|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020显示文摘African swine fever virus(ASFV)has been circulating in China for more than two years,and it is not clear whether the biological properties of the virus have changed.Here,we report on our surveillance of ASFVs in seven provinces of China,from June to December,2020.A total of 22 viruses were isolated and characterized as genotype II ASFVs,with mutations,deletions,insertions,or short-fragment replacement occurring in all isolates compared with Pig/HLJ/2018(HLJ/18),the earliest isolate in China.Eleven isolates had four different types of natural mutations or deletion in the EP402R gene and displayed a nonhemadsorbing(non-HAD)phenotype.Four isolates were tested for virulence in pigs;two were found to be as highly lethal as HLJ/18.However,two non-HAD isolates showed lower virulence but were highly transmissible;infection with 106 TCID50 dose was partially lethal and caused acute or sub-acute disease,whereas 103 TCID50 dose caused non-lethal,sub-acute or chronic disease,and persistent infection.The emergence of lower virulent natural mutants brings greater difficulty to the early diagnosis of ASF and creates new challenges for ASFV control. | Encheng Sun Zhenjiang Zhang Zilong Wang Xijun He Xianfeng Zhang Lulu Wang Wenqing Wang Lianyu Huang Fei Xi Haoyue Huangfu Ghebremedhin Tsegay Hong Huo Jianhong Sun Zhijun Tian Wei Xia Xuewu Yu Fang Li Renqiang Liu Yuntao Guan Dongming Zhao Zhigao Bu | 2021 | Science China(Life Sciences)2021，64，5： | 46 |
| 2 | Use of a disposable circumcision suture device versus conventional circumcision: a systematic review and meta-analysis显示文摘这系统的评论在冗余的包皮和 phimosis 的治疗估计了可处理的割礼缝术设备(DCSD ) 和常规割礼(CC ) 的安全和功效。二个独立评论家在中国和国外为冗余的包皮或 phimosis 的处理用 DCSD 和 CC 为使随机化的控制试用(RCT ) 进行了文学搜索。九 RCT (1898 个盒子) 被包括。与 CC 组相比, DCSD 组有一更短的起作用的时间(标准化吝啬的差别[SMD ]= 21.44;95% 信心间隔[95% CI ][25.08, 17.79 ] ;P < 0.00001 ) ,更短的创伤愈合时间(SMD = 3.66;95% CI [5.46, 1.85 ] ;P < 0.0001 ) ,更少的 intraoperative 血损失(SMD = 9.64;95% CI [11.37, 7.90 ] ;P < 0.00001 ) ,更好化妆的阴茎外观(机会比率[或]=8.77;95% CI [5.90, 13.02 ] ;P < 0.00001 ) ,更低的 intraoperative 疼痛分数,更低的 24-h 手术后的疼痛分数,感染的更低的发生,更少的切口浮肿,和更少不利事件。在裂开,或 hematoma 的发生的 CC 和 DCSD 组之间没有差别。这元分析的结果显示 DCSD 看起来比 CC 更安全、更有效。然而,有更大的学习人口的另外的高质量的 RCT 被需要。 | Zhong-Chao Huo Gang Liu Xiao-Yan Li Fei Liu Wen-Ju Fan Ru-Hua Guan Pei-Feng Li De-Yang Mo Yong-Zhi He | 2017 | Asian Journal of Andrology2017，19，3： | 19 |
| 3 | Combined effect of atorvastatin and probucol on plasma cystatin C levels and severity of coronary lesion in patients with borderline coronary lesion显示文摘 | GE Chang-jiang LU Shu-zheng FENG Li-xia HUO Yong SONG Xian-tao CHEN Xin MENG Kang YUAN Fei | 2012 | Chinese Medical Journal2012，，14： | 10 |
| 4 | Antioxidant Effect of Human Selenium-containing Single-chain Fv in Rat Cardiac Myocytes显示文摘Reactive oxygen species(ROS) plays a key role in human heart diseases. Glutathione peroxidase(GPX) functions as an antioxidant as it catalyzes the reduction of hydroperoxide. In order to investigate the antioxidant effect of human selenium-containing single-chain Fv(Se-scFv-B3), a new mimic of GPX, a model system of hydrogen peroxide(H2O2)-induced rat cardiac myocyte damage was established. The cardiac myocyte damage was characterized in terms of cell viability, lipid peroxidation, cell membrane integrity, and intracellular H2O2 level. The Se-scFv-B3 significantly reduced H2O2-induced cell damage as shown by the increase of cell viability, the decline of malondialdehyde(MDA) production, lactate dehydrogenase(LDH) release, and intracellular H2O2 level. So Se-scFv-B3 may have a great potential in the treatment of human heart diseases induced by ROS. | HUO Rui SHI Yi XU Jun-jie YAN Fei LV Shao-wu SU Jia-ming DUAN Yu-jing FAN Jia NING Bo CONG Deng-li YAN Gang-lin LUO Gui-min WEI Jing-yan | 2009 | Chemical Research in Chinese Universities2009，25，2： | 8 |
| 5 | Method for calculating non-point source pollution distribution in plain rivers显示文摘The land area in a river network is divided into certain-scale square cells for the sake of precision,and,based on the physical mechanisms of rainfall-runoff processes and runoff pollution,the non-point source pollution from cells is estimated using the export coefficients of different land use types.The non-point source pollution from a land cell should all go into the closest river reach,so it is distributed according to the terrain of the plain river network area and the positions of land cells and river network reaches.A relationship between a single land cell and its pollution-receiving reach can be determined using this system.In view of the above,a spatial distribution model of the rainfall runoff and non-point source pollution in reaches of a plain river network area was established.This model can provide technological support for further research on the dynamic effects of non-point source pollution on water quality. | Long-xi HAN Fei HUO Juan SUN | 2011 | Water Science and Engineering2011，4，1： | 7 |
| 6 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 7 | An efficient and fast polarity optimization approach for mixed polarity Reed-Muller logic circuits显示文摘尽管基因算法广泛地在混合极性芦苇思考(MPRM ) 逻辑电路的极性优化被使用了,很少研究考虑了极性变换顺序。以便改进 MPRM 逻辑电路的极性优化的效率,我们就极性变换顺序而言建议一条有效、快的极性优化途径(FPOA ) 。第一,在 FPOA 后面的主要想法是那等评估的极性集合的最好的极性变换顺序被使用建议混合基因算法(HGA ) 获得;第二,每在极性集合的极性根据 HGA 获得的最好的极性变换顺序被变换。我们的建议 FPOA 在 C 被实现,比较分析为 MCNC 基准电路被介绍了。试验性的结果证明为有更多的变量的电路, FPOA 在与极性变换顺序和改进极性优化与启发式的技术接近疏忽的传统的极性优化途径相比改进 MPRM 逻辑电路的极性优化的效率是高度有效的。 | Zhenxue HE Limin XIAO Fei GU Tongsheng XIA Shubin SU Zhisheng HUO Rong ZHANG Longbing ZHANG Li RUAN Xiang WANG | 2017 | Frontiers of Computer Science2017，11，4： | 6 |
| 8 | Microbial bioavailability of dissolved organic nitrogen(DON) in the sediments of Lake Shankou,Northeastern China显示文摘Dissolved organic nitrogen(DON)extracted from Lake Shankou sediments using KCl was isolated into hydrophobic and hydrophilic fractions.The bioavailabilities of the hydrophobic and hydrophilic fractions to three types of bacterial communities collected from sediments,activated sludge and compost products were examined.The DON recoveries obtained by DAX-8 and cation exchange resins treatment were 96.17% ± 1.58% and 98.14% ±0% for the samples obtained from N4 and N14 stations,respectively.After 25 days of incubation at 25°C,most DON(59% to 96%)was degraded.Hydrophilic DON exhibited a higher reduction rate than hydrophobic DON during the growth phase.Untreated wastewater from Changshuihe town was the main degradable DON source to station N4,and 93% of hydrophilic DON and 80% of hydrophobic DON were degraded.Station N14 received a large amount of refractory DON from forest soils and exhibited DON degradation rates of 82% and 71% for the hydrophilic and hydrophobic fractions,respectively.Amino acid contents and fluorescence intensities were also analyzed.Approximately 27% to 74% of amino acids were taken up by day 5,and their concentration gradually increased in the following days due to the decomposition of dissolved proteins.Parallel factor analysis resulted in identification of tryptophan-like proteins,tyrosine-like proteins and FA-like substances.During the growth phase,40%–51% of the tryptophan-like proteins were taken up by bacteria,and the accumulation of tyrosine-like proteins was attributed to the release of biotic substances.The concentration of the FA-like substances decreased due to microbial decomposition. | Mingzhou Su Jingtian Zhang Shouliang Huo Beidou Xi Fei Hua Fengyu Zan Guangren Qian Jianyong Liu | 2016 | Journal of Environmental Sciences2016，28，4： | 5 |
| 9 | A Power and Area Optimization Approach of Mixed Polarity Reed-Muller Expression for Incompletely Specified Boolean Functions显示文摘力量和芦苇思考(RM ) 电路的区域优化广泛地被担心了。然而,几乎没有退出的力量和区域,优化来临能获得所有 Pareto 原版的最佳的答案问题并且足够有效。而且,他们没认为 dont 是照顾术语,它使电路成为性能不能进一步优化。在这糊,我们建议混合极性 RM 的一条力量和区域优化途径为不完全地指定的布尔功能的表示(MPRM ) 基于非统治的排序基因算法 II (NSGA-II ) 。第一,不完全地指定的布尔功能不完全地被转变成零极性由使用的指定 MPRM (ISMPRM ) 一篇小说 ISMPRM 获得算法。第二,极性和分配 ISMPRM 的照顾术语没作为染色体被编码。最后, Pareto 最佳的答案被使用 NSGA-II 获得,在里面哪个 MPRM 相应于给定的染色体被使用一个染色体获得变换算法。结果上重要力量和区域改进能与存在力量和区域优化相比被做的电路表演 RM 接近的不完全地指定的布尔功能和 MCNC 基准电路。 | Zhen-Xue He Li-Min Xiao Li Ruan Fei Gu Zhi-Sheng Huo Guang-Jun Qin Ming-Fa Zhu F Long-Bing Zhang Rui Liu Xiang Wang | 2017 | Journal of Computer Science & Technology2017，32，2： | 4 |
| 10 | Recent advances in developing small-molecule inhibitors against SARS-CoV-2显示文摘The COVID-19 pandemic caused by the novel SARS-CoV-2 virus has caused havoc across the entire world.Even though several COVID-19 vaccines are currently in distribution worldwide,with others in the pipeline,treatment modalities lag behind.Accordingly,researchers have been working hard to understand the nature of the virus,its mutant strains,and the pathogenesis of the disease in order to uncover possible drug targets and effective therapeutic agents.As the research continues,we now know the genome structure,epidemiological and clinical features,and pathogenic mechanism of SARS-CoV-2.Here,we summarized the potential therapeutic targets involved in the life cycle of the virus.On the basis of these targets,small-molecule prophylactic and therapeutic agents have been or are being developed for prevention and treatment of SARS-CoV-2 infection. | Rong Xiang Zhengsen Yu Yang Wang Lili Wang Shanshan Huo Yanbai Li Ruiying Liang Qinghong Hao Tianlei Ying Yaning Gao Fei Yu Shibo Jiang | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
| 11 | Surgery for sinus of Valsalva aneurysm: 33-year of a single center experience显示文摘 | Yan Fei Murat Abudureheman Huo Qiang Askaer Shabiti Zhu Tao Liu Zhen | 2014 | Chinese Medical Journal2014，，23： | 3 |
| 12 | Algal uptake of dissolved organic nitrogen in wastewater treatment plants显示文摘The algal uptake of dissolved organic nitrogen(DON) in the anaerobic–anoxic–oxic(A_2O)process was investigated in this study. Anaerobic, aerobic and effluent DON samples from two wastewater treatment plants(WWTPs) were separated into hydrophilic and hydrophobic fractions using a DAX-8 resin coupled with an anion exchange resin and a nanofiltration(NF)pretreatment. Hydrophilic DON accounted for 66.66%–88.74% of the entire DON for the two plants evaluated. After a 15-day incubation, 16.95%–91.75% DON was bioavailable for algal growth, and untreated samples exhibited higher DON bioavailability, with 52.83% DON average uptake rates, compared with the hydrophilic and hydrophobic fractions(45.53% and 44.40%, respectively) because the pretreatment caused the inorganic salt to be resistant to algae. Anaerobic untreated samples, hydrophilic fractions and hydrophobic fractions showed higher DON reduction rates and higher biomass accumulation compared with the other DON fractions due to the decomposition of resistant organics by anaerobic and anoxic bacteria.DON in aerobic and effluent samples of plant A was more bioavailable than that of plant B with usages of 27.49%–55.26% DON. DON bioavailability in the anaerobic–anoxic–oxic process decreased in the following order: anaerobic > effluent > aerobic. The DON contents were reduced after anaerobic treatment in the two plants. The EEM-PARAFAC model identified three DON components, including two humic acid-like substances and one protein-like substance in plant A and two protein-like substances and one humic acid-like substance in plant B. | Jingtian Zhang Mingzhou Su Beidou Xi Guangren Qian Jianyong Liu Fei Hua Shouliang Huo | 2016 | Journal of Environmental Sciences2016，28，12： | 3 |
| 13 | Successful treatment with tocilizumab in a patient with rapidly progressive interstitial lung disease with positive anti-melanoma differentiation-associated gene-5 antibody显示文摘To the Editor:Anti-melanoma differentiation-associated gene 5(MDA-S)positive interstitial lung disease(ILD)is featured by rapidly progressing respiratory failure and limited hospital survival.No standard therapy has been established or proven to be beneficial.Herein,we report a case of a rapidly progressing patient diagnosed of ILD with positive anti-MDA-5 antibody receiving tocilizumab treatment. | Fei Teng Jin-Min Peng Qian Wang Xin-Lun Tian Zhen Huo Li Weng | 2021 | Chinese Medical Journal2021，，8： | 3 |
| 14 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 15 | Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study显示文摘Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women. | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 2 |
| 16 | Novel completed biodegradable polymer sirolimus-eluting stent versus durable polymer sirolimus-eluting stent in de novo lesions: nine-month angiographic and three-year clinical outcomes of HOPE trial显示文摘 | Yuan Fei Chen Xin Song Xiantao Wang Dongqi Zhang Zheng Li Weimin Li Zhanquan Li Hui Chen Xinyi Huo Yong Wang Lefeng Lu Caiyi Lu Qinghua Xu Bo Li Wei Lyu Shuzheng | 2014 | Chinese Medical Journal2014，，14： | 2 |
| 17 | Supramolecular binding of amines with functional magnesium tetraphenylporphyrin for CO_2 capture显示文摘In this work,magnesium tetraphenylporphyrin(MgTPP) was used as a new supramolecular amine-fixing agent.Once introduced,CO_2 easily competes with MgTPP for amines,leading to the release of MgTPP. The processes can be explained by the fact that the association constant(K_(assoc)) values of MgTPP with amines were in the range of 0.6(ethanolamine) to 3.9(ethylenediamine),which are lower than the K_(assoc) values of CO_2 with these amines.MgTPP interacted with aniline,ethanolamine,pyrrolidine,or ethylenediamine to form 1:1 adducts.Ethylenediamine presents a stronger K_(assoc) value for MgTPP,so it was considered an optimal agent for CO_2 capture. | Fei Gao Jian-Bin Zhang Chun-Ping Li Tian-Rui Huo Xiong-Hui Wei | 2013 | Chinese Chemical Letters2013，24，3： | 2 |
| 18 | In Vitro Assessment of Probiotic Potential of Lactobacilus acidophilus and Antagonistic Activity Against Escherichia coli O157:H7显示文摘The antagonistic activity of Lactobacillus acidophilus KLDS1.0901,KLDS1.0902,KLDS1.1003 and NCFM against Escherichia coli O157:H7 were investigated in this study.The culture supernatants of all the L.acidophilus stains showed high bacteriostatic activities against E.coli O157:H7 and the bacteriostatic substances of their Cell-Free Supernatants(CFS)were preliminarily determined from organic acids.The bacteriostatic activity from CFS or viable L.acidophilus against E.coli O157:H7was also assessed by using co-incubation methods,CFS had high bactericidal activity against E.coli O157:H7,no viable E.coli O157:H7 was detected when 5×107 cfu of E.coli O157:H7 was added to 5 m L of CFS and incubated at 37℃for 2 h.However,L.acidophilus themselves had no bacteriostatic activity after directly contacted with E.coli O157:H7.The inhibition E.coli O157:H7adhesion and colonization of L.acidophilus were also investigated based on competition,exclusion and displacement assays.L.acidophilus KLDS1.0901,KLDS1.1003 and NCFM strains were effective to displace E.coli O157:H7 from a Caco-2 cell layer in competition and exclusion assays.However,in displacement assay,all of the strains showed no signifi cant antagonistic activities.Meanwhile,the probiotic potential of L.acidophilus strains was investigated based on adhesion assay to Caco-2 cells and antiinfl ammatory effects by IL-8 produced in Caco-2 cells.The adhesion ability and anti-infl ammatory effects of L.acidophilus strains showed a strain-dependent manner.In general,L.acidophilus KLDS1.0901 and NCFM showed better probiotic potential than KLDS1.0902 and KLDS1.1003.Thus,the use of L.acidophilus KLDS1.0901 and NCFM to prevent or treat of diseases associated induced E.coli O157:H7 in vivo was suggested. | Du Jin-cheng Liu Fei Li Bai-liang Bian Xin Smith Etareri Evivie Xu Min Ding Xiu-yun Huo Gui-cheng | 2017 | Journal of Northeast Agricultural University(English Edition)2017，24，1： | 1 |
| 19 | Development and evaluation of a loop-mediated isothermal amplification method for detecting Escherichia coli O157 in raw milk显示文摘 | WANG Deguo LIU Fei HUO Guicheng | 2009 | Journal of Rapid Methods and Automation in Microbiology2009，17，： | 1 |
| 20 | Effect of copper content on Cu-Mn-Zn/zeolite-Y catalysts for the synthesis of dimethyl ether from syngas 显示文摘 | Fei Jin-Hua Tang Xiu-Juan Huo Zhou-Yin | 2006 | Catal Cnmmun2006，7，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员