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| 1 | COVID-19 Super Spreading Event Amongst Elderly Individuals—Jilin Province,China,January 2021显示文摘Summary What is already known on this topic?Clusters of COVID-19 cases often happened in small settings(e.g.,families,offices,school,or workplaces)that facilitate person-to-person virus transmission,especially from a common exposure.What is added by this report?On January 10 and 11,2021,an individual gave three product promotional lectures in Tonghua City. | Laishun Yao Mingyu Luo Tiewu Jia Xingang Zhang Zhulin Hou Feng Gao Xin Wang Xiaogang Wu Weihua Cheng Guoqian Li Jing Lu Bing Zhao Tao Li Enfu Chen Dapeng Yin Biao Huang | 2021 | China CDC weekly2021，3，10： | 13 |
| 2 | Global network of embodied water flow by systems input-output simulation显示文摘全球水资源网络与可得到的统计数据并且与大多数详细数据崩溃在现在的工作被模仿最近的目标年。系统 inputoutput 模拟的一条自顶向下的途径被采用追踪在 2004 为全球化的经济与经济流动联系的表达的水流动。数字模拟从 4928 个制片人,用在全球规模的效率的直接、间接的水之间的差别基于被讨论为所有经济商品提供表达的水紧张的一个数据库。直接、表达的水使用在大陆人水平被分析。而且,商品需求用区域为世界以及为三主要的水以表达的水使用以钱的开销和水需求被比较,即,印度,中国,和美国。结果证明那个食物产品为水需求贡献重要部分,尽管有价值关于区域的经济地位显著地变化[出版摘要] | Zhanming CHEN Guoqian CHEN Xiaohua XIA Shiyun XU | 2012 | Frontiers of Earth Science2012，6，3： | 8 |
| 3 | Machine Learning for Lung Cancer Diagnosis,Treatment,and Prognosis显示文摘The recent development of imaging and sequencing technologies enables systematic advances in the clinical study of lung cancer.Meanwhile,the human mind is limited in effectively handling and fully utilizing the accumulation of such enormous amounts of data.Machine learningbased approaches play a critical role in integrating and analyzing these large and complex datasets,which have extensively characterized lung cancer through the use of different perspectives from these accrued data.In this review,we provide an overview of machine learning-based approaches that strengthen the varying aspects of lung cancer diagnosis and therapy,including early detection,auxiliary diagnosis,prognosis prediction,and immunotherapy practice.Moreover,we highlight the challenges and opportunities for future applications of machine learning in lung cancer. | Yawei Li Xin Wu Ping Yang Guoqian Jiang Yuan Luo | 2022 | Genomics, Proteomics & Bioinformatics2022，20，5： | 4 |
| 4 | Effect of Gubi prescription on caveolin-1 expression and phosphoinositide 3 kinase/protein kinase B and Fas signal pathways in rats with knee osteoarthritis显示文摘OBJECTIVE: To investigate the effects of Gubi prescription on the expression of caveolin-1, and the phosphoinositide 3 kinase/protein kinase B(PI3 K/Akt) and Fas signal pathways in rats with knee osteoarthritis(KOA).METHODS: Forty KOA model rats were established using a modification of Hulth's method. Rats were divided into five groups by the random number method: model, positive drug(Vicolli group), and high-, medium-, and low-dose Gubi prescription groups(n = 8/group). In the sham surgery group(n = 8), only anterior and posterior cruciate ligaments of rats were exposed during surgery. A normal group(n = 8) consisted of rats with no treatment. Rats were intragastrically administered corresponding drugs once every day for eight consecutive weeks. Then, rat synovial membranes were extracted and histomorphological changes were recorded. m RNA expression was measured by q-PCR.Serum superoxide dismutase(SOD), malondialdehyde(MDA), nitric oxide(NO), and interleukin 1β(IL-1β) levels were measured. Western blotting determined the effects of Gubi prescription on protein expressions of caveolin-1, Bax, Bcl-2, Fas, and caspase-3 in chondrocytes from KOA rats. The knee cartilage of rats was excised and cultured under aseptic conditions. After coincubation of chondrocytes with Gubi prescription-containing serum, IL-1β, and si RNA, Western blotting was used to determine the protein expressions of caveolin-1, Bax, Bcl-2, Fas, and caspase-3.RESULTS: The morphological score of the articular synovium in the model group was significantly higher than in the normal group(P < 0.01). The morphological score in the high-and mediumdose Gubi prescription groups was lower than in the model group(P < 0.05). Chondrocytes from the decoction-containing serum group had a lower expression of Bax(P < 0.05), and higher expressions of Bcl-2(P < 0.05) and caspase-3(P < 0.05) compared with the model group. Chondrocytes in the decoction-containing serum group had higher expressions of Bax and Bcl-2(P < 0.01) and lower expressions of caveolin-1 and Fas(P < 0.05) compared with the model group. Compared with the model group, Bax and caspase-3 expressions were reduced in the chondrocytes of all three Gubi prescription groups(P < 0.05) whereas Bcl-2 expression was increased(P < 0.05). Compared with the model group, the expressions of caveolin-1 and Fas(P < 0.05) were reduced in groups that received high-and medium-doses of Gubi prescription. Gubi prescription increased the serum level of SOD and significantly reduced those of MDA, NO and IL-1β(P < 0.05).CONCLUSION: Gubi prescription suppressed the chondrocyte-related PI3 K/Akt and Fas signal pathways and inhibited the overexpression of caveolin-1 in rat chondrocytes. | He Xiaojin Wang Lei Zhou Xueping Xu Luzhou Cao Jing Wang Ruirui Wang Min Xie Guoqian | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 3 |
| 5 | The C-terminal 17 amino acids of the photoreceptor UVR8 is involved in the fine-tuning of UV-B signaling^FA显示文摘Plant UV-B responses are mediated by the photoreceptor UV RESISTANCE LOCUS 8 (UVR8). In re-sponse to UV-B irradiation, UVR8 homodimers dissociate into monomers that bind to the E3 ubiquitin ligase CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1). The in-teraction of the C27 domain in the C-terminal tail of UVR8 with the WD40 domain of COP1 is critical for UV-B sig-naling. However, the function of the last 17 amino acids (C17) of the C-terminus of UVR8, which are adjacent to C27, is unknown, although they are largely conserved in land plants. In this study, we established that Arabidopsis thaliana UVR8 C17 binds to full-length UVR8, but not to COP1, and reduces COP1 binding to the remaining portion of UVR8, including C27. We hypothesized that overexpression of C17 in a wild-type background would have a dominant negative effect on UVR8 activity;however, C17 overexpression caused strong silencing of endogenous UVR8, precluding a detailed analysis. We therefore generated YFP-UVR8N423 transgenic lines, in which C17 was deleted, to examine C17 function in-directly. YFP-UVR8N423 was more active than YFP-UVR8, suggesting that C17 inhibits UV-B signaling by attenuating binding between C27 and COP1. Our study reveals an inhibitory role for UVR8 C17 in fine-tuning UVR8–COP1 interactions during UV-B signaling. | Li Lin Huaxi Dong Guoqian Yang Ruohe Yin | 2020 | Journal of Integrative Plant Biology2020，62，9： | 3 |
| 6 | Using MiddRAD-seq data to develop polymorphic microsatellite markers for an endangered yew species显示文摘Microsatellites are highly polymorphic markers which have been used in a wide range of genetic studies.In recent years, various sources of next-generation sequencing data have been used to develop new microsatellite loci, but compared with the more common shotgun genomic sequencing or transcriptome data, the potential utility of RAD-seq data for microsatellite ascertainment is comparatively under-used.In this study, we employed MiddRAD-seq data to develop polymorphic microsatellite loci for the endangered yew species Taxus florinii. Of 8,823,053 clean reads generated for ten individuals of a population, 94,851(~1%) contained microsatellite motifs. These corresponded to 2993 unique loci, of which 526(~18%) exhibited polymorphism. Of which, 237 were suitable for designing microsatellite primer pairs, and 128 loci were randomly selected for PCR validation and microsatellite screening. Out of the 128 primer pairs, 16 loci gave clear, reproducible patterns, and were then screened and characterized in 24 individuals from two populations. The total number of alleles per locus ranged from two to ten(mean=4.875), and within-population expected heterozygosity from zero to 0.789(mean = 0.530),indicating that these microsatellite loci will be useful for population genetics and speciation studies of T. florinii. This study represents one of few examples to mine polymorphic microsatellite loci from ddRAD data. | Hantao Qin Guoqian Yang Jim Provan Jie Liu Lianming Gao | 2017 | Plant Diversity2017，39，5： | 3 |
| 7 | Improvement of machining consistency during through-mask electrochemical large-area machining显示文摘Electrochemical machining(ECM) is an important machining technique for the aeronautical manufacturing industry. Through-mask ECM is a form of ECM for machining metal parts with a hole array. In order to extend the machining area, a serpentine flow channel with multiple curves was used for through-mask ECM. With the extension of the flow channel, ensuring a machining consistency along the flow channel has been a challenge. The electrolyte conductivity is the main factor affecting the machining consistency. To analyze the change rules of the electrolyte conductivity, variations in the bubble rate and the temperature of the electrolyte in the electrolyte flow were explored under different power sources. Results indicate that pulse-power machining can reduce variations in the bubble rate and the temperature in the serpentine flow channel, and then the electrolyte conductivity can be stabilized within a very small range. Experiments using through-mask ECM were conducted in two types of power sources. Experimental results support the importance of pulse-power machining. A 14×28 hole array with a 2.5 mm diameter was fabricated by a pulsed power source. The aperture deviation of the hole array is less than 0.05 mm, and the roundness deviation is less than 15 lm when fabricated with pulse machining. | Guoqian WANG Hansong LI Chao ZHANG Di ZHU | 2019 | Chinese Journal of Aeronautics2019，32，4： | 3 |
| 8 | Expression of nerve growth factor precursor, mature nerve growth factor and their receptors during cerebral ischemia-reperfusion injury显示文摘We investigated nerve growth factor precursor (proNGF) and mature NGF expression in ischemic and non-ischemic cortices after cerebral ischemia-reperfusion injury. In both ischemic and non-ischemic cortices, proNGF was found to be present in the extracellular space and cytoplasm. In addition, mature NGF was expressed in extracellular space, but with a very low signal. In ischemic cortex only, proNGF was significantly decreased, reaching a minimal level at 1 day. Mature NGF was increased at 4 hours, then reached a minimal level at 3 days. The p75 neurotrophin receptor (p75NTR) was significantly decreased after ischemia, and increased at 3 days after ischemia. These results confirmed that proNGF was the predominant form of NGF during the pathological process of cerebral ischemia-reperfusion injury. In addition, our findings suggest that ischemic injury may influence the conversion of proNGF to mature NGF, and that proNGF/p75NTR may be involved in reperfusion injury. | Guoqian He Jian Guo Jiachuan Duan Wenming Xu Ning Chen Hongxia Li Li He | 2011 | Neural Regeneration Research2011，6，22： | 3 |
| 9 | Filaments in high-speed counter-streaming plasma interactions driven by high-power laser pulses显示文摘Interactions of two counter-streaming plasmas driven by high power laser pulses are studied on Shenguang II laser facility.Filamentary structures were observed in the interaction region after the electrostatic shockwave decay.Theoretical analysis and observations indicate that the filaments are because of collisionless mechanisms,which are caused by the electromagnetic instability,such as the beam-Weibel instability.Collision experiments were also carried out for comparison and no filaments were generated. | YUAN DaWei LI YuTong SU LuNing LIAO GuoQian YIN ChuanLei ZHU BaoJun ZHANG Jie | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，12： | 2 |
| 10 | Laser-driven plasma collider for nuclear studies显示文摘A novel method of initiating nuclear fusion reactions in a full plasma environment was suggested, and a proof-of-concept experiment was carried out with the D t D ! n t3 He reaction. In this new approach, two plasma jets generated by high-intensity lasers collide headon-head. The center-of-mass energy of the nuclei increases accordingly, and therefore, reaction products can be significantly enhanced, especially in the sub-Coulomb barrier ranges. As a result of the fusion reaction, up to 7:6 105 neutrons had been observed. This new type of ‘‘plasma collider'' could provide an innovative tool to study nuclear reactions under astrophysical conditions. | Changbo Fu Jie Bao Liming Chen Jianjun He Long Hou Liang Li Yanfei Li Yutong Li Guoqian Liao Yongjoo Rhee Yang Sun Shiwei Xu Dawei Yuan Xiaopeng Zhang Gang Zhao Jiarui Zhao Baojun Zhu Jianqiang Zhu Jie Zhang | 2015 | Science Bulletin2015，60，13： | 2 |
| 11 | Context-based ontology building support in clinical domains using formal concept analysis显示文摘 | Guoqian J Katsuhiko O Akira E | 2003 | Intemational Journal of Medical Informatics2003，71，1： | 1 |
| 12 | Environmental dispersivity in free-water-surface-effect dominated wetland:multi-scale analysis显示文摘Distinct from the case with width-dominated shallow wetland flows,the longitudinal evolution of contaminant concentration in the most-typical pattern of wetland as dominated by free-water-surface-effect is characterized by a multi-scale analysis in the present study.An environmental dispersion model for the evolution of the mean concentration is deduced as an extension of Taylor's classical formulation by Mei’s multi-scale analysis.Corresponding environmental dispersivity is found identical to that determined by the method of concentration moments. | Zi WU Zhi LI Li ZENG Ling SHAO Hansong TANG Qing YANG Guoqian CHEN | 2011 | Frontiers of Environmental Science & Engineering2011，5，4： | 1 |
| 13 | Numerical simulation of line puff via RNG k-e model显示文摘 | Lee J H W Chen Guoqian | 1996 | Communication in Nonlinear Science and Numerical Simulation1996，，4： | 1 |
| 14 | Mechanisms of thermal shock failure for ultra-high temperature ceramic显示文摘 | MENG Songhe LIU Guoqian GUO Yue | 2009 | Materials and Design2009，30，6： | 1 |
| 15 | From innovation to adaptation:lessons from 20 years of the SHIFT forest management system in Sanmin,China显示文摘 | Yajie Song Guoqian Wang William R | 2004 | Forest Economics and Policy2004，191，13： | 1 |
| 16 | Downregulation of Annexin A1 by short hairpin RNA inhibits the osteogenicdifferentiation of rat bone marrow-derived mesenchymal stem cells显示文摘 | Xinyuan Pan Liu Peng Guoqian Yin | 2015 | International Journal of Molecular Medicine2015，，2： | 1 |
| 17 | Proton radiography of magnetic fields generated with an open-ended coil driven by high power laser pulses显示文摘Recently generation of strong magnetic(B)fields has been demonstrated in capacitor coils heated by high power laser pulses[S.Fujioka et al.,Sci.Rep.3,1170(2013)].This paper will present a direct measurement of B field generated with an open-ended coil target driven by a nanosecond laser pulse using ultrafast proton radiography.The radiographs are analyzed with particle-tracing simulations.The B field at the coil center is inferred to be ~50 T at an irradiance of ~5×10^(14) W·cm^(-2).The B field generation is attributed to the background cold electron flow pointing to the laser focal spot,where a target potential is induced due to the escape of energetic electrons. | Guoqian Liao Yutong Li Baojun Zhu Yanfei Li Fang Li Mengchao Li Xuan Wang Zhe Zhang Shukai He Weiwu Wang Feng Lu Faqiang Zhang Lei Yang Kainan Zhou Na Xie Wei Hong Yuqiu Gu Zongqing Zhao Baohan Zhang Jie Zhang | 2016 | Matter and Radiation at Extremes2016，1，4： | 1 |
| 18 | Effects of vitamins on the lactic acid biosynthesis of Lactobacillus paracasei NERCB 0401 显示文摘 | XU Guoqian CHU Ju ZHUANG Yingping | 2008 | Biochemical Engineering Journal2008，38，2： | 1 |
| 19 | Emergy analysis of Chinese agriculture显示文摘 | Chen Guoqian Jiang M M Chen B | 2006 | Agriculture Ecosystems & Environment2006，115，3： | 1 |
| 20 | Ecological footprint accounting based on emergy: A case study of the Chinese society显示文摘 | Chen Bin Chen Guoqian | 2006 | Ecological Modelling2006，198，1： | 1 |
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