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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | Application of latent heat thermal energy storage inbuildings : State -of-the -art and outlook 显示文摘 | Zhang Yinping Zhou Guobing Lin Kunping | 2007 | Buildingand Environment2007，42，6： | 1 |
| 3 | Application of latent heat thermal energy storage in buildings: State-of-the-art and outlook显示文摘 | Zhang Yinping Zhou Guobing Lin Kunping | 2007 | Building and Environment2007，42，： | 1 |
| 4 | Thermal analysis of a direct-gain room with shape-stabilized PCM plates显示文摘 | ZHOU Guobing ZHANG Yinping LIN Kunping | 2008 | Renewable Energy2008，6，33： | 1 |
| 5 | Application of latent heat thermal energy storage in buildings: State-of-the-art and outlook显示文摘 | Zhang Yinping Zhou Guobing Lin Kunping | 2007 | Building and Environment2007，42，： | 1 |
| 6 | Application of latent heat thermal energy storage in buildings: State-of-the-art and outlook显示文摘 | Zhang Yinping Zhou Guobing Lin Kunping | 2007 | Building and Environment2007，42，6： | 1 |
| 7 | Application of latent heat thermal energy storage in buildings : State-of-the-art and outlook 显示文摘 | Zhang Yinping Zhou Guobing Lin Kunping | 2007 | Building and Environment2007，42，6： | 1 |
| 8 | Appli- cation of latent heat thermal energy 5storage in buildings: State-of-the-art and outlook显示文摘 | Zhang Yinping Zhou Guobing Lin Kunping | 2007 | Building Environ2007，42，： | 1 |
| 9 | Application of latent heat thermal energy storage in buildings:state-of-the-art and outlook显示文摘 | Zhang Yinping Zhou Guobing Lin Kunping | 2007 | Buildings and Environment2007，42，6： | 1 |
| 10 | Construction of algal-bacterial consortia using green microalgae Chlorella vulgaris and As(Ⅲ)-oxidizing bacteria:As tolerance and metabolomic profiling显示文摘Bioremediation became a promising technology to resolve arsenic(As)contamination in aquatic environment.Since monoculture such as microalgae or bacteria was sensitive to environmental disturbance and vulnerable to contamination,green microalgae Chlorella vulgaris and arsenite(As(Ⅲ))-oxidizing bacteria Pseudomonas sp.SMS11 were co-cultured to construct algal-bacterial consortia in the current study.The effects of algae-bacteria(A:B)ratio and exposure As(Ⅲ)concentration on algal growth,As speciation and metabolomic profile were investigated.Algal growth arrested when treated with 100 mg/L As(Ⅲ)without the co-cultured bacteria.By contrast,co-cultured with strain SMS11 significantly enhanced As tolerance in C.vulgaris especially with A:B ratio of 1:10.All the As(Ⅲ)in culture media of the consortia were oxidized into As(Ⅴ)on day 7.Methylation of As was observed on day 14.Over 1% and 0.5% of total As were converted into dimethylarsinic acid(DMA)after 21days cultivation when the initial concentrations of As(Ⅲ)were 1 and 10 mg/L,respectively.Metabolomic analysis was further performed to reveal the response of consortia metabolites to external As(Ⅲ).The enriched metabolomic pathways were associated with carbohydrate,amino acid and energy metabolisms.Tricarboxylic acid cycle and glyoxylate and dicarboxylate metabolism were upregulated under As stress due to their biological functions on alleviating oxidative stress and protecting cells.Both carbohydrate and amino acid metabolisms provided precursors and potential substrates for energy production and cell protection under abiotic stress.Alterations of the pathways relevant to carbohydrate or amino acid metabolism were triggered by energy requirement. | Xiaoman He Guobing Lin Jiayuan Zeng Zhaoguang Yang Lin Wang | 2024 | Journal of Environmental Sciences2024，，5： | 0 |
| 11 | THE GROWTH OF MONOCRYSTALLINE SILICON THIN FILM ON INSULATOR (SOI) BY SCANNING ELECTRON BEAM显示文摘An experiment for preparation of SOI films by using the scanning electron beam to modify the polycrystalline silicon on SiO2 is presented. This method takes on the epitaxial lateral growth of liquid phase with the crystallon to form monocrystalline silicon films. The effects of the beam power density, scanning velocity, temperature of the substrates and the construction of samples on the quality of the monocrystalline silicon films were discussed. A good experimental result has been obtained, the monocrystalline silicon zone is nearly 200×25μm2. | Lin Shichang Zhang Yansheng(institute of E/ectronics, Academia Sinica, Beijing 100080) Zhang Guobing Wang Yangyuan(Peking University, Beijing 100871) | 1996 | Journal of Electronics(China)1996，13，2： | 0 |
| 12 | Weakened humoral immune responses of inactivated SARS-CoV-2 vaccines in patients with solid tumors显示文摘Dear Editor Coronavirus disease 19(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),remains a pandemic.Cancer patients have a higher risk of poor outcomes for SARS-CoV-2 infection than the general population[1].Vaccines were shown to effectively prevent SARS-CoV-2 infection,severe disease progression,and mortality.Inactivated SARS-CoV-2 vaccines(BBIBPCorV and CoronaVac)have been approved and widely used in China,with the former shown to be more effective than the latter[2].Hence,there is an urgent need to investigate the safety and humoral immune responses of inactivated vaccines in cancer patients. | Zhiwei Chen Peng Zhu Zuojin Liu Bin Zhu Guobing Yin Jia Ming Rui Song Qingbo Pan Tong Li Xingwei Jiang Bing Wang Shuaibin Liu Hongxing Cai Jingjie Wang Yuling Han Zijing Lin Yang Hong Min Chen Mingli Peng Lina Hu Dachuan Cai Hong Ren | 2023 | Cancer Communications2023，43，2： | 0 |
| 13 | Ionome profiling and arsenic speciation provide evidence of arsenite detoxification in rice by phosphate and arsenite-oxidizing bacteria显示文摘Arsenite(As(III))as the most toxic and mobile form is the dominant arsenic(As)species in flooded paddy fields,resulting in higher accumulation of As in paddy rice than other terrestrial crops.Mitigation of As toxicity to rice plant is an important way to safeguard food production and safety.In the current study,As(III)-oxidizing bacteria Pseudomonas sp.strain SMS11 was inoculated with rice plants to accelerate conversion of As(III)into lower toxic arsenate(As(V)).Meanwhile,additional phosphate was supplemented to restrict As(V)uptake by the rice plants.Growth of rice plant was significantly inhibited under As(III)stress.The inhibition was alleviated by the introduction of additional P and SMS11.Arsenic speciation showed that additional P restricted As accumulation in the rice roots via competing common uptake pathways,while inoculation with SMS11 limited As translocation from root to shoot.Ionomic profiling revealed specific characteristics of the rice tissue samples from different treatment groups.Compared to the roots,ionomes of the rice shoots were more sensitive to environmental perturbations.Both extraneous P and As(III)-oxidizing bacteria SMS11 could alleviate As(III)stress to the rice plants through promoting growth and regulating ionome homeostasis. | Guobing Lin Xiaoman He Jiayuan Zeng Zhaoguang Yang Lin Wang | 2023 | Journal of Environmental Sciences2023，，6： | 0 |
| 14 | Interfacial potassium induced enhanced Raman spectroscopy for single-crystal TiO2 nanowhisker显示文摘Structural control and element doping are two popular strategies to produce semiconductors with surface enhanced Raman spectroscopy(SERS)properties.For TiO2 based SERS substrates,maintaining a good crystallinity is critical to achieve excellent Raman scattering.At elevated temperatures(N600°C),the phase transition from anatase to rutile TiO2 could result in a poor SERS performance.In this work,we report the successful synthesis of TiO2 nanowhiskers with excellent SERS properties.The enhancement factor,an index of SERS performance,is 4.96×106 for methylene blue molecule detecting,with a detection sensitivity around 10-7 mol·L-1.Characterizations,such as XRD,Raman,TEM,UV–vis and Zeta potential measurement,have been performed to decrypt structural and chemical characteristics of the newly synthesized TiO2 nanowhiskers.The photo absorption onset of MB adsorbed TiO2 nanowhiskers was similar to that of bare TiO2 nanowhiskers.In addition,no new band was observed from the UV–vis of MB modified TiO2 nanowhiskers.Both results suggest that the high enhancement factor cannot be explained by the charge-transfer mechanism.With the support of ab initio density functional theory calculations,we reveal that interfacial potassium is critical to maintain thermal stability of the anatase phase up to 900°C.In addition,the deposition of potassium results in a negatively charged TiO2 nanowhisker surface,which favors specific adsorption of methylene blue molecules and significantly improves SERS performance via the electrostatic adsorption effect. | Fan Pan Guobing Zhou Liangliang Huang Wei Li Mingshen Lin Chang Liu | 2020 | Chinese Journal of Chemical Engineering2020，28，3： | 0 |
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