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| 1 | Linking atmospheric pollution to cryospheric change in the Third Pole region: current progress and future prospects显示文摘The Tibetan Plateau and its surroundings are known as the Third Pole(TP). This region is noted for its high rates of glacier melt and the associated hydrological shifts that affect water supplies in Asia. Atmospheric pollutants contribute to climatic and cryospheric changes through their effects on solar radiation and the albedos of snow and ice surfaces; moreover, the behavior and fates within the cryosphere and environmental impacts of environmental pollutants are topics of increasing concern. In this review, we introduce a coordinated monitoring and research framework and network to link atmospheric pollution and cryospheric changes(APCC) within the TP region. We then provide an up-to-date summary of progress and achievements related to the APCC research framework, including aspects of atmospheric pollution’s composition and concentration, spatial and temporal variations, trans-boundary transport pathways and mechanisms, and effects on the warming of atmosphere and changing in Indian monsoon, as well as melting of glacier and snow cover. We highlight that exogenous air pollutants can enter into the TP’s environments and cause great impacts on regional climatic and environmental changes. At last, we propose future research priorities and map out an extended program at the global scale. The ongoing monitoring activities and research facilitate comprehensive studies of atmosphere–cryosphere interactions, represent one of China’s key research expeditions to the TP and the polar regions and contribute to the global perspective of earth system science. | Shichang Kang Qianggong Zhang Yun Qian Zhenming Ji Chaoliu Li Zhiyuan Cong Yulan Zhang Junming Guo Wentao Du Jie Huang Qinglong You Arnico K.Panday Maheswar Rupakheti Deliang Chen Orjan Gustafsson Mark H.Thiemens Dahe Qin | 2019 | National Science Review2019，6，4： | 35 |
| 2 | Inhibitory Activity of Honeysuckle Extracts against Influenza A Virus In Vitro and In Vivo显示文摘Honeysuckle has been used in the treatment of influenza virus infection for thousands of years in China.However,its main active components and the functional mechanisms remain to be elucidated.Here,four honeysuckle extracts,including acids extract,flavonoids extract,total extract and acids-flavonoids mixture,were prepared to clarify the main active antiviral components.The cytopathic effect reduction assay showed that all the four extracts inhibited the replication of influenza viruses H1N1,H3N2 and the oseltamivir-resistant mutant strain H1N1-H275Y.The acids-flavonoids mixture had the strongest inhibitory effects in vitro with EC_(50) values of 3.8,4.1,and >20 lg/m L against H1N1,H3N2 and H1N1-H275Y,respectively,showing competitive antiviral activity with oseltamivir and ribavirin.Honeysuckle acids extract also showed the most significant antiviral activity in vivo.Oral administration of the acids extract at a dosage of 600 mg/kg/d effectively alleviated viral pneumonia,maintained body weight and improved the survival rate to 30% of the mice infected with a lethal dose of H1N1.The results of time-of-drug addition experiment and neuraminidase (NA) inhibition assay showed that honeysuckle extracts had a broad-spectrum inhibitory effect against influenza virus NAs.The flavonoid extract showed the strongest inhibitory effect on the NA of influenza virus H7N9 with an IC_(50) of 24.7 lg/m L.These results suggested that these extracts might exert their antiviral activity by suppressing the release of influenza viruses.Briefly,our findings demonstrate that acids and flavonoids extracts of honeysuckle are the major antiviral active components,and the acids extract has the potential to be developed into an antiviral agent against influenza virus,especially for oseltamivirresistant viruses. | Mengwei Li Yuxu Wang Jing Jin Jie Dou Qinglong Guo Xue Ke Changlin Zhou Min Guo | 2021 | Virologica Sinica2021，36，3： | 11 |
| 3 | Induction of fibroblasts to neurons through adenoviral gene delivery显示文摘 | Fengxi Meng Siye Chen Qinglong Miao Kechun Zhou Qicheng Lao Xiaohui Zhang Wenyi Guo Jianwei Jiao | 2012 | Cell Research2012，22，2： | 4 |
| 4 | Network Virtualization Based Seamless Networking Scheme for Fiber-Wireless (FiWi) Networks显示文摘In order to reduce cost and complexity,fiber-wireless(FiWi) networks emerge,combining the huge amount of available bandwidth of fiber networks and the flexibility,mobility of wireless networks.However,there is still a long way to go before taking fiber and wireless systems as fully integrated networks.In this paper,we propose a network visualization based seamless networking scheme for FiWi networks,including hierarchical model,service model,service implementation and dynamic bandwidth assignment(DBA).Then,we evaluate the performance changes after network virtualization is introduced.Throughput for nodes,bandwidth for links and overheads leaded by network virtualization are analyzed.The performance of our proposed networking scheme is evaluated by simulation and real implementations,respectively.The results show that,compared to traditional networking scheme,our scheme has a better performance. | DAI Qinglong ZOU Jianfeng SHOU Guochu HU Yihong GUO Zhigang | 2014 | China Communications2014，11，5： | 3 |
| 5 | Preparation of Mg,N-co-doped lignin adsorbents for enhanced selectivity and high adsorption capacity of As(Ⅴ) from wastewater显示文摘Among various environmental problems,water pollution has drawn more and more attention.To develop an adsorbent with enhanced selectivity and high capacity for As(V)oxyanion,a novel lignin-based adsorbent was prepared by doping with N and modifying with Mg^(2+),using thiethylenetetramine(TETA)and MgCl_(2) as the source of N and Mg^(2+),respectively.N-doped lignin(NL)shows a high selectivity for As(Ⅴ),which is further enhanced by modifying with Mg^(2+)(MNL).MNL shows an excellent reusability.The adsorption isotherms and kinetics of MNL for As(Ⅴ)follow Langmuir isotherms model and pseudo-second-order kinetics model,respectively.The adsorption of MNL for As(Ⅴ)achieved a maximum adsorption capacity of 687.46 mg g^(−1) and the equilibrium was established within 30 min.This study offers a novel idea on the recycle of the waste of paper industry and provides a new technology for As(Ⅴ)adsorption from wastewater. | Xiaofeng Shi Junmao Hong Chao Wang Sifang Kong Junhua Li Duo Pan Jing Lin Qinglong Jiang Zhanhu Guo | 2021 | Particuology2021，19，5： | 2 |
| 6 | Natural products against hematological malignancies and identification of their targets显示文摘Naturally occurring molecules derived from higher plants, animals, microorganisms and minerals play an important role in the discovery and development of novel therapeutic agents. The identification of molecular targets is of interest to elucidate the mode of action of these compounds, and it may be employed to set up target-based assays and allow structure-activity relationship studies to guide medicinal chemistry efforts toward lead optimization. In recent years, plant-derived natural compounds possessing potential anti-tumor activities have been garnering much interest and efforts are underway to identify their molecular targets. Here, we attempt to summarize the discoveries of several natural compounds with activities against hematological malignancies, such as adenanthin, oridonin, gambogic acid and wogonoside, the identification of their targets, and their modes of actions. | XU Ying LIU JinBao WU YingLi GUO QingLong SUN HanDong CHEN GuoQiang | 2015 | Science China(Life Sciences)2015，58，12： | 2 |
| 7 | Oroxylin A inhibits matrix metalloproteinase-2/9 expression and activation by up-regulating tissue inhibitor of metalloproteinase-2 and suppressing the ERK1/2 signaling pathway显示文摘 | Zhijian Lu Na Lu Chenglin Li Fanni Li Kai Zhao Biqi Lin Qinglong Guo | 2012 | Toxicology Letters2012，，3： | 2 |
| 8 | Tumor inhibitory effect of YCP (a marine fugal polysaccharide) (I)显示文摘 | Chen Zhen Guo Qinglong Gao Xiangdong | 2005 | Chin J Nat Med2005，3，6： | 1 |
| 9 | Tumor inhibitory effect of YCP (a marine fugal polysaccharide)(I)显示文摘 | Chen Zhen Guo Qinglong Gao Xiangdong | 2005 | Chin J Nat Med2005，3，6： | 1 |
| 10 | Growth Inhibitory Effect of GGAsOn Experimental Tumor in Mice and Human Tumor Cell Cultured in vitro显示文摘 | WU Zhaoqiu GUO Qinglong YOU Qidong | 2003 | Chin J NatMed2003，1，2： | 1 |
| 11 | Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy:Dynamic analysis on cytotoxic effects of LW-218显示文摘The integrity of lysosomes is of vital importance to survival of tumor cells.We demonstrated that LW-218,a synthetic flavonoid,induced rapid lysosomal enlargement accompanied with lysosomal membrane permeabilization in hematological malignancy.LW-218-induced lysosomal damage and lysosome-dependent cell death were mediated by cathepsin D,as the lysosomal damage and cell apoptosis could be suppressed by depletion of cathepsin D or lysosome alkalization agents,which can alter the activity of cathepsins.Lysophagy,was initiated for cell self-rescue after LW-218 treatment and correlated with calcium release and nuclei translocation of transcription factor EB.LW-218 treatment enhanced the expression of autophagy-related genes which could be inhibited by intracellular calcium chelator.Sustained exposure to LW-218 exhausted the lysosomal capacity so as to repress the normal autophagy.LW-218-induced enlargement and damage of lysosomes were triggered by abnormal cholesterol deposition on lysosome membrane which caused by interaction between LW-218 and NPC intracellular cholesterol transporter 1.Moreover,LW-218 inhibited the leukemia cell growth in vivo.Thus,the necessary impact of integral lysosomal function in cell rescue and death were illustrated. | Po Hu Hui Li Wenzhuo Sun Hongzheng Wang Xiaoxuan Yu Yingjie Qing Zhanyu Wang Mengyuan Zhu Jingyan Xu Qinglong Guo Hui Hui | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 1 |
| 12 | VI-14, a novel flavonoid derivative, inhibits migration and invasion of human breast cancer cells显示文摘 | Fanni Li Chenglin Li Haiwei Zhang Zhijian Lu Zhiyu Li Qidong You Na Lu Qinglong Guo | 2012 | Toxicology and Applied Pharmacology2012，，： | 1 |
| 13 | Resistance of Aphis gossypii ( Homoptera: Aphididae) to selected insecticides on cotton from five cotton production regions in Shandong, China显示文摘 | WANG Kaiyun GUO Qinglong XIA Xiaoming | 2007 | Pestic Sci2007，32，4： | 1 |
| 14 | Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression显示文摘 | Zhang Kun Guo Qinglong You Qidong | | 0，，04： | 1 |
| 15 | Tumor inhibitory effect of YCP(a marine fugal polysaccharide) (I)显示文摘 | Chen Zhen Guo Qinglong Gao Xiangdong | 2005 | Chin J Nat Med2005，3，6： | 1 |
| 16 | A quick-and-novel method in evaluating the producing performance of single-layer in the multi- layered sandstone oilfield显示文摘 | Du Qinglong Zhu Lihong Guo Junhui | 2010 | SPE1314822010，，： | 1 |
| 17 | Resistance of Aphis gossypii ( Homoptera : Aphididae ) to selected insecticides on cotton from five cotton production regions in Shandong, China 显示文摘 | Wang Kaiyun Guo Qinglong Xia Xiaoming | 2007 | J Pestic Sci2007，32，： | 1 |
| 18 | Growth Inhibitory Effect of GGAs on Experimental Tumor in Mice and Human Tumor Cell Cultured in vitro显示文摘 | WU ZhaoQiu GUO QingLong YOU QiDon | 2003 | Chin J Nat Med2003，1，2： | 1 |
| 19 | Resistance ofAphis gossypii(Homoptera:Aphididae)to selected insecticides oncotton from five cotton production regions in Shandong,China显示文摘 | Wang Kaiyun Guo Qinglong Xia Xiaoming | 2007 | Journal of Pesticide Science2007，32，4： | 1 |
| 20 | Ambient Temperature and Years of Life Lost:A National Study in China显示文摘Although numerous studies have investigated premature deaths attributable to temperature,effects of temperature on years of life lost(YLL)remain unclear.We estimated the relationship between temperatures and YLL,and quantified the YLL per death caused by temperature in China.We collected daily meteorological and mortality data,and calculated the daily YLL values for 364 locations(2013–2017 in Yunnan,Guangdong,Hunan,Zhejiang,and Jilin provinces,and 2006–2011 in other locations)in China.A time-series design with a distributed lag nonlinear model was first employed to estimate the location-specific associations between temperature and YLL rates(YLL/100,000 population),and a multivariate meta-analysis model was used to pool location-specific associations.Then,YLL per death caused by temperatures was calculated.The temperature and YLL rates consistently showed U-shaped associations.A mean of 1.02(95%confidence interval:0.67,1.37)YLL per death was attributable to temperature.Cold temperature caused 0.98 YLL per death with most from moderate cold(0.84).The mean YLL per death was higher in those with cardiovascular diseases(1.14),males(1.15),younger age categories(1.31 in people aged 65–74 years),and in central China(1.34)than in those with respiratory diseases(0.47),females(0.87),older people(0.85 in people R75 years old),and northern China(0.64)or southern China(1.19).The mortality burden was modified by annual temperature and temperature variability,relative humidity,latitude,longitude,altitude,education attainment,and central heating use.Temperatures caused substantial YLL per death in China,which was modified by demographic and regional characteristics. | Tao Liu Chunliang Zhou Haoming Zhang Biao Huang Yanjun Xu Lifeng Lin Lijun Wang Ruying Hu Zhulin Hou Yize Xiao Junhua Li Xiaojun Xu Donghui Jin Mingfang Qin Qinglong Zhao Weiwei Gong Peng Yin Yiqing Xu Jianxiong Hu Jianpeng Xiao Weilin Zeng Xing Li Siqi Chen Lingchuan Guo Zuhua Rong Yonghui Zhang Cunrui Huang Yaodong Du Yuming Guo Shannon Rutherford Min Yu Maigeng Zhou Wenjun Ma | 2021 | The Innovation2021，2，1： | 1 |
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