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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 3 | Chance-constrained Coordinated Optimization for Urban Electricity and Heat Networks显示文摘Urban electricity and heat networks(UEHN)consist of the coupling and interactions between electric power systems and district heating systems,in which the geographical and functional features of integrated energy systems are demonstrated.UEHN have been expected to provide an effective way to accommodate the intermittent and unpredictable renewable energy sources,in which the application of stochastic optimization approaches to UEHN analysis is highly desired.In this paper,we propose a chance-constrained coordinated optimization approach for UEHN considering the uncertainties in electricity loads,heat loads,and photovoltaic outputs,as well as the correlations between these uncertain sources.A solution strategy,which combines the Latin Hypercube Sampling Monte Carlo Simulation(LHSMCS)approach and a heuristic algorithm,is specifically designed to deal with the proposed chance-constrained coordinated optimization.Finally,test results on an UEHN comprised of a modified IEEE 33-bus system and a 32-node district heating system at Barry Island have verified the feasibility and effectiveness of the proposed framework. | Zhinong Wei Juan Sun Zhoujun Ma Guoqiang Sun Haixiang Zang Sheng Chen Side Zhang Kwok W.Cheung | 2018 | CSEE Journal of Power and Energy Systems2018，4，4： | 6 |
| 4 | Removing Endotoxin from Protein Solution by Chitosan Modified Affinity Membrane显示文摘Affinity membrane was prepared with chitosan immobilized on the hydrophile- modified poly(vinylidene fluoride) (PVDF) membrane. Fourier transform infrared spectroscopy (FTIR.) analysis indicated that the contents of —NH2 and —OH groups increased and fluoride decreased on the membrane surface after modification. Using this kind of affinity membrane, the effects of operation parameters such as pH, ionic strength and flow rate, on the amount of endotoxin removed were investigated. The results showed that the equilibrium adsorption capacity and the dissociation constant of the affinity membrane to endotoxin were 21.4 EU·mg-1 membrane and 0.50EU·ml-1, respectively, at pH 7.0 and ionic strength 0.2 mol·L-1. Adsorption appeared to follow a typical Langmuir adsorption isotherm. At pH 5.0, ionic strength of 0.2 mol·L-1, the removal rate of endotoxin from BSA solution with the chitosan affinity membrane was up to 88.6% (11.50 EU·mg-1 membrane), and the recovery of BSA was 93.4% (0.187mg·mg-1 membrane), while at pH 11.0, ionic strength of 0.2mol·L-1, the removal rate of endotoxin from lysozyme solution was 72.4% (9.92EU·mg-1 membrane), and the recovery of lysozyme was 92.3% (0.104 mg·mg-1 membrane). | SUN Haixiang(孙海翔) ZHANG Lin(张林) CHAI Hong(柴红) CHEN Huanlin(陈欢林) | 2005 | Chinese Journal of Chemical Engineering2005，13，4： | 5 |
| 5 | MicroRNA-145 suppresses mouse granulosa cell proliferation by targeting activin receptor IB显示文摘 | Guijun Yan Lianxiao Zhang Ting Fang Qun Zhang Shaogen Wu Yue Jiang Haixiang Sun Yali Hu | 2012 | FEBS Letters2012，，19： | 2 |
| 6 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
| 7 | MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2显示文摘 | Anyi Dai Haixiang Sun Ting Fang Qun Zhang Shaogen Wu Yue Jiang Lijun Ding Guijun Yan Yali Hu | 2013 | FEBS Letters2013，，15： | 1 |
| 8 | Study of human-globulin adsorption capacity of PVDF hollow fiber affinity membranes containing different amino acid ligands显示文摘 | Sun Haixiang Zhang Lin Chai Hong | 2006 | Sep Purif Technol2006，48，： | 1 |
| 9 | MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2显示文摘 | Anyi Dai Haixiang Sun Ting Fang Qun Zhang Shaogen Wu Yue Jiang Lijun Ding Guijun Yan Yali Hu | 2013 | FEBS Letters2013，，15： | 1 |
| 10 | Surface modification of poly(tetrafluoroethylene) films via plasma treatment and graft copolymerization of acrylic acid 显示文摘 | SUN Haixiang ZHANG Lin | 2006 | Desalination2006，192，1： | 1 |
| 11 | Rotor End Factors for 2-D FEA of Induction Motors with Smooth or Slitted Solid Rotor显示文摘Modifying the equivalent rotor resistivity with rotor end factor in 2-dimension(2-D)finite element analysis(FEA)is an effective way to analyze the 3-dimension(3-D)solid rotor problems.For the smooth solid rotor,five different rotor end factors are discussed and compared with each other.It is theoretically clarified that the resistivity of rotor in 2-D FEA should be multiplied by the square of rotor end factors to take the 3-D end effect of solid rotor into account.For the slitted solid rotor,an improved rotor end factor is proposed based on the equivalent area algorithm of eddy currents in rotor,since the end factors of smooth solid rotor are not applicable.Finally,the time-harmonic finite element method(FEM)combined with the rotor end factor is applied to analyze the performance of solid rotor induction motor.The tested and computed results are in good agreement,which proves the effectiveness of rotor end factor for the simplication of 3-D solid rotor problems. | Shanming Wang Ziguo Huang Yuguang Sun Haixiang Cao | 2017 | CES Transactions on Electrical Machines and Systems2017，1，2： | 1 |
| 12 | Cardo polyimides/TiO 2 mixed matrix membranes: Synthesis, characterization, and gas separation property improvement显示文摘 | Haixiang Sun Cheng Ma Bingbing Yuan Tao Wang Yanyan Xu Qingzhong Xue Peng Li Ying Kong | 2014 | Separation and Purification Technology2014，，： | 1 |
| 13 | Evaluation of SRAP markers efficiency in genetic diversity of Aspergillus flavus from peanut-cropped soils in China显示文摘In order to evaluation the efficiency of SRAP markers on genetic diversity of Aspergillus flavus,we screened out 17sets of primer pairs which could produce clear and reproducible SRAP bands from 150 SRAP primer pairs.The size of SRAP fragments ranged from 120 to 2100 bp.Primer pair Me10/Em9 produced the maximum number of polymorphic bands(12 bands),while Me8/Em13 produced the fewest number of polymorphic bands(only 1).Through analysis genetic diversity ability of different sets of primer pairs,the set of 12 primer pairs was selected for SRAP genetic marker of A.flavus.Cluster analysis was performed based on the genetic similarity coefficients,which ranged from 0.53 to 0.89.A dendrogram assembled using the unweighted pair-group method with arithmetic averages grouped A.flavus samples into 5 main clusters.The results suggested that SRAP marker is a useful molecular technology for the diversity of A.flavus from peanut soils in China. | Chushu Zhang Lifei Zhu Mian Wang Yueyi Tang Haixiang Zhou Qi Sun Qiang Yu Jiancheng Zhang | 2022 | Oil Crop Science2022，7，3： | 0 |
| 14 | The mRNA–miRNA–lncRNA Regulatory Network and Factors Associated with Prognosis Prediction of Hepatocellular Carcinoma显示文摘The aim of this study was to identify novel prognostic mRNA and microRNA(miRNA)biomarkers for hepatocellular carcinoma(HCC)using methods in systems biology.Differentially expressed mRNAs,miRNAs,and long non-coding RNAs(lncRNAs)were compared between HCC tumor tissues and normal liver tissues in The Cancer Genome Atlas(TCGA)database.Subsequently,a prognosis-associated mRNA co-expression network,an mRNA–miRNA reg-ulatory network,and an mRNA–miRNA–lncRNA regulatory network were constructed to identify prognostic biomarkers for HCC through Cox survival analysis.Seven prognosis-associated mRNA co-expression modules were obtained by analyzing these differentially expressed mRNAs.An expression module including 120 mRNAs was significantly corre-lated with HCC patient survival.Combined with patient survival data,several mRNAs and miRNAs,including CHST4,SLC22A8,STC2,hsa-miR-326,and hsa-miR-21 were identified from the network to predict HCC patient prognosis.Clinical significance was investigated using tissue microarray analysis of samples from 258 patients with HCC.Functional annotation of hsa-miR-326 and hsa-miR-21-5p indicated specific associations with several cancer-related pathways.The present study provides a bioinformatics method for biomarker screening,leading to the identification of an integrated mRNA–miRNA–lncRNA regulatory network and their co-expression patterns in relation to predicting HCC patient survival. | Bo Hu Xiaolu Ma Peiyao Fu Qiman Sun Weiguo Tang Haixiang Sun Zhangfu Yang Mincheng Yu Jian Zhou Jia Fan Yang Xu | 2021 | Genomics, Proteomics & Bioinformatics2021，19，6： | 0 |
| 15 | Effect of autologous bone marrow stem cells-scaffold transplantation on the ongoing pregnancy rate in intrauterine adhesion women:a randomized,controlled trial显示文摘Intrauterine adhesion is a major cause of female reproductive disorders.Although we and others uncontrolled pilot studies showed that treatment with autologous bone marrow stem cells made a few patients with severe intrauterine adhesion obtain live birth,no large sample randomized controlled studies on this therapeutic strategy in such patients have been reported so far.To verify if the therapy of autologous bone marrow stem cells-scaffold is superior to traditional treatment in moderate to severe intrauterine adhesion patients in increasing their ongoing pregnancy rate,we conducted this randomized controlled clinical trial.Totally 195 participants with moderate to severe intrauterine adhesion were screened and 152 of them were randomly assigned in a 1:1 ratio to either group with autologous bone marrow stem cells-scaffold plus Foley balloon catheter or group with only Foley balloon catheter(control group)from February 2016 to January 2020.The per-protocol analysis included 140 participants:72 in bone marrow stem cells-scaffold group and 68 in control group.The ongoing pregnancy occurred in 45/72(62.5%)participants in the bone marrow stem cells-scaffold group which was significantly higher than that in the control group(28/68,41.2%)(RR=1.52,95%CI 1.08–2.12,P=0.012).The situation was similar in live birth rate(bone marrow stem cells-scaffold group 56.9%(41/72)vs.control group 38.2%(26/68),RR=1.49,95%CI 1.04–2.14,P=0.027).Compared with control group,participants in bone marrow stem cells-scaffold group showed more menstrual blood volume in the 3rd and 6th cycles and maximal endometrial thickness in the 6th cycle after hysteroscopic adhesiolysis.The incidence of mild placenta accrete was increased in bone marrow stem cells-scaffold group and no severe adverse effects were observed.In conclusion,transplantation of bone marrow stem cells-scaffold into uterine cavities of the participants with moderate to severe intrauterine adhesion increased their ongoing pregnancy and live birth rates,and this therapy was relatively safe. | Hui Zhu Taishun Li Peizhen Xu Lijun Ding Xianghong Zhu Bin Wang Xiaoqiu Tang Juan Li Pengfeng Zhu Huiyan Wang Chenyan Dai Haixiang Sun Jianwu Dai Yali Hu | 2024 | Science China(Life Sciences)2024，67，1： | 0 |
| 16 | Umbilical cord artery-derived perivascular stem cells for treatment of ovarian failure through CD146 signaling显示文摘Dear Editor,Chemotherapy-induced ovarian failure significantly diminishes ovarian blood flow,ovarian size,and follicular development.Angiogenesis plays a vital role in repairing ovarian damage.1 Perivascular stem cells(PSCs),known as mural cells covering the vasculature,are essential for blood vessel formation and postulated as progenitors of mesenchymal stem cells(MSCs).2,3 We previously established umbilical cord artery-derived PSCs(UCA-PSCs)and Wharton’s jelly-derived MSCs(WJ-MSCs)and UCAPSCs display optimal angiogenic capacity in vitro.4 Therefore,we explored the angiogenesis and pro-angiogenesis mechanisms of UCA-PSCs and provided them as an efficient treatment strategy for ovarian failure. | Lu Xu Yanjun Yang Lingling Zhang Guijun Yan Shiyuan Li Yifan Li Yali Hu Lijun Ding Bruno Péault Haixiang Sun | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
| 17 | Damage Characteristics and Control Measures of Maize Head Smut显示文摘Maize head smut is a worldwide disease,widely occurred in most maize fields. The disease had occurred in large area in the late 1970 s,and became a limiting factor restricting the improvement of maize yield and total yield in China. After efforts of several generations of agricultural scientific workers,the symptoms,pathogen,infection pathway,infection conditions,infection regularity and resistance genetic law of maize head smut have been studied. This paper introduces the incidence symptoms,pathogen sources,infection pathway,infection conditions,and physiological races of maize head smut,and put forwards the corresponding prevention measures,such as crop rotation,selection of resistant varieties,seed dressing,soil treatment with fungicides,promoting seedling emergence and strengthening field management. | Bai Yanfeng Jiang Long Ren Haixiang Wang Yanping Wang Xiaomei Zong Chunmei Sun Xiaohuan Qi Yuxin | 2014 | Plant Diseases and Pests2014，5，5： | 0 |
| 18 | Niobium fluoride-modified hydrogen evolution reaction of magnesium borohydride diammoniate显示文摘Metal borohydride ammoniates have become one of the most promising hydrogen storage materials due to their ultrahigh capacities.However,their application is still restricted by the high temperature of hydrogen desorption and the release of ammonia.Here,to promote the dehydrogenation evolution and suppress the ammonia release,different amounts of NbF 5 were introduced into Mg(BH4)2·2NH3.Compared to the pure Mg(BH_(4))_(2)·2NH_(3),the Mg(BH_(4))_(2)·2NH_(3)-NbF_(5) composites exhibit lower onset dehydriding temperatures(53–57℃)and higher dehydriding capacities(5.6 wt.%–8.2 wt.%)at below 200℃,with the complete suppression of ammonia.In addition,7.4 wt.%H_(2) could be released from Mg(BH_(4))_(2)·2NH_(3)–5 mol%NbF5 composite at 200℃ within 20 min and the apparent activation energy is calculated to be 60.28 kJ mol^(-1),which is much lower than that of pure Mg(BH_(4))_(2)·2NH_(3)(92.04 kJ mol^(-1)).Mg(BH_(4))_(2)·2NH_(3) should mechanochemically react with NbF5,forming dual-metal(Mg,Nb)borohydride ammoniate and spherical MgF2.The introduction of electronegative Nb cation results in-situ formation of(Mg,Nb)borohydride ammoniate towards a lower dehydrogenation temperature and a higher hydrogen release purity.The increased phase boundaries among the Mg(BH_(4))_(2)·2NH_(3),dual-metal(Mg,Nb)borohydride ammoniate,and MgF2 phases further facilitate the hydrogen diffusion during the dehydrogenation of the composites. | Yujie Lv Bao Zhang Haixiang Huang Bogu Liu Wei Lv Jianguang Yuan Guanglin Xia Xuebin Yu Dalin Sun Ying Wu | 2023 | Journal of Materials Science & Technology2023，，25： | 0 |
| 19 | Convective Storm VIL and Lightning Nowcasting Using Satellite and Weather Radar Measurements Based on Multi-Task Learning Models显示文摘Convective storms and lightning are among the most important weather phenomena that are challenging to forecast.In this study,a novel multi-task learning(MTL)encoder-decoder U-net neural network was developed to forecast convective storms and lightning with lead times for up to 90 min,using GOES-16 geostationary satellite infrared brightness temperatures(IRBTs),lightning flashes from Geostationary Lightning Mapper(GLM),and vertically integrated liquid(VIL)from Next Generation Weather Radar(NEXRAD).To cope with the heavily skewed distribution of lightning data,a spatiotemporal exponent-weighted loss function and log-transformed lightning normalization approach were developed.The effects of MTL,single-task learning(STL),and IRBTs as auxiliary input features on convection and lightning nowcasting were investigated.The results showed that normalizing the heavily skew-distributed lightning data along with a log-transformation dramatically outperforms the min-max normalization method for nowcasting an intense lightning event.The MTL model significantly outperformed the STL model for both lightning nowcasting and VIL nowcasting,particularly for intense lightning events.The MTL also helped delay the lightning forecast performance decay with the lead times.Furthermore,incorporating satellite IRBTs as auxiliary input features substantially improved lightning nowcasting,but produced little difference in VIL forecasting.Finally,the MTL model performed better for forecasting both lightning and the VIL of organized convective storms than for isolated cells. | Yang LI Yubao LIU Rongfu SUN Fengxia GUO Xiaofeng XU Haixiang XU | 2023 | Advances in Atmospheric Sciences2023，40，5： | 0 |
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