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| 1 | Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies显示文摘Chronicity of hepatitis B(CHB)infection is characterized by a weak immune response to the virus.Entecavir(ETV)and adefovir dipivoxil(ADV)are effective in suppressing hepatitis B virus(HBV)replication.However,the underlying immune mechanism in the antiviral response of patients treated with nucleoside or nucleotide analogs is not clearly understood.In this study,regulatory T cells(Tregs)and intracellular cytokines,including IL-2,interferon(IFN)-γ,tumor-necrosis factor(TNF)-α and IL-4,were measured prior to and at 12,24,36 and 48 weeks after treatment with ETV or ADV.The cytokines were increased from 24 to 48 weeks after treatment.Higher levels of Th1 cytokines were observed with ETV(n=29)versus ADV(n=28)treatment.By contrast,the numbers of Tregs in both groups were decreased.The altered cytokine profile and cellular component was accompanied by a decrease in HBV DNA levels in both groups,which may contribute to their therapeutic effect in CHB infection.Our findings suggest that the antiviral effect of the drugs may be attributed not only to their direct effect on virus suppression but also to their immunoregulatory capabilities. | Yanfang Jiang Wanyu Li Lei Yu Jingjing Liu Guijie Xin Hongqing Yan Pinghui Sun Hong Zhang Damo Xu Junqi Niu | 2011 | Cellular & Molecular Immunology2011，8，1： | 16 |
| 2 | Design and control of methyl acetate-methanol separation via heat-integrated pressure-swing distillation显示文摘Design and control of pressure-swing distillation(PSD) with different heat integration modes for the separation of methyl acetate/methanol azeotrope are explored using Aspen Plus and Aspen Dynamics. First, an optimum steady-state separation configuration conditions are obtained via taking the total annual cost(TAC) or total reboiler heat duty as the objective functions. The results show that about 27.68% and 25.40% saving in TAC can be achieved by the PSD with full and partial heat integration compared to PSD without heat integration. Second,temperature control tray locations are obtained according to the sensitivity criterion and singular value decomposition(SVD) analysis and the single-end control structure is effective based on the feed composition sensitivity analysis. Finally, the comparison of dynamic controllability is made among various control structures for PSD with partial and full heat integration. It is shown that both control structures of composition/temperature cascade and pressure-compensated temperature have a good dynamic response performance for PSD with heat integration facing feed flowrate and composition disturbances. However, PSD with full heat integration performs the poor controllability despite of a little bit of economy. | Zhishan Zhang Qingjun Zhang Guijie Li Meiling Liu Jun Gao | 2016 | Chinese Journal of Chemical Engineering2016，24，11： | 12 |
| 3 | Studies on Reducing Nitrogen Excretion: Ⅰ. Net Energy Requirement of Finishing Pigs Maximizing Performance and Carcass Quality Fed Low Crude Protein Diets Supplemented with Crystalline Amino Acids显示文摘Two experiments were conducted to investigate the effects of net energy (NE) level on the performance and carcass traits of finishing pigs fed low crude protein (CP) diets supplemented with crystalline amino acids (CAA). A total of 216 (Exp.1) and 360 (Exp.2) barrows (Yorkshire×Landrace×Duroc) were allotted to one of six treatments (n=6). The experimental diets were based on corn and soybean meal, and consisted of a highCP diet that contained approximately 16% CP and 2.50 Mcal/kg of NE as well as five lowCP diets in which the CP level of the diet was reduced by approximately four percentage units but was supplemented with crystalline lysine, methionine, threonine, and tryptophan. The low CP diets provided 2.64, 2.58, 2.50, 2.42, or 2.36 Mcal/kg in Exp.1 as well as 2.45, 2.40, 2.35, 2.30, or 2.25 Mcal/kg in Exp.2. In Exp.1, a linear (P=0.03) increase in weight gain was observed with decreasing NE level while the ratio of gain to feed was unaffected (P>0.05) by NE level. There was a linear increase (P=0.01) in the percentage of fatfree lean and a linear decrease (P=0.03) in the percentage of total fat with decreasing NE levels. In Exp.2, a significant quadratic (P=0.03) effect of NE level was observed for weight gain. The ratio of gain to feed demonstrated a significant (P<0.01) quadratic effect with pigs fed 2.35 and 2.40 Mcal/kg of NE. Pigs fed the diet containing 2.40 Mcal/kg of NE had the lowest percentage of total fat (36.95%) and the highest percentage of fatfree lean (49.36%). The overall results of these experiments indicate that feeding either a surplus or a deficiency of NE is detrimental to both pig performance and carcass composition when low CP diets supplemented with CAA are fed. Our results indicate that when the CP content of the diet is reduced by four percentage units and the diet is properly supplemented with CAA, maximum performance and carcass quality will be obtained if the diet provides approximately 2.42 Mcal/kg of NE. | Hongyu Chen Xuewu Yi Guijie Zhang Ning Lu Licui Chu P. A. Thacker Shiyan Qiao | 2011 | Journal of Animal Science and Biotechnology2011，2，2： | 9 |
| 4 | O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an “O-Follow-N” rule显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),the causative agent of coronavirus disease 2019(COVID-19),emerged in late 2019 and has since caused a pandemic.Although there have been extensive studies worldwide,our understanding of this newly emerged pathogen is far from sufficient.The pathogenesis of the SARS-CoV-2 infection is not fully understood,although a“two-stage”hypothesis was proposed in our previous study. | Wenmin Tian Delin Li Nan Zhang Guijie Bai Kai Yuan Haixia Xiao Feng Gao Yang Chen Catherine C.L.Wong George Fu Gao | 2021 | Cell Research2021，31，10： | 9 |
| 5 | Genetic variation and selection of introduced provenances of Siberian Pine(Pinus sibirica) in frigid regions of the Greater Xing'an Range,Northeast China显示文摘Siberian Pine(Pinus sibirica) is an ecologically and economically important species in pristine forests throughout northern Russia. Four provenances of P. sibirica were introduced from Mongolia and Russia to the Greater Xing'an Range(the Daxing'anling), northeast China in 1993. The aim of this research was to study genetic variation and selection of the introduced four Pinus sibirica provenances. Heights(H), basal diameters(BD), survival rates(SR) and crown lengths(CL) of different families were measured as primary outcomes in different growth years. Results of data analyses demonstrated high coefficients of phenotypic variation(PCV) and heritability(H2) for H, BD and CL at 18 years after introduction. PCV and H2 increased with age. Correlations of growth traits between any two growth years were all significantly positive, but the correlation coefficient was smaller when the growth year interval was larger. Correlations between H and the original environment factors decreased gradually, indicating that with long-term subsistence in the new environment, the influence of the source environment declined. Colligation of multiple traits to estimate provenances showed that Novosibirsk, Tomsk, and Altai Mountains had higher survival rates and biomass, and proved more suitable for introduction and plantation in the Greater Xing'an Range in China. | Xiyang Zhao Cheng Wang Shuchun Li Wei Hou Shiqing Zhang Guijie Han Deng Pan Ping Wang Yufei Cheng Guifeng Liu | 2014 | Journal of Forestry Research2014，25，3： | 6 |
| 6 | Dynamic microwave-assisted extraction combined with liquid phase microextraction based on the solidification of a floating drop for the analysis of organochlorine pesticides in grains followed by GC显示文摘A convenient,cost-effective and fast method using dynamic microwave-assisted extraction and liquid phase microextraction based on the solidification of a floating drop was proposed to analyze organochlorine pesticides in grains including rice,maize and millet.Twelve samples can be processed simultaneously in the method.During the extraction process,10%acetonitrile-water solutions containing 110μL of n-hexadecane were used to extract organochlorine pesticides.Subsequently,1.0 g sodium chloride was placed in the extract,and then centrifuged and cooled.The n-hexadecane drops containing the analytes were solidifi ed and transferred for determination by gas chromatography-electron capture detector without any further filtration or cleaning process.Limits of detection for organochlorine pesticides were 0.97–1.01μg/kg and the RSDs were in the range of 2.6%–8.5%.The developed technology has succeeded in analyzing six real grains samples and the recoveries of the organochlorine pesticides were 72.2%–94.3%.Compared with the published extraction methods,the developed method was used to analyze organochlorine pesticides in grains,being more environmentally friendly,which is suitable for the daily determination of organochlorine pesticides. | Guijie Li Xu Zhang Tingting Liu Hongxiu Fan Hongcheng Liu Shangyu Li Dawei Wang Lan Ding | 2021 | Food Science and Human Wellness2021，10，3： | 4 |
| 7 | SARS-CoV-2 non-structural protein 13 (nspl3) hijacks host deubiquitinase USP13 and counteracts host antiviral immune response显示文摘Dear Editor,COVID-19(Coronavirus Disease-2019),a respiratory disease caused by the novel virus strain,SARS-CoV-2(severe acute respiratory syndrome coronavirus 2),an enveloped,positive-sense,single-stranded RNA betacoronavirus of the family Corona-viridae,has spread worldwide.1 Notably,SARS-CoV-2 infection led to poor induction of typeⅠ interferon response,and the impaired type Ⅰ IFN responses have been shown to be associated with severe COVID-19 disease.2 However,molecular mechanisms by which SARS-CoV-2 suppresses type Ⅰ IFN production,and how host cells respond to the inhibition of type Ⅰ IFN response during SARS-CoV-2 infection,remain largely unknown. | Guijie Guo Ming Gao Xiaochen Gao Bibo Zhu Jinzhou Huang Kuntian Luo Yong Zhang Jie Sun Min Deng Zhenkun Lou | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
| 8 | Depletion of VPS35 attenuates metastasis of hepatocellular carcinoma by restraining the Wnt/PCP signaling pathway显示文摘Vesicle Protein Sorting 35(VPS35)is a novel oncogene that promotes tumor growth through the PI3K/AKT signaling in hepatocellular carcinoma(HCC).However,the role of VPS35 in HCC metastasis and the underlying mechanisms remain largely unclear.In this study,we observed that overexpression of VPS35 enhanced hepatoma cell invasion and metastasis by inducing epithelialemesenchymal transition(EMT)-related gene expression.Conversely,knockout of VPS35 significantly inhibited hepatoma cell migration and invasion.Furthermore,depletion of VPS35 decreased the lung metastasis of HCC in nude mice.By transcriptome analysis,we determined that VPS35 promoted HCC metastasis by activating the Wnt/non-canonical planar cell polarity(PCP)pathway.Mechanistically,VPS35 activated the PCP pathway by regulating membrane sorting and trafficking of Frizzled-2(FZD2)and ROR1 in hepatoma cells.Collectively,our results indicate that VPS35 promotes HCC metastasis via enhancing the Wnt/PCP signaling,thus providing a potential prognostic marker and therapeutic target for HCC. | Yi Liu Haijun Deng Li Liang Guiji Zhang Jie Xia Keyue Ding Ni Tang Kai Wang | 2021 | Genes & Diseases2021，8，2： | 2 |
| 9 | High velocity flyer plates launched by magnetic pressure on pulsed power generator CQ-4 and applied in shock Hugoniot experiments显示文摘 | Xuping Zhang Guiji Wang Jianheng Zhao | 2014 | Review of Scientific Instruments2014，85，05： | 1 |
| 10 | Hypolipidemic effect of the polysaccharide from Pholiota nameko 显示文摘 | Haiping Li Mingming Zhang and Guiji Ma | 2010 | Nutrition2010，26，： | 1 |
| 11 | Self-trapped exciton emission in inorganic copper(Ⅰ)metal halides显示文摘The broad emission and high photoluminescence quantum yield of self-trapped exciton(STE)radiative recombination emitters make them an ideal solution for single-substrate,white,solid-state lighting sources.Unlike impurities and defects in semiconductors,the formation of STEs requires a lattice distortion,along with strong electron–phonon coupling,in low electrondimensional materials.The photoluminescence of inorganic copper(Ⅰ)metal halides with low electron-dimensionality has been found to be the result of STEs.These materials were of significant interest because of their leadfree,all-inorganic structures,and high luminous efficiencies.In this paper,we summarize the luminescence characteristics of zero-and one-dimensional inorganic copper(I)metal halides with STEs to provide an overview of future research opportunities. | Boyu ZHANG Xian WU Shuxing ZHOU Guijie LIANG Qingsong HU | 2021 | Frontiers of Optoelectronics2021，14，4： | 1 |
| 12 | Fast determination of sulfonamides and their acetylated metabolites from environmental water based on magnetic molecularly imprinted polymers显示文摘 | Haiyan Chen Yiqun Zhang Bo Gao Yang Xu Qi Zhao Juan Hou Jin Yan Guijie Li Hui Wang Lan Ding Jie Ding Chun Zhao | 2013 | Environmental Science and Pollution Research2013，，12： | 1 |
| 13 | Hypolipidemic effect of the polysaccharide from pholiota nameko显示文摘 | LI Haiping ZHANG Mingming MA Guiji | 2010 | Nutrition2010，26，5： | 1 |
| 14 | Recent development of monolithic materials as matrices in micro- column separation systems显示文摘 | ZHU Guijie ZHANG Lihua YUAN Huiming | 2007 | J Sep Sci2007，30，6： | 1 |
| 15 | Selection and optimization procedure of synbiotic for cholesterol removal显示文摘 | Fang Zhang Xiaomin Hang Xiaobing Fan Guijie Li Hong Yang | 2007 | Anaerobe2007，，5： | 1 |
| 16 | Groups-dependent phosphines as the organic redox for point defects elimination in hybrid perovskite solar cells显示文摘Lead(Pb)^(0) and iodine(I)^(0) point defects generated during perovskite solar cell(PSC)fabrication and photoconversion form deep band energy levels as the carriers’recombination centers.These defects not only deteriorate device efficiency,but also facilitate chemical degradation with ion migration,resulting in restricted device lifetime.Herein,we present a novel type of phosphines as the point defects stabilizer for hybrid perovskite solar cells with enhanced performances.Three phosphines with varied side groups of tributyl,trioctyl and triphenyl are exampled as the dopants in perovskite films.The group dependent redox properties were observed in the perovskite film,dependent on their molecular weights and steric hinderances of phosphines.The partially oxidized tributyl phosphine(TBUP)with additional tributyl phosphine oxides(TBPO)is efficient in reduction of lead(Pb)^(0) and iodine(I)^(0) concentrations during the device fabrication and operation.The device with TBUP-TBPO pair showed enhanced power conversion efficiency(PCE)to 20.48% and maintain 91.7% of their initial PCEs after 500 h at 65℃ thermal annealing.Thus,this work presents an efficient route of utilize the phosphine species to reduce point defects in the perovskite film,which promoting further development of novel phosphorous additives with defects stabilization,interface passivation and encapsulation for low-cost solution processed PSCs. | Zhengli Wu Miao Zhang Yifan Liu Yuxi Dou Yinjie Kong Lin Gao Weitao Han Guijie Liang Xiao Li Zhang Fuzhi Huang Yi-Bing Cheng Jie Zhong | 2021 | Journal of Energy Chemistry2021，30，3： | 1 |
| 17 | 2D/2D covalent organic framework/CdS Z-scheme heterojunction for enhanced photocatalytic H_(2) evolution:Insights into interfacial charge transfer mechanism显示文摘Covalent organic frameworks(COFs)with high crystallinity and flexible designability have been consid-ered as promising candidates for photocatalytic hydrogen evolution.However,the existence of unpropi-tious exciton effects in COFs leads to poor charge separation,and thus results in low photocatalytic effi-ciency.Herein,to improve the photoelectron migration efficiency,we designed a 2D/2D organic/inorganic direct Z-scheme COF-based heterojunction(TpTAP/CdS),by the in-situ growing of CdS nanosheets on the COF copolymerized via 2,4,6-tris(4-aminophenyl)-1,3,5-triazine(TAP)and 1,3,5-triformylphloroglucinol(Tp).The femtosecond transient absorption(fs-TA)decay kinetics of TpTAP-COF and TpTAP/CdS further reveal the processes of shallow electron trapping and the recombination of the free photogenerated electron-hole pairs.In particular,the transient absorption traces for TpTAP-COF and TpTAP/CdS normal-ized to the photoinduced absorption peak can effectively verify the Z-scheme charge transfer between TpTAP-COF and CdS,which could enhance the charge mobility and separation,thus reducing the pho-tocorrosion of CdS.Additionally,ultraviolet photoelectron spectroscopy(UPS),in-situ X-ray photoelec-tron spectroscopy(XPS),transient photovoltage measurements,and electron spin resonance(ESR)spec-troscopy further confirm the establishment of the internal electric field(IEF).This work demonstrates the important role of COFs in the construction of 2D/2D organic/inorganic direct Z-scheme heterojunctions and offers a new avenue to explain the criticality of dynamics of the photogenerated carriers for the construction of Z-scheme heterojunctions. | Ruiqi Gao Junxian Bai Rongchen Shen Lei Hao Can Huang Lei Wang Guijie Liang Peng Zhang Xin Li | 2023 | Journal of Materials Science & Technology2023，，6： | 1 |
| 18 | Similarity-based privacy protection for publishing k-anonymous trajectories显示文摘1 Introduction and main contributions The combination of location technology and wireless communication technology has spawned a number of location-based services(LBS).Trusted location service providers(LSP)obtain a large amount of users’trajectories.The knowledge obtained from mining trajectory data can be used in many fields and may lead to privacy disclosure of users.The data owner(LSP)should process the trajectory data to protect privacy before publishing.Clusterreconstruction of trajectories is a common privacy protection method for publishing trajectories. | Shuai WANG Chunyi CHEN Guijie ZHANG | 2022 | Frontiers of Computer Science2022，16，3： | 0 |
| 19 | Tuning the Excited State of Tetradentate Pd(ll) and Pt(ll) Complexes through Benzannulated N-Heteroaromatic Ring and Central Metal显示文摘A series of tetra de ntate Pd(ll)and Pt(ll)complexes containing fused 5/6/6 metallocycles with phe nyl/V-heteroaromatic ben-zo[d]imidazole(pbiz),benzo[d]oxazole(pboz)or benzo[d]thiazole(pbthz)-containing ligands was developed.Systematic studies by experiments and theoret:ical calculations reveal that both the central metal and the benzannulated A/-heteroaromatic ring have sig-n ificant in flue nee on the electrochemical,photophysical and excited-state properties of the Pd(ll)and Pt(ll)complexes.In identical condition,compared to pb/z-based Pd(ll)and Pt(ll)complexes,the corresponding metal complexes with pboz and pbthz-containing ligand show significant red-shift emission spectra. | Guijie Hua Guo Xiaoli Fang Yun-Fang Yang Yulu Sun Weiwei Lou Qisheng Zhang Yuanbin She | 2022 | Chinese Journal of Chemistry2022，40，2： | 0 |
| 20 | The antiviral effect of jiadifenoic acids C against coxsackievirus B3显示文摘Coxsackievirus B type 3(CVB3)is one of the major causative pathogens associated with viral meningitis and myocarditis,which are widespread in the human population and especially prevalent in neonates and children.These infections can result in dilated cardiomyopathy(DCM)and other severe clinical complications.There are no vaccines or drugs approved for the prevention or therapy of CVB3-induced diseases.During screening for anti-CVB3 candidates in our previous studies,we found that jiadifenoic acids C exhibited strong antiviral activities against CVB3 as well as other strains of Coxsackie B viruses(CVBs).The present studies were carried out to evaluate the antiviral activities of jiadifenoic acids C.Results showed that jiadifenoic acids C could reduce CVB3 RNA and proteins synthesis in a dose-dependent manner.Jiadifenoic acids C also had a similar antiviral effect on the pleconaril-resistant variant of CVB3.We further examined the impact of jiadifenoic acids C on the synthesis of viral structural and non-structural proteins,finding that jiadifenoic acids C could reduce VP1 and 3D protein production.A time-course study with Vero cells showed that jiadifenoic acids C displayed significant antiviral activities at 0–6 h after CVB3 inoculation,indicating that jiadifenoic acids C functioned at an early step of CVB3 replication.However,jiadifenoic acids C had no prophylactic effect against CVB3.Taken together,we show that jiadifenoic acids C exhibit strong antiviral activities against all strains of CVB,including the pleconaril-resistant variant.Our study could provide a significant lead for anti-CVB3 drug development. | Miao Ge Huiqiang Wang Guijie Zhang Shishan Yu Yuhuan Li | 2014 | Acta Pharmaceutica Sinica B2014，4，4： | 0 |
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