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| 1 | Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis显示文摘Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders,including COVID-19.However,there are still no effective drugs to treat lung injury and fibrosis.In this study,we report the generation of clinical-grade human embryonic stem cells(hESCs)-derived immunity-and matrix-regulatory cells(IMRCs)produced under good manufacturing practice requirements,that can treat lung injury and fibrosis in vivo.We generate IMRCs by sequentially differentiating hESCs with serum-free reagents.IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells(UCMSCs),such as higher expression levels of proliferative,immunomodulatory and anti-fibrotic genes.Moreover,intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury,and significantly improves the survival rate of the recipient mice in a dose-dependent manner,likely through paracrine regulatory mechanisms.IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone,with an excellent efficacy and safety profile in mice and monkeys.In light of public health crises involving pneumonia,acute lung injury and acute respiratory distress syndrome,our findings suggest that IMRCs are ready for clinical trials on lung disorders. | Jun Wu Dingyun Song Zhongwen Li Baojie Guo Yani Xiao Wenjing Liu Lingmin Liang Chunjing Feng Tingting Gao Yanxia Chen Ying Li Zai Wang Jianyan Wen Shengnan Yang Peipei Liu Lei Wang Yukai Wang Liang Peng Glyn Nigel Stacey Zheng Hu Guihai Feng Wei Li Yan Huo Ronghua Jin Ng Shyh-Chang Qi Zhou Liu Wang Baoyang Hu Huaping Dai Jie Hao | 2020 | Cell Research2020，30，9： | 7 |
| 2 | Research status on underwater wireless sensor networks显示文摘 | Chen Jinming Chen Guihai Yan Yunpei | | 0，，09： | 1 |
| 3 | SVFD: a ver- satile online fault detection scheme via checking of stability violation 显示文摘 | YAN Guihai HAN Yinhe Li Xiaowei | 2011 | IEEE Transactions on VLSI System2011，19，9： | 1 |
| 4 | SVFD: A Versatile Online Fault Detection Scheme via Checking of Stability Violation 显示文摘 | Guihai Yan G Yan Y Han X Li | 2011 | Journal of IEEE Transaction on VLSI Systems Hawaii2011，19，9： | 1 |
| 5 | SVFD: A Versatile Online Fault Detection Scheme via Checking of Stability Violation 显示文摘 | Guihai Yan Yinhe Han Xiaowei Li | 2011 | IEEE Transactions on VLSI System2011，19，9： | 1 |
| 6 | SVFD:A Versatile Online Fault Detection Scheme via Checking of Stability Violation显示文摘 | Yan Guihai Han Yinhe Li Xiaowei | 2011 | IEEE Transactions on Very Large Scale Integration Systems2011，19，9： | 1 |
| 7 | Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial显示文摘Immunity-and-matrix-regulatory cells(IMRCs)derived from human embryonic stem cells have unique abilities in modulating immunity and regulating the extracellular matrix,which could be mass-produced with stable biological properties.Despite resemblance to mesenchymal stem cells(MSCs)in terms of self-renew and tri-lineage differentiation,the ability of IMRCs to repair the meniscus and the underlying mechanism remains undetermined.Here,we showed that IMRCs demonstrated stronger immunomodulatory and pro-regenerative potential than umbilical cord MSCs when stimulated by synovial fluid from patients with meniscus injury.Following injection into the knees of rabbits with meniscal injury,IMRCs enhanced endogenous fibrocartilage regeneration.In the dose-escalating phase I clinical trial(NCT03839238)with eighteen patients recruited,we found that intra-articular IMRCs injection in patients was safe over 12 months post-grafting.Furthermore,the effective results of magnetic resonance imaging(MRI)of meniscus repair and knee functional scores suggested that 5×107 cells are optimal for meniscus injury treatment.In summary,we present the first report of a phase I clinical trial using IMRCs to treat meniscus injury.Our results demonstrated that intra-articular injection of IMRCs is a safe and effective therapy by providing a permissive niche for cartilage regeneration. | Liangjiang Huang Song Zhang Jun Wu Baojie Guo Tingting Gao Sayed Zulfiqar Ali Shah Bo Huang Yajie Li Bo Zhu Jiaqi Fan Liu Wang Yani Xiao Wenjing Liu Yao Tian Zhengyu Fang Yingying Lv Lingfeng Xie Sheng Yao Gaotan Ke Xiaolin Huang Ying Huang Yujuan Li Yi Jia Zhongwen Li Guihai Feng Yan Huo Wei Li Qi Zhou Jie Hao Baoyang Hu Hong Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
| 8 | 胚胎干细胞体外减数分裂获得功能配子显示文摘随着不孕不育症的全球性高发,通过体外培养的方式获得功能配子被认为是解决不孕不育症生殖细胞缺乏问题最为有效的途径,但过往的研究表明真实的再现减数分裂过程是体外获得功能配子难以逾越的障碍。 | Quan Zhou Mei Wang Yan Yuan Xuepeng Wang Rui Fu Haifeng Wan Mingming Xie Mingxi Liu Xuejiang Guo Ying Zheng Guihai Feng Qinghua Shi 赵小阳 沙家豪 周琪 | 2017 | 科学新闻2017，19，4： | 0 |
| 9 | Fault tolerance on-chip:a reliable computing paradigm using self-test,self-diagnosis,and self-repair (3S)approach显示文摘If your computer crashes, you can revive it by a reboot, an empirical solution that usually turns out to be effective. The rationale behind this solution is that transient faults, either in hardware or software,can be fixed by refreshing the machine state. Such a 'silver bullet', however, could be futile in the future because the faults, especially those existing in the hardware such as Integrated Circuit(IC) chips, cannot be eliminated by refreshing. What we need is a more sophisticated mechanism to steer the system back to the right track. The 'magic cure' is the Fault Tolerance On-Chip(FTOC) mechanism, which relies on a suite of built-in design-for-reliability logic, including fault detection, fault diagnosis, and error recovery, working in a self-supportive manner. We have exploited the FTOC to build a holistic solution ranging from on-chip fault detection to error recovery mechanisms to address faults caused by chips progressively aging. Besides fault detection, the FTOC paradigm provides attractive benefits, such as facilitating graceful performance degradation, mitigating the impact of verification blind spots, and improving the chip yield. | Xiaowei LI Guihai YAN Jing YE Ying WANG | 2018 | Science China(Information Sciences)2018，61，11： | 0 |
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