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| 1 | Biological therapy in inflammatory bowel diseases:Access in Central and Eastern Europe显示文摘Biological drugs opened up new horizons in the management of inflammatory bowel diseases(IBD).This study focuses on access to biological therapy in IBD patients across 9 selected Central and Eastern European(CEE)countries,namely Bulgaria,the Czech Republic,Estonia,Hungary,Latvia,Lithuania,Poland,Romania and Slovakia.Literature data on the epidemiology and disease burden of IBD in CEE countries was systematically reviewed.Moreover,we provide an estimation on prevalence of IBD as well as biological treatment rates.In all countries with the exception of Romania,lower biological treatment rates were observed in ulcerative colitis(UC)compared to Crohn’s disease despite the higher prevalence of UC.Great heterogeneity(up to 96-fold)was found in access to biologicals across the CEE countries.Poland,Bulgaria,Romania and the Baltic States are lagging behind Hungary,Slovakia and the Czech Republic in their access to biologicals.Variations of reimbursement policy may be one of the factors explaining the differences to a certain extent in Bulgaria,Latvia,Lithuania,and Poland,but association with other possible determinants(differences in prevalence and incidence,price of biologicals,total expenditure on health,geographical access,and cost-effectiveness results)was not proven.We assume,nevertheless,that healthdeterioration linked to IBD might be valued differently against other systemic inflammatory conditions in distinct countries and which may contribute to the immense diversity in the utilization of biological drugs for IBD.In conclusion,access to biologicals varies widely among CEE countries and this difference cannot be explained by epidemiological factors,drug prices or total health expenditure.Changes in reimbursement policy could contribute to better access to biologicals in some countries. | Fanni Rencz Márta Péntek Martin Bortlik Edyta Zagorowicz Tibor Hlavaty Andrzej Sliwczyński Mihai M Diculescu Limas Kupcinskas Krisztina B Gecse László Gulácsi Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，6： | 4 |
| 2 | expression and regulation of bcl-2, bcl-xl, and bax correlate with p53 statics and sensitivity to apoptosis in childhood acute lymphoblastic leukemia 显示文摘 | Findley H W Gul P Reager A M | 1997 | Blood1997，89，8： | 1 |
| 3 | Sweet cherry (Prunus avium): Critical factors affecting the composition and shelf life显示文摘 | Wani A A Singh P Gul K | 2014 | Food Packaging & Shelf Life2014，1，1： | 1 |
| 4 | An improved generalized Amber force field(GAFF)for urea显示文摘 | GUL A O WOLFGANG P TIMOTHY C | 2010 | Journal of Molecular Modeling2010，16，9： | 1 |
| 5 | Laparoscopic central pancreatectomy: our technique and long-term results in 14 patients显示文摘 | Senthilnathan P Gul S I Gurumurthy S S Palanivelu P R Parthasarathi R Palanisamy N V | 2015 | J Minim Access Surg2015，11，： | 1 |
| 6 | Long-term outcome after selective posterior rhizotomy in children with spastic cerebral palsy显示文摘 | Gul SM Steinbok P McLeod K | 1999 | Pediatr Neurosurg1999，31，2： | 1 |
| 7 | Co-supervision of doctoral students:enhancing the learning experience显示文摘 | Paul P Olson J K Gul R B | 2014 | Int J Nurs Educ Scholarsh2014，11，1： | 1 |
| 8 | Dynamic optical projec-tion of acquired luminescence for aiding oncologic surgery显示文摘 | Sarder P Gul icksrud K Mondal S | | 0，，12： | 1 |
| 9 | RNA cleaving' 10- 23' DNA enzymes with enhanced stability and activity显示文摘 | SCHUBERT S GUL D C GRUNERT H P | 2003 | Nucleic Acids Res2003，31，20： | 1 |
| 10 | Long-term outcome after selective posterior rhizotomy in children with spastic cerebral palsy显示文摘 | Gul SM Steinbok P McLeod K | 1999 | Pediatr Neurosurg1999，31，2： | 1 |
| 11 | Evaluation of a new chro mogenic medium for isolation and identification of corn mon urinary tract pathogens显示文摘 | Ciragil P Gul M Aral M | 2006 | Eur J Clin Microbiol In fect Dis2006，25，： | 1 |
| 12 | expression and regulation of bcl-2,bcl-xl,and bax correlate with p53 statics and sensitivity to apoptosis in childhood acute lymphoblastic leukemia显示文摘 | FINDLEY HW GUL P REAGER AM | 1997 | Blood1997，89，8： | 1 |
| 13 | Transferability of results of cost utility analyses for biologicals in inflammatory conditions for Central and Eastern European countries显示文摘 | László Gulácsi Fanni Rencz Márta Péntek Valentin Brodszky Ruth Lopert Noémi V. Hevér Petra Baji | 2014 | The European Journal of Health Economics2014，，1： | 1 |
| 14 | Work disability and productivity loss in patients with inflammatory bowel diseases in Hungary in the era of biologics显示文摘 | Mandel D. Michael Anita Bálint Barbara D. Lovász László Gulácsi Bálint Strbák Petra A. Golovics Klaudia Farkas Zsuzsanna Kürti Blanka K. Szilágyi Anna Mohás Tamás Molnár Péter L. Lakatos | 2014 | The European Journal of Health Economics2014，，1： | 1 |
| 15 | Biological therapy in inflammatory rheumatic diseases: issues in Central and Eastern European countries显示文摘 | Márta Péntek Gyula Poór Piotr Wiland Martina Olejárová Marek Brzosko Catalin Codreanu Nóra Brodszky László Gulácsi | 2014 | The European Journal of Health Economics2014，，1： | 1 |
| 16 | Analysis of the anthraquinones aloe-emodin and aloin by gas chromatography/mass spectrometry显示文摘 | ELSOHLY MAHMOUD A GUL WASEEM MURPHY TIMOTHY P | 2004 | International Immunopharmacology2004，4，14： | 1 |
| 17 | Biosimilars for the management of rheumatoid arthritis:economic considerations显示文摘 | Gulácsi L Brodszky V Baji P | 2015 | Expert Rev Clin Immunol2015，11，1： | 1 |
| 18 | Determination of site-specific carotid-intima media thickness: common -carotid artery and carotid bifurcation in hypercholesterolemia patients 显示文摘 | Perwaiz Khan S Gul P Khemani S | 2013 | Pak J Med Sci2013，29，5： | 1 |
| 19 | Supratentorial Primitive Neuroectodermal Tumors显示文摘 | Singhal A Gul S Steinbok P | 2010 | Oncology of CNS Tumors2010，，： | 1 |
| 20 | Comparative efficacy and safety of biosimilar infliximab and other biological treatments in ankylosing spondylitis: systematic literature review and meta-analysis显示文摘 | Petra Baji Márta Péntek Sándor Szántó Pál Géher László Gulácsi Orsolya Balogh Valentin Brodszky | 2014 | The European Journal of Health Economics2014，，1： | 1 |
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