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| 1 | Tumor necrosis factor gene polymorphisms and endometriosis in Asians: a systematic review and meta-analysis显示文摘 | Lyu Jiangtao Yang Hua Lang Jinghe Tan Xianjie | 2014 | Chinese Medical Journal2014，，9： | 11 |
| 2 | Comparison of screening strategies for Lynch syndrome in patients with newly diagnosed endometrial cancer:a prospective cohort study in China显示文摘Background: The prevalence of Lynch syndrome and screening strategies for this disorder in Chinese patients with endometrial cancer have seldom been investigated. Such data would be essential for the screening, prevention, genetic counseling, and treatment of Lynch syndrome. The purpose of this prospective study was to determine the accuracy of the mismatch repair (MMR) protein immunohistochemistry (IHC), microsatellite instability (MSI) test, and clinical diagnostic criteria in screening for Lynch syndrome-associated endometrial cancer (LS-EC) in a prospective Chinese cohort. Methods: All patients with newly diagnosed endometrial cancer (EC) were evaluated using clinical diagnostic criteria (Amsterdam II criteria and the revised Bethesda guidelines), MSI test, and IHC of MMR proteins in tumor tissues. For all patients, the screening results were compared with results of germline sequencing for pathogenic variants of MMR genes. Results: Between December 2017 and August 2018, a total of 111 unselected patients with newly diagnosed EC were enrolled. Six patients (5.4%) harbored a pathogenic germline mutation of MMR genes: 1 had a mutation in MutL homolog 1 (MLH1), 2 in MutS homolog 2 (MSH2), and 3 in MutS homolog 6 (MSH6). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for identifying LS-EC were 33.3%, 88.6%, 14.3%, and 95.9%, for the clinical criteria, 66.7%, 75.0%, 14.3%, and 97.3% for IHC of MMR proteins, 100%, 89.9%, 33.3%, and 100% for MSI test, and 100%, 72.4%, 20.0% and 100% for combined IHC and MSI test, respectively. The combination of IHC and MSI test had higher sensitivity and PPV than the clinical criteria (p = 0.030). MSI test and IHC were highly concordant for LS-EC screening (73/77, 94.8%). Conclusion: The accuracy of the combination of IHC of MMR proteins and MSI test for screening LS among Chinese patients with EC was superior to that of the clinical criteria. | Xiaopei Chao Lei Li Ming Wu Shuiqing Ma Xianjie Tan Sen Zhong Yalan Bi Jinghe Lang | 2019 | Cancer Communications2019，39，1： | 8 |
| 3 | A study on service capacity of primary medical and health institutions for cervical cancer screening in urban and rural areas in China显示文摘Objective: To provide a decision-making basis for sustainable and effective development of cervical cancer screening.Methods: This cross-sectional study assesses the service capacity to conduct cervical cancer screening with a sample of 310 medical staff, medical institutions and affiliated township health centers from 20 countylevel/district-level areas in 14 Chinese provinces in 2016.Results: The county-level/district-level institutions were the main prescreening institutions for cervical cancer screening. More medical staff have become engaged in screening, with a significantly higher amounts in urban than in rural areas(P<0.05). The number of human papillomavirus(HPV) testers grew the fastest(by 225% in urban and 125% in rural areas) over the course of the project. HPV testing took less time than cytology to complete the same number of screening tasks in both urban and rural areas. The proportion of mid-level professionals was the highest among the medical staff, 40.0% in urban and 44.7% in rural areas(P=0.406), and most medical staff had a Bachelor’s degree, accounting for 76.3% in urban and 52.0% in rural areas(P<0.001). In urban areas, 75.0% were qualified medical staff, compared with 68.0% in rural areas, among which the lowest proportion was observed for rural cytology inspectors(22.7%). The medical equipment for cervical pathology diagnosis in urban areas was better(P<0.001). HPV testing equipment was relatively adequate(typing test equipment was 70% in urban areas, and non-typing testing equipment was 70% in rural areas).Conclusions: The service capacity of cervical cancer screening is insufficient for the health needs of the Chinese population. HPV testing might be an optimal choice to fill the needs of cervical cancer screening given current Chinese medical health service capacity. | Yang Li Li Ma Chunxia Yang Zhangya Chen Yuqian Zhao Le Dang Jinghe Lang Youlin Qiao | 2019 | Chinese Journal of Cancer Research2019，31，5： | 5 |
| 4 | Economic evaluation of cervical cancer screening strategies in urban China显示文摘Objective:This study evaluated the feasibility of different cervical cancer screening strategies in urban China.Methods:A Markov model was constructed to simulate a hypothetical cohort of 100,000 females aged 30-59 years in a 20-year period.Screening strategies included liquid-based cytology(LBC)every three years,human papillomavirus(HPV)DNA testing every three and five years,respectively,and a combination of HPV DNA testing and LBC(HPV+LBC)every three and five years,respectively.Model outcomes included cumulative incidence over 20 years,cumulative risk of cervical cancer,costs,life year saved(LYS),quality-adjusted life years(QALYs)and benefits.The cost-effectiveness ratios(CERs),incremental cost-effectiveness ratios(ICERs),costutility ratios(CURs),and benefit-cost ratios(BCRs)were used as outcomes in the health economic evaluation analysis.Univariate sensitivity analyses were performed to examine the stability of the results.Results:The cumulative incidence of the five screening strategies ranged from 833.02 to 1,158.07 cases per100,000 females.HPV DNA testing was most effective in reducing the cumulative risk of cervical cancer,saving life years and QALYs and gaining benefits.The CERs of HPV DNA testing every three and five years,and LBC every three years were considered to be very cost-effective if they were below China's GDP per capita.The CERs of HPV+LBC were considered to be cost-effective if they were below three times GDP per capita.The incremental cost-effectiveness analysis showed that HPV DNA testing every three and five years,LBC every three years and HPV+LBC every five years were dominant strategies.Conclusions:The findings of this study indicated that HPV DNA testing every five years or LBC every three years should be recommended in urban China. | Li Ma Yuying Wang Xiaohong Gao Yi Dai Yu Zhang Zhaojing Wang Xiaoxia Wang Limin Wang Jing Jiang Xinhua Jing Chunxia Yang Fanghui Zhao Jinghe Lang Youlin Qiao | 2019 | Chinese Journal of Cancer Research2019，31，6： | 4 |
| 5 | An anatomical comparison of two minimally invasive pelvic reconstructive surgeries using fresh female cadavers显示文摘 | Wang Wenyan Zhu Lan Wei Bing Lang Jinghe | 2014 | Chinese Medical Journal2014，，8： | 3 |
| 6 | Evaluation of triage strategies for high-risk human papillomavirus-positive women in cervical cancer screening:A multicenter randomized controlled trial in different resource settings in China显示文摘Objective:We aimed to evaluate the effectiveness of different triage strategies for high-risk human papillomavirus(hrHPV)-positive women in primary healthcare settings in China.Methods:This study was undertaken in 11 rural and 9 urban sites.Women aged 35-64 years old were enrolled.HrHPV-positive women were randomly allocated to liquid-based cytology(LBC),visual inspection with acetic acid and Lugol’s iodine(VIA/VILI)(rural only)triage,or directly referred to colposcopy(direct COLP).At 24 months,hrHPV testing,LBC and VIA/VILI were conducted for combined screening.Results:In rural sites,1,949 hrHPV-positive women were analyzed.A total of 852,218 and 480 women were randomly assigned to direct COLP,LBC and VIA/VILI.At baseline,colposcopy referral rates of LBC or VIA/VILI triage could be reduced by 70%-80%.LBC(n=3 and n=7)or VIA/VILI(n=8 and n=26)could significantly decrease the number of colposcopies needed to detect one cervical intraepithelial neoplasia(CIN)2 or worse and CIN3+compared with direct COLP(n=14 and n=23).For the 24-month cumulative detection rate of CIN2+,VIA/VILI triage was 0.50-fold compared with LBC triage and 0.46-fold with the direct COLP.When stratified by age,baseline LBC triage+performed best(P<0.001),peaking among women aged 35-44 years(Ptrend=0.002).In urban sites,1,728 women were hrHPV genotyping test positive.A total of 408,571 and 568women were randomly assigned to direct COLP for HPV16/18+,direct COLP for other hrHPV subtypes+,and LBC triage for other hrHPV subtypes+.LBC(n=12 and n=31)significantly decreased the number of colposcopies needed to detect one CIN2+and CIN3+compared with direct COLP(n=14 and n=44).HPV16/18+increased the 24-month cumulative detection rate of CIN2+(17.89%,P<0.001).Conclusions:LBC triage for hrHPV-positive women in rural settings and direct COLP for HPV16/18+women and LBC triage for other hrHPV subtype+women in urban settings might be feasible strategies. | Le Dang Linghua Kong Yuqian Zhao Yi Dai Li Ma Lihui Wei Shulan Zhang Jihong Liu Mingrong Xi Long Chen Xianzhi Duan Qing Xiao Guzhalinuer Abulizi Guonan Zhang Ying Hong Qi Zhou Xing Xie Li Li Mayinuer Niyazi Zhifen Zhang Jiyu Tuo Yiling Ding Youlin Qiao Jinghe Lang | 2022 | Chinese Journal of Cancer Research2022，34，5： | 2 |
| 7 | Nanomechanical behaviors of (110) and (111) CdZnTe crystals investigated by nanoindentation显示文摘The nanomechanical behaviors of (110) and (111) CdZnTe crystals were investigated by nanoindentation. It was found that the indenter tip was adhered by the removed materials in scanning testing area although the scanning force on the tested surface was very small (1000 nN), which would affect the testing result of nanoindentation, so the indenter was clean before nanoindentation test. The experimemtal results showed that the hardness and Young's modulus decreased with the increase of indentation loads on the same plane. Because of the anisotropy of the CdZnTe crystal,the average hardness of (110) plane is 35% lower than that of (111) plane, and there are about 30% difference of the hardness along different crystallographic directions on the same plane. The hardness in 0° and 120° testing directions was the same due to the threefold symmetry of a Berkovich indenter. And the anisotropy affected the surface quality during machining of CdZnTe crystal. | LI Yan KANG Renke GAO Hang WANG Jinghe LANG Yanjua | 2009 | Rare Metals2009，28，6： | 2 |
| 8 | Transobturator tape procedure versus tension-free vaginal tape for treat- ment of stress urinary incontinence显示文摘 | Wang Wenyan Lan Zhu Lang Jinghe | 2009 | Int J Gynaeeol Obstet2009，104，2： | 1 |
| 9 | Clinical analysis of endometrial cancer patients younger than 45显示文摘 | Gao Jinsong Shen Ken g Lang Jinghe | 2004 | Chin J Obstet Gynecol2004，39，： | 1 |
| 10 | Chnical characteristics of 70 patients with Herlyn-Werner-Wunderlieh syndrome 显示文摘 | Tong Jiali Zhu Lan Lang Jinghe | 2013 | Inte J Gynecol Obstet2013，121，2： | 1 |
| 11 | Clinical characteristics of 70 patients with Herlyn-Werner-Wunderlich syndrome 显示文摘 | Jiali Tong Lan Zhu Jinghe Lang | 2013 | Interna- tional Journal of Gynecology and Obstetrics2013，12，： | 1 |
| 12 | Clinical characteris- tics and treatment of Herlyn-Werner-Wunderlich syndrome 显示文摘 | Jinhui Wang Lan Zhu Jinghe Lang | 2014 | Arch Gynecol Obstet2014，290，： | 1 |
| 13 | Clinical characteristics and treatment of Herlyn-Werner-Wunderlich syndrome显示文摘 | Jinhui Wang Lan Zhu Jinghe Lang | 2014 | Arch Gynecol Obstet2014，，： | 1 |
| 14 | Vascular stent as a treatment for refractory cervical stenosis显示文摘Cervical stenosis is a clinical condition involving partial or complete obstruction of the endocervical canal.In 1996,Bauldauf proposed that the definition of cervical stenosis is a cervical canal into which a 2.5# Hegar dilator cannot be inserted.1 Acquired cervical stenosis can be a complication of surgical procedures such as conization,trachelectomy,and curettage.It is a serious complication because of the clinical repercussions,which can include amenorrhea,hematometra,dysmenorrhea,infertility,infection,and endometriosis.Various surgical techniques are used in dilation and cervix reconstruction.However,in some cases,unsuccessful dilation with refractory recurrent stenosis may lead to hysterectomy.A successful case in which a self-expanding nitinol vascular stent was used to treat cervical stenosis was described by Grund et al.2 Here we report two additional cases in which vascular stents were used to treat patients with recurrent cervical stenosis after cervical surgeries. | Yang Jie Zhu Lan Lang Jinghe | 2014 | Chinese Medical Journal2014，，5： | 1 |
| 15 | Validation of the Chinese version of the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire short form (PISQ-12)显示文摘 | Lan Zhu Sijun Yu Tao Xu Xin Yang Yongxian Lu Jinghe Lang | 2011 | International Journal of Gynecology and Obstetrics2011，，： | 1 |
| 16 | Expression of vascular endothelial growth factor and thrombospondin-1 mRNA in patients with endometriosis 显示文摘 | Tan Xianjie Lang Jinghe Liu Dongyuan | 2002 | Fertil Steril2002，78，1： | 1 |
| 17 | Presentation and management of perineal endometriosis显示文摘 | LAN ZHU JINGHE LANG HANBI WANG | 2009 | International Journal of Gynecology & Obstetrics2009，105，3： | 1 |
| 18 | Expectant treatment of cesarean scar pregnancy: two case reports and a glimpse at the natural courses显示文摘 | Haiyuan Liu Jinhua Leng Honghui Shi Jinghe Lang | 2010 | Archives of Gynecology and Obstetrics2010，，4： | 1 |
| 19 | Ex- pression of vascular endothelial growth factor and thrombospondin mRNA in patients with endometrio-sis显示文摘 | Tan Xianjie Lang Jinghe Liu Dong Yuan | 2002 | Fertil Steril2002，78，1： | 1 |
| 20 | LAMC1, LAMA2 and LAMA3 gene polymorphisms and the risk for severe pelvic organ prolapse显示文摘Pelvic organ prolapse (POP) is the descent of the pelvic organs,including bladder, uterus, vagina and rectum, resulting in pelvic discomfort, urinary and fecal incontinence and sexual dysfunction(1)The prevalence of symptomatic POP in China is 9.56%according to a cross-sectional study involving 54,000 adult women in six provinces in the mainland of China (unpublished data). The etiology of this disorder is multifactorial, including race, age, body mass index(BMI), parity and menopause (1)The loss of the integrity of vaginal connective tissue has been demonstrated to weaken the pelvic floor support and promote the development of POP. | Lei Li Jia Kang Ye Zhang Meng Mao Yuxiang Yang Jinghe Lang Zhijing Sun Juan Chen Lan Zhu | 2019 | Science Bulletin2019，64，7： | 1 |
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