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| 1 | Small sphincterotomy combined with endoscopic papillary large balloon dilation versus sphincterotomy显示文摘AIM:To compare small sphincterotomy combined with endoscopic papillary large balloon dilation(SES+ ELBD)and endoscopic sphincterotomy(EST)for large bile duct stones. METHODS:We compared prospectively SES+ELBD (group A,n=27)with conventional EST(group B, n=28)for the treatment of large bile duct stones(≥ 15 mm).When the stone could not be removed with a normal basket,mechanical lithotripsy was performed. We compared the rates of complete stone removal with one session and application of mechanical lithotripsy. RESULTS:No significant differences were observed in the mean largest stone size(A:20.8 mm,B:21.3 mm), bile duct diameter(A:21.4 mm,B:20.5 mm),number of stones(A:2.2,B:2.3),or procedure time(A:18 min, B:19 min)between the two groups.The rates of complete stone removal with one session was 85%in group A and 86%in group B(P=0.473).Mechanical lithotripsy was required for stone removal in nine of 27 patients(33%)in group A and nine of 28 patients (32%,P=0.527)in group B.CONCLUSION:SES+ELBD did not show significant benefits compared to conventional EST,especially for the removal of large(≥15 mm)bile duct stones. | Hyun Gun Kim Young Koog Cheon Young Deok Cho Jong Ho Moon Do Hyun Park Tae Hoon Lee Hyun Jong Choi Sang-Heum Park Joon Seong Lee Moon Sung Lee | 2009 | World Journal of Gastroenterology2009，15，34： | 34 |
| 2 | Targeted and effective photodynamic therapy for cancer using functionalized nanomaterials显示文摘Photodynamic therapy(PDT) is an emerging, non-invasive therapeutic strategy that involves photosensitizer(PS) drugs and external light for the treatment of diseases. Despite the great progress in PS-mediated PDT, their clinical applications are still hampered by poor water solubility and tissue/cell specificity of conventional PS drugs. Therefore, great efforts have been made towards the development of nanomaterials that can tackle fundamental challenges in conventional PS drug–mediated PDT for cancer treatment. This review highlights recent advances in the development of nano-platforms, in which various functionalized organic and inorganic nanomaterials are integrated with PS drugs, for significantly enhanced efficacy and tumor-selectivity of PDT. | Eun Ji Hong Dae Gun Choi Min Suk Shim | 2016 | Acta Pharmaceutica Sinica B2016，6，4： | 22 |
| 3 | HER2-induced metastasis is mediated by AKT/JNK/EMT signaling pathway in gastric cancer显示文摘AIM To investigated the relationships between HER2, c-Jun N-terminal kinase(JNK) and protein kinase B(AKT) with respect to metastatic potential of HER2-positive gastric cancer(GC) cells.METHODS Immunohistochemistry was performed on tissue array slides containing 423 human GC specimens. Using HER2-positve GC cell lines SNU-216 and NCI-N87, HER2 expression was silenced by RNA interference, and the activations of JNK and AKT were suppressed by SP600125 and LY294002, respectively. Transwell assay, Western blot, semi-quantitative reverse transcriptionpolymerase chain reaction and immunofluorescence staining were used in cell culture experiments. RESULTS In GC specimens, HER2, JNK, and AKT activations were positively correlated with each other. In vitro analysis revealed a positive regulatory feedback loop between HER2 and JNK in GC cell lines and the role of JNK as a downstream effector of AKT in the HER2/AKT signaling pathway. JNK inhibition suppressed migratory capacity through reversing EMT and dual inhibition of JNK and AKT induced a more profound effect on cancer cell motility.CONCLUSION HER2, JNK and AKT in human GC specimens are positively associated with each other. JNK and AKT, downstream effectors of HER2, co-operatively contribute to the metastatic potential of HER2-positive GC cells. Thus, targeting of these two molecules in combination with HER2 downregulation may be a good approach to combat HER2-positive GC. | Yiseul Choi Young San Ko Jinju Park Youngsun Choi Younghoon Kim Jung-Soo Pyo Bo Gun Jang Douk Ho Hwang Woo Ho Kim Byung Lan Lee | 2016 | World Journal of Gastroenterology2016，22，41： | 4 |
| 4 | Trigonelline attenuates the adipocyte differentiation and lipid accumulation in 3T3-L1 cells显示文摘 | Soundharrajan Ilavenil Mariadhas Valan Arasu Jeong-Chae Lee Da Hye Kim Sang Gun Roh Hyung Su Park Gi Jun Choi Vijayakumar Mayakrishnan Ki Choon Choi | 2013 | Phytomedicine2013，，： | 2 |
| 5 | 16S rRNA基因测序技术在肝脓疡细菌鉴定中的作用(英文)显示文摘目的评价16S核糖体RNA(rRNA)基因测序在肝脓疡中细菌鉴定中的应用价值。方法2012年1月—2013年12月间共20例肝脓疡行经皮置管引流的患者,分别行脓液培养,血培养和16S rRNA基因测序。利用454 GS Junior System对脓液基因组DNA行PCR和16S rRNA基因测序。脓液培养,血液培养和16S rRNA基因测序结果进行分别评价。结果脓液和血液培养阳性的患者分别是9例(45%)和4例(20%)。16S rRNA基因测序细菌鉴定率为90%,明显高于传统的培养方法。结论 16S rRNA基因测序方法较传统的培养方法能更准确和有效对肝脓疡进行细菌鉴定。 | 宋伦圭 Yun Gyu Song Sang Gun Shim Kwang Min Kim Dae Soo Kim Sang Haeng Choi Jae Young Song Kon Ho Lee Hyung-Lyun Kang Seung-Chul Baik Woo-Kon Lee Myung Je Cho Kwang Ho Rhee Dong Hae Lee | 2014 | 介入放射学杂志2014，23，10： | 2 |
| 6 | Extending the limitations of liver surgery: outcomes of initial human experience in a high-volume center performing single-port laparoscopic liver resection for hepatocellular carcinoma显示文摘 | Guruprasad Shetty Young You Ho Choi Gun Na Tae Hong Dong-Goo Kim | 2012 | Surgical Endoscopy2012，，6： | 2 |
| 7 | Prevention and risk factors of hepatitis B recurrence after living donor liver transplantation显示文摘 | Gun Hyung Na Dong Goo Kim Jae Hyun Han Eun Young Kim Soo Ho Lee Tae Ho Hong Young Kyoung You Jong Young Choi | 2014 | J Gastroenterol Hepatol2014，，1： | 2 |
| 8 | Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NFκB pathway 显示文摘 | Byeong Hyeok Choi Chang Gun Kim Yoongho Lira | 2008 | Cancer Letters2008，259，1： | 1 |
| 9 | Water saving by shallow intermittent irrigation and growth of rice显示文摘 | Jong Gun Won Jang Soo Choi Seung Phil Lee | 2005 | Plant Production Science2005，8，4： | 1 |
| 10 | Observation of metal ions adsorption on novel polymeric chelating fiber and activated carbon fiber 显示文摘 | Ko Young Gun Choi Ung Su | 2007 | Separation and Purification Technology2007，57，： | 1 |
| 11 | Antifungal activity and mode of action of silver nano-particles on Candida albicans显示文摘 | Keuk-Jun Kim Woo Sang Sung Bo Kyoung Suh Seok-Ki Moon Jong-Soo Choi Jong Guk Kim Dong Gun Lee | 2009 | BioMetals2009，，2： | 1 |
| 12 | Cur- cumin down - regulates the muhidrug - resistance mdrl b gene by inhibiting the PI3K/Akt/NFjB pathway 显示文摘 | Byeong Hyeok Choi Chang Gun Kim Yoongho Lim | 2008 | Cancer Letters2008，259，： | 1 |
| 13 | Adhesion hysteresis studies of extracted poly (dimethylsiloxane) using contact mechanics 显示文摘 | Gun Young Choi Soojin Kim Abraham Ulman | 1997 | Langmuir1997，13，23： | 1 |
| 14 | Steel plate shear walls with various infill plate designs显示文摘 | CHOI IN- RAK PARK HONG- GUN | 2009 | Journal of Structural Engineering2009，135，7： | 1 |
| 15 | Antifungal activity and mode of action of silver nano-particles on Candida albicans显示文摘 | Keuk-Jun Kim Woo Sang Sung Bo Kyoung Suh Seok-Ki Moon Jong-Soo Choi Jong Guk Kim Dong Gun Lee | 2009 | BioMetals2009，，2： | 1 |
| 16 | Cu 2+ sequestration by amine-functionalized silica nanotubes显示文摘 | Young Gun Ko Hyun Jeong Lee Hyun Chul Oh Ung Su Choi | 2013 | Journal of Hazardous Materials2013，，： | 1 |
| 17 | Risk of developing seizure after percutaneous endoscopic lumbar discectomy 显示文摘 | Gun Choi | 2011 | J Spinal Disord Tech2011，24，2： | 1 |
| 18 | 显示文摘 | Je Hong Ryu Ki Seop Choi Whan Gun Kim | 2005 | Journal of Applied Polymer Science2005，96，： | 1 |
| 19 | Identification of 5' and 3' cis-acting elements of the porcine reproductive and respiratory syndrome virus:acquisition of novel 5' AU-rich sequences restored replication of a 5' -proximal 7-nucleotide deletion mutant显示文摘 | Choi Y J gun S I Kang S Y | 2006 | J Yiro12006，，2： | 1 |
| 20 | Inverted Tako-Tsubo Cardiomyopathy Associated with Bronchoalveolar Lavage显示文摘 | Kyeong Sam Ok Bong Gun Song Kyoung Sik Park Hyun Gul Jung Hye-Jin Jung I. Nae Park Ho-Kee Yum Wook-Hyun Cho Suk-Koo Choi | 2011 | Heart Lung and Circulation2011，，7： | 1 |
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