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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 3 | 气候变化下旱区农业生态系统的可持续性显示文摘农业生产是将自然资源不断转化为农产品的过程。简单的说就是将阳光、空气、水和土壤等无机资源转化为可以供人类消费的有机产物。农业生态系统必须对全球气候变化、市场竞争、自然环境的恶化、经济等政策法规和人民的需求等因素做出灵活的应对策略,同时还要保证自然生态系统的稳定性。在发展中国家, | 李凤民 Kadambot H. M Siddique Neil C Turner 欧阳志云 Guijun Yan 熊友才 | 2011 | 生态学报2011，31，9： | 5 |
| 4 | Pravastatin alleviates lipopolysaccharide-induced placental TLR4 over-activation and promotes uterine arteriole remodeling without impairing rat fetal development显示文摘Preeclampsia is associated with over-activation of the innate immune system in the placenta,in which toll-like receptor 4(TLR4) plays an essential part.With their potent anti-inflammatory effects,statins have been suggested as potential prevention or treatment of preeclampsia,although evidence remains inadequate.Herewith,we investigated whether pravastatin could ameliorate preeclampsia-like phenotypes in a previously established lipopolysaccharide(LPS)-induced rat preeclampsia model,through targeting the TLR4/NF-κB pathway.The results showed that pravastatin reduced the blood pressure [maximum decline on gestational day(GD) 12,(101.33±2.49) mmHg vs.(118.3±1.37) mmHg,P<0.05] and urine protein level [maximum decline on GD9,(3,726.23± 1,572.86) μg vs.(1,991.03 ±609.37)μg,P< 0.05],which were elevated following LPS administration.Pravastatin also significantly reduced the rate of fetal growth restriction in LPS-treated rats(34.10% vs.8.99%,P<0.05).Further pathological analyses suggested a restoration of normal spiral artery remodeling in preeclampsia rats by pravastatin treatment.These effects of pravastatin were associated with decreased TLR4/NF-κB protein levels in the placenta and IL-6/MCP-1 levels in serum.Additionally,no obvious abnormalities in fetal liver,brain,and kidney were found after administration of pravastatin.These results provide supportive evidence for use of pravastatin in preventing preeclampsia. | Muyi Yang Zhenyu Diao Zhiyin Wang Guijun Yan Guangfeng Zhao Mingming Zheng Anyi Dai Yimin Dai Yali Hu | 2018 | The Journal of Biomedical Research2018，32，4： | 5 |
| 5 | 第二届生态系统评估与管理(EAM)国际会议综述显示文摘自2005年联合国《千年生态系统评估》发布以来,旱区农业生态系统评估与管理研究越来越受到世界各国的广泛关注和重视。综述了2010年7月19日至25日在兰州大学举行的第二届生态系统评估与管理(Ecosystem assessment and management,EAM)国际会议28场特邀专家报告,围绕'气候变化与旱区农业生态系统管理'主题,分别从生态系统时空格局、全球变化生态学、植物逆境适应机制、植物与土壤关系和生态系统管理五个方面进行总结,旨在探讨全球气候变化条件下如何提高干旱与半干旱脆弱农业生态系统生产力和可持续性发展的创新理论研究。对生态系统评估与管理的未来发展趋势和目标进行了探讨,并对该会议将来的举办和组织形式提出了建议。 | 李朴芳 赵旭喆 程正国 Kadambot H. M Siddique Neil C Turner 李凤民 Guijun Yan 熊友才 | 2011 | 生态学报2011，31，9： | 3 |
| 6 | MicroRNA-145 suppresses mouse granulosa cell proliferation by targeting activin receptor IB显示文摘 | Guijun Yan Lianxiao Zhang Ting Fang Qun Zhang Shaogen Wu Yue Jiang Haixiang Sun Yali Hu | 2012 | FEBS Letters2012，，19： | 2 |
| 7 | The neonatal ketone body is important for primordial follicle pool formation and regulates ovarian ageing in mice显示文摘Adverse nutritional conditions during the perinatal stage are related to early menopause in adulthood;however,the underlying mechanism is still unclear.Herein,we revealed that colostrum-activated ketone body elevation during the postnatal stage regulated primordial follicle reservoir size and then affected ovarian ageing.We found that the expression of the ketogenesis rate-limiting enzyme 3-hydroxy-3-methylglutaryl-CoA synthase 2(Hmgcs2)was largely enhanced during primordial follicle pool formation after birth and might be activated in the ovaries by colostrum.Reactive oxygen species(ROS)elevation in the ovaries leads to follicle apoptosis to deplete damaged follicles,while Hmgcs2 deficiency enhances follicle apoptosis and thus decreases the size of the primordial follicle pool and leads to premature ovarian ageing(POA),which might be related to the activation of cellular endogenous antioxidant system.All these defects could be rescued by ketone body administration,which suppressed ROS-activated follicle apoptosis.Our results suggest that the internal metabolic homeostasis of newborn mice is critical for the primordial reservoir and that any intrauterine and perinatal undernutrition could result in POA. | Xin-Ying Wang Xin-Ge Zhang Yong-Juan Sang Dan-Yang Chong Xiao-Qiang Sheng Hai-Quan Wang Chao-Fan Yang GuiJun Yan Hai-Xiang Sun Chao-Jun Li | 2022 | Life Metabolism2022，1，2： | 1 |
| 8 | Mode demuhi- plexing based on multimodulus blind equalization algorithm 显示文摘 | Chang Yuxin Hu Guijun Yan Li | 2014 | Optics Communications2014，324，： | 1 |
| 9 | MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2显示文摘 | Anyi Dai Haixiang Sun Ting Fang Qun Zhang Shaogen Wu Yue Jiang Lijun Ding Guijun Yan Yali Hu | 2013 | FEBS Letters2013，，15： | 1 |
| 10 | Visible-light- driven hydrogen production with extremely high quantum efficiency on Pt-PdS/CdS photocatalyst 显示文摘 | Yan Hongjian Yang Jinhui Ma Guijun | 2009 | Journal of Catalysis2009，266，2： | 1 |
| 11 | Activation of sphingosine kinase-1 mediates inhibition of vascular smooth muscle cell apoptosis by hyperglycemia显示文摘 | YOU Bei REN Aixia YAN Guijun | 2007 | Diabetes2007，56，5： | 1 |
| 12 | MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2显示文摘 | Anyi Dai Haixiang Sun Ting Fang Qun Zhang Shaogen Wu Yue Jiang Lijun Ding Guijun Yan Yali Hu | 2013 | FEBS Letters2013，，15： | 1 |
| 13 | Direct splitting of H 2 S into H 2 and S on CdS-based photocatalyst under visible light irradiation显示文摘 | Guijun Ma Hongjian Yan Jingying Shi Xu Zong Zhibing Lei Can Li | 2008 | Journal of Catalysis2008，，1： | 1 |
| 14 | 油料作物育种的分子工具和技术创新显示文摘油料作物的主要育种目标是提高产量、品质和抗逆性。目前,就产量而言,全球主要油料作物依次为大豆、油菜、向日葵和花生。本文综述了这些主要油料作物育种的分子工具和技术创新,包括基因组选择、基因组编辑、分子设计育种等新技术,指出了当前在遗传研究和育种实践中存在的主要问题,并对技术进展和未来应用前景进行了展望,旨在为油料作物高产、优质、高效育种提供借鉴。 | 许玲 Hui LIU Guijun YAN Wallace COWLING 周伟军 路战远 | 2023 | 浙江大学学报(农业与生命科学版)2023，49，4： | 1 |
| 15 | Visible-light-driven hydrogen production with extremely high quantum efficiency on Pt–PdS/CdS photocatalyst显示文摘 | Hongjian Yan Jinhui Yang Guijun Ma Guopeng Wu Xu Zong Zhibin Lei Jingying Shi Can Li | 2009 | Journal of Catalysis2009，，2： | 1 |
| 16 | High-energy-density plasma in femtosecond-laser-irradiated nanowire-array targets for nuclear reactions显示文摘In this work,the high-energy-density plasmas(HEDP)evolved from joule-class-femtosecond-laser-irradiated nanowire-array(NWA)targets were numerically and experimentally studied.The results of particle-in-cell simulations indicate that ions accelerated in the sheath field around the surfaces of the nanowires are eventually confined in a plasma,contributing most to the high energy densities.The protons emitted from the front surfaces of the NWA targets provide rich information about the interactions that occur.We give the electron and ion energy densities for broad target parameter ranges.The ion energy densities from NWA targets were found to be an order of magnitude higher than those from planar targets,and the volume of the HEDP was several-fold greater.At optimal target parameters,8%of the laser energy can be converted to confined protons,and this results in ion energy densities at the GJ/cm^(3) level.In the experiments,the measured energy of the emitted protons reached 4 MeV,and the changes in energy with the NWA’s parameters were found to fit the simulation results well.Experimental measurements of neutrons from 2H(d,n)3He fusion with a yield of(24±18)×10^(6)/J from deuterated polyethylene NWA targets also confirmed these results. | Defeng Kong Guoqiang Zhang Yinren Shou Shirui Xu Zhusong Mei Zhengxuan Cao Zhuo Pan Pengjie Wang Guijun Qi Yao Lou Zhiguo Ma Haoyang Lan Wenzhao Wang Yunhui Li Peter Rubovic Martin Veselsky Aldo Bonasera Jiarui Zhao Yixing Geng Yanying Zhao Changbo Fu Wen Luo Yugang Ma Xueqing Yan Wenjun Ma | 2022 | Matter and Radiation at Extremes2022，7，6： | 1 |
| 17 | Physical Activity,Sedentary Behavior,and the Risk of Cardiovascular Disease in Type 2 Diabetes Mellitus Patients:The MIDiab Study显示文摘The aim of this study was to explore the associations of moderate-to-vigorous-intensity physical activity(MVPA)time and sedentary(SED)time with a history of cardiovascular disease(CVD)and multifactorial(i.e.,blood pressure(BP),body mass index(BMI),low-density lipoprotein cholesterol(LDL-C),and glycated hemoglobin A1c(HbA1c))control status among type 2 diabetes mellitus(T2DM)patients in China.A cross-sectional analysis of 9152 people with type 2 diabetes from the Multifactorial Intervention on Type 2 Diabetes(MIDiab)study was performed.Patients were grouped according to their self-reported MVPA time(low,<150 min·week−1;moderate,150 to<450 min·week−1;high,≥450 min·week−1)and SED time(low,<4 h·d–1;moderate,4 to<8 h·d–1;high,≥8 h·d–1).Participants who self-reported a history of CVD were identified as having a CVD risk.Odds ratios(ORs)and 95%confidence intervals(CIs)of CVD risk and multifactorial control status associated with MVPA time and SED time were estimated using mixed-effect logistic regression models,adjusting for China’s geographical region characteristics.The participants had a mean±standard deviation(SD)age of(60.87±8.44)years,44.5%were women,and 25.1%had CVD.After adjustment for potential confounding factors,an inverse association between high MVPA time and CVD risk that was independent of SED time was found,whereas this association was not observed in the moderate-MVPA group.A higher MVPA time was more likely to have a positive effect on the control of BMI.Compared with the reference group(i.e.,those with MVPA time≥450 min·week−1 and SED time<4 h·d–1),CVD risk was higher in the low-MVPA group:The OR associated with an SED time<4 h·d–1 was 1.270(95%CI,1.040–1.553)and that associated with an SED time≥8 h·d–1 was 1.499(95%CI,1.149–1.955).We found that a high MVPA time(i.e.,≥450 min·week−1)was associated with lower odds of CVD risk regardless of SED time among patients with T2DM. | Yafei Wu Guijun Qin Guixia Wang Libin Liu Bing Chen Qingbo Guan Zhongshang Yuan Xu Hou Ling Gao Chao Xu Haiqing Zhang Xu Zhang Qiu Li Yongfeng Song Fei Jing Shizhan Ma Shanshan Shao Meng Zhao Qingling Guo Nanwei Tong Hongyan Zhao Xiaomin Xie Chao Liu Zhongyan Shan Zhifeng Cheng Xuefeng Yu Shulin Chen Tao Yang Yangang Wang Dongmei Li Zhaoli Yan Lixin Guo Qiuhe Ji Wenjuan Wang Jiajun Zhao | 2023 | Engineering2023，，1： | 1 |
| 18 | A new method for producing allohexaploid Brassica through unreduced gametes显示文摘 | Annaliese S. Mason Guijun Yan Wallace A. Cowling Matthew N. Nelson | 2012 | Euphytica2012，，2： | 1 |
| 19 | Umbilical cord artery-derived perivascular stem cells for treatment of ovarian failure through CD146 signaling显示文摘Dear Editor,Chemotherapy-induced ovarian failure significantly diminishes ovarian blood flow,ovarian size,and follicular development.Angiogenesis plays a vital role in repairing ovarian damage.1 Perivascular stem cells(PSCs),known as mural cells covering the vasculature,are essential for blood vessel formation and postulated as progenitors of mesenchymal stem cells(MSCs).2,3 We previously established umbilical cord artery-derived PSCs(UCA-PSCs)and Wharton’s jelly-derived MSCs(WJ-MSCs)and UCAPSCs display optimal angiogenic capacity in vitro.4 Therefore,we explored the angiogenesis and pro-angiogenesis mechanisms of UCA-PSCs and provided them as an efficient treatment strategy for ovarian failure. | Lu Xu Yanjun Yang Lingling Zhang Guijun Yan Shiyuan Li Yifan Li Yali Hu Lijun Ding Bruno Péault Haixiang Sun | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
| 20 | Thermoelectric Power and l/f Noise in the Normal State of YBa_(2)Cu_(3)O_(7-δ)/PrBa_(2)Cu_(3)O_(7-δ) Superlattice显示文摘The thermoelectric power(TEP)and l/f noise of a series of YBa_(2)Cu_(3)O_(7-δ)/PrBa_(2)Cu_(3)O_(7-δ)(YBCO/PrBCO)superlattice samples have been measured from 80 to 270K.The TEP of the superlattices has large and positive values.For samples with thick YBCO layers,it varies linearly with temperature and has a positive slope.The noise power of superlattice samples is about two orders of magnitude lower than that in bulk YBCO film. | LIU Guoliang LIU Sangtian WANG Min LIAN Guijun LI Guohong XIONG Guangcheng YAN Shousheng | 1994 | Chinese Physics Letters1994，11，12： | 0 |
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