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| 1 | Novel immunological and nutritional-based prognostic index for gastric cancer显示文摘AIM: To assess the prognostic significance of immunological and nutritional-based indices, including the prognostic nutritional index(PNI), neutrophillymphocyte ratio(NLR), and platelet-lymphocyte ratio in gastric cancer.METHODS: We retrospectively reviewed 632 gastric cancer patients who underwent gastrectomy between1998 and 2008. Areas under the receiver operating characteristic curve were calculated to compare the predictive ability of the indices, together with estimating the sensitivity, specificity and agreement rate.Univariate and multivariate analyses were performed to identify risk factors for overall survival(OS). Propensity score analysis was performed to adjust variables to control for selection bias.RESULTS: Each index could predict OS in gastric cancer patients in univariate analysis, but only PNI had independent prognostic significance in multivariate analysis before and after adjustment with propensity scoring(hazard ratio, 1.668; 95% confidence interval:1.368-2.035). In subgroup analysis, a low PNI predicted a significantly shorter OS in patients with stage Ⅱ-Ⅲ disease(P = 0.019, P < 0.001), T3-T4 tumors(P <0.001), or lymph node metastasis(P < 0.001). Canton score, a combination of PNI, NLR, and platelet, was a better indicator for OS than PNI, with the largest area under the curve for 12-, 36-, 60-mo OS and overall OS(P = 0.022, P = 0.030, P < 0.001, and P = 0.024,respectively). The maximum sensitivity, specificity, and agreement rate of Canton score for predicting prognosis were 84.6%, 34.9%, and 70.1%, respectively.CONCLUSION: PNI is an independent prognostic factor for OS in gastric cancer. Canton score can be a novel preoperative prognostic index in gastric cancer. | Kai-Yu Sun Jian-Bo Xu Shu-Ling Chen Yu-Jie Yuan Hui Wu Jian-Jun Peng Chuang-Qi Chen Pi Guo Yuan-Tao Hao Yu-Long He | 2015 | World Journal of Gastroenterology2015，21，19： | 18 |
| 2 | A nano-cocrystal strategy to improve the dissolution rate and oral bioavailability of baicalein显示文摘Baicalein(BE) is one of the main active flavonoids representing the variety of pharmacological effects including anticancer, anti-inflammatory and cardiovascular protective activities, but it's very low solubility, dissolution rate and poor oral absorption limit the therapeutic applications. In this work, a nano-cocrystal strategy was successfully applied to improve the dissolution rate and bioavailability of BE. Baicalein-nicotinamide(BE-NCT) nanococrystals were prepared by high pressure homogenization and evaluated both in vitro and in vivo. Physical characterization results including scanning electron microscopy, dynamic light scattering, powder X-ray diffraction and differential scanning calorimetry demonstrated that BE-NCT nano-cocrystals were changed into amorphous state with mean particle size of 251.53 nm. In the dissolution test, the BE-NCT nano-cocrystals performed 2.17-fold and 2.54-fold enhancement than BE coarse powder in FaSSIF-V2 and FaSSGF. Upon oral administration, the integrated AUC0-t of BE-NCT nano-cocrystals(6.02-fold) was significantly higher than BE coarse powder(1-fold), BE-NCT cocrystals(2.87-fold) and BE nanocrystals(3.32-fold). Compared with BE coarse powder, BE-NCT cocrystals and BE nanocrystals, BENCT nano-cocrystals possessed excellent performance both in vitro and in vivo evaluations.Thus, it can be seen that nano-cocrystal is an appropriate novel strategy for improving dissolution rate and bioavailability of poor soluble natural products such as BE. | Jiaxin Pi Shuya Wang Wen Li Dereje Kebebe Ying Zhang Bing Zhang Dongli Qi Pan Guo Nan Li Zhidong Liu | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，2： | 12 |
| 3 | No association between low-dose reserpine use and depression in older hypertensive patient: result of a multicenter, cross-sectional study显示文摘Background Reserpine is currently used by millions of Chinese hypertensive patients, in spite of the continued concern of its depressogenic effect, even when used in low dose. This study aimed to investigate the association between low-dose reserpine use and depression in older Chinese hypertensive patient. Methods In this cross-sectional, case-control study, we recruited patient aged 60 years or over who had regularly taken one or two tables of “compound reserpine and triamterene tablets (CRTTs)” for more than one year (reserpine user) from 26 community health centers located in 10 provinces in China. For each patient who took CRTTs, we selected an age (within five years) and sex matched hypertensive patient who had never taken any drugs containing reserpine (non-reserpine user) as control. Depressive symptoms were evaluated using a Chinese depression scale adapted from the Zung Self-Rating Depression Scale. Demographic, clinical data and laboratory examination results within six months were collected. Results From August 2018 to December 2018, 787 reserpine user and 787 non-reserpine user were recruited. The mean age of all study subjects was 70.3 years, with about equal numbers of males and females. The mean depression score was 40.4 in reserpine users and 40.6 in non-reserpine users (P = 0.7). The majority of study subject had a depression score < 53 (87.6% in reserpine users and 88.2% in non-reserpine users, respectively). There were no significant differences in the prevalence of mild, moderate or severe depression in reserpine users and non-reserpine users. Conclusions There is no association between low-dose reserpine use and depression in older hypertensive patient. The role of reserpine in the treatment and control of hypertension should be reconsidered;and further studies, especially randomized, controlled clinical trials to compare efficacy and safety of reserpine and other widely recommended anti-hypertensive agents are needed. | Guo-Hua ZHU Xi-Peng SUN Jing LI Lin PI Hai-Qin TANG Hai-Qing GAO Hong-Liang CONG Peng QU Xin-Zheng LU Xin-Jun ZHANG Luo-Sha ZHAO Yi-Fang GUO Dong-Xia LIU Liang-Qing ZHANG Hua TANG Yi-Xin HU Li FAN Qi HUA | 2019 | Journal of Geriatric Cardiology2019，16，8： | 8 |
| 4 | Evaluation of emergency tourniquets for prehospital use in China显示文摘客观巨大的出血在武装冲突期间是威胁生活的。止血带是过去常减少在损伤的严重流血的重要医药设备。这研究的目的是以经验为主地评估在中国使用的当前的止血带并且在选择适当止血带提供信息给紧急情况护士。方法五条止血带由 20 个健康参加者是自我适用的。对止血带地点远侧的血流动用脉管的 Doppler 超声被估计。应用程序时间,疼痛,麻木,和另外的参数被评估。结果膀胱止血带和吊起止血带有效地堵塞了有成功的动脉的血流动在两个比 75% 高评价上面、更低的极限。货物带最快适用,拿(7. | GUO Jun-yan LIU Yu MA Yan-lan PI Hong-ying WANG Jian-rong | 2011 | Chinese Journal of Traumatology2011，14，3： | 5 |
| 5 | Radioimmunoimaging of colorectal cancer using ^(99m)Tc-labeled monoclonal antibody显示文摘Radioimmunoimagingofcolorectalcancerusing99mTclabeledmonoclonalantibodyHUJinYue1,SUJiaanZhi2,PIZhiMing3,ZHUJianGao1,ZHO... | HU JinYue1, SU JianZhi2, PI ZhiMing3, ZHU JianGao1, ZHOU GuoHua1 and SUN QuBing1Keywords colorectal neoplasms/radioimmunoimaging antibody, monoclonal isotope labeling technium/diagnostic use | 1998 | World Journal of Gastroenterology1998，4，4： | 4 |
| 6 | Moisture sorption and diffusion determination of Chinese herbal granules:Moisture-resistant effects of fluidized bed granulation with dextrin显示文摘Objective: To investigate the effects of fluidized bed granulation with dextrin on moisture sorption and diffusion of Zexie Decoction granules.Methods: The particle characterization was studied by the particle size, scanning electron microscopy(SEM), differential scanning calorimetry(DSC), and Fourier transform infrared(FTIR). The moisture sorption isotherm, equilibrium moisture content(EMC), and moisture diffusion coefficients were determined by using the saturated salt solution method.Results: The particle size increased from 6.04 μm(powder) to 1201.47 μm(granule). The glass transition temperature of dextrin, Zexie Decoction powder, and granule was 107.13 °C, 94.82 °C, and 126.25 °C. As the increase of temperature, the initial rate of moisture sorption become higher. Furthermore, the initial rate of moisture sorption of Zexie Decoction granules was lower than those of powders and dextrin. The EMC and moisture diffusion coefficients were reduced significantly after granulation(P < 0.01). Critical relative humidity and diffusion activation energy of granules were higher than powders.Conclusion: Results suggested that fluidized bed granulation with dextrin could reduce the hygroscopicity of the Zexie Decoction extract powders and inhibited moisture diffusion, which is mainly related to the microstructure reorganization by fluidized bed granulation and anti-plasticizing effects of dextrin. | Peng-jun Han Zhi-feng Xue Li-na Zhang Bing Zhang Dong-li Qi Jia-xin Pi Nan Li Pan Guo Zhi-dong Liu | 2018 | Chinese Herbal Medicines2018，10，3： | 4 |
| 7 | Organic Carbon Isotope Geochemistry of the Neoproterozoic Doushantuo Formation,South China显示文摘The Neoproterozoic Doushantuo Formation on the Yangtze Platform,South China,documents a sedimentary succession with different sedimentary facies from carbonate platform to slope and to deep sea basin,and hosts one of the world-class phosphorite deposits.In these strata,exquisitely preserved fossils have been discovered:the Weng’an biota.This study presents carbon isotope geochemistry which is associated paired carbonate and organic matter from the Weng’an section of a carbonate platform(shelf of the Yangtze Platform,Guizhou Province)from the Songtao section and Nanming section of a transition belt(slope of the Yangtze Platform,Guizhou Province)and from the Yanwutan section(basin area of the Yangtze Platform,Hunan Province).Environmental variations and bio-events on the Yangtze Platform during the Late Neoproterozoic and their causal relationship are discussed.Negative carbon isotope values for carbonate and organic carbon(mean δ13Corg = ?35.0‰)from the uppermost Nantuo Formation are followed by an overall increase in δ13C up-section.Carbon isotope values vary between ?9.9‰ and 3.6‰ for carbonate and between ?35.6‰ and ?21.5‰ for organic carbon,respectively.Heavier δ13Ccarb values suggest an increase in organic carbon burial,possibly related to increasing productivity(such as the Weng’an biota).The δ13C values of the sediments from the Doushantuo Formation decreased from the platform via the slope to basin,reflecting a reduced environment with minor dissolved inorganic carbon possibly due to a lower primary productivity.It is deduced that the classical upwelling process,the stratification structure and the hydrothermal eruption are principally important mechanisms to interpret the carbon isotopic compositions of the sediments from the Doushantuo Formation. | GUO Qingjun LIU Congqiang Harald STRAUSS Tatiana GOLDBERG ZHU Maoyan PI Daohui WANG Jian | 2006 | Acta Geologica Sinica(English Edition)2006，80，5： | 3 |
| 8 | Ambient TSP concentration and dustfall variation in Urumqi,China显示文摘Total suspended particulate(TSP, particle diameter≤100 μm) was the dominant air pollutant and significantly influenced local air quality. In this paper, we investigated the interannual and seasonal variations of TSP and dustfall of the atmosphere over Urumqi, the capital city of Xinjiang Uygur autonomous region, northwestern China, basing on environmental monitoring records and meteorological data from 1986–2012. The results showed that during the study period, annual average TSP concentration decreased from 716 to 260 μg/m3, with an average level of 422.9 μg/m3, while dustfall intensity reduced from 350.4 to 166.6 t/(km2?a), with an average level of 259 t/(km2?a). Over 50% of the annual pollution days were induced mainly by TSP. Spring and winter had relatively higher dustfall intensities, and dense traffic and residential areas had the highest dustfall intensities in the Urumqi metropolitan area. With an annual average precipitation of less than 300 mm, atmospheric particulates in Urumqi could be hardly removed through wet deposition. During spring and summertime prevailing winds from northwest and northeast could carry aeolian dust particles from sandy deserts to Urumqi. Aeolian dusts from deserts would remain to be a priority regarding air pollution control in arid oasis cities. | XiaoXiao ZHANG Xi CHEN YuHong GUO ZiFa WANG LianYou LIU Cottle PAUL ShengYu LI HuaWei PI | 2014 | Journal of Arid Land2014，6，6： | 3 |
| 9 | The Gravitational-wave physics Ⅱ: Progress显示文摘It has been a half-decade since the first direct detection of gravitational waves, which signifies the coming of the era of the gravitational-wave astronomy and gravitational-wave cosmology. The increasing number of the detected gravitational-wave events has revealed the promising capability of constraining various aspects of cosmology, astronomy, and gravity. Due to the limited space in this review article, we will briefly summarize the recent progress over the past five years, but with a special focus on some of our own work for the Key Project 'Physics associated with the gravitational waves' supported by the National Natural Science Foundation of China. In particular,(1) we have presented the mechanism of the gravitational-wave production during some physical processes of the early Universe, such as inflation, preheating and phase transition, and the cosmological implications of gravitational-wave measurements;(2) we have put constraints on the neutron star maximum mass according to GW170817 observations;(3) we have developed a numerical relativity algorithm based on the finite element method and a waveform model for the binary black hole coalescence along an eccentric orbit. | Ligong Bian Rong-Gen Cai Shuo Cao Zhoujian Cao He Gao Zong-Kuan Guo Kejia Lee Di Li Jing Liu Youjun Lu Shi Pi Jian-Min Wang Shao-Jiang Wang Yan Wang Tao Yang Xing-Yu Yang Shenghua Yu Xin Zhang | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，12： | 2 |
| 10 | Zircon U–Pb dating of Pubei granite and strontium isotope from sphalerite of the Xinhua Pb–Zn–(Ag) deposit,Yunkai Area of Guangxi Province,South China显示文摘The Yunkai Area is located at the southern South China Block and is part of the Qinzhou Bay-Hangzhou Bay Metallogenic Belt, which is a famous polymetallic mineralization belt. The Xinhua Pb–Zn–(Ag)deposit is located in the western part of Yunkai Area, with an abundance of Pubei batholiths. Zircon U–Pb geochronology of Pubei batholiths shows that crystallization age ranges from 251.9 ± 2.2 to 244.3 ± 1.8 Ma, thus belonging to Indosinian orogeny. Geochemistry and Sr isotopic compositions of the Pubei batholiths show that it is derived from the partial melting of large scale crustal melting during the stage of exhumation and uplifting of the lower-middle crust. In addition, strontium isotope of sphalerite from the Xinhua Pb–Zn–(Ag) deposit, has limited ranges in ^(87)Rb/^(86)Sr and ^(87)Sr/^(86)Sr, ranging from 0.4077 to 1.0449, and 0.718720 to 0.725245, respectively. The initial ^(87)Sr/^(86)Sr ratios of sphalerite ranges between 0.718720 and 0.725245, which is higher than that of upper continental crust and lower than that of the Pubei batholiths, illustrating the fluid might be derived from the mixing of Pubei pluton and upper continental crust. | Minfang Wang Xubo Zhang Daohui Pi Xiaonan Guo | 2016 | Acta Geochimica2016，35，2： | 2 |
| 11 | Study of penetration mechanism of labrasol on rabbit cornea by Ussing chamber, RT-PCR assay, Western blot and immunohistochemistry显示文摘Labrasol, as a non-ionic surfactant, can enhance the permeation and absorption of drugs, and is extensively used in topical, transdermal, and oral pharmaceutical preparations as an emulsifier and absorption enhancer. Recent studies in our laboratory have indicated that labrasol has a strong absorption enhancing effect on different types of drugs in vitro and in vivo. This study was performed to further elucidate the action mechanism of labrasol on the corneal penetration. In this research, the fluorescein sodium, a marker of passive paracellular transport of tight junction, was selected as the model drug to assess the effect of labrasol on in vitro corneal permeability. To investigate the continuous and real-time influence of labrasol on the membrane permeability and integrity, the Ussing chamber system was applied to monitor the electrophysiological parameters. And, furthermore, we elucidated the effect of labrasol on excised cornea at the molecular level by application of RT-PCR, Western blot, and immunohistochemical staining. The results indicated that labrasol obviously enhance the transcorneal permeability of fluorescein sodium, and the enhancement was realized by interacting with and down-regulating the associated proteins, such as Factin, claudin-1 and β-catenin, which were contributed to cell-cell connections, respectively. | Pan Guo Nan Li Lili Fan Jun Lu Boying Liu Bing Zhang Yumei Wu Zhidong Liu Jiawei Li Jiaxin Pi Dongli Qi | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，3： | 2 |
| 12 | Experimental study on compressive strengths o{ thick-walled cold-formed sections显示文摘 | Yao Jie Guo Ai-Zhu Zhu Yong-Lin Pi | 2007 | Journal of Constructional Steel Research2007，，63： | 1 |
| 13 | IRE1α-XBP1s Induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis显示文摘 | Zhang H Guo PE Ji PI | 2012 | Cell Metab2012，16，4： | 1 |
| 14 | The kinetic studies of elimination of HCl during thermal decomposition of PVC in the presence of transition metal oxides显示文摘 | Pi H Xiong Y Guo SY | 2005 | Polymer-plastics Technology and Engineering2005，44，2： | 1 |
| 15 | Out-of-plane strength design of spatially trussed arches with a rectangular lattice section显示文摘 | Yan-Lin Guo Si-Yuan Zhao Chao Dou Yong-Lin Pi | 2013 | Journal of Constructional Steel Research2013，，： | 1 |
| 16 | Effect of Astragalusmem branaceus on natrual killer cell activity and induction of α- and β-interferon inpatlents with Coxsackie B virul myocarditis显示文摘 | Yang Yinzhen Jin Peiyin Guo Pi | 1990 | Chin Med J1990，103，4： | 1 |
| 17 | Elastic out-of-plane buckling load of circular steel tubular truss arches incorporating shearing effects显示文摘 | Chao Dou Yan-Lin Guo Si-Yuan Zhao Yong-Lin Pi Mark Andrew Bradford | 2013 | Engineering Structures2013，，： | 1 |
| 18 | Mechanochemical improvement of the flame retardant and mechanical properties of zinc borate and borate-aluminum trihydrate filled poly(vinyl chloride)显示文摘 | H PI S-Y GUO Y NING | 2003 | J Appl Polym Sci2003，89，： | 1 |
| 19 | Experimental study on compressive strengths of thick-walled cold-formed sections显示文摘 | Yao-Jie Guo Ai-Zhu Zhu Yong-Lin Pi Francis Tin-Loi | 2006 | Journal of Constructional Steel Research2006，，5： | 1 |
| 20 | Experimental study on compressive strengths of thick- walled cold-formed sections 显示文摘 | Guo Yaojie Zhu Aizhu Pi Yonglin | 2007 | Journal of Constructional Steel Research2007，63，5： | 1 |
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