示文摘MicroRNAs (miRNAs ) 是否定地 post-transcriptionally 调整基因表示的小、非编码的 RNA (22 核苷酸) 的一个类,通过目标 mRNAs 的翻译抑制或降级的任何一个。我们揭开了在在在在在用 microarray 分析的老鼠的臀部的神经的切除术以后的 1, 4, 7,和 14 天的背面的根 ganglia (DRG ) 的 miRNAs 的表示的以前未知的改变。32 显著地, upregulated 和 18 downregulated miRNAs 在跟随臀部的神经损害的四个次点在 DRG 被识别。四的表示连续地 deregulated miRNAs,由即时 Taqman 聚合酶链反应分析了,与 microarray 数据一致(upregulated:miR-21, miR-221;downregulated:miR-500, miR-551b ) 。为这些 miRNAs 的潜在的目标,在臀部的神经切除术以后改变了,主要涉及细胞的进程的神经系统开发,多细胞的 organismal 开发,和规定。这研究在一只老鼠在臀部的神经的切除术以后在 DRG 表明了 miRNAs 的不同参与模型,和它可以也在说明为神经新生负责的分子的机制作出贡献。 | Bin Yu Songlin Zhou Tianmei Qian Yongjun Wang Fei Ding Xiaosong Gu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，11： | 9 |
| 6 | Application of stem cells in peripheral nerve regeneration显示文摘Traumatic peripheral nerve injury is a worldwide clinical issue with high morbidity.The severity of peripheral nerve injury can be classified as neurapraxia,axonotmesis or neurotmesis,according to Seddon’s classification,or five different degrees according to Sunderland’s classification.Patients with neurotmesis suffer from a complete transection of peripheral nerve stumps and are often in need of surgical repair of nerve defects.The applications of autologous nerve grafts as the golden standard for peripheral nerve transplantation meet some difficulties,including donor nerve sacrifice and nerve mismatch.Attempts have been made to construct tissue-engineered nerve grafts as supplements or even substitutes for autologous nerve grafts to bridge peripheral nerve defects.The incorporation of stem cells as seed cells into the biomaterial-based scaffolds increases the effectiveness of tissue-engineered nerve grafts and largely boosts the regenerative process.Numerous stem cells,including embryonic stem cells,neural stem cells,bone marrow mesenchymal stem cells,adipose stem cells,skin-derived precursor stem cells and induced pluripotent stem cells,have been used in neural tissue engineering.In the current review,recent trials of stem cell-based tissue-engineered nerve grafts have been summarized;potential concerns and perspectives of stem cell therapeutics have also been contemplated. | Sheng Yi Yu Zhang Xiaokun Gu Li Huang Kairong Zhang Tianmei Qian Xiaosong Gu | 2020 | Burns & Trauma2020，8，1： | 7 |
| 7 | Biophysical Regulation of Cell Behavior-Cross Talk between Substrate Stiffness and Nanotopography显示文摘细胞外基质(ECM)的刚性和纳米拓扑结构影响生物体发育及生理和病理进程。因此,这些生物物理特征被用于调节细胞黏附、铺展至增殖、分化的各种细胞行为。描述细胞行为的生物物理调节对合理设计新型生物材料、植入物和医疗装置十分关键。已有学者就基质刚性和纳米拓扑结构特征对细胞行为的影响分别进行了综述,然而,刚性和纳米拓扑结构与细胞行为的交织影响尚未有人总结。此次,我们首次综述了基质刚性和纳米拓扑结构对细胞行为的影响,然后聚焦于生物物理信号从整合素到细胞核的细胞内传递,并试图将细胞行为的细胞外调节与基质的生物物理学特征联系在一起。最后,我们讨论了在剖析细胞行为的生物物理调节和将基质的刚性和纳米拓扑结构生物力学特性转化到组织工程和再生医学时存在的挑战。 | Yong Yang Kai Wang Xiaosong Gu Kam W. Leong | 2017 | Engineering2017，3，1： | 7 |
| 8 | Dog sciatic nerve gap repaired by artificial tissue nerve graft显示文摘The feasibility of repairing dog sciatic nerve damage by using a biodegradable artificial tissue nerve graft enriched with neuroregenerating factors is investigated. The artificial nerve graft was implanted to a 30 mm gap of the sciatic nerve damage in 7 dogs. The dogs with the same nerve damage that were repaired by interposition of the autologous nerve or were given no treatment served as control group 1 or 2, respectively. The observations include gross and morphological observations, immune reaction, electrophysiological examination, fluorescence tracing of the neuron formation and the number of the neurons at the experimental sites, etc. Results showed that 6 months after the implantation of the graft, the regenerated nerve repaired the damage of the sciatic nerve without occurrence of rejection and obvious inflammatory reaction in all 7 dogs, and the function of the sciatic nerve recovered with the nerve conduction velocity of (23.91±11.35)m/s. The regenerated neurons and the forming of axon could be observed under an electron microscope. This proves that artificial tissue nerve graft transplantation can bridge the damaged nerve ends and promote the nerve regeneration. | GU Xiaosong, ZHANG Peiyun, WANG Xiaodong, DING Fei, PENG Luping and CHENG Hongbing(Nantong Medical College, The Key Laboratory of Neuroregeneration of Jiangsu Province, Nantong 226001, China) | 2003 | Progress in Natural Science:Materials International2003，13，8： | 6 |
| 9 | Biocompatibility studies of silk fibroin-based artificial nerve grafts in vitro and in vivo显示文摘Silk fibroin(SF)has been used extensively in the biomedical field including tissue engineering for the generation of artificial bones,skins or ligaments.We have previously reported on good in vitro biocompatibility of SF fibers with peripheral nerve tissues and cells.In the present study,we developed a novel design of the SF-based artificial nerve graft(SF graft)which was composed of a SF-nerve guidance conduit(NGC)inserted with SF fibers.MTT assay was performed to determine the cytotoxicity of the SF-NGC extract fluid on the cultured L929 cells derived from an immortalized mouse fibroblast cell line.In addition,this SF graft was implanted into adult rats for bridging a 10-mm long sciatic nerve defect.The following-up experiments at initial stage(1-4 week)of nerve regeneration including routine blood tests and histochemical investigation were conducted to evaluate the in vivo biocompatibility of the SF graft with peripheral nerves.The results demonstrated that the SF-NGC graft was biocompatible with the surrounding tissues and cells due to its low inflammatory potential with a grade 0 under the U.S.Pharmacopeia guidelines and it was generally suitable to a certain degree for bridging peripheral nerve defects in virtue of supporting Schwann cell adherence,expansion and migration.Therefore the SF graft is a promising alternative to classical autografts for peripheral nerve repair. | Chen Xuemei Yang Yumin Wu Jian Zhao Yahong Ding Fei Gu Xiaosong | 2007 | Progress in Natural Science:Materials International2007，17，9： | 5 |
| 10 | The Achyranthes bidentata polypeptide k fraction enhances neuronal growth in vitro and promotes peripheral nerve regeneration after crush injury in vivo显示文摘We have previously shown that Achyranthes bidentata polypeptides(ABPP), isolated from Achyranthes bidentata Blume(a medicinal herb), exhibit neurotrophic and neuroprotective effects on the nervous system. To identify the major active component of ABPP, and thus optimize the use of ABPP, we used reverse-phase high performance liquid chromatography to separate ABPP. We obtained 12 fractions, among which the fraction of ABPPk demonstrated the strongest neuroactivity. Immunocytochemistry and western blot analysis showed that ABPPk promoted neurite growth in cultured dorsal root ganglion explant and dorsal root ganglion neurons, which might be associated with activation of Erk1/2. A combination of behavioral tests, electrophysiological assessment, and histomorphometric analysis indicated that ABPPk enhanced nerve regeneration and function restoration in a mouse model of crushed sciatic nerve. All the results suggest that ABPPk, as the key component of ABPP, can be used for peripheral nerve repair to yield better outcomes than ABPP. | Qiong Cheng Chunyi Jiang Caiping Wang Shu Yu Qi Zhang Xiaosong Gu Fei Ding | 2014 | Neural Regeneration Research2014，9，24： | 5 |
| 11 | Tweezing and manipulating micro- and nanoparticles by optical nonlinear endoscopy显示文摘The precise control and manipulation of micro-and nanoparticles using an optical endoscope are potentially important in biomedical studies,bedside diagnosis and treatment in an aquatic internal organ environment,but they have not yet been achieved.Here,for the first time,we demonstrate optical nonlinear endoscopic tweezers(ONETs)for directly controlling and manipulating aquatic micro-and nanobeads as well as gold nanorods.It is found that two-photon absorption can enhance the trapping force on fluorescent nanobeads by up to four orders of magnitude compared with dielectric nanobeads of the same size.More importantly,two-photon excitation leads to a plasmon-mediated optothermal attracting force on nanorods,which can extend far beyond the focal spot.This new phenomenon facilitates a snowball effect that allows the fast uploading of nanorods to a targeted cell followed by thermal treatment within 1 min.As two-photon absorption allows an operation wavelength at the center of the transmission window of human tissue,our work demonstrates that ONET is potentially an unprecedented tool for precisely specifying the location and dosage of drug particles and for rapidly uploading metallic nanoparticles to individual cancer cells for treatment. | Min Gu Hongchun Bao Xiaosong Gan Nicholas Stokes Jingzhi Wu | 2014 | Light(Science & Applications)2014，3，1： | 5 |
| 12 | Gene expression profiling of the rat sciatic nerve in early Wallerian degeneration after injury显示文摘Wallerian degeneration is an important area of research in modern neuroscience.A large number of genes are differentially regulated in the various stages of Wallerian degeneration,especially during the early response.In this study,we analyzed gene expression in early Wallerian degeneration of the distal nerve stump at 0,0.5,1,6,12 and 24 hours after rat sciatic nerve injury using gene chip microarrays.We screened for differentially-expressed genes and gene expression patterns.We examined the data for Gene Ontology,and explored the Kyoto Encyclopedia of Genes and Genomes Pathway.This allowed us to identify key regulatory factors and recurrent network motifs.We identified 1 546 differentially-expressed genes and 21 distinct patterns of gene expression in early Wallerian degeneration,and an enrichment of genes associated with the immune response,acute inflammation,apoptosis,cell adhesion,ion transport and the extracellular matrix.Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed components involved in the Jak-STAT,ErbB,transforming growth factor-β,T cell receptor and calcium signaling pathways.Key factors included interleukin-6,interleukin-1,integrin,c-sarcoma,carcinoembryonic antigen-related cell adhesion molecules,chemokine(C-C motif) ligand,matrix metalloproteinase,BH3 interacting domain death agonist,baculoviral IAP repeat-containing 3 and Rac.The data were validated with real-time quantitative PCR.This study provides a global view of gene expression profiles in early Wallerian degeneration of the rat sciatic nerve.Our findings provide insight into the molecular mechanisms underlying early Wallerian degeneration,and the regulation of nerve degeneration and regeneration. | Dengbing Yao Meiyuan Li Dingding Shen Fei Ding Shibi Lu Qin Zhao Xiaosong Gu | 2012 | Neural Regeneration Research2012，7，17： | 5 |
| 13 | Microelectronics-embedded channel bridging and signal regeneration of injured spinal cords显示文摘Due to the dificulty in spinal cord regeneration with biological methods,the microelectronic neural bridge,a new concept based on microelectronic technology,is presented.The microelectronic system has been realized in the forms of hybrid and integrated circuits.The integrated circuits forneural signal detection,stimulation,and regeneration are realized in a CMOS process.In animal experiments with 100 toads,48 rats,and 3 rabbits,nerve signals have been successfully detected from spinal cords and sciatic nerves,and functional electrical stimulation has been carried out for spinal cords and sciatic nerves.When the microelectronic system is bridged between the controlling and stimulated nerve,the relevant motion of legs and nerve signal waveforms,which are stimulated by the evoked or spontaneous nerve signal through such a system,have been observed.Therefore,the feasibility of the presented method was demonstrated. | Zhigong Wang Xiaosong Gu Xiaoying Lǔ Zhenglin Jiang Wenyuan Li Guangming Lǔ Yufeng Wang Xiaoyan Shen Xintai Zhao Huiling Wang Zhenyu Zhang Hongmei Shen Yang Wu Weixing Shen Jingyang Zhang Dong Chen Xiaoyi Mao Huaxiang Shen | 2009 | Progress in Natural Science:Materials International2009，19，10： | 5 |
| 14 | Noncoding RNAs and Their Potential Therapeutic Applications in Tissue Engineering显示文摘Tissue engineering is a relatively new but rapidly developing field in the medical sciences. Noncoding RNAs(ncRNAs) are functional RNA molecules without a protein-coding function; they can regulate cellular behavior and change the biological milieu of the tissue. The application of ncRNAs in tissue engineering is starting to attract increasing attention as a means of resolving a large number of unmet healthcare needs, although ncRNA-based approaches have not yet entered clinical practice. In-depth research on the regulation and delivery of ncRNAs may improve their application in tissue engineering.The aim of this review is: to outline essential ncRNAs that are related to tissue engineering for the repair and regeneration of nerve, skin, liver, vascular system, and muscle tissue; to discuss their regulation and delivery; and to anticipate their potential therapeutic applications. | Shiying Li Tianmei Qian Xinghui Wang Jie Liu Xiaosong Gu | 2017 | Engineering2017，3，1： | 4 |
| 15 | Achyranthes bidentata Blume extract promotes neuronal growth in cultured embryonic rat hippocampal neurons显示文摘We have prepared an aqueous extract of Achyranthes bidentata Blume, a commonly prescribed Chinese medicinal herb, and reported, in previous studies, that A. bidentata extract benefits nerve growth and prevents neuron apoptosis. In this study, we investigated the actions of A. bidentata extract on survival and growth of primarily cultured rat hippocampal neurons. The morphological observation revealed that neurite growth from hippocampal neurons was significantly enhanced by A. bidentata extract with similar effects to those induced by nerve growth factor (NGF), and the greatest neurite growth appeared on treatment with A. bidentata extract at 1 lg/ml for 24 h. DNA microarray analysis indicated that there were 25 upregulated genes and 47 downregulated genes exhibiting significantly differential expression in hippocampal neurons treated with A. bidentata extract at 1 lg/ml for 6 h when compared to those in untreated hippocampal neurons. Real-time quantitative RT-PCR and Western blot analysis demonstrated that the expression of growth-associated protein-43 in hippocampal neurons was upregulated at both mRNA and protein levels after treatment with A. bidentata extract, and the optimal dosage of the extract was also 1 lg/ml. These data confirm that A. bidentata extract could promote in vitro hippocampal neuronal growth in a dose-and time-dependent manner. | Xin Tang Yiren Chen Xiaosong Gu Fei Ding | 2009 | Progress in Natural Science:Materials International2009，19，5： | 4 |
| 16 | Spin-manipulated nanoscopy for single nitrogenvacancy center localizations in nanodiamonds显示文摘Due to their exceptional optical and magnetic properties,negatively charged nitrogen-vacancy(NV−)centers in nanodiamonds(NDs)have been identified as an indispensable tool for imaging,sensing and quantum bit manipulation.The investigation of the emission behaviors of single NV−centers at the nanoscale is of paramount importance and underpins their use in applications ranging from quantum computation to super-resolution imaging.Here,we report on a spin-manipulated nanoscopy method for nanoscale resolutions of the collectively blinking NV−centers confined within the diffraction-limited region.Using wide-field localization microscopy combined with nanoscale spin manipulation and the assistance of a microwave source tuned to the optically detected magnetic resonance(ODMR)frequency,we discovered that two collectively blinking NV−centers can be resolved.Furthermore,when the collective emitters possess the same ground state spin transition frequency,the proposed method allows the resolving of each single NV−center via an external magnetic field used to split the resonant dips.In spin manipulation,the three-level blinking dynamics provide the means to resolve two NV−centers separated by distances of 23 nm.The method presented here offers a new platform for studying and imaging spin-related quantum interactions at the nanoscale with superresolution techniques. | Martina Barbiero Stefania Castelletto Xiaosong Gan Min Gu | 2017 | Light(Science & Applications)2017，6，1： | 3 |
| 17 | Neurological function following intra-neural injection of fluorescent neuronal tracers in rats显示文摘Fluorescent neuronal tracers should not be toxic to the nervous system when used in long-term labeling.Previous studies have addressed tracer toxicity,but whether tracers injected into an intact nerve result in functional impairment remains to be elucidated.In the present study,we examined the functions of motor,sensory and autonomic nerves following the application of 5% Fluoro-Gold,4% True Blue and 10% Fluoro-Ruby (5μL) to rat tibial nerves via pressure injection.A set of evaluation methods including walking track analysis,plantar test and laser Doppler perfusion imaging was used to determine the action of the fluorescent neuronal tracers.Additionally,nerve pathology and ratio of muscle wet weight were also observed.Results showed that injection of Fluoro-Gold significantly resulted in loss of motor nerve function,lower plantar sensibility,increasing blood flow volume and higher neurogenic vasodilatation.Myelinated nerve fiber degeneration,unclear boundaries in nerve fibers and high retrograde labeling efficacy were observed in the Fluoro-Gold group.The True Blue group also showed obvious neurogenic vasodilatation,but less severe loss of motor function and degeneration,and fewer labeled motor neurons were found compared with the Fluoro-Gold group.No anomalies of motor and sensory nerve function and no myelinated nerve fiber degeneration were observed in the Fluoro-Ruby group.Experimental findings indicate that Fluoro-Gold tracing could lead to significant functional impairment of motor,sensory and autonomic nerves,while functional impairment was less severe following True Blue tracing.Fluoro-Ruby injection appears to have no effect on neurological function. | Wen Hu Dan Liu Yanping Zhang Zhongyi Shen Tianwen Gu Xiaosong Gu Jianhui Gu | 2013 | Neural Regeneration Research2013，8，14： | 3 |
| 18 | Progress and perspectives of neural tissue engineering显示文摘对神经系统的创伤的损害与相当高的发生导致一个普通临床的问题并且影响生活的病人质量。把增加的兴趣基于,神经织物工程的一个新奇答应领域出现了,种,并且吸引当前的治疗学的干预还没为这些疾病探讨的主要挑战。这评论在这个领域里提供最近的进步的一篇简短摘要,特别在有作者组的研究经验的联合。与织物有关的几个重要方面设计了神经,包括在他们的构造,进诊所的翻译,在制造技术的改进,和再生环境的形成的理论,被描出并且讨论。而且,为神经织物工程的未来发展的潜在的研究方向被建议。 | Xiaosong Gu | 2015 | Frontiers of Medicine2015，9，4： | 3 |
| 19 | miR-20a Promotes the Axon Regeneration of DRG Neurons by Targeting Nr4a3显示文摘Dear Editor,The peripheral nervous system(PNS)regenerates more easily after injury than the central nervous system(CNS)[1].Sensory neurons in the L4–L6 dorsal root ganglia(DRGs)extend axons to form the sciatic nerve along with motor axons.The DRG neuron is one of the exceptional mature neurons whose axons can regenerate after injury. | Lili Zhao Leilei Gong Ping Li Jing Qin Lingchi Xu Qiyao Wei Huimin Xie Susu Mao Bin Yu Xiaosong Gu Songlin Zhou | 2021 | Neuroscience Bulletin2021，37，4： | 3 |
| 20 | Scar-modulating treatments for central nervous system injury显示文摘Traumatic injury to the adult mammalian central nervous system(CNS) leads to complex cellular responses. Among them, the scar tissue formed is generally recognized as a major obstacle to CNS repair, both by the production of inhibitory molecules and by the physical impedance of axon regrowth. Therefore, scar-modulating treatments have become a leading therapeutic intervention for CNS injury. To date, a variety of biological and pharmaceutical treatments, targeting scar modulation, have been tested in animal models of CNS injury, and a few are likely to enter clinical trials. In this review, we summarize current knowledge of the scar-modulating treatments according to their specific aims:(1) inhibition of glial and fibrotic scar formation, and(2) blockade of the production of scar-associated inhibitory molecules. The removal of existing scar tissue is also discussed as a treatment of choice. It is believed that only a combinatorial strategy is likely to help eliminate the detrimental effects of scar tissue on CNS repair. | Dingding Shen Xiaodong Wang Xiaosong Gu | 2014 | Neuroscience Bulletin2014，30，6： | 3 |
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