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| 1 | 通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病显示文摘 AIM:To evaluate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.METHODS:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liver biopsies,the first at surgery and the second after 16 ± 3 mo of weight loss.Biopsies were evaluated and compared in a blinded fashion.The presence of metabolic syndrome,anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy.RESULTS:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prevalence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P < 0.001).Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery.There were improvements in steatosis(P < 0.001),lobular(P < 0.001) and portal(P < 0.05) inflammation and fibrosis(P < 0.001) at the second biopsy.There were 25(96.1%) patients with non alcoholic steatohepatitis(NASH) in their index biopsy and only four(15.3%) of the repeat biopsies fulfilled the criteria for NASH.The persistence of fibrosis(F > 1) was present in five patients at second biopsy.Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery.CONCLUSION:Restrictive mildly malabsorptive surgery provides significant weight loss,resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients. | Víctor Vargas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 2 | Role of roots and shoots in the regulation of the Fe efficiency responses in sunflower and cucumber显示文摘 | ROMERA F J ALCANTARA E DELA GUARDIA M D | 1992 | Plant Physiol1992，85，： | 1 |
| 3 | Vita- min C is an ideal substitute for hydrazine in the reduction of graphene oxide suspensions显示文摘 | Ferndndez-Merino M J Guardia L Paredes J I | 2010 | J Phys Chem C2010，114，： | 1 |
| 4 | Rapid detection of lamivudine-resistant hepatitis B virus polymerase gene variants显示文摘 | Jardi R Buti M Rodriguez FF Cotrina M Costa X Pascual C Esteban R Guardia J | | 0，，： | 1 |
| 5 | Flavanones in Citrus fruit:Structure-antioxidant activity relationships显示文摘 | Majo D D Giammanco M Guardia M L Tripoli E Giammanco S Finotti E | 2005 | Food Research International2005，38，： | 1 |
| 6 | Hepatobiliary complications associated with total parenteral nutrition显示文摘 | Angelico M Della Guardia P | 2000 | Aliment Pharmacol Ther2000，14，2： | 1 |
| 7 | Detailed polybrominated diphenyl ether (PBDE) congener composition of the widely used pent,a-, octa-, and deea-PBDE technical flame-retardant mixtures 显示文摘 | Guardia M J Hale R C Hale R C | 2006 | Environmental Science and Technology2006，40，20： | 1 |
| 8 | Flavanones in citrus fruit: structure-antioxidant activity relationships显示文摘 | MAJO D D GIAMMANCO M GUARDIA M L | 2005 | Food Research International2005，38，10： | 1 |
| 9 | Citrus flavonoids: Molecular structure, biological activity and nutritional properties : A review显示文摘 | Tripoli E Guardia M Giammanco S | 2007 | Food Chemistry2007，104，2： | 1 |
| 10 | Brominated flame retardant concentrations and trends in abiotic media显示文摘 | HALE R C LA GUARDIA M J HARVEY E GAYLOR M O MAINOR T M | 2006 | Chemosphere2006，64，2： | 1 |
| 11 | Solid-phase FT-Raman determination of caffeine in energy drinks显示文摘 | ARMENTA S GARR1GUES S GUARDIA M | | 0，，02： | 1 |
| 12 | PLS-NIR determination of total sugar, glucose, fructose and sucrose in aqueous solutions of fruit juices 显示文摘 | Rambla F J Garrigues S Guardia M De la | 1997 | Analytica Chimica Acta1997，344，： | 1 |
| 13 | Efficiency of the microwave-assisted extraction of hydrocarbons and pesticides from sediments 显示文摘 | Pastora A Vazquezb E Ciscar R Guardia M de la | 1997 | Analytica Chimica Acta1997，344，： | 1 |
| 14 | Determination of edible oil parameters by near in- frared spectrometry显示文摘 | AMENTA S GARRIGUES S DE LA GUARDIA M | 2007 | Anal Chim Acta2007，596，2： | 1 |
| 15 | Detailed polybrominated diphenyl ether (PBDE) congener composi- tion of the widely used penta-, octa- and deca-PBDE technical flame-retardant mixtures显示文摘 | La Guardia M J Hale R C Harvey E | 2006 | Environmental Science and Technology2006，40，20： | 1 |
| 16 | Evidence of debromination of decabromodiphenyl ether( BDE-209 )in biota from a wastewater receiving stream显示文摘 | La Guardia M J Hale R C Harvey E | 2007 | Environmental Science & Technology2007，41，19： | 1 |
| 17 | Recent developments in flow-analysis vibrational spectroscopy显示文摘 | Armenta S Garrigues S Guardia M | 2007 | TrAC Trends in Analytical Chemistry2007，26，8： | 1 |
| 18 | Treatment and valo- rization of leather industry solid wastes : a review 显示文摘 | Tahiri S Guardia M | 2009 | Journal of the American Leather Chemists Association2009，104，： | 1 |
| 19 | Assessment of high hydrostatic pressure starter culture on the quality properties of low-acid fermented sausages显示文摘 | MARCOS B AYMERICH T GUARDIA M D | | 0，，01： | 1 |
| 20 | Determination of total arsenic in soft drinks by hydride generation atomic fluorescence spectrometry显示文摘 | EL-HADRI F MORALES-RUBIO A de la GUARDIA M | 2007 | Food Chemistry2007，105，3： | 1 |
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