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| 1 | Natural and engineered bacterial outer membrane vesicles显示文摘Bacterial outer membrane vesicle(OMV)is a kind of spherical lipid bilayer nanostructure naturally secreted by bacteria,which has diverse functions such as intracellular and extracellular communication,horizontal gene transfei;transfer of contents to host cells,and eliciting an immune response in host cells.In this review,several methods including ultracentrifugation and precipNation for isolating OMVs were summarized.The latest progresses of OMVs in biomedical fields,especially in vaccine development,cancer treatment,infection control,and bioimaging and detection were also summarized in this review.We highlighted the importance of genetic engineering for the safe and effective application and in facilitating the rapid development of OMVs.Finally,we discussed the bottleneck problems about OMVs in preparation and application at present and put forward our own suggestions about them.Some perspectives of OMVs in biomedical field were also provided. | Guangchao Qing Ningqiang Gong Xiaohui Chen Jing Chen Hong Zhang Yongchao Wang Ruifang Wang Shouwen Zhang Zhen Zhang Xianxian Zhao Yang Luo Xing-Jie Liang | 2019 | Biophysics Reports2019，5，4： | 4 |
| 2 | Effect of physicochemical properties on in vivo fate of nanoparticle-based cancer immunotherapies显示文摘Current advances of immunotherapy have greatly changed the way of cancer treatment.At the same time,a great number of nanoparticle-based cancer immunotherapies(NBCIs)have also been explored to elicit potent immune responses against tumors.However,few NBCIs are nearly in the clinical trial which is mainly ascribed to a lack understanding of in vivo fate of nanoparticles(NPs)for cancer immunotherapy.NPs for cancer immunotherapy mainly target the immune organs or immune cells to enable effcient antitumor immune responses.The physicochemical properties of NPs including size,shape,elasticity and surface properties directly affect their interaction with immune systems as well as their in vivo fate and therapeutic effect.Hence,systematic analysis of the physicochemical properties and their effect on in vivo fate is urgently needed.In this review,we frst recapitulate the fundamentals for the in vivo fate of NBCIs including physio-anatomical features of lymphatic system and strategies to modulate immune responses.Moreover,we highlight the effect of physicochemical properties on their in vivo fate including lymph nodes(LNs)drainage,cellular uptake and intracellular transfer.Challenges and opportunities for rational design of NPs for cancer immunotherapy are also discussed in detail. | Yongchao Wang Jinjin Wang Dandan Zhu Yufei Wang Guangchao Qing Yuxuan Zhang Xiaoxuan Liu Xing-Jie Liang | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 1 |
| 3 | ELECTROCHEMICAL ALLOYING OF Ni IN MOLTEN NaCl-KCl-PrCl_3显示文摘The cyclic voltammetry,electrode potential-time curve after potentiostatic electrolysis,potential-step method and X-ray diffraction were used to study the electrode processof Pr(Ⅲ)reduced on Ni electrode in molten NaCl-KCl-PrCl3.The PrNi5 formsat first and then the intermetallic compounds of Pr-Ni containing more Pr form insequence.The metallic Pr deposits at last.The standard free energies of formationfor PrNi5 determined are-123.6,-118.9 and-114.4 kJ mol-1 at 1023,1073 and 1123K respectively.The diffusion coefficient of Pr into PrNi5 phase determined is 3×10-11cm2 s-1 at 1073 K. | YANG Qiqin LIU Guankun TONG Yexiang LIANG Guangchao Zhongshan University,Guangzhou,China | 1992 | Acta Metallurgica Sinica(English Letters)1992，5，11： | 1 |
| 4 | Structure,far-infrared spectroscopy,microwave dielectric properties,and improved low-temperature sintering characteristics of tri-rutile Mg_(0.5)Ti_(0.5)TaO_(4) ceramics显示文摘In this study,tri-rutile type Mg_(0.5)Ti_(0.5)TaO_(4) ceramics were synthesized,where the structure–property relationship,especially the structural configuration and intrinsic dielectric origin of Mg_(0.5)Ti_(0.5)TaO_(4) ceramics,and the low-firing characteristics were studied.It is found that the tri-rutile structural type is unambiguously identified through the Rietveld refinement analysis,the selected area electron diffraction(SAED),and the high-resolution transmission electron microscopy(HRTEM)along the[110]zone axis.With the increase in sintering temperature,the densification and uniformity of crystal growth play important roles in regulating the microwave dielectric properties of Mg_(0.5)Ti_(0.5)TaO_(4) ceramics.Intrinsically,theoretical dielectric properties calculated by the far-infrared reflective spectra approached the experimental values,indicating the importance of structural features to dielectric properties.Furthermore,a glass additive with high matching relevance with ceramics has been developed to decrease the high sintering temperature of Mg_(0.5)Ti_(0.5)TaO_(4) ceramics,where 2–4 wt%Li_(2)O–MgO–ZnO–B_(2)O_(3)–SiO_(2)(LMZBS)glass frit was adopted to reduce the suitable temperature from 1275 to 1050℃ without significantly deteriorating the microwave dielectric characteristics.Specifically,Mg_(0.5)Ti_(0.5)TaO_(4) ceramics containing 2 wt% glass addition sintered at 1050℃for 4 h possess excellent microwave dielectric properties:dielectric constant(ε_(r))=44.3,quality factor multiplied by resonant frequency(Q×f)=23,820 GHz(f=6.2 GHz),and the temperature coefficient of resonant frequency(τ_(f))=123.2 ppm/℃. | Hongyu YANG Liang CHAI Guangchao LIANG Mengjiang XING Zixuan FANG Xing ZHANG Tianying QIN Enzhu LI | 2023 | Journal of Advanced Ceramics2023，12，2： | 1 |
| 5 | Parameter Optimization via Orthogonal Experiment to Improve Accuracy of Metakaolin Ceramics Fabricated by Direct Ink Writing显示文摘Kaolin/metakaolin-insulating ceramic components fabricated using direct ink writing(DIW)have important ap-plication prospects in architecture and aerospace.The accuracy of the entire process including the forming and sintering accuracy of ceramics greatly limits the application scope,and high-accuracy ceramic samples can meet the usage requirements in many scenarios.The orthogonal experiment was designed with four process parame-ters,including nozzle internal diameter,filling rate,printing layer height/nozzle internal diameter,and printing speed,to investigate the evolution of the DIW forming accuracy,sintering shrinkage rate and surface roughness of metakaolin-based ceramics with different process parameters.The influence of each process parameter and its mechanism were analyzed to obtain the DIW parameters for high-accuracy metakaolin ceramics.Multiple linear regression models between the dimensional change rate,surface roughness,and process parameters of the ceramic samples were established and validated.The results show that comprehensively considering the forming accuracy of the ceramic green bodies,sintering shrinkage rate and surface roughness,the optimal DIW process parameters were a 0.41 mm nozzle internal diameter,100%filling rate,50%printing layer height/nozzle inter-nal diameter,and a 15 mm/s printing speed.Multiple linear regression models were developed for the process parameters and the printing accuracy,sintering shrinkage rate and surface roughness.The error rates between the theoretical results obtained by substituting the optimal process parameters into the multiple linear regression models and the actual results obtained by printing the samples with the optimal parameters were extremely small,all less than 0.8%.This verified the correctness and predictability of the multiple linear regression models.This work provides a reference basis for rapid fabrication of high-accuracy ceramics via DIW and accuracy prediction with different process parameters. | Ming Wu Fuchu Liu Yuxiao Lin Miao Wang Shilin Zhou Chi Zhang Yingpeng Mu Guangchao Han Liang Hao | 2023 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2023，2，4： | 0 |
| 6 | Sound speed profiles in high spatiotemporal resolution using multigrid three-dimensional variational method:a coastal experiment off northern Shandong Peninsula显示文摘It is essential to ac quire sound speed profiles(SSPs)in high-precision spatiotemporal resolution for undersea acoustic activities.However,conventional observation methods cannot obtain high-resolution SSPs.Besides,S SPs are complex and changeable in time and space,especially in coastal areas.We proposed a new space-time multigrid three-dimensional variational method with weak constraint term(referred to as STC-MG3DVar)to construct high-precision spatiotemporal resolution SSPs in coastal areas,in which sound velocity is defined as the analytical variable,and the Chen-Millero sound velocity empirical formula is introduced as a weak constraint term into the cost function of the STC-MG3DVar.The spatiotemporal correlation of sound velocity observations is taken into account in the STC-MG3DVar method,and the multi-scale information of sound velocity observations from long waves to short waves can be successively extracted.The weak constraint term can optimize sound velocity by the physical relationship between sound velocity and temperature-salinity to obtain more reasonable and accurate SSPs.To verify the accuracy of the STC-MG3DVar,SSPs observations and CTD observations(temperature observations,salinity observations)are obtained from field experiments in the northern coastal area of the Shandong Peninsula.The average root mean square error(RMSE)of the STC-MG3DVar-constructed SSPs is 0.132 m/s,and the STC-MG3DVar method can improve the SSPs construction accuracy over the space-time multigrid 3DVar without weak constraint term(ST-MG3DVar)by 10.14%and over the spatial multigrid 3DVar with weak constraint term(SC-MG3DVar)by 44.19%.With the advantage of the constraint term and the spatiotemporal correlation information,the proposed STC-MG3DVar method works better than the ST-MG3DVar and the SCMG3DVar in constructing high-precision spatiotemporal re solution SSPs. | Guangchao HOU Jingsheng ZHAI Qi SHAO Yanling ZHAO Wei LI Guijun HAN Kangzhuang LIANG | 2023 | Journal of Oceanology and Limnology2023，41，1： | 0 |
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