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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | mtDNA Diversity,Population Structure,and Conservation Genetics of Four Native Carps within the Yangtze River,China显示文摘 | Lu Guoqing Li Sifa Bernatchez L | 1997 | Can J Fish Aqua Sci1997，54，： | 1 |
| 3 | Positive expression of LSD1 and negative expression of E-cadherin correlate with metastasis and poor prognosis of colon cancer显示文摘 | Jie D Zhongmin Z Guoqing L | 2013 | Dig Dis Sei2013，58，6： | 1 |
| 4 | Suitability of yeast-an Escherichiacoli-expressed hepatitis B derivatives for detection of antiHBc antibodies in human sera显示文摘 | Zhaoxia L Guoqing Hong Li Lin | 2007 | Protein Expression and Purification2007，56，： | 1 |
| 5 | Positive expression of LSD1 and negative expression of E-cadherin correlate with metastasis and poor prognosis of colon cancer 显示文摘 | Jie D Zhongmin Z Guoqing L | 2013 | Dig Dis Sci2013，58，6： | 1 |
| 6 | High heat flux test of SiC coated doped graphite显示文摘 | GuoQ G Liu Zh J LiJ G Noda N Liu L | | Journal of Nuclear Materials0，，15： | 1 |
| 7 | Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase ac- tivity and telomerase reverse transcriptase mRNA ex- pression in the cells 显示文摘 | WuZ Q GuoQ L YouQ D | 2004 | Biological & Pharmaceutical Butletin2004，27，： | 1 |
| 8 | Effects of plasma homo- cysteine levels on serum HTase/PON activity in patients with type 2 diabetes 显示文摘 | Weijun G Juming L Guoqing Y | 2008 | Adv Ther2008，25，9： | 1 |
| 9 | Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation显示文摘 | GuoQ Sebastian L Sopher BL | | 0，，： | 1 |
| 10 | Computationally efficient bandwidth allocation and power control for OFDMA显示文摘 | K1VANC D GUOQING L HUI L | 2003 | IEEE Transactions on Wireless Communications2003，2，6： | 1 |
| 11 | Positive expression ofLSDl and negative expression of E-cadherin correlate with me-tastasis and poor prognosis of colon cancer显示文摘 | Jie D Zhongmin Z Guoqing L | 2013 | Dig Dis Sci2013，586，： | 1 |
| 12 | Dynamics of fertilizer-derived organic nitrogen fractions in an arable soil during a growing season显示文摘 | Huijie Lü Hongbo He Jinsong Zhao Wei Zhang Hongtu Xie Guoqing Hu Xiao Liu Yeye Wu Xudong Zhang | 2013 | 2013 (1-2)2013，，1： | 1 |
| 13 | Analysis of twin nozzle scanning spray forming process and spray formed high speed steel (HSS) 显示文摘 | Zhang Yong Zhang Guoqing L i Zhou | 2007 | Journal of Iron and Steel Research International2007，，： | 1 |
| 14 | Dynamics of fertilizer-derived organic nitrogen fractions in an arable soil during a growing season显示文摘 | Huijie Lü Hongbo He Jinsong Zhao Wei Zhang Hongtu Xie Guoqing Hu Xiao Liu Yeye Wu Xudong Zhang | 2013 | Plant and Soil (-)2013，，1： | 1 |
| 15 | Marker-assisted introgression of qHSR1 to improve maize resistance to head smut显示文摘 | Xianrong Zhao Guoqing Tan Yuexian Xing Lai Wei Qing Chao Weiliang Zuo Thomas Lübberstedt Mingliang Xu | 2012 | Molecular Breeding2012，，2： | 1 |
| 16 | Mogroside IIE,an in vivo metabolite of sweet agent,alleviates acute lung injury via Pla2g2a-EGFR inhibition显示文摘In the face of increasingly serious environmental pollution,the health of human lung tissues is also facing serious threats.Mogroside IIE(M2E)is the main metabolite of sweetening agents mogrosides from the anti-tussive Chinese herbal Siraitia grosvenori.The study elucidated the anti-inflammatory action and molecular mechanism of M2E against acute lung injury(ALI).A lipopolysaccharide(LPS)-induced ALI model was established in mice and MH-S cells were employed to explore the protective mechanism of M2E through the western blotting,co-immunoprecipitation,and quantitative real time-PCR analysis.The results indicated that M2E alleviated LPS-induced lung injury through restraining the activation of secreted phospholipase A2 type IIA(Pla2g2a)-epidermal growth factor receptor(EGFR).The interaction of Pla2g2a and EGFR was identified by co-immunoprecipitation.In addition,M2E protected ALI induced with LPS against inflammatory and damage which were significantly dependent upon the downregulation of AKT and m TOR via the inhibition of Pla2g2a-EGFR.Pla2g2a may represent a potential target for M2E in the improvement of LPS-induced lung injury,which may represent a promising strategy to treat ALI. | Weichao Lü Guoqing Ren Kuniyoshi Shimizu Renshi Li Chaofeng Zhang | 2024 | Food Science and Human Wellness2024，13，1： | 0 |
| 17 | Repair Welding of Casting Magnesium Alloys:A Review显示文摘Magnesium (Mg) alloys have broad application prospects in the fields of aerospace,national defense,and military industries,owing to their advantages of high specific strength and stiffness,good damping properties,and excellent castabilities. However,defects such as oxidation inclusions,shrinkage cavities and porosities,and hot cracks are readily generated in Mg alloy components,which seriously reduce the performance stability of the products. Related repair welding technologies for Mg alloys can greatly reduce the rejection rate and production cost,and exhibit significant value in scientific research and engineering application. In this review,the weldability of Mg alloys is introduced firstly according to their physical and chemical properties. Then,various repair welding technologies and pre-weld treatments applicable to Mg alloys are systematically summarized,and the effects of welding parameters as well as heat treatments on the microstructure and performance of the repaired joints are clarified. Finally,the existing problems and development trends of repair welding technologies for Mg alloys are summarized based on the actual engineering application requirements. | WU Guohua TONG Xin WANG Qiman ZHANG Guoqing XIAO Lü | 2022 | 上海航天(中英文)2022，39，1： | 0 |
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