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| 1 | Standard pancreatoduodenectomy versus extended pancreatoduodenectomy with modified retroperitoneal nerve resection in patients with pancreatic head cancer:a multicenter randomized controlled trial显示文摘Background:The extent of pancreatoduodenectomy for pancreatic head cancer remains controversial,and more high-level clinical evidence is needed.This study aimed to evaluate the outcome of extended pancreatoduodenectomy(EPD)with retroperitoneal nerve resection in pancreatic head cancer.Methods:This multicenter randomized trial was performed at 6 Chinese highvolume hospitals that enrolled patients between October 3,2012,and September 21,2017.Four hundred patients with stage I or II pancreatic head cancer and without specific pancreatic cancer treatments(preoperative chemotherapy or chemoradiation)within three months were randomly assigned to undergo standard pancreatoduodenectomy(SPD)or EPD,with the latter followed by dissection of additional lymph nodes(LNs),nerves and soft tissues 270◦on the right side surrounding the superior mesenteric artery and celiac axis.The primary endpoint was overall survival(OS)by intention-to-treat(ITT).The secondary endpoints were disease-free survival(DFS),mortality,morbidity,and postoperative pain intensity.Results:TheR1 ratewas slightly lower with EPD(8.46%)thanwith SPD(12.56%).The morbidity and mortality rates were similar between the two groups.The median OS was similar in the EPD and SPD groups by ITT in the whole study cohort(23.0 vs.20.2 months,P=0.100),while the median DFS was superior in the EPD group(16.1 vs.13.2 months,P=0.031).Patients with preoperative CA19–9<200.0 U/mL had significantly improved OS and DFS with EPD(EPD vs.SPD,30.8 vs.20.9 months,P=0.009;23.4 vs.13.5 months,P<0.001).The EPD group exhibited significantly lower locoregional(16.48%vs.35.20%,P<0.001)andmesenteric LNrecurrence rates(3.98%vs.10.06%,P=0.022).The EPD group exhibited less back pain 6 months postoperation than the SPD group.Conclusions:EPD for pancreatic head cancer did not significantly improve OS,but patients with EPD treatment had significantly improved DFS.In the subgroup analysis,improvements in bothOS and DFS in the EPD armwere observed in patients with preoperative CA19–9<200.0 U/mL.EPD could be used as an effective surgical procedure for patients with pancreatic head cancer,especially those with preoperative CA19–9<200.0 U/mL. | Qing Lin Shangyou Zheng Xianjun Yu Meifu Chen Yu Zhou Quanbo Zhou Chonghui Hu Jing Gu Zhongdong Xu LinWang Yimin Liu Qingyu Liu MinWang Guolin Li He Cheng Dongkai Zhou Guodong Liu Zhiqiang Fu Yu Long Yixiong Li Weilin Wang Renyi Qin Zhihua Li Rufu Chen | 2023 | Cancer Communications2023，43，2： | 3 |
| 2 | A cubic triboelectric generator as a self-powered orientation sensor显示文摘Recently, triboelectric generator(TEG) has attracted a lot of attention due to its high output voltage and low-cost fabrication process. Here, a novel cubic TEG box is designed, which has separated electrodes on different surfaces. Thanks to the specially designed structure, it can scavenge vibration energy from all directions. Firstly the device is investigated through finite element method(FEM) simulation. Then the device is evaluated by experiments. The measuremental results show that this device can generate an amount of 25 n C charge during once shake by charging a 10 n F capacitor. Besides, an output voltage about 100 V is obtained, which is able to directly light up several light-emitting diodes(LEDs) simultaneously. At last, the device is utilized as a self-powered orientation sensor, which shows explicit directivity. This work extends the applications of TEG for ambient vibration energy harvesting techniques and the self-powered orientation sensor. | QIU GuoLin LIU Wen HAN MengDi CHENG XiaoLiang MENG Bo SMITHA Ankanahalli Shankaregowda ZHAO JiangMing ZHANG HaiXia | 2015 | Science China(Technological Sciences)2015，58，5： | 2 |
| 3 | A Novel Rhodobacter sphaeroides Expression System for Real-Time Evaluation of Heterologous Protein Expression Levels显示文摘 | Zhiping Zhao Zongli Hu Xin Nie Lijing Cheng Guolin Ding Min Luo Yu Pan Yan Liang Guoping Chen | 2011 | Protein and Peptide Letters2011，，6： | 1 |
| 4 | Base-Promoted Synthesis of 3-Alkenyl-2-pyridones from N-Propargyl-β-enaminones and Aryl Aldehydes显示文摘Main observation and conclusion In this article,we report a base-promoted sequential cyclization/aldol-type condensation/isomerization cascade reaction of N-propargyl-β-enaminones with aryl aldehydes.The key step in this protocol is the generation of 1,4-oxazepine anions from N-propargyl-β-enaminones under basic conditions,which are captured by aryl aldehydes.The method allows the formation of one pyridone core and one C—C double bond in“one pot”,and the preparation of a variety of densely decorated pyridone derivatives in moderate to good yields with broad functional group tolerance. | Qingyu Tian Shangyun Xiao Guolin Cheng | 2021 | Chinese Journal of Chemistry2021，39，10： | 0 |
| 5 | Joint Effect of East Asia-Pacific and Eurasian Teleconnections on the Summer Precipitation in North Asia显示文摘The East Asia-Pacific(EAP)and Eurasian(EU)teleconnections are independent of each other on the seasonal timescale(with a correlation coefficient of only 0.03).But they may occur concurrently with consistent or opposite phases.This paper investigates their synergistic effect on the summer precipitation in North Asia.Based on the signs/phases of EAP and EU indices,the EAP and EU teleconnection anomalies occur in four cases:(Ⅰ)positive EAP+positive EU,(Ⅱ)negative EAP+negative EU,(Ⅲ)positive EAP+negative EU,and(Ⅳ)negative EAP+positive EU.Further analyses show that these four configurations of EAP and EU anomalies are coherently related to different atmospheric circulations over the midlatitude Eurasian continent,leading to different summer precipitation modes in North Asia.CategoryⅠ(Ⅱ)corresponds to a zonal tripole structure of the geopotential height at 500 hPa over eastern Europe and the Sea of Japan,leading to less(more)than normal precipitation in eastern Europe,Japan,and the surrounding areas,and more(less)precipitation from central China to Lake Baikal and eastern Russia.CategoryⅢ(Ⅳ)corresponds to a meridional dipole structure of the geopotential height at 500 hPa over North Asia,leading to more(less)precipitation in the northern North Asia and less(more)precipitation in most of the southern North Asia.Independent analysis reveals that the EAP teleconnection itself is positively correlated with the precipitation in the region between the eastern part of Lake Baikal and Okhotsk Sea,and negatively correlated with the precipitation in the region between Northeast China and Japan.Coincidently,the EU pattern and precipitation have negative correlations in Ural Mountain and Okhotsk Sea areas and positive correlations in the Lake Baikal area.The respective relations of EAP and EU with the summer precipitation in North Asia suggest that the EAP northern lobe overlapped with the EU central and eastern lobes could extend the geopotential anomalies over Lake Baikal to Russian Far East,creating an EAP-EU synergistic effect on the summer precipitation in North Asia. | Po HU Guolin FENG Muhammad Mubashar DOGAR Jianbo CHENG Zhiqiang GONG | 2020 | Journal of Meteorological Research2020，34，3： | 0 |
| 6 | Carbon-based supports for the electrocatalysis under industrially relevant conditions显示文摘1 Introduction.Carbon materials are ideal catalyst supports for functional metal components due to their appropriate physicochemical characteristics,such as high surface areas,tunable pore structures,variable morphologies and versatile surface properties based on chemical modifications,low cost and facile preparations from diverse precursors[1,2]. | Xue Yang Xianrui Gu Yang Song Guolin Hou Cheng Wang Lichen Liu Wei Lin | 2024 | Science China Chemistry2024，67，4： | 0 |
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