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您的检索式：作者名="Guangde Dong"
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| 1 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 2 | Multi-stage Coordinated Robust Optimization for Soft Open Point Allocation in Active Distribution Networks with PV显示文摘To optimize the placement of soft open points(SOPs)in active distribution networks(ADNs),many aspects should be considered,including the adjustment of transmission power,integration of distributed generations(DGs),coordination with conventional control methods,and maintenance of economic costs.To address this multi-objective planning problem,this study proposes a multi-stage coordinated robust optimization model for the SOP allocation in ADNs with photovoltaic(PV).First,two robust technical indices based on a robustness index are proposed to evaluate the operation conditions and robust optimality of the solutions.Second,the proposed coordinated allocation model aims to optimize the total cost,robust voltage offset index,robust utilization index,and voltage collapse proximity index.Third,the optimization methods of the multiand single-objective models are coordinated to solve the proposed multi-stage problem.Finally,the proposed model is implemented on an IEEE 33-node distribution system to verify its effectiveness.Numerical results show that the proposed index can better reveal voltage offset conditions as well as the SOP utilization,and the proposed model outperforms conventional ones in terms of robustness of placement plans and total cost. | Anqi Tao Niancheng Zhou Yuan Chi Qianggang Wang Guangde Dong | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，5： | 0 |
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