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| 1 | Molecular network-based analysis of Guizhi- Shaoyao-Zhimu decoction, a TCM herbal formula, for treatment of diabetic peripheral neuropathy显示文摘目的: Guizhi-Shaoyao-Zhimu 煎(GSZ ) ,繁体中文药(TCM ) 草药的公式,被显示出在糖尿病的外部神经病(DPN ) 的治疗有效。在这研究,网络分析被执行译解在 DPN 的处理的 GSZ 的分子的机制。 | Ning ZHAO Jian LI Li LI Xu-yan NIU Miao JIANG Xiao-juan HE Zhao-xiang BIAN Ge ZHANG Ai-ping LU | 2015 | Acta Pharmacologica Sinica2015，36，6： | 21 |
| 2 | Inhibition of 12-lipoxygenase reduces proliferation and induces apoptosis of hepatocellular carcinoma cells in vitro and in vivo显示文摘BACKGROUND:12-lipoxygenase(12-LOX) has been reported to be an important gene in cancer cell proliferation and survival,and tumor metastasis.However,its role in hepatocellular carcinoma(HCC) cells remains unknown.METHODS:Expression of 12-LOX was assessed in a diethylnitrosamine-induced rat HCC model,and in SMMC-7721,HepG2 and L-02 cells using immunohistochemical staining and reverse transcriptase-polymerase chain reaction(RT-PCR).GST-π and Ki-67 were determined in vivo by immunohistochemical staining.Apoptosis was evaluated by TUNEL assay.Cell viability and apoptosis were determined by MTT assay and flow cytometry,respectively.Apoptosis-related proteins in SMMC-7721 and HepG2 cells were detected by Western blotting.RESULTS:Immunohistochemical staining and RT-PCR showed that 12-LOX was over-expressed in rat HCC and two HCC cell lines,while the expression was inhibited by baicalein,a specific inhibitor of 12-LOX.Baicalein inhibited cell proliferation and induced apoptosis in rat HCC and both cell lines in a dose-and time-dependent manner.Our in vivo study demonstrated that baicalein also reduced neoplastic nodules.Mechanistically,baicalein reduced Bcl-2 protein expression coupled with a slight increase of the expression of Bax and activation of caspase-3.Furthermore,baicalein inhibited the activation of ERK-1/2(phosphorylated).Interestingly,the effects of baicalein were reversed by 12(S)-HETE,a metabolite of 12-LOX.CONCLUSIONS:Inhibition of 12-LOX leads to reduced numbers of HCC cells,partially caused by increased apoptosis.12-LOX may be a potential molecular target for HCC prevention and treatment. | Xi-Ming Xu,Guang-Jin Yuan,Jun-Jian Deng,Hong-Ting Guo,Miao Xiang,Fang Yang,Wei Ge and Shi-You Chen Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, China Cancer Center, the 82nd Hospital of the Chinese PLA, Huai’an 223001, China Department of Physiology, Medical College of Wuhan University, Wuhan 430071, China Department of Physiology & Pharmacology, University of Georgia, Athens, GA 30602, USA | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 20 |
| 3 | Endoscopic transpancreatic septotomy as a precutting technique for difficult bile duct cannulation显示文摘AIM: To evaluate the technique of transpancreatic septotomy(TS) for cannulating inaccessible common bile ducts in endoscopic retrograde cholangiopancreatography(ERCP).METHODS: Between May 2012 and April 2013, 1074 patients were referred to our department for ERCP. We excluded 15 patients with previous Billroth Ⅱ gastrectomy, Roux-en-Y anastomosis, duodenal stenosis, or duodenal papilla tumor. Among 1059 patients who underwent ERCP, there were 163 patients with difficult bile duct cannulation. Pancreatic guidewire or pancreatic duct plastic stent assistance allowed for successful ERCP completion in 94 patients. We retrospectively analyzed clinical data from 69 failed patients(36 transpancreatic septotomies and 33 needle-knife sphincterotomies). RESULTS: Of the 69 patients who underwent precut papillotomy, common bile duct cannulation was successfully achieved in 67. The success rates in the TS and needle knife sphincterotomy(NKS) groups were 97.2%(35/36) and 96.9%(32/33), respectively, which were not significantly different(P > 0.05). Complications occurred in 11 cases, including acute pancreatitis(n = 6), bleeding(n = 2), and cholangitis(n = 3). The total frequency of complications in the TS group was lower than that in the NKS group(8.3% vs 24.2%, P < 0.05).CONCLUSION: Pancreatic guidewire or pancreatic duct plastic stent assistance improves the success rate of selective bile duct cannulation in ERCP. TS and NKS markedly improve the success rate of selective bile duct cannulation in ERCP. TS precut is safer as compared with NKS. | Lin Miao Quan-Peng Li Ming-Hui Zhu Xian-Xiu Ge Hong Yu Fei Wang Guo-Zhong Ji | 2015 | World Journal of Gastroenterology2015，21，13： | 13 |
| 4 | Inhalation treatment of primary lung cancer using liposomal curcumin dry powder inhalers显示文摘Lung cancer is the leading cause of cancer-related deaths. Traditional chemotherapy causes serious toxicity due to the wide bodily distribution of these drugs. Curcumin is a potential anticancer agent but its low water solubility, poor bioavailability and rapid metabolism significantly limits clinical applications. Here we developed a liposomal curcumin dry powder inhaler(LCD) for inhalation treatment of primary lung cancer. LCDs were obtained from curcumin liposomes after freeze-drying. The LCDs had a mass mean aerodynamic diameter of 5.81 μm and a fine particle fraction of 46.71%, suitable for pulmonary delivery. The uptake of curcumin liposomes by human lung cancer A549 cells was markedly greater and faster than that of free curcumin. The high cytotoxicity on A549 cells and the low cytotoxicity of curcumin liposomes on normal human bronchial BEAS-2B epithelial cells yielded a high selection index partly due to increased cell apoptosis. Curcumin powders, LCDs and gemcitabine were directly sprayed into the lungs of rats with lung cancer through the trachea. LCDs showed higher anticancer effects than the other two medications with regard to pathology and the expression of many cancer-related markers including VEGF, malondialdehyde, TNF-α, caspase-3 and BCL-2. LCDs are a promising medication for inhalation treatment of lung cancer with high therapeutic efficiency. | Tongtong Zhang Yanming Chen Yuanyuan Ge Yuzhen Hu Miao Li Yiguang Jin | 2018 | Acta Pharmaceutica Sinica B2018，8，3： | 12 |
| 5 | The dimension and morphology of alveolar bone at maxillaryanterior teeth in periodontitis: a retrospective analysis usingCBCT显示文摘The morphology of the alveolar bone at the maxillary anterior teeth in periodontitis patients was evaluated by cone-beam computed tomography(CBCT) to investigate the distribution of alveolar defects and provide guidance for clinical practice. Ninety periodontitis patients and 30 periodontally healthy individuals were selected to determine the morphology of the alveolar bone at the maxillary anterior teeth according to the degree of bone loss, tooth type, sex and age. The differences in the dimensions between periodontitis patients and healthy individuals were compared, and the distribution of alveolar bone defects was analyzed.A classification system was established regarding the sagittal positions and angulations of the teeth. The buccal residual bone was thicker and the lingual bone was thinner in the periodontitis patients than in the periodontally healthy individuals, and there were differences between the different tooth types, sexes and age subgroups. The buccal undercut was close to the alveolar ridge, while fenestration was reduced and the apical bone height was higher in periodontitis patients than in periodontally healthy individuals.The apical bone height increased with the aggravation of bone loss and age. The proportions of different sagittal positions changed with the aggravation of bone loss. Moreover, the teeth moved more buccally regarding the positions of the maxillary anterior teeth.The morphology of the alveolar bone at the maxillary anterior teeth differed between periodontitis patients and healthy individuals,and the differences were related to the degree of bone loss, tooth type, sex and age. | Xue Zhang Yuchao Li Ziming Ge Haijiao Zhao Lei Miao Yaping Pan | 2020 | International Journal of Oral Science2020，12，1： | 10 |
| 6 | Nonlinear fault detection based on locally linear embedding显示文摘In this paper,a new nonlinear fault detection technique based on locally linear embedding(LLE)is developed.LLE can effciently compute the low-dimensional embedding of the data with the local neighborhood structure information preserved.In this method,a data-dependent kernel matrix which can reflect the nonlinear data structure is defned.Based on the kernel matrix,the Nystr o¨m formula makes the mapping extended to the testing data possible.With the kernel view of the LLE,two monitoring statistics are constructed.Together with the out of sample extensions,LLE is used for nonlinear fault detection.Simulation cases were studied to demonstrate the performance of the proposed method. | Aimin MIAO Zhihuan SONG Zhiqiang GE Le ZHOU Qiaojun WEN | 2013 | 控制理论与应用(英文版)2013，11，4： | 8 |
| 7 | Monovalent cation perm-selective membranes(MCPMs)'New developments and perspectives显示文摘As one of the most typical and promising membrane processes, electrodialysis(ED) technique plays a more and more significant role in industrial separation. Especially, the separation of monovalent cations and multivalent cations is currently a hot topic, which is not only desirable for many industries but also challenging for academic explorations. The main aim of the present contribution is to view the advances of a wide variety of monovalent cation perm-selective membranes(MCPMs) and their preparation technologies including(1) covalent crosslinking,(2) surface modification,(3) polymer blending,(4) electrospinning,(5) nanofiltration alike membrane,and(6) organic–inorganic hybrid. The relevant advantages and disadvantages with respect to some specific cases have been discussed and compared in detail. Furthermore, we elaborately discuss the opportunities and challenges of MCPMs, the fabricating strategies to take and the future perspectives. | Liang Ge Bin Wu Dongbo Yu Abhishek N.Mondal Linxiao Hou Noor U1 Afsar Qiuhua Li Tingting Xu Jibin Miao Tongwen Xu | 2017 | Chinese Journal of Chemical Engineering2017，25，11： | 8 |
| 8 | Resveratrol protects PC12 cells against OGD/ R-induced apoptosis via the mitochondrial-mediated signaling pathway显示文摘在这研究,我们对导致的氧葡萄糖 deprivation/reoxygenation (OGD/R ) 调查了 resveratrol 的 neuroprotective 潜力在区分得好的 PC12 房间和内在的机制的 apoptotic 损坏。房间当面在正常状况或 OGD/R 下面被孵化或 10 M resveratrol 的缺席。房间生存能力与 methyl-thiazolyl-tetrazolium (MTT ) 被决定试金。Apoptotic 比率与 Hoechst 33342 染色和 Annexin V-FITC/PI 两倍染色被决定。氧化应力被测量细胞内部的反应的氧评估 superoxide dismutase (草皮) 和过氧化氢酶(猫) 的种类(ROS ) , mitochondrial superoxide, malondialdehyde (MDA ) 内容,和这些活动。细胞内部的钙([Ca 2+]i) 被 Fluo-3/AM 估计。mitochondrial 膜潜力(MMP ) 被 5,5,6,6-tetrachloro-1,1,3,3-tetraethyl-benzimidazolyl-carbocyanine 碘化物(JC-1 ) 和玫瑰精评估 123 (Rh123 ) 。mitochondrial 渗透转变毛孔(MPTP ) 的开始被 Calcein/Co 2+-quenching 技术决定。细胞色素 c, Bcl-2, Bax,劈开的 caspase-9,和劈开的 caspase-3 的蛋白质层次被西方的污点分析检测。结果证明 10 M resveratrol 稀释了 OGD/R-induced 房间生存能力损失和房间 apoptosis,它在在 SOD 和猫活动的 MDA 内容和增加与减少被联系。而且,细胞内部的 ROS 和 mitochondrial superoxide 的累积,骚乱[Ca 2+]i 动态平衡, MMP 的减小, MPTP 的开始,和在 OGD/R-injured 房间观察的 mitochondrial 细胞色素 c 的版本,在调停 mitochondrial 的 apoptotic 小径上显示了一个开关,都被 resveratrol 颠倒。这些结果建议 resveratrol 管理可以经由 modulating 起一个 neuroprotective 作用在 OGD/R-induced PC12 房间损害的调停 mitochondrial 的发信号小径。 | Xuan Liu Xiangyang Zhu Miao Chen Qinmin Ge Yong Shen Shuming Pan | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 8 |
| 9 | Pneumonia relevant to lung transplantation and pathogen distribution显示文摘 | HE Xuan DAI Hua-ping CHEN Qi-rui MIAO Jin-bai SUN Bing BAO Na HU Bin LI Hui WU An-shi BAN Cheng-jun GE Su-juan WANG Chen HOU Sheng-cai | 2013 | Chinese Medical Journal2013，，17： | 7 |
| 10 | The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis显示文摘 | Fang Wang Wei Song Hongmei Zhao Yanni Ma Yuxia Li Di Zhai Jingnan Pi Yanmin Si Jiayue Xu Lei Dong Rui Su Mengmeng Zhang Yong Zhu Xiaoxia Ren Fei Miao Wenjie Liu Feng Li Junwu Zhang Aibin He Ge Shan Jingyi Hui Linfang Wang Jia Yu | 2017 | Cell Research2017，27，3： | 7 |
| 11 | Soundscape of the West Lake Scenic Area with profound cultural background—a case study of Evening Bell Ringing in Jingci Temple,China显示文摘From the case study of Evening Bell Ringing at Nanping Hill,one of the West Lake Cultural Landscapes in Hangzhou,China,we investigated the soundscape of a scenic area with a profound cultural background.First,we conducted the soundscape physical index of the area in both winter and spring seasons to analyze its objective graphical expression.Second,we focused on people's reactions to the soundscape in order to obtain a subjective evaluation of each component in the soundscape and integrated environment.Then,the relationship between the objective data and the subjective evaluation was analyzed.Finally,the impacts of the natural environment,history,and cultural factors on the evaluation of the Jingci Temple soundscape were studied.It was found that natural sounds,cultural sounds,and historic sounds were widely acclaimed in people's subjective feelings,which indicated the close relationships among historical and cultural background,soundscape,and natural environment.Thus,the conclusion was made that soundscape should be consistent with the local natural environment and the historical and cultural background. | Jian GE Min GUO Miao YUE | 2013 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2013，14，3： | 7 |
| 12 | Degradation induces changes in the soil C:N:P stoichiometry of alpine steppe on the Tibetan Plateau显示文摘Due to the Tibetan Plateau’s unique high altitude and low temperature climate conditions,the region’s alpine steppe ecosystem is highly fragile and is suffering from severe degradation under the stress of increasing population,overgrazing,and climate change.The soil stoichiometry,a crucial part of ecological stoichiometry,provides a fundamental approach for understanding ecosystem processes by examining the relative proportions and balance of the three elements.Understanding the impact of degradation on the soil stoichiometry is vital for conservation and management in the alpine steppe on the Tibetan Plateau.This study aims to examine the response of soil stoichiometry to degradation and explore the underlying biotic and abiotic mechanisms in the alpine steppe.We conducted a field survey in a sequent degraded alpine steppe with seven levels inNorthern Tibet.The plant species,aboveground biomass,and physical and chemical soil properties such as the moisture content,temperature,pH,compactness,total carbon(C),total nitrogen(N),and total phosphorus(P)were measured and recorded.The results showed that the contents of soil C/N,C/P,and N/P consistently decreased along intensifying degradation gradients.Using regression analysis and a structural equation model(SEM),we found that the C/N,C/P,and N/P ratios were positively affected by the soil compactness,soil moisture content and species richness of graminoids but negatively affected by soil pH and the proportion of aboveground biomass of forbs.The soil temperature had a negative effect on the C/N ratio but showed positive effect on the C/P and N/P ratios.The current study shows that degradation-induced changes in abiotic and biotic conditions such as soil warming and drying,which accelerated the soil organic carbon mineralization,as well as the increase in the proportion of forbs,whichwere difficult to decompose and input less organic carbon into soil,resulted in the decreases in soil C/N,C/P,and N/P contents to a great extent.Our results provide a sound basis for sustainable conservation and management of the alpine steppe. | ZHANG Zhen-chao HOU Ge LIU Miao WEI Tian-xing SUN Jian | 2019 | Journal of Mountain Science2019，16，10： | 7 |
| 13 | Landscape design method for a green community based on green building design theory显示文摘Landscape design for a green community should be favorable for the ambient ecological environment and for enhancement of both the local climate of a residential area and the environmental quality of life. This paper presents optimization methods for plant landscape design that take account of results of comparisons of noise reduction effects, heat island temperature decreases and effects on ventilation. These methods are based on different plant configurations and various luminous environments, such as exterior sunshine and shaded areas after the simulation of exterior luminous, acoustic and thermal environments of a residential area using the analytic software ECOTECT, CADNA/A, and PHEONICS. Three different types of residential buildings are simulated including a faculty apartment in the Xixi Campus of Zhejiang University, the Huaqing Villa and the Gangwan Jiayuan faculty apartment of Zhejiang University, China, based on green building design theory. In addition, the methods and process flow of landscape design of green residential areas are also described for the improvement of the exterior physical living environment. | Hong-feng GUO Jian GE Miao YUE Xiao ZHOU Wu JIN | 2010 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2010，11，9： | 5 |
| 14 | Preparation of PDVB/TiO2 composites and the study on the oil-water separation and degradation performances显示文摘The traditional superhydrophobic materials are not ideal for treating residual pollutants after oil-water separation. In this paper, a simple and economical method was developed for the fabrication of multi-functional superhydrophobic materials PDVBx/TiO2 composites, through in situ polymerization. The performance of the superhydrophobic composite was studied. The results showed that the low surface energy of PDVB2.5/TiO2 composite with the micro-nano scale roughness would result in excellent superhydrophobicity. In addition, the PDVB2.5/TiO2 composite exhibits optimum effect on the degradation of methyl orange(MO) with the degradation efficiency of 97.8%. What is more, the applications of the composite materials could be expanded to other fields, such as the degradation of drug ciprofloxacin hydrochloride(CIP). Finally, we expanded the application of the PDVBx/TiO2 composites to tribology, and found its excellent performance in reducing wear and antiwear. | MIAO Xiao HAN Lu WANG Lei WANG Min SUN XiaoHui ZHU XiaoTao GE Bo | 2019 | Science China(Technological Sciences)2019，62，7： | 4 |
| 15 | Endoscopic retrieval of 28 foreign bodies in a 100-year-old female after attempted suicide显示文摘Foreign body ingestion is a common emergency situation in children with one or a few objects having been ingested. Here we report our experience using endo-scopic retrieval in a female centenarian with dyspnea and foreign bodies in the esophagus. She attempted suicide by swallowing 26 coins and two other foreign bodies. A gastroscope was used to remove all foreign bodies in the lower esophagus. In total, 26 coins, one ferrous ring and one cylindrical plastic object were retrieved. To our knowledge, this is the first clinical report on retrieval of so many foreign bodies in a single case. | Quan-Peng Li Xian-Xiu Ge Guo-Zhong Ji Zhi-Ning Fan Fa-Ming Zhang Yun Wang Lin Miao | 2013 | World Journal of Gastroenterology2013，19，25： | 4 |
| 16 | Cytotoxic effects of betaxolol on healthy corneal endothelial cells both in vitro and in vivo显示文摘AIM: To demonstrate the cytotoxic effect of betaxolol and its underlying mechanism on human corneal endothelial cells(HCE cells) in vitro and cat corneal endothelial cells(CCE cells) in vivo,providing experimental basis for safety anti-glaucoma drug usage in clinic of ophthalmology. ·METHODS: In vivo and in vitro experiments were conducted to explore whether and how betaxolol participates in corneal endothelial cell injury. The in vitro morphology,growth status,plasma membrane permeability,DNA fragmentation,and ultrastructure of HCE cells treated with 0.021875-0.28g/L betaxolol were examined by light microscope,3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide(MTT) assay,acridine orange(AO)/ethidium bromide(EB) double-fluorescent staining,DNA agarose gel electrophoresis,and transmission electron microscope(TEM). The in vivo density,morphology,and ultrastructure of CCE cells,corneal thickness,and eye pressure of cat eyes treated with 0.28g/L betaxolol were investigated by specular microscopy,applanation tonometer,alizarin red staining,scanning electron microscope(SEM),and TEM. · RESULTS: Exposure to betaxolol at doses from 0.0875g/L to 2.8g/L induced morphological and ultrastructural changes of in vitro cultured HCE cells such as cytoplasmic vacuolation,cellular shrinkage,structural disorganization,chromatin condensation,and apoptotic body appearance. Simultaneously,betaxolol elevated plasma membrane permeability and induced DNA fragmentation of these cells in a dose-dependent manner in AO/EB staining. Furthermore,betaxolol at adose of 2.8g/L also induced decrease of density of CCE cells in vivo,and non-hexagonal and shrunk apoptotic cells were also found in betaxolol-treated cat corneal endothelia. ·CONCLUSION: Betaxolol has significant cytotoxicity on HCE cells in vitro by inducing apoptosis of these cells,and induced apoptosis of CCE cells in vivo as well. The findings help provide new insight into the apoptosis-inducing effect of anti-glaucoma drugs in eye clinic. | Ying Miao Qian Sun Qian Wen Yue Qiu Yuan Ge Miao-Miao Yu Ting-Jun Fan | 2014 | International Journal of Ophthalmology(English edition)2014，7，1： | 3 |
| 17 | Diagnosis and treatment of infantile malignant solid tumors in Beijing,China:A multicenter 10-year retrospective study显示文摘Importance:Cancer is the main cause of death by disease in children.Children experience the highest incidence of cancer in the first year of life.However,there is no comprehensive registration system for children with tumors in China.Objective:To summarize the diagnosis and treatment of infant cancer and analyze the status of standardized diagnosis and management among several treatment centers in Beijing,China,thereby providing evidence to guide further clinical research.Methods:From January 1,2010 to December 31,2019,patients with newly diagnosed infantile malignant solid tumors were admitted to six large tertiary pediatric solid tumor diagnosis and treatment centers in Beijing.The epidemiology,clinical features,and therapeutic effects of tumors in these patients were analyzed retrospectively.All patients were followed up until March 31,2020.Results:In total,938 patients were enrolled in this study.There were 530 boys(56.5%)and 408 girls(43.5%);the median age was 6.0 months(range,0-12.0 months).The three most common tumors were retinoblastoma in 366 patients(39.0%),neuroblastoma in 266 patients(28.4%),hepatoblastoma in 133 patients(14.2%),and central nervous system tumors in 52 patients(5.5%).The estimated 5-year overall survival rate was 81.3%±1.8%,and the 5-year event-free survival rate was 71.8%±2.9%.The 5-year overall survival rates of non-rhabdomyosarcoma soft tissue sarcoma,neuroblastoma,and retinoblastoma were 100%,88%±2.2%,and 86.9%±2.1%,respectively.The 5-year event-free survival rates were 81.1%±2.7%for neuroblastoma,81.6%±9.8%for non-rhabdomyosarcoma soft tissue sarcoma,and 72.7%±14.1%for extracranial malignant germ cell tumors.Interpretation:The three most common infantile malignant solid tumors were retinoblastoma,neuroblastoma,and hepatoblastoma.Multidisciplinary combined diagnosis and treatment is needed for infantile tumors. | Mei Jin Zhi Tian Yao Xie Zhaoxia Zhang Miao Li YaxiongYu Weiling Zhang Junyang Zhao Huanmin Wang Qi Zeng Long Li Ming Ge Ning Sun Xiaolun Zhang Jian Gong Wanshui Wu Rong Liu Weihong Zhao Dongsheng Huang Xiaoli Ma | 2020 | Pediatric Investigation2020，4，3： | 3 |
| 18 | Impact of clinical research on public health policy of neonatal screening for congenital heart disease in China显示文摘Congenital heart disease(CHD)is one of the most common congenital malformations,with a prevalence of approximately 1%in live births.[1,2]Among them,1/4 to 1/3 are major CHD,including critical CHD(CCHD)and serious CHD,which require surgical or catheter intervention before 1 year of age.[3]Major CHD,if left untreated,may cause serious outcomes,such as heart failure,cardiogenic shock,acidosis,and hypoxic-ischemic brain damage,and is one of the leading causes of infant death and childhood disability.[4]The missed diagnosis rate of CCHD in four nurseries ranges from 13%to 48%in developed countries,[4,5]but in China,is>71%before serious symptoms occur after birth.[6]Therefore,screening for CHD is useful for early detection,diagnosis,and treatment and helps to improve prognosis and reduces the medical,economic,and mental burden to both the family and the society.[5,7] | Miao Yang Youping Tian Pin Jia Xiaojing Ma Xiaoling Ge Xiaojing Hu Quming Zhao Fang Liu Bing Jia Weili Yan Qing Gu Guoying Huang | 2022 | Chinese Medical Journal2022，，11： | 3 |
| 19 | Diagnosis and Treatment of Infective Endocarditis in Chronic Hemodialysis Patients显示文摘Objective To analyze the clinical features of hemodialysis patients complicated by infective endo-carditis.Methods The clinical features of six such patients admitted to Peking Union Medical College Hospital during the year 1990 to 2009 were analyzed.All of them were diagnosed based on Chinese Children Diagnostic Criteria for Infective Endocarditis.Results The average age of the six patients was 52.3±19.3 years old.Four were males.Vascular accesses at the onset of infective endocarditis were as follows:permanent catheters in three,temporary catheters in two,and arteriovenous fistula in one.Three were found with mitral valve involvement,two with aortic valve involvement,and one with both.Five vegetations were found by transthoracic echocardiography,and one by transesophageal echocardiography.Four had positive blood culture results.The catheters were all removed.Four of the patients were improved by antibiotics treatment,in which two were still on hemodialysis in the following 14-24 months and the other two were lost to follow-up.One patient received surgery,but died of heart failure after further hemodialysis for three months.One was well on maintenance hemodialysis for three months after surgery.Conclusions Infective endocarditis should be suspected when hemodialysis patients suffer from long-term fever,for which prompt blood culture and transthoracic echocardiography confirmation could be performed.Transesophageal echocardiography could be considered even when transthoracic echocardiography produces negative findings.With catheters removed,full course of appropriate sensitive antibiotics and surgery if indicated could improve the outcome of chronic hemodialysis patients complicated by infective endocarditis. | Jian-ling Tao Jie Ma Guang-li Ge Li-meng Chen Hang Li Bao-tong Zhou Yang Sun Wen-ling Ye Qi Miao Xue-mei Li Xue-wang Li | 2010 | Chinese Medical Sciences Journal2010，25，3： | 3 |
| 20 | Toll-like receptor 5-mediated signaling enhances liver regeneration in mice显示文摘Background:Toll-like receptor 5(TLR5)-mediated pathways play critical roles in regulating the hepatic immune response and show hepatoprotective effects in mouse models of hepatic diseases.However,the role of TLR5 in experimental models of liver regeneration has not been reported.This study aimed to investigate the role of TLR5 in partial hepatectomy(PHx)-induced liver regeneration.Methods:We performed 2/3 PHx in wild-type(WT)mice,TLR5 knockout mice,or TLR5 agonist CBLB502 treated mice,as a model of liver regeneration.Bacterial flagellin content was measured with ELISA,and hepatic TLR5 expression was determined with quantitative PCR analyses and flow cytometry.To study the effects of TLR5 on hepatocyte proliferation,we analyzed bromodeoxyuridine(BrdU)incorporation and proliferating cell nuclear antigen(PCNA)expression with immunohistochemistry(IHC)staining.The effects of TLR5 during the priming phase of liver regeneration were examined with quantitative PCR analyses of immediate early gene mRNA levels,and with Western blotting analysis of hepatic NF-κB and STAT3 activation.Cytokine and growth factor production after PHx were detected with real-time PCR and cytometric bead array(CBA)assays.Oil Red O staining and hepatic lipid concentrations were analyzed to examine the effect of TLR5 on hepatic lipid accumulation after PHx.Results:The bacterial flagellin content in the serum and liver increased,and the hepatic TLR5 expression was significantly up-regulated in WT mice after PHx.TLR5-deficient mice exhibited diminished numbers of BrdU-and PCNA-positive cells,suppressed immediate early gene expression,and decreased cytokine and growth factor production.Moreover,PHx-induced hepatic NF-κB and STAT3 activation was inhibited in Tlr5–/–mice,as compared with WT mice.Consistently,the administration of CBLB502 significantly promoted PHx-mediated hepatocyte proliferation,which was correlated with enhanced production of proinflammatory cytokines and the recruitment of macrophages and neutrophils in the liver.Furthermore,Tlr5–/–mice displayed significantly lower hepatic lipid concentrations and smaller Oil Red O positive areas than those in control mice after PHx.Conclusions:We reveal that TLR5 activation contributes to the initial events of liver regeneration after PHx.Our findings demonstrate that TLR5 signaling positively regulates liver regeneration and suggest the potential of TLR5 agonist to promote liver regeneration. | Wen Zhang Lei Wang Xue-Hua Sun Xian Liu Yang Xiao Jie Zhang Ting Wang Hui Chen Yi-Qun Zhan Miao Yu Chang-Hui Ge Chang-Yan Li Guang-Ming Ren Rong-Hua Yin Xiao-Ming Yang | 2021 | Military Medical Research2021，8，4： | 3 |
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