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您的检索式：作者名="Tianying QIN"
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| 1 | Curcumin inhibits the replication of enterovirus 71 in vitro显示文摘Human enterovirus 71(EV71)is the main causative pathogen of hand,foot,and mouth disease(HFMD)in children.The epidemic of HFMD has been a public health problem in Asia-Pacific region for decades,and no vaccine and effective antiviral medicine are available.Curcumin has been used as a traditional medicine for centuries to treat a diversity of disorders including viral infections.In this study,we demonstrated that curcumin showed potent antiviral effect again EV71.In Vero cells infected with EV71,the addition of curcumin significantly suppressed the synthesis of viral RNA,the expression of viral protein,and the overall production of viral progeny.Similar with the previous reports,curcumin reduced the production of ROS induced by viral infection.However,the antioxidant property of curcumin did not contribute to its antiviral activity,since N-acetyl-L-cysteine,the potent antioxidant failed to suppress viral replication.This study also showed that extracellular signal-regulated kinase(ERK)was activated by either viral infection or curcumin treatment,but the activated ERK did not interfere with the antiviral effect of curcumin,indicating ERK is not involved in the antiviral mechanism of curcumin.Unlike the previous reports that curcumin inhibited protein degradation through ubiquitin–proteasome system(UPS),we found that curcumin had no impact on UPS in control cells.However,curcumin did reduce the activity of proteasomes which was increased by viral infection.In addition,the accumulation of the short-lived proteins,p53 and p21,was increased by the treatment of curcumin in EV71-infected cells.We further probed the antiviral mechanism of curcumin by examining the expression of GBF1 and PI4KB,both of which are required for the formation of viral replication complex.We found that curcumin significantly reduced the level of both proteins.Moreover,the decreased expression of either GBF1 or PI4KB by the application of siRNAs was sufficient to suppress viral replication.We also demonstrated that curcumin showed anti-apoptotic activity at the early stage of viral infection.The results of this study provide solid evidence that curcumin has potent anti-EV71 activity.Whether or not the down-regulated GBF1 and PI4KB by curcumin contribute to its antiviral effect needs further studies. | Ying Qin Lexun Lin Yang Chen Shuo Wu Xiaoning Si Heng Wu Xia Zhai Yan Wang Lei Tong Bo Pan Xiaoyan Zhong Tianying Wang Wenran Zhao Zhaohua Zhong | 2014 | Acta Pharmaceutica Sinica B2014，4，4： | 5 |
| 2 | Structure,far-infrared spectroscopy,microwave dielectric properties,and improved low-temperature sintering characteristics of tri-rutile Mg_(0.5)Ti_(0.5)TaO_(4) ceramics显示文摘In this study,tri-rutile type Mg_(0.5)Ti_(0.5)TaO_(4) ceramics were synthesized,where the structure–property relationship,especially the structural configuration and intrinsic dielectric origin of Mg_(0.5)Ti_(0.5)TaO_(4) ceramics,and the low-firing characteristics were studied.It is found that the tri-rutile structural type is unambiguously identified through the Rietveld refinement analysis,the selected area electron diffraction(SAED),and the high-resolution transmission electron microscopy(HRTEM)along the[110]zone axis.With the increase in sintering temperature,the densification and uniformity of crystal growth play important roles in regulating the microwave dielectric properties of Mg_(0.5)Ti_(0.5)TaO_(4) ceramics.Intrinsically,theoretical dielectric properties calculated by the far-infrared reflective spectra approached the experimental values,indicating the importance of structural features to dielectric properties.Furthermore,a glass additive with high matching relevance with ceramics has been developed to decrease the high sintering temperature of Mg_(0.5)Ti_(0.5)TaO_(4) ceramics,where 2–4 wt%Li_(2)O–MgO–ZnO–B_(2)O_(3)–SiO_(2)(LMZBS)glass frit was adopted to reduce the suitable temperature from 1275 to 1050℃ without significantly deteriorating the microwave dielectric characteristics.Specifically,Mg_(0.5)Ti_(0.5)TaO_(4) ceramics containing 2 wt% glass addition sintered at 1050℃for 4 h possess excellent microwave dielectric properties:dielectric constant(ε_(r))=44.3,quality factor multiplied by resonant frequency(Q×f)=23,820 GHz(f=6.2 GHz),and the temperature coefficient of resonant frequency(τ_(f))=123.2 ppm/℃. | Hongyu YANG Liang CHAI Guangchao LIANG Mengjiang XING Zixuan FANG Xing ZHANG Tianying QIN Enzhu LI | 2023 | Journal of Advanced Ceramics2023，12，2： | 1 |
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