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| 1 | Evaluation of triage strategies for high-risk human papillomavirus-positive women in cervical cancer screening:A multicenter randomized controlled trial in different resource settings in China显示文摘Objective:We aimed to evaluate the effectiveness of different triage strategies for high-risk human papillomavirus(hrHPV)-positive women in primary healthcare settings in China.Methods:This study was undertaken in 11 rural and 9 urban sites.Women aged 35-64 years old were enrolled.HrHPV-positive women were randomly allocated to liquid-based cytology(LBC),visual inspection with acetic acid and Lugol’s iodine(VIA/VILI)(rural only)triage,or directly referred to colposcopy(direct COLP).At 24 months,hrHPV testing,LBC and VIA/VILI were conducted for combined screening.Results:In rural sites,1,949 hrHPV-positive women were analyzed.A total of 852,218 and 480 women were randomly assigned to direct COLP,LBC and VIA/VILI.At baseline,colposcopy referral rates of LBC or VIA/VILI triage could be reduced by 70%-80%.LBC(n=3 and n=7)or VIA/VILI(n=8 and n=26)could significantly decrease the number of colposcopies needed to detect one cervical intraepithelial neoplasia(CIN)2 or worse and CIN3+compared with direct COLP(n=14 and n=23).For the 24-month cumulative detection rate of CIN2+,VIA/VILI triage was 0.50-fold compared with LBC triage and 0.46-fold with the direct COLP.When stratified by age,baseline LBC triage+performed best(P<0.001),peaking among women aged 35-44 years(Ptrend=0.002).In urban sites,1,728 women were hrHPV genotyping test positive.A total of 408,571 and 568women were randomly assigned to direct COLP for HPV16/18+,direct COLP for other hrHPV subtypes+,and LBC triage for other hrHPV subtypes+.LBC(n=12 and n=31)significantly decreased the number of colposcopies needed to detect one CIN2+and CIN3+compared with direct COLP(n=14 and n=44).HPV16/18+increased the 24-month cumulative detection rate of CIN2+(17.89%,P<0.001).Conclusions:LBC triage for hrHPV-positive women in rural settings and direct COLP for HPV16/18+women and LBC triage for other hrHPV subtype+women in urban settings might be feasible strategies. | Le Dang Linghua Kong Yuqian Zhao Yi Dai Li Ma Lihui Wei Shulan Zhang Jihong Liu Mingrong Xi Long Chen Xianzhi Duan Qing Xiao Guzhalinuer Abulizi Guonan Zhang Ying Hong Qi Zhou Xing Xie Li Li Mayinuer Niyazi Zhifen Zhang Jiyu Tuo Yiling Ding Youlin Qiao Jinghe Lang | 2022 | Chinese Journal of Cancer Research2022，34，5： | 2 |
| 2 | Different role of second phase in the micro-galvanic corrosion of WE43 Mg alloy in NaCl and Na_(2)SO_(4) solution显示文摘Effect of the second phase in the micro-galvanic corrosion of a commercial Mg alloy containing rare earth elements, cast WE43 alloy,was investigated in 0.6 M NaCl solution and 0.6 M Na_(2)SO_(4)solution by scanning electron microscopy(SEM) observations, scanning Kelvin probe force microscopy(SKPFM) analysis, hydrogen evolution, weight loss measurement, and electrochemical techniques. It is confirmed that the second phase of cast WE43 alloy is more active than Mg matrix and exhibits an anodic role in the micro-galvanic corrosion with α-Mg matrix as cathode and dissolves preferentially in Na_(2)SO_(4)solution, in contrast to the situation in NaCl solution. The corrosion rate of cast WE43 alloy in Na_(2)SO_(4)solution is much higher than that in NaCl solution, which is different from the conventional wisdom and could be attributed to the different role of the second phase in the micro-galvanic corrosion in two solutions. | Baojing Feng Guonan Liu Peixu Yang Sensen Huang Dongqing Qi Peng Chen Chengduo Wang Jiang Du Shaojun Zhang Jinhui Liu | 2022 | Journal of Magnesium and Alloys2022，10，6： | 2 |
| 3 | Nanogold–polyaniline–nanogold microspheres-functionalized molecular tags for sensitive electrochemical immunoassay of thyroid-stimulating hormone显示文摘 | Yuling Cui Huafeng Chen Li Hou Bing Zhang Bingqian Liu Guonan Chen Dianping Tang | 2012 | Analytica Chimica Acta2012，，： | 1 |
| 4 | The elec- trogenerated chemiluminescent behavior of hemin and its catalytic activity for the electrogenerated chemilu- minescence of lucigenin 显示文摘 | Chen Guonan Zhang Lin Lin Ronger | 2000 | Talanta2000，50，6： | 1 |
| 5 | Determination of the hydrolysis rate constants and activation energy of aesculin with capillary electrophoresis end-column amperometric detection 显示文摘 | Lan Zhang Ping Tong Guonan Chen | 2005 | Journal of Chromatography A2005，1098，： | 1 |
| 6 | Simultaneous determination of allantoin, choline and 1 - arginine in Rhizoma Dioscoreae by capillary electrophoresis 显示文摘 | Lan Zhang Yuanhuan Liu Guonan Chen | 2004 | Journal of Chromatography A2004，1043，： | 1 |
| 7 | Ovarian metastasis in patient with endometrial carcinoma 显示文摘 | Zhou Fengzhi Chen Yinan Zhang Guonan | 2005 | Chinese Journal of Cancer Researeh2005，17，3： | 1 |
| 8 | Research and Development on an Embedded Digital Storage Oscillo-scope Based on PXA 270显示文摘This paper discusses the chief techniques and design principles of an embedded digital storage oscilloscope based on PXA 270, using FPGA as logic controller cell. The data acquisition partition consists of pre-process circuit, A/D converter, on-board memories, and control circuit integrated in FPGA. In the PB and EVC development environment, developers realized the part of em-bedded software. Actual test showed that the highest real-time sampling rate of the oscilloscope is up to lGHz/s, which has achieved the desired design requirements. | Pengyun Zhang Guonan Feng Zhiqiang He | 2018 | Modern Electronic Technology2018，2，2： | 0 |
| 9 | Boosting Green Development in China’s River Valley Economy显示文摘In line with the requirements of Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era,we need analyze the characteristics of China’s river valley economy,fully consider the development constraints posed by water resources.In addition,advancing the“three water treatments,”which covers water pollution control,water ecological restoration,and water resources protection,is of great theoretical and practical significance in helping to realize the concept of a mountain-river-forest-farmland-lake-grass community of shared life.It also requires effectively coordinating the upper and lower reaches,both riverbanks,the trunk streams and tributaries,and on-shore industrial cities within the area,to foster integration and interaction between major national strategies and create a new pattern for promoting ecological progress. | JIA Ruoxiang ZHANG Yan WANG Jiyuan DOU Hongtao ZHENG Guonan | 2020 | China Economic Transition2020，3，2： | 0 |
| 10 | Identification of QTLs for Cadmium Tolerance During Seedling Stage and Validation of qCDSL1 in Rice显示文摘Cadmium(Cd)is a non-essential toxic metal that is harmful to plants.To investigate the genetic mechanism of Cd tolerance in rice,quantitative trait loci(QTLs)associated with Cd tolerance at the seedling stage were analyzed using a recombinant inbred line(RIL)population derived from a cross between PA64s and 93-11.A total of 36 QTLs associated with shoot length,root length,shoot dry weight,root dry weight and total dry weight were detected in Hangzhou and Lingshui of China.Among them,15 QTLs were identified under the control condition and 15 QTLs were identified under the Cd stress condition,and 6 QTLs for Cd tolerant coefficient were detected on chromosomes 1,3,7 and 9.The qCDSL1.1 and qCDSL1.2 were identified in Hangzhou and Lingshui,respectively,and had overlapping intervals on chromosome 1.To further confirm the effects of qCDSL1.1 and qCDSL1.2,we developed a chromosome segment substitution line(CSSL),CSSLqCDSL1,in 93-11 background harboring qCDSL1.1/qCDSL1.2 from PA64s.Compared to 93-11,CSSLqCDSL1 had increased shoot length under the Cd stress condition.These results pave the way for further isolation of those genes controlling Cd tolerance in rice and marker-assistant selection of rice elite varieties with Cd tolerance. | Ding Shilin Liu Chaolei Shang Lianguang Yang Shenglong Zhang Anpeng Jiang Hongzhen Ruan Banpu Fang Guonan Tian Biao Ye Guoyou Guo Longbiao Qian Qian Gao Zhenyu | 2021 | Rice science2021，28，1： | 0 |
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