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| 1 | Focal depth research of earthquakes in China's Mainland: Implication for tectonics显示文摘Focal depth data of earthquakes in China's Mainland are processed and analyzed in this paper, as well as the relationship between the focal depths and large-scale tectonic structures. As a basic parameter for earthquakes, focal depth is used to investigate deep environment of seis-mogenic regions, tectonic backgrounds for concentration and release of seismic energy, the inner crustal deformation and its mechanic features. Depth data of 31282 ML≥2.0 events with 1st class and 2nd class precision in China's Mainland from Jan. 1, 1970 to May 31, 2000 are used to get spatial features of earthquakes distributed with depth and to provide average depth for each grid area throughout China. Researches show that the average depth (D) for all the earthquakes used in this paper is (16±7) km, and (13±6) km and (18±8) km for the events in eastern China and western China, respectively. The area with the deepest focal depth is located in southwest Xinjiang region, near the western and southwestern ends of the Tarim | ZHANG Guomin WANG Suyun LI Li ZHANG Xiaodong MA Hongsheng | 2002 | Chinese Science Bulletin2002，47，12： | 38 |
| 2 | Quercetin induces apoptosis by activating caspase-3 and regulating Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells显示文摘橡黄素是自然地发生之一饮食的黄酮醇混合物。它在植物富有地是在场的并且有 chemopreventive 和 anticancer 效果。调查它的 anticancer 机制,我们对尖锐白血病房间线检验了橡黄素的活动, HL-60。我们的结果证明橡黄素禁止了房间增长并且在一个时间依赖者和剂量依赖者举止导致了 apoptosis。而且,橡黄素下面调整 anti-apoptosis 蛋白质 Bcl-2 的表示并且起来调整 pro-apoptosis 蛋白质 Bax 的表示。Caspase-3 被橡黄素也激活,它开始了一条 caspase-3-depended mitochodrial 小径导致 apoptosis。橡黄素禁止了 cycloocygenase-2 (Cox-2 ) 的表示,这也被发现 mRNA 和 Cox-2 蛋白质。一起拿,这些调查结果建议橡黄素由禁止 Cox-2 表示在一条 caspase-3-dependent 小径导致 apoptosis 并且调整下游的 apoptotic 部件的表示,包括 Bcl-2 和 Bax。橡黄素能是可能安全地在白血病治疗被使用的一个有势力和有希望的药。 | Guomin Niu Songmei Yin Shuangfeng Xie Yiqing Li Danian Nie Liping Ma Xiuju Wang Yudan Wu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，1： | 28 |
| 3 | Hypoxia-regulated microRNAs in human cancer显示文摘 | Guomin SHEN Xiaobo LI Yong-feng JIA Gary A PIAZZA Yaguang XI | 2013 | Acta Pharmacologica Sinica2013，34，3： | 18 |
| 4 | Additive manufacturing of high-strength CrMnFeCoNi high-entropy alloys-based composites with WC addition显示文摘Laser melting deposition with WC addition has been developed to fabricate high-strength CrMnFeCoNibased high-entropy alloys-based composites.By this technique,a microstructure of compact refined equiaxed grains can be achieved,and the tensile strength can be remarkably improved.The sample with 5 wt%WC addition shows a promising mechanical performance with a tensile strength of 800 MPa and an elongation of 37%.The improvement in mechanical property may be attributed to the formation of Cr(23)C6 reinforcement precipitates,which could promote the heterogeneous nucleation of grains and hinder the propagation of slip bands. | Jinfeng Li Shuo Xiang Hengwei Luan Abdukadir Amar Xue Liu Siyuan Lu Yangyang Zeng Guomin Le Xiaoying Wang Fengsheng Qu Chunli Jiang Guannan Yang | 2019 | Journal of Materials Science & Technology2019，35，11： | 13 |
| 5 | Resistance reduction by bionic coupling of the earthworm lubrication function显示文摘Based on the biological coupling theory, the resistance reduction characteristic of the surface morphology and surface wettability of the earthworm were studied in this paper. The parameters of surface dorsal pore and corrugation were extracted. According to these parameters, the lubrication mechanism of the earthworm surface was analyzed. The distribution of the pores and surface morphology were designed and the bionic coupling samples were prepared. The positive pressure, lubricant flow rate and advancing velocity were selected as the experiment factors while the soil friction resistance as observed object. According to the obtained data of bionic coupling samples from the testing system of biologic signal for tiny soil adhesion test, the optimal samples from the bionic coupling resistance reduction tests were selected through the range analysis. Compared to the normal ones, the soil resistance of bionic coupling samples was reduced by 76.8%. This is of great significance and offers bright prospects for reducing energy loss in terrain mechanics. | LI JianQiao*, KOU BingXue, LIU GuoMin, FAN WenFeng & LIU LinLin Key Laboratory of Bionic Engineering (Jilin University), Ministry of Education of China, Changchun 130022, China | 2010 | Science China(Technological Sciences)2010，53，11： | 10 |
| 6 | Analysis of genetic architecture and favorable allele usage of agronomic traits in a large collection of Chinese rice accessions显示文摘Genotyping and phenotyping large natural populations provide opportunities for population genomic analysis and genome-wide association studies(GWAS). Several rice populations have been re-sequenced in the past decade;however, many major Chinese rice cultivars were not included in these studies. Here, we report large-scale genomic and phenotypic datasets for a collection mainly comprised of 1,275 rice accessions of widely planted cultivars and parental hybrid rice lines from China. The population was divided into three indica/Xian and three japonica/Geng phylogenetic subgroups that correlate strongly with their geographic or breeding origins. We acquired a total of 146 phenotypic datasets for 29 agronomic traits under multi-environments for different subpopulations. With GWAS, we identified a total of 143 significant association loci, including three newly identified candidate genes or alleles that control heading date or amylose content. Our genotypic analysis of agronomically important genes in the population revealed that many favorable alleles are underused in elite accessions, suggesting they may be used to provide improvements in future breeding efforts. Our study provides useful resources for rice genetics research and breeding. | Xiuxiu Li Zhuo Chen Guomin Zhang Hongwei Lu Peng Qin Ming Qi Ying Yu Bingke Jiao Xianfeng Zhao Qiang Gao Hao Wang Yunyu Wu Juntao Ma Liyan Zhang Yongli Wang Lingwei Deng Shanguo Yao Zhukuang Cheng Diqiu Yu Lihuang Zhu Yongbiao Xue Chengcai Chu Aihong Li Shigui Li Chengzhi Liang | 2020 | Science China(Life Sciences)2020，63，11： | 8 |
| 7 | Evaluation of groundwater quality in the Xinjiang Plain Area显示文摘Groundwater is the main source of drinking water for the urban and rural residents in the plain area of the Xinjiang Uygur Autonomous Region,China.The quality of groundwater has a direct relationship with human health.Thus,386 groundwater samples collected from April to August in 2003 were analyzed.The samples were collected in basic evaluation units which are determined on the basis of watersheds.Total dissolved solids,total hardness,pH value,NH3–N,C6H5OH,Chemiluminescence detection of permanganate index(CODMn)and intestinal germ group were evaluated according to the guidelines of Groundwater Quality Standard(GB/T14848-93).The quality of the groundwater in each evaluation unit was classified by using the One Veto Method(a unified approach stipulated by the Ministry of Water Resources).The results indicate that the groundwater in the mainstream area of the Tarim Basin and the Yerqiang River Sub-basin belongs to Category V;the groundwater in the Wulungu River Sub-basin,the KaiduKongque River Sub-basin,the Kashgar River Sub-basin,the Cherchen River Sub-basin and the Hotan River Subbasin belongs to Category IV;the groundwater in the Aibi Lake System belongs to Category II,and the groundwater of other evaluation units belongs to Category III.The causes of water quality formation were concisely analyzed.The results can be useful for the evaluation and management of water resources in the Xinjiang Plain Area. | Jinlong ZHOU Xinguang DONG Guomin LI Yiping WANG Xiaojing GUO | 2010 | Frontiers of Environmental Science & Engineering2010，4，2： | 8 |
| 8 | Effectiveness of Catch-Up Vaccinations after COVID-19 Containment--China,2020显示文摘Introduction:In the early stages of the coronavirus disease 2019(COVID-19)epidemic in China,the highest level of public health emergency response(Level 1 Response)was launched in all province-level administrative divisions(PLADs)across the country.Provision of vaccination services was selectively suspended due to the physical distancing and gathering restrictions required of Level 1 Response.The purpose of this paper is to evaluate the impact of COVID-19 on vaccination services and the effectiveness of selective vaccination service suspension and catch-up vaccinations in China.Methods:Vaccine doses administered,routine vaccination coverage levels,catch-up vaccine doses administered,and coverage levels after the catch-up campaign were determined from individual vaccination records in sampled clinics,standard routine immunization administrative coverage reports,and catch-up vaccination activity reports submitted by PLADs between October 2019 and October 2020.Results:National Immunization Program(NIP)and non-NIP vaccine doses administered in sampled clinics decreased by 80% and 90%,respectively,compared with doses administered before the COVID-19 pandemic.Coverage with the birth dose of hepatitis B vaccine(HepB1)and the Bacillus Calmette-Guérin vaccine(BCG)—two vaccinations recommended to continue throughout the epidemic due to their timecritical nature—were maintained at over 85%,while coverage of other NIP vaccines decreased to below 60%by February 2020.Catch-up vaccination coverage of the 29 PLADs,excluding Xinjiang and Xizang(Tibet),began in April 2020 and exceeded 90%;Hubei catch-up coverage was 95% by October 2020.Conclusions and Implications for Public Health Practice:The COVID-19 pandemic had a great impact on China’s vaccination services.During the epidemic and time of local transmission of the coronavirus,HepB1,BCG,rabies vaccine for postexposure prophylaxis,and tetanus antitoxin(TAT)for wound prophylaxis were maintained at high levels.Of the 69 million vaccine doses postponed during the time of local transmission of the coronavirus,94% were administered in the catch-up campaign.China’s pandemic immunization practices may provide evidence for other countries’immunization programs. | Jing Wu Wenzhou Yu Lei Cao Lingsheng Cao Lance Rodewald Jiakai Ye Yifan Song Li Li Xiaoxue Liu Ning Wen Fuzhen Wang Lixin Hao Yixing Li Hui Zheng Keli Li Chao Ma Dan Wu Yanmin Liu Guomin Zhang Zhijie An Huaqing Wang Zundong Yin | 2020 | China CDC weekly2020，2，50： | 6 |
| 9 | Influence of fault geometry and fault interaction on strain partitioning within western Sichuan and its adjacent region显示文摘There are several major active fault zones in the western Sichuan and its vicinity. Slip rates and seismicity vary on different fault zones. For example, slip rates on the Xianshuihe fault zone are higher than 10 mm/a. Its seismicity is also intense. Slip rates on the Longmenshan fault zone are low. However, Wenchuan Ms8.0 earthquake occurred on this fault zone in 2008. Here we study the impact of fault geometry on strain partitioning in the western Sichuan region using a three-dimensional viscoe- lastoplastic model. We conclude that the slip partitioning on the Xianshuihe-Xiaojiang fault presents as segmented, and it is related to fault geometry and fault structure. Slip rate is high on fault segment with simple geometry and structure, and vice versa. Strain rate outside the fault is localized around the fault segment with complex geometry and fault structure. Strain partitioning on the central section of the Xianshuihe-Xiaojiang fault zone is influenced by the interaction between the Anninghe-Zemuhe fault and the Daliangshan fault zone. Striking of the Longmenshan fault zone is nearly orthogonal to the direction of eastward extrusion in the Tibetan Plateau. It leads to low slip rate on the fault zone. | WANG Hui LIU Jie SHEN XuHui LIU Mian LI QingSong SHI YaoLin ZHANG GuoMin | 2010 | Science China Earth Sciences2010，53，7： | 5 |
| 10 | Group Strong Earthquakes and Triggering by Tidal Stress显示文摘The results obtained using the group model of earthquakes generated in tectonic blocks are further used in this paper to analyze the relationship between the M S≥7.0 events in Chinese mainland and the modulation and triggering from the earth tides. The research shows that the M S 7.0 events in Chinese mainland have been significantly triggered by the tidal stress, especially within the active period with group strong earthquakes. In the quiescence period of strong earthquakes, no M S7.0 events were triggered, while within the active period, over 82.4% of strong earthquakes took place within a special moon phase, which is 36.4% higher than the average. Therefore, the modulation and triggering of tidal stress can be used to distinguish the active periods and to forecast the time of the strong earthquakes within the active period. The relationship between the tidal triggering and the tectonic dynamic condition is investigated and the mechanism of the modulation is simulated with the group model of earthquakes generated in tectonic blocks. | Zhang Guomin, Li Li, Li Kaiwu, and Ma HongshengCenter for Analysis and Prediction, China Seismological Bureau, Beijing 100036, China | 2001 | Earthquake Research in China2001，15，4： | 4 |
| 11 | Mining of a streptothricin gene cluster from Streptomyces sp.TP-A0356 genome via heterologous expression显示文摘Streptothricins (STs) are used commercially to treat bacterial and fungal diseases in agriculture. Mining of the sequenced microbial genomes uncovered two cryptic ST clusters from Streptomyces sp. C and Streptomyces sp. TP-A0356. The ST cluster from S. sp. TP-A0356 was verified by successful heterologous expression in Streptomyces coelicolor M145. Two new ST analogs were produced together with streptothricin F and streptothricin D in the heterologous host. The ST cluster was further confirmed by inactivation of gene stnO, which was proposed encoding an aminomutase supplying -lysines for the poly-β-Lys chain formation. A putative biosynthetic pathway for STs is proposed based on bioinformatics analyses of the ST genes and experimental evidence. | LI JinE GUO ZhengYan HUANG Wei MENG XiangXi AI GuoMin TANG GongLi CHEN YiHua | 2013 | Science China(Life Sciences)2013，56，7： | 3 |
| 12 | Effect of Draw Ratio on the Morphologies and Properties of BPDA/PMDA/ODA Polyimide Fibers显示文摘 | ZHANG Chunling ZHANG Qiong XUE Yanhu LI Guomin LIU Fangfang QIU Xuepeng JI Xiangling GAO Lianxun | 2014 | Chemical Research in Chinese Universities2014，30，1： | 3 |
| 13 | Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway显示文摘Cardiac fibroblast(CF)differentiation into myofibroblasts is a crucial cause of cardiac fibrosis,which increases in the extracellular matrix(ECM)stiffness.The increased stiffness further promotes CF differentiation and fibrosis.However,the molecular mechanism is still unclear.We used bioinformatics analysis to find new candidates that regulate the genes involved in stiffnessinduced CF differentiation,and found that there were binding sites for the POU-domain transcription factor,POU2F1(also known as Oct-1),in the promoters of 50 differentially expressed genes(DEGs)in CFs on the stiffer substrate.Immunofluorescent staining and Western blotting revealed that pathological stiffness upregulated POU2F1 expression and increased CF differentiation on polyacrylamide hydrogel substrates and in mouse myocardial infarction tissue.A chromatin immunoprecipitation assay showed that POU2F1 bound to the promoters of fibrosis repressors IL1R2,CD69,and TGIF2.The expression of these fibrosis repressors was inhibited on pathological substrate stiffness.Knockdown of POU2F1 upregulated these repressors and attenuated CF differentiation on pathological substrate stiffness(35 kPa).Whereas,overexpression of POU2F1 downregulated these repressors and enhanced CF differentiation.In conclusion,pathological stiffness upregulates the transcription factor POU2F1 to promote CF differentiation by inhibiting fibrosis repressors.Our work elucidated the crosstalk between CF differentiation and the ECM and provided a potential target for cardiac fibrosis treatment. | Mingzhe Li Jimin Wu Guomin Hu Yao Song Jing Shen Junzhou Xin Zijian Li Wei Liu Erdan Dong Ming Xu Youyi Zhang Han Xiao | 2021 | Science China(Life Sciences)2021，64，2： | 3 |
| 14 | Gedunin Degrades Aggregates of Mutant Huntingtin Protein and Intranuclear Inclusions via the Proteasomal Pathway in Neurons and Fibroblasts from Patients with Huntington’s Disease显示文摘Huntington's disease(HD) is a deadly neurodegenerative disease with abnormal expansion of CAG repeats in the huntingtin gene. Mutant Huntingtin protein(m HTT) forms abnormal aggregates and intranuclear inclusions in specific neurons, resulting in cell death. Here,we tested the ability of a natural heat-shock protein 90 inhibitor, Gedunin, to degrade transfected m HTT in Neuro-2 a cells and endogenous m HTT aggregates and intranuclear inclusions in both fibroblasts from HD patients and neurons derived from induced pluripotent stem cells from patients. Our data showed that Gedunin treatment degraded transfected m HTT in Neuro-2 a cells, endogenous m HTT aggregates and intranuclear inclusions in fibroblasts from HD patients, and in neurons derived from induced pluripotent stem cells from patients in a dose-and time-dependent manner, and its activity depended on the proteasomal pathway rather than the autophagy route. These findings also showed that although Gedunin degraded abnormal m HTT aggregates and intranuclear inclusions in cells from HD patient, it did not affect normal cells, thus providing a new perspective for using Gedunin to treat HD. | Weiqi Yang Jingmo Xie Qiang Qiang Li Li Xiang Lin Yiqing Ren Wenlei Ren Qiong Liu Guomin Zhou Wenshi Wei Hexige Saiyin Lixiang Ma | 2019 | Neuroscience Bulletin2019，35，6： | 2 |
| 15 | The role of AMP-activated protein kinase in quercetin-induced apoptosis of HL-60 cells显示文摘我们的以前的研究证明了橡黄素禁止 Cox-2 和 Bcl-2 表情,并且导致人的白血病 HL-60 cellapoptosis。以便在 HL-60cells 的导致橡黄素的 apoptosis 上调查激活安培的蛋白质 kinase (AMPK ) 的角色,我们使用了流动 cytometry 检测房间 apoptosis。LKB1, phosphorylated AMPK (p-AMPK ) ,和 Cox-2 proteinwere 的表情由西方的污点在 HL-60 房间和正常的外部血 mononuclear 房间(PBMC ) 检测了。LKB1, p-AMPK,和 Cox-2 的表情与橡黄素在文化以后在 HL-60 房间被检测。p-AMPK 的表情与 AMPK 禁止者混合物 C 在文化以后在 HL-60cells 被检测。然后, LKB1, p-AMPK,和 Cox-2 的表情与独自一个的橡黄素或橡黄素 + 混合物 C 在文化以后在 HL-60cells 被检测。在 PBMC 和 HL-60 之间没有重要 differencein LKB1,这被发现。在 PBMC 的 p-AMPK 在 HL-60 比那高,当 Cox-2 更低时。在 HL-60with 橡黄素的文化以后, p-AMPK 被增加, Cox-2 被减少,但是 LKB1 仍然保持未改变。在有 CompoundC 的 HL-60 的文化以后, p-AMPK 被减少。在 LKB1 在之间没有重要差别橡黄素独自一个并且橡黄素 + CompoundC 组。p-AMPK 更显著地减少了,当 Cox-2 在橡黄素 + 混合物 C groupsthan 更显著地增加了时那些在橡黄素独自一个的组。一起拿,这些调查结果建议橡黄素激活独立于 LKB1 激活的 AMPK expressionin HL-60 房间,由激活 AMPK 禁止 Cox-2 表示,并且进一步调整施加它的反白血病效果的 apoptosis 的 Bcl-2-dependentpathways。 | Jie Xiao Guomin Niu Songmei Yin Shuangfeng Xie Yiqing Li Danian Nie Liping Ma Xiuju Wang Yudan Wu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，5： | 2 |
| 16 | An areal recharge and discharge simulating method for MODFLOW 显示文摘 | Dong Yanhui Li Guomin Xu Haizhen | 2012 | Computers & Geosciences2012，42，： | 1 |
| 17 | Inhibition of CO2 corrosion of carbon steel by rosin amide 显示文摘 | Li Guomin | 2003 | Anti -Corrosion Methods and Materials2003，50，6： | 1 |
| 18 | Numerical modeling of the regional ground water flow in Beishan area, Gansu Province显示文摘The characterization of the regional ground water flow system is very important to high-level radioactive waste geological disposal. The Beishan area, located in northwestern Gansu Province, China, is selected as a potential site for disposal repository. The area includes about 100000 km2 and has complicated hydrogeological conditions, which greatly increase the computational effort of regional ground water flow models. In order to reduce computing time, parallel computing scheme was applied to regional ground water flow simulation. Models with over one million cells were used to simulate how the faults and different recharge conditions impact regional ground water flow, both in steady and transient state. The results of this study provide regional ground water flow information for site characterization of the potential high-level radioactive waste disposal. | DONG YanHui LI GuoMin LIMing | 2009 | Chinese Science Bulletin2009，54，17： | 1 |
| 19 | Inhibition of CO2 corrosion of carbon steel by rosin amide显示文摘 | Li Guomin | 2003 | AntiCorrosion Methods and Materials2003，50，6： | 1 |
| 20 | Inhibition of CO2 corrosion of carbon steel by rosin amide显示文摘 | Li Guomin | 2003 | Anti-Corrosion Methods and Materials2003，50，6： | 1 |
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