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| 1 | IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity显示文摘Obesity and associated metabolic diseases are characterized by a chronic low-grade inflammatory state with the infiltration of many inflammatory cells,especially macrophages.Immune molecules,including some cytokines,have a close relationship with metabolism.Interleukin(IL)-25 is a member of the IL-17 cytokine family that can regulate macrophages and alleviate some metabolic dysfunction;however,its role and mechanisms in lipid metabolism remain to be extensively clarified.Human serum and liver biopsy specimens,high-fat diet-induced obesity mice and DB/DB(Lepr−/−)animal models were used to examine IL-25 expression in obesity and nonalcoholic fatty liver diseases(NAFLD).To observe the role of IL-25 in lipid metabolism,model mice were administered with IL-25 or adoptively transferred with IL-25-educated macrophages in vivo,whereas bone marrow-derived macrophages,the macrophage cell line RAW264.7 and adipocytes differentiated from 3T3-L1 were used in vitro.IL-25 was decreased in NAFLD patients and obese mice.In addition,IL-25 reduced body weight gain and lipid accumulation,enhanced lipid uptake by macrophages and increased the expression of lipolysis andβ-oxidation enzymes via alternatively activating macrophages.IL-25 also promoted lipolysis and suppressed lipogenesis in adipocytes co-cultured with the IL-25-educated macrophages.Furthermore,IL-25 improved the mitochondrial respiratory capacity and oxygen consumption rate of macrophages and produced more NAD+/NADH and ATP.In conclusion,IL-25 can stimulate M2 macrophage polarization and thereby promote lipolysis and mitochondrial respiratory capacity,highlighting the potential for IL-25 to be used as a therapeutic agent against obesity and associated metabolic syndromes. | Juan Feng Lingyi Li Zhiying Ou Qiao Li Baoyong Gong Zhenxian Zhao Weiwei Qi Ti Zhou Jun Zhong Weibin Cai Xia Yang Aiping Zhao Guoquan Gao Zhonghan Yang | 2018 | Cellular & Molecular Immunology2018，15，5： | 10 |
| 2 | Inhibition of adipogenic differentiation by myostatin is alleviated by arginine supplementation in porcine-muscle-derived mesenchymal stem cells显示文摘Porcine mesenchymal stem cells in postnatal muscle have been demonstrated to differentiate into adipocytes.This increases adipocyte number and lipid accumulation,and is thought to be the origin of intramuscular fat.In this study,the effects of myostatin and arginine on adipogenic differentiation in mesenchymal stem cells derived from porcine muscle (pMDSCs) were investigated in vitro.Intracellular triglyceride levels were reduced by exogenous myostatin and increased by arginine supplementation or myostatin antibody (P<0.01).The inhibition of lipid accumulation by myostatin in pMDSCs was alleviated by arginine supplementation (P<0.01).Expression patterns of adipogenic transcription factors showed that exogenous myostatin suppressed PPARγ2 and aP2 expression (P<0.01),while supplemental arginine or myostatin antibody promoted ADD1 expression (P<0.01).Furthermore,compared with the addition of either myostatin protein or antibody alone,ADD1 and PPARδ expression were promoted by the combination of arginine and myostatin (P<0.01),and arginine combined with myostatin antibody promoted the expression of ADD1,PPAR,C/EBP,PPAR 2 and LPL in pMDSCs (P<0.05).These results suggest that myostatin inhibits adipogenesis in pMDSCs,and that this can be alleviated by arginine supplementation,at least in part,through promoting ADD1 and PPAR expression. | LEI HuLong YU Bing YANG XueRong LIU ZeHui HUANG ZhiQing MAO XiangBing TIAN Gang HE Jun HAN GuoQuan CHEN Hong MAO Qian CHEN DaiWen | 2011 | Science China(Life Sciences)2011，54，10： | 4 |
| 3 | Integrated lithium niobate single-mode lasers by the Vernier effect显示文摘Microcavity lasers based on erbium-doped lithium niobate on insulator(LNOI),which are key devices for LNOI integrated photonics,have attracted significant attention recently.In this study,we report the realization of a C-band single-mode laser using the Vernier effect in two coupled erbium-doped LNOI microrings with different radii under the pump of a 980-nm continuous laser.The laser,operating stably over a large range of pumping power,has a pump threshold of about 200μW and a side-mode suppression ratio exceeding 26 dB.The high-performance LNOI single-mode laser will promote the development of lithium niobate integrated photonics. | Ru Zhang Chen Yang ZhenZhong Hao Di Jia Qiang Luo DaHuai Zheng HongDe Liu XuanYi Yu Feng Gao Fang Bo YongFa Kong GuoQuan Zhang JingJun Xu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，9： | 4 |
| 4 | Microdisk lasers on an erbium-doped lithium-niobite chip显示文摘Lithium niobate on insulator(LNOI) provides a platform for the fundamental physics investigations and practical applications of integrated photonics. However, as an indispensable building block of integrated photonics, lasers are in short supply. In this paper, erbium-doped LNOI laser in the 1550-nm band was demonstrated in microdisk cavities with high quality factors fabricated in batches by UV exposure, inductively coupled plasma reactive ion etching, and chemomechanical polishing. The threshold and conversion efficiency of the erbium-doped LNOI microdisk laser were measured to be lower than 1 m W and 6.5×10^(-5)%, respectively. This work will benefit the development of integrated photonics based on LNOI. | Qiang Luo ZhenZhong Hao Chen Yang Ru Zhang DaHuai Zheng ShiGuo Liu HongDe Liu Fang Bo YongFa Kong GuoQuan Zhang JingJun Xu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，3： | 4 |
| 5 | Thermodynamic Research on Precipitates in Low Carbon Nb-Microalloyed Steels Produced by Compact Strip Production显示文摘在紧缩的 stripproduction ( CSP )生产的钢处理的低碳的 Microalloying 元素 Nb 在禁止再结晶起一个重要作用,减少 thetransformation 温度和谷物 refinement.With 减少滚动温度, dislocationscan 被 carbonitrides 卡住,力量是二个 sublattice 模型上的 increased.Based , withmetal 原子 sublattice 和空隙的原子 sublattice ,为 carbonitride wasestablished | Song XIANG Guoquan LIU Yang LI Changrong LI Andong WANG | 2007 | Journal of Materials Science & Technology2007，23，2： | 3 |
| 6 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 7 | Differentiations of geographic distribution and subsistence strategies between Tibetan and other major ethnic groups are determined by the physical environment in Hehuang Valley显示文摘The people of the Tibetan Plateau have received extensive attention from scholars because of their unique adaptability to the low temperature and anoxic environments. However, the Tibetan communities and their habitats in the low-altitude regions of the plateau have rarely been studied in a scientific manner. Based on the extraction of geographic information of 197 towns in the Hehuang Valley and on variance analysis, this study examines the habitats and subsistence strategies of the Tibetans and other major ethnic groups in the low-latitude region of the Tibetan Plateau. Our statistical results show that the annual average temperature of Tibetan habitats in the Hehuang Valley is relatively high. The relatively warm environment of the valley allows the Tibetans in that area to cultivate wheat and barley and raise cattle and sheep—a subsistence strategy significantly different from that of other Tibetans in the high-altitude regions in the Tibetan Plateau. In addition, the Tibetan communities in the Hehuang Valley include similar agri-pastoral ethnic groups (including Hui and Salar), both of which adopt similar subsistence strategies. The agricultural ethnic groups (Han and Tu) live in a relatively cool and humid environment facilitating agricultural production, while the agri-pastoral ethnic groups (Tibetan, Hui, and Salar) inhabit relatively warm and arid environment in the valley. Due to the lack of agricultural activities, agri-pastoral groups must also engage in animal husbandry to supplement their diet. In the Ando Tibetan region, the subsistence strategies of the ethnic groups are closely related to their physical environment.Those ethnic groups communicate among themselves, integrate, and influence each other, resulting in a diversified culture. This study proves that the habitat variation at a regional scale corresponds significantly to the variation of subsistence strategies. Our findings may further refine knowledge about the human-environmental relationships of Tibetans and lead future research towards using quantitative methods to analyse the intersection of physical environment and ethnic groups' distribution. | Xin JIA Harry F.LEE Mengchun CUI Guoquan CHENG Yang ZHAO Hong DING Ricci P.H.YUE Huayu LU | 2019 | Science China Earth Sciences2019，62，2： | 2 |
| 8 | Full-spectrum responsive photocatalytic activity via non-noble metal Bi decorated mulberry-like BiVO_(4)显示文摘Due to its appropriate bandgap(~2.4 e V)and efficient light absorption,bismuth vanadate(Bi VO_(4))shows promising photocatalysis activity.However,the charge carrier recombination and poor electron transmission often induce poor photocatalytic performance.Herein,we report a new method to in-situ synthesize non-noble metal Bi decorated mulberry-like Bi VO_(4)by a two-step calcination process.Comprehensive characterizations reveal that non-noble metal Bi nanoparticles grown in-situ on Bi VO_(4)result in the red-shift of the absorbance edge,greatly extending the light absorption from the ultraviolet into the near-infrared region.The surface plasmon resonance excitation of Bi nanoparticles and synergetic effects between Bi and Bi VO_(4)effectively improve the photocatalytic efficiency and promote the separation of photoinduced electron-hole pairs in mulberry-like Bi VO_(4).Density functional theory(DFT)calculation results further verify that the electrons are transferred from Bi to Bi VO_(4)and the formation of·OH radical in Bi/Bi VO_(4)is attributed to the lower simulated free energy,which supports our experimental outcomes.This work provides a novel strategy to enhance light absorption and promote efficient solar utilization of photocatalysts for practical applications. | Yaxin Bi Yanling Yang Xiao-Lei Shi Lei Feng Xiaojiang Hou Xiaohui Ye Li Zhang Guoquan Suo Siyu Lu Zhi-Gang Chen | 2021 | Journal of Materials Science & Technology2021，，24： | 2 |
| 9 | Construction of SnS2/SnO2 heterostructures with enhanced potassium storage performance显示文摘Increasing attention has been focused on potassium ion batteries(KIBs) as promising energy-sto rage system(ESS) owing to the abundance and low-cost of potassium resources.Here,SnS2/SnO2 hete rostructures were successfully fixed onto stainless steel mesh(SnS2/SnO2/SSM) through a facile two-step hydrothermal method and used as anodes for KIBs.Due to the advantages of SnS2/SnO2 heterostructures and good conductivity of SSM substrate,the SnS2/SnO2/SSM anodes display enhanced electrochemical performance.The SnS2/SnO2/SSM anodes deliver specific capacity of 394 mA h g^-1 at 50 mA g^-1 over 100 cycles,better than SnO2/SSM.Even at 500 mA g^-1 after 250 cycles,high capacity of 155 mA h g^-1 can still be obtained. | Guoquan Suo Dan Li Lei Feng Xiaojiang Hou Xiaohui Ye Li Zhang Qiyao Yu Yanling Yang Wei(Alex)Wang | 2020 | Journal of Materials Science & Technology2020，52，20： | 1 |
| 10 | Miocene Pliocene planktonic foraminiferal biostratigraphy of the Pearl River Mouth Basin,northern South China Sea | Liu Chunlian 1,2,,Huang Yi 1,Wu Jie 1,Qin Guoquan 3,Yang Tingting 1,2,Xia Lianze 1,Zhang Suqing 1 1.Department of Earth Sciences,Sun Yat-Sen University,Guangzhou 510275,China 2.Guangdong Provincial Key Laboratory of Mineral Resources & Geological Processes,Guangzhou 510275,China 3.Nanhai East Company of China National Offshore Oil Corporation,Guangzhou 510240,China | 2012 | Journal of Palaeogeography2012，1，1： | 1 |
| 11 | ENERGY TRAPPING OF THICKNESS-SHEAR AND THICKNESS-TWIST MODES IN A PARTIALLY ELECTRODED AT-CUT QUARTZ RESONATOR显示文摘The thickness-shear and thickness-twist vibrations of a finite and partially electroded AT-cut quartz resonator are investigated. The equations of anisotropic elasticity are used with the omission of the small elastic constant c 56 . An analytical solution is obtained using Fourier series from which the free vibration resonant frequencies, mode shapes, and energy trapping are calculated and examined. | Huijing He Guoquan Nie Jinxi Liu Jiashi Yang | 2012 | Acta Mechanica Solida Sinica2012，25，6： | 1 |
| 12 | Kine- matic analysis and simulation on parallel vibration reduc- tion seat显示文摘 | Yang Qizhi Huang Guoquan Chen Long | 2011 | Key Engineering Materials2011，464，： | 1 |
| 13 | New lysine-acetylated proteins screened by immunoaffinity and liquid chromatography-mass spectrometry显示文摘The lack of selective extraction specific for lysine-acetylated proteins has been a major problem in the field of acetylation biology,though acetylation plays a key role in many biological processes.In this paper,we report for the first time the proteomic screening of lysine-acetylated proteins from a mouse liver tissue,by a new approach of immunoaffinity purification of lysine-acetylated peptides combined with nano-HPLC/MS/MS analysis.We have found 20 lysine-acetylated proteins with 21 lysine-acetylated sites,among which 12 lysine-acetylated proteins and 16 lysine-acetylated sites have never been reported before.Notably,three acetyltransferases harboring in mitochondrion are newly discovered acetyltransferases responsible for the acetylation of nonhistone proteins.We have explored the significant patterns of residue preference by the hierarchical clustering analysis of amino acid residues surrounding acetylation sites,which could be helpful to the prediction of new sites of lysine acetylation.Our findings provide more candidates for studying the important roles played by acetylation in diverse cellular pathways and related human diseases. | ZHANG Bing ZHAO Chao LUO KaiXuan YAN GuoQuan YAO Jun WANG YingYin LU HaoJie FAN HuiZhi YANG PengYuan | 2010 | Science China Chemistry2010，53，1： | 1 |
| 14 | Delay-dependent stability criterion for neural networks of neutral-type with interval time-varying delays and nonlinear perturbations 显示文摘 | Liu Guoquan Yang S X Fu Wei | 2011 | Advances in Swarm Intelligence2011，6728，： | 1 |
| 15 | Concurrent gemcitabine and cisplatin combined with 3D conformal radiotherapy for stage III non-small cell lung cancer显示文摘对加 cisplatin 的并发的 gemcitabine 的毒性和功效为阶段 III 非小的房间肺癌症(NSCLC ) 与三维的保角的放射疗法相结合的学习客观。有病理地诊断的 NSCLC 的 36 个病人收到了放射疗法和并发的化疗的方法。与 IIIb 有有阶段 IIIa 和 14 个病人的 22 个病人。放射疗法在常规分别被给 60 70 Gy 的一个总数。化疗包括了 gemcitabine (600 mg/m 2) 和 cisplatin (20 mg/m 2), 一次每星期。结果 32 个病人收到了 60 72 Gy 的全部的剂量。二个病人收到了二个病人收到了的 56 Gy 和另外一个 58 Gy。34 个病人 6 星期化疗收到了 4,当二个病人收到了仅仅化疗的 2 个星期时。全面反应率(CR + PR ) ,完全的反应率(CR ) ,部分反应率(PR ) 是 83.3%(30/36 ) , 11.1%(4/36 ) 并且 72.2%(26/36 ) 分别地。中部的后续持续时间是 18.4 个月。1 年、 2 年的全面幸存率是 77.8%(28/36 ) 并且 55.6%(20/36 ) 分别地。为阶段 III 非小的房间肺癌症与三维的保角的放射疗法相结合的结论并发的 gemcitabine 和 cisplatin 有效、很好容忍。孤独术语的结果需要推进学习。 | Qinghua Ke Guoquan Fu Yaowu Bian Daiwen Jiang Jiyuan Yang | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，3： | 1 |
| 16 | Thermoelectric performance enhancement by manipulation of Sr/Ti doping in two sublayers of Ca_(3)Co_(4)O_(9)显示文摘Thermoelectric(TE)performance of Ca_(3)Co_(4)O_(9)(CCO)has been investigated extensively via a doping strategy in the past decades.However,the doping sites of different sublayers in CCO and their contributions to the TE performance remain unrevealed because of its strong correlated electronic system.In this work,Sr and Ti are chosen to realize doping at the[Ca_(2)CoO_(3)]and[CoO_(2)]sublayers in CCO.It was found that figure of merit(ZT)at 957 K of Ti-doped CCO was improved 30% than that of undoped CCO whereas 1 at% Sr doping brought about a 150% increase in ZT as compared to undoped CCO.The significant increase in electronic conductivity and the Seebeck coefficient are attributed to the enhanced carrier concentration and spin-entropy of Co^(4+) originating from the Sr doping effects in[Ca_(2)CoO_(3)]sublayer,which are evidenced by the scanning electron microscope(SEM),Raman,Hall,and X-ray photoelectron spectroscopy(XPS)analysis.Furthermore,the reduced thermal conductivity is attributed to the improved phonon scattering from heavier Sr doped Ca site in[Ca_(2)CoO_(3)]sublayer.Our findings demonstrate that doping at Ca sites of[Ca_(2)CoO_(3)]layer is a feasible pathway to boost TE performance of CCO material through promoting the electronic conductivity and the Seebeck coefficient,and reducing the thermal conductivity simultaneously.This work provides a deep understanding of the current limited ZT enhancement on CCO material and provides an approach to enhance the TE performance of other layered structure materials. | Li ZHANG Yichen LIU Thiam Teck TAN Yi LIU Jian ZHENG Yanling YANG Xiaojiang HOU Lei FENG Guoquan SUO Xiaohui YE Sean LI | 2020 | Journal of Advanced Ceramics2020，9，6： | 1 |
| 17 | Hydrolysis hydrogen production mechanism of Mg10Ni10Ce alloy surface modified by SnO_(2) nanotubes in different aqueous systems显示文摘(Mg-10wt%Ni)-10wt%Ce(Mg10Ni10Ce)was ball-milled with SnO_(2)nanotubes and Mg10Ni10Ce-xSnO_(2)(x¼0,5,10 and 15 wt%)composites have been prepared.The phase compositions,microstructures,morphologies and hydrolysis H2 generation performance in different aqueous systems(distilled water,tap water and simulated seawater)have been investigated and the corresponding hydrolysis mechanism of Mg10Ni10Ce and Mg10Ni10CeeSnO_(2)has been proposed.Adding a small amount of SnO_(2)nanotubes can significantly enhance the hydrolysis reaction of Mg10Ni10Ce,especially the initial hydrolysis kinetics and the final H_(2) generation yield.Unfortunately,the Mg10Ni10Ce-xSnO_(2)hardly reacts with distilled water at room temperature.The hydrolysis reaction rate of Mg10Ni10Cee5SnO_(2)composite in tap water is still very slow with only 17.3%generation yield after 1 h at 303 K.Fortunately,in simulated seawater(3.5 wt%NaCl solution),the hydrolytic H2 generation behavior of the Mg10Ni10Cee5SnO_(2)composite has been greatly improved,which can release as high as 468.6 mL g^(-1 )H_(2) with about 60.9%generation yield within 30 s at 303 K.The Cl destroys the passivation layer on MgeNieCe alloy surface and the added SnO_(2)nanotubes accelerate the hydrolysis reaction rate and enhance the H2 generation yield.The Mg10Ni10Cee5SnO_(2)composite can rapidly generate a large amount of H2 in simulated seawater in a short time,which is expected to be applied on portable H2 generators in the future. | Xiaojiang Hou Lu Yang Kaiming Hou Hongchang Shi Lei Feng Guoquan Suo Xiaohui Ye Li Zhang Yanling Yang | 2021 | Green Energy & Environment2021，6，1： | 1 |
| 18 | Response of peptide intensity to concentration in ESI–MS-based proteome显示文摘High-throughput quantification with label-free methods has received considerable attention in electrospray ionization(ESI)-mass spectrometry(MS),but the manner by which MS signals respond to peptide concentration remains unclear in proteomics.We developed a new mathematical formula to describe the intrinsic log-log relationship between the MS intensity response and peptide concentration in an analytical ESI process.Experimental results showed that the calibration curve is fairly fit to the log-log formula with a linear dynamic range of approximate four to five orders of magnitude.However,we found that the ionization of analytical peptides can be severely suppressed by coexisting matrix peptides,such that the calibration curve can be poorly leveled off on both ends.Our study suggests that the interferences from coexisting matrix peptides should be reduced in the ESI process to use the log-log calibration curve successfully for the high-throughput quantification. | LU WenYuan YIN XueFei LIU XiaoHui YAN GuoQuan YANG PengYuan | 2014 | Science China Chemistry2014，57，5： | 1 |
| 19 | Electrocatalytic reduction of dioxygen at glassy carbon electrodes modified with polypyrrole/anthraquinonedisulphonate composite film in various pH solutions显示文摘 | Guoquan Zhang Fenglin Yang | 2007 | Electrochimica Acta2007，，24： | 1 |
| 20 | Study on figuration technique of grades extrusion fir making metal robber material 显示文摘 | Yang Jianchun Liu Guoquan Bai Hongbai | 2010 | Advance Materials Research2010，，： | 1 |
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