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| 1 | Efficacy and cost analysis of transrectal ultrasound-guided prostate biopsy under monitored anesthesia显示文摘镇静可以在指导的 transrectal 超声(TRUS ) 期间疼痛地导致减小前列腺活体检视。我们试图在在护理费用的指导 TRUS 的前列腺活体检视和相关增加期间评估 propofol 和 remifentanil 注入的联合的功效和安全。从 1 月到 2010 年 9 月,经历 transrectal 前列腺活体检视的 100 个人被使随机化进二个组。在组 1, 50 个病人收到了 propofol 和 remifentanil 的联合注入;在组 2, 50 个病人收到了 lidocaine 果冻。在指导 TRUS 的活体检视被执行以后,疼痛和耐心的满足被一个 10 点评估视觉模拟规模(管) ,和一张费用相关的耐心的满足问询表被所有病人完成。病人们也被问他们是否将愿意由一样的方法经历重复活体检视。在 1 看了显著地更低的管的组的病人在组 2 比那些得分(吝啬的管分数:0.9 ± 1.1 对 6.3 ± 2.5;P< 0.001 ) 。另外,耐心的满足规模在组 1 是显著地更高的(P=0.002 ) 。尽管全面费用在组 1 是显著地更高的(P=0.006 ) ,就费用而言的耐心的满足规模在这个组(P=0.009 ) 也是更高的。propofol 和 remifentanil 的联合在指导 TRUS 的前列腺活体检视期间是到减少病人疼痛和增加病人满足的一条安全、有效的路。尽管费用在收到了镇静,期望的组是更高的,病人展出了提高的满足和心甘情愿由一样的方法重复活体检视。 | Sung Gu Kang Bum Sik Tae Sam Hong Min Young Hwii Ko Seok Ho Kang Jeong Gu Lee Je Jong Kim Jun Cheon | 2011 | Asian Journal of Andrology2011，13，5： | 5 |
| 2 | The biochemical efficacy of primary cryoablation combined with prolonged total androgen suppression compared with radiotherapy on high-risk prostate cancer: a 3-year pilot study显示文摘为了在高风险的前列腺癌症,联合本地治疗的一条综合途径和雄激素剥夺治疗(ADT ) 的管理获得有益的效果,被使用。我们比较了在与与 ADT 相结合的延长 ADT 和放射相结合的前列腺(CSAP ) 的主要 cryosurgical 脱离之间的生物化学的回答,它是在高风险的疾病的确定的形式。收到的 CSAP 在治疗以后与 ADT 相结合 3 个月在前并且直到 24 个月的 33 个高风险的病人的一个总数。这个耐心的组与另外一个被匹配为 ADT 与一样的协议经历了三维的保角的放射治疗(3D-CRT ) 的 33 个病人。生物化学的复发(BCR ) 被美国社会为治疗学的放射肿瘤学(ASTRO ) 估计 0.5 ng mL 的定义,菲尼克斯定义和前列腺特定的抗原(PSA ) 截止 ? 1。中部的后续是为 CSAP + ADT 的 11.9 个月组织的 61.0 卤和为 3D-CRT + ADT 的 15.8 个月组织的 86.0 卤。在 CSAP 组,包括 rectourethral 管和不能自制的主要复杂并发症没被注意。在 CSAP + ADT 组, 57.0% 用 ASTRO 定义有 BCR, 21.2% 使用菲尼克斯定义并且 54.5% 使用 0.5 ng mL 的 PSA 截止 ? 1。在 3D-CRT + ADT 组, 54.5% , 21.2% 和 54.5% 分别地用 ASTRO,菲尼克斯和 PSA 定义有 BCR。在 CSAP + ADT 组, BCR 免费的幸存(BRFS ) 是 54 卤用 ASTRO 定义的 10 个月, 65 卤用菲尼克斯定义的 5 个月和 51 卤用 0.5 ng mL 的 PSA 截止的 4 个月 ? 1。在 3D-CRT + ADT 组, BRFS 是 68 卤 12, 93 卤 19 和 70 卤分别地使用 ASTRO,菲尼克斯和 PSA 定义的 18 个月。由木头等级测试,为每个组的 BRFS 价值不是统计上不同的。这中间术语的结果显示与延长 ADT 相结合的主要 CSAP 在高风险的前列腺癌症与放射疗法相比提供平行生物化学的回答。 | Young Hwii Ko Seok Ho Kang Young Je Park Hong Seok Park Du Geon Moon Jeong Gu Lee Duck Ki Yoon Je Jong Kim Jun Cheon | 2010 | Asian Journal of Andrology2010，12，6： | 3 |
| 3 | Do microRNA 96, 145 and 221 expressions really aid in Lhe prognosis of prostate carcinoma?显示文摘MicroRNAs (米尔) 是被报导了正在答应诊断工具的小 noncoding RNA。我们使用了量的即时反向的抄写 PCR (RT-qPCR ) 分析在前列腺肿瘤的表示 miRNAs 取样决定它的预示的价值的差别。从 2007 ~ 2009,肿瘤纸巾从 73 个激进的前列腺切除术标本被获得。差别表示了 miR-96, -145 和 -221 被 TaqMan RT-qPCR 用所有 73 纸巾验证。预示的价值用 Kaplan-Meier 和考克斯回归分析以生物化学的复发被估计。为我们的耐心的队,吝啬的年龄是 64.7 年(50-76 年) ,吝啬的前列腺特定的抗原(PSA ) 是 7.5 ng ml −1 。在后续时期期间(平均数, 19.4 个月) , 73 中的 14 个(19.2 %) 病人们发展了生物化学的复发。miR-96, -145 和 -221 的表示与对方一起强烈相关,但是在 miRNA 表示和 clinicopathologic 参数之间没有关联。用木头等级测试的 Kaplan-Meier 幸存曲线与病理学的舞台显示出减少的生物化学的没有复发的间隔(P< 0.001 ) 。另外,有超过 8 的格利森分数的病人, 6 与格利森一起与那些相比得分,在 Kaplan-Meier 分析(P=0.001 ) 显示出减少的生物化学的没有复发的间隔。然而, miR-96, -145 和 -221 的表示没用考克斯在 Kaplan-Meier 幸存曲线或由 multivariate 分析与生物化学的复发间隔相关比例的危险回归模型也。在结论,我们没观察在 miR-96, -145 和 -221 和 clinicopathologic 参数的表达式之间的重要关联。为了在临床的实践作为一个诊断工具利用 miRNA,更多的研究被需要理解 miRNA 机制,识别 miRNA 目标,并且进一步描绘 miRNA,工作。 | Sung Gu Kang Young Ran Ha Seo Jin Kim Seok Ho Kang Hong Seok Park Jeong Gu Lee Jun Cheon | 2012 | Asian Journal of Andrology2012，14，5： | 2 |
| 4 | A real maximum power point tracking method for mismatching compensation in PV array under partially shaded conditions 显示文摘 | Ji Y H Jung D Y Kim Jun Gu | 2011 | IEEE Transactions on Power Electronics2011，26，4： | 1 |
| 5 | Risk Reduction of Adverse Effects Due to Di-(2-Ethylhexyl) Phthalate (DEHP) by Utilizing Microbial Degradation显示文摘 | Ji Hye Baek Man Bock Gu Byoung-In Sang Seung Jun Kwack Kyu Bong Kim Byung Mu Lee | 2009 | Journal of Toxicology and Environmental Health, Part A . 2009 (21-2)2009，，21： | 1 |
| 6 | An Anatomic Study of the Superficial Peroneal Nerve Accessory Artery Perforator Flaps显示文摘 | Jun Sik Kim Dae Gu Son Tac Hyun Choi | 2008 | Annals of Plastic Surgery2008，5，6： | 1 |
| 7 | Comparison of the efficacy and tolerability of pitavastatin and atorvastatin: An 8-week, multicenter, randomized, open-label, dose-titration study in korean patients with hypercholesterolemia显示文摘 | Sang Hak Lee Namsik Chung Jun Kwan Doo-Il Kim Won Ho Kim Chee Jeong Kim Hyun Seung Kim Si Hoon Park Hong Seog Seo Dong Gu Shin Yung Woo Shin Wan-Joo Shim Tae Hoon Ahn Kyeong Ho Yun Myeong-Ho Yoon Kwang-Soo Cha Si-Wan Choi Seong Wook Han Min Su Hyon | 2007 | Clinical Therapeutics2007，，11： | 1 |
| 8 | Development of building materials by using micro - encapsulated phase change material 显示文摘 | SEE HOON LEE SANG JUN YOON YONG GU KIM | 2007 | Korean J Chem Eng2007，24，2： | 1 |
| 9 | Metabolomic and transcriptomic study to understand changes in metabolic and immune responses in steers under heat stress显示文摘Heat stress(HS)damages livestock by adversely affecting physiological and immunological functions.However,fundamental understanding of the metabolic and immunological mechanisms in animals under HS remains elusive,particularly in steers.To understand the changes on metabolic and immune responses in steers under HS condition,we performed RNA-sequencing and proton nuclear magnetic resonance spectroscopy-based metabolomics on HS-free(temperature humidity index[THI]value:64.92±0.56)and HS-exposed(THI value:79.13±0.56)Jersey steer(n=8,body weight:559.67±32.72 kg).This study clarifies the metabolic changes in 3 biofluids(rumen fluid,serum,and urine)and the immune responses observed in the peripheral blood mononuclear cells of HS-exposed steers.This integrated approach allowed the discovery of HS-sensitive metabolic and immunological pathways.The metabolomic analysis indicated that HS-exposed steers showed potential HS biomarkers such as isocitrate,formate,creatine,and riboflavin(P<0.05).Among them,there were several integrative metabolic pathways between rumen fluid and serum.Furthermore,HS altered mRNA expression and immune-related signaling pathways.A meta-analysis revealed that HS decreased riboflavin metabolism and the expression of glyoxylate and dicarboxylate metabolism-related genes.Moreover,metabolic pathways,such as the hypoxia-inducible factor-1 signaling pathway,were downregulated in immune cells by HS(P<0.05).These findings,along with the datasets of pathways and phenotypic differences as potential biomarkers in steers,can support more in-depth research to elucidate the interrelated metabolic and immunological pathways.This would help suggest new strategies to ameliorate the effects of HS,including disease susceptibility and metabolic disorders,in Jersey steers. | Jun Sik Eom Da Som Park Sang Jin Lee Bon-Hee Gu Shin Ja Lee Sang-Suk Lee Seon-Ho Kim Byeong-Woo Kim Sung Sill Lee Myunghoo Kim | 2022 | Animal Nutrition2022，，4： | 1 |
| 10 | Optimized solid-state synthesis of LiFePO 4 cathode materials using ball-milling显示文摘 | Hee-Cheol Kang Dae-Kyoo Jun Bo Jin En Mei Jin Kyung-Hee Park Hal-Bon Gu Ki-Won Kim | 2008 | Journal of Power Sources2008，，1： | 1 |
| 11 | High-dose dietary zinc promotes prostate intraepithelial neoplasia in a murine tumor induction mode显示文摘 | Young Hwii Ko Yu Jeong Woo Jin Wook Kim Hoon Choi Seok Ho Kang Jeong Gu Lee Je Jong Kim Hong Seok Park Jun Cheon | 2010 | Asian Journal of Andrology2010，12，2： | 1 |
| 12 | Elevated level of peripheral CD8 + CD28 ? T lymphocytes are an independent predictor of progression-free survival in patients with metastatic breast cancer during the course of chemotherapy显示文摘 | Guohong Song Xiaoli Wang Jun Jia Yanhua Yuan Fengling Wan Xinna Zhou Huabing Yang Jun Ren Jiezhun Gu Herbert Kim Lyerly | 2013 | Cancer Immunology Immunotherapy2013，，6： | 1 |
| 13 | Adenocarcinoma of the small intestine: a multi-institutional study of 197 surgically resected cases显示文摘 | Hee-Kyung Chang Eunsil Yu Jihun Kim Young Kyung Bae Kee-Taek Jang Eun Sun Jung Ghil Suk Yoon Joon Mee Kim Young-Ha Oh Han-Ik Bae Gwang Il Kim Soo Jin Jung Mi Jin Gu Jung Yeon Kim Kyu Yun Jang Sun-Young Jun Dae Woon Eom Kye Won Kwon Gyeong Hoon Kang Jae Bo | 2010 | Human Pathology2010，，8： | 1 |
| 14 | A prospective phase II trial of S-1 and cisplatin-based chemoradiotherapy for locoregionally advanced esophageal cancer显示文摘 | Hyun Chang Sung Kwan Shin Byoung Chul Cho Chang-Geol Lee Choong Bai Kim Dae Joon Kim Jin Gu Lee Jin Hur Chang Young Lee Mi Kyung Bae Hye Ryun Kim Sang Kil Lee Jun Chul Park Hyuk Lee Hyoung-Il Kim Hyunsoo Chung Jihye Cha Yong Chan Lee Joo-Hang Kim | 2014 | Cancer Chemotherapy and Pharmacology2014，，： | 1 |
| 15 | An Anatomic Study of the Superficial Peroneal Nerve Accessory Artery Perforator Flaps显示文摘 | Jun Sik Kim Dae Gu Son Tac Hyun Choi | 2008 | An- nals of Plastic Surgery2008，5，6： | 1 |
| 16 | Fabrication of sonicated chitosan nanotiber mat with enlarged porosity for use as hemostatic materials显示文摘 | Bon Kang Gu Sang Jun Park Min Sup Kim | 2013 | Carbohydrate Polymers2013，97，： | 1 |
| 17 | Light-stabilized FHA2 suppresses miRNA biogenesis through interactions with DCL1 and HYL1显示文摘The precise regulation of microRNA(miRNA)biogenesis is crucial for plant development,which requires core microprocessors and many fine tuners to coordinate their miRNA processing activity/specificity in fluctuating cellular environments.During de-etiolation,light triggers a dramatic accumulation of core microprocessors and primary miRNAs(pri-miRNAs)but decreases pri-miRNA processing activity,resulting in relatively constant miRNA levels.The mechanisms underlying these seemingly contradictory regulatory changes remain unclear.In this study,we identified forkhead-associated domain 2(FHA2)as a light-stabilized suppressor of miRNA biogenesis.We found that FHA2 deficiency increased the level of mature miRNAs,accompanied by a reduction in pri-miRNAs and target mRNAs.Biochemical assays showed that FHA2 associates with the core microprocessors DCL1,HYL1,and SE,forming a complex to suppress their pri-miRNA processing activity.Further analyses revealed that FHA2 promotes HYL1 binding but inhibits the binding of DCL1-PAZ-RNase-RNA-binding domains(DCL1-PRR)to miRNAs,whereas FHA2 does not directly bind to these RNAs.Interestingly,we found that FHA2 protein is unstable in the dark but stabilized by light during de-etiolation.Consistently,disruption of FH A led to defects in light-triggered changes in miRNA expression and reduced the survival rate of deetiolated seedlings after prolonged light deprivation.Collectively,these data suggest that FHA2 is a novel light-stabilized suppressor of miRNA biogenesis and plays a role in fine-tuning miRNA processing during de-etiolation. | Seung Jun Park Suk Won Choi Gu Min Kim Christian Moller Hyun-Sook Pai Seong Wook Yang | 2021 | Molecular Plant2021，14，4： | 1 |
| 18 | An inactivated vaccine to control the current H9N2 low pathogenic avian influenza in Korea显示文摘 | Jun Gu Choi Youn Jeong Lee Yong Joo Kim | 2008 | J Vet Sic2008，9，1： | 1 |
| 19 | Follicle-stimulating hormone receptor gene polymorphism and ovarian responses to controlled ovarian hyperstimulation for IVF-ET显示文摘 | Jong Kwan Jun Ji Sung Yoon Seung-Yup Ku Young Min Choi Kyu Ri Hwang Seo Young Park Gyoung Hoon Lee Won Don Lee Seok Hyun Kim Jung Gu Kim Shin Yong Moon | 2006 | Journal of Human Genetics2006，，8： | 1 |
| 20 | 在初始PSA和Gleason评分较高的前列腺癌病人中前列腺活检术后分期MRI对T3疾病的预测力会降低显示文摘为提高预测囊外扩展(ECE)和精囊浸润(SVI)的准确性,我们评估了影响MRI(磁共振成像)预测的变量,并估计了这些变量对术前MRI分期和病理结果之间准确性的影响。121名行机器手前列腺癌根治术(RALP)的局限性或局限性晚期前列腺癌病人,经直肠活检后,所有入选病人都接受了MRI的检查进行分期诊断。经过RALP后,只有43.8%(53/121)的病人与MRI的预测分期相匹配。与在ECE预测中的匹配组相比,非匹配组的初始前列腺特异抗原(PSA)明显高于匹配组(非匹配组12.8ng mL-1,匹配组8.1ng mL-1,P=0.048).在对SVI的预测中,非匹配组中,初始PSA8.1w.17.3ng mL-1,P=0.009和穿刺活检Gleason评分6.5w.7.6,P=-0.035均显著高于匹配组。如果把10ng mL-1和20ng mL-1的PSA水平作为临床临界值,预测ECE时,对于PSA水平高于20ng mL-1的病人,MRJ准确性会下降(75.6%,64.5%,37.5%,P=0.01);对这组病人预测SVI时,MRI的准确性也会明显下降(91.5%,77.4%,37.5%,P〈0.01)。如果把Gleason评分为7分作为临床临界值,对Gleason评分高于7分的病人,预测SvI时MRI的准确性也会显著下降(93.9%,82.1%,62.9%,P=0.01)。因此,对于这些患者,为了获得前列腺癌根治术过程中的切缘阴性,能提供大量信息的是手术发现而不是活检后的MRI图像,暗示在前列腺活检以前进行MRI检查在临床上更有优势。 | Young Hwii Ko Deuk Jae Sung Sung Gu Kang Seok Ho Kang Jeong Gu Lee Je Jong Kim Jun Cheon | 2011 | Asian Journal of Andrology2011，13，3： | 0 |
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