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| 1 | 计及时变系统完整非线性的振荡模式分析显示文摘提出评估非自治非线性因素对振荡行为影响程度的指标。其绝对值在定常的线性模型下严格为0,并随着时变性或非线性影响的增强而增加。据此,可量化地比较不同因素的影响。受扰轨迹完整地反映了时滞环节及离散控制等本质非线性因素和时变因素对系统动态行为的影响。采用小波脊方法估算受扰轨迹在适当宽度的时间窗口内的振荡模式,并随着窗口的滑动得到振荡模式的时间序列。用该序列可以量化非自治非线性振荡的特性,并指导对大振幅低频振荡的分析与控制。仿真发现,即使是3机9节点的小系统,其动态行为也可能不同于平衡点特征根的描述,而平衡点特征根甚至可能丢掉最危险的非线性模式。 | 薛禹胜 潘学萍 Guorui ZHANG Zhaoyang DONG Gerard LEDWICH | 2008 | 电力系统自动化2008，32，18： | 22 |
| 2 | Contrasting elevational diversity patterns for soil bacteria between two ecosystems divided by the treeline显示文摘Above- and below-ground organisms are closely linked, but how elevational distribution pattern of soil microbes shifting across the treeline still remains unknown. Sampling of 140 plots with transect, we herein investigated soil bacterial distribution pattern from a temperate forest up to a subalpine meadow along an elevational gradient using Illumina sequencing. Our results revealed distinct elevational patterns of bacterial diversity above and below the treeline in responding to changes in soil conditions:a hollow elevational pattern in the forest(correlated with soil temperature, pH, and C:N ratio) and a significantly decreasing pattern in the meadow(correlated with soil pH, and available phosphorus). The bacterial community structure was also distinct between the forest and meadow, relating to soil pH in the forest and soil temperature in the meadow. Soil bacteria did not follow the distribution pattern of herb diversity, but bacterial community structure could be predicted by herb community composition. These results suggest that plant communities have an important influence on soil characteristics, and thus change the elevational distribution of soil bacteria. Our findings are useful for future assessments of climate change impacts on microbial community. | Guixiang Li Guorui Xu Congcong Shen Yong Tang Yuxin Zhang Keming Ma | 2016 | Science China(Life Sciences)2016，59，11： | 9 |
| 3 | Electro-mechanically controlled assembly of reconfigurable 3D mesostructures and electronic devices based on dielectric elastomer platforms显示文摘The manufacture of 3D mesostructures is receiving rapidly increasing attention,because of the fundamental significance and practical applications across wide-ranging areas.The recently developed approach of buckling-guided assembly allows deterministic formation of complex 3D mesostructures in a broad set of functional materials;with feature sizes spanning nanoscale to centimeter-scale.Previous studies mostly exploited mechanically controlled assembly platforms using elastomer substrates;which limits the capabilities to achieve on-demand local assembly;and to reshape assembled mesostructures into distinct 3D configurations.This work introduces a set of design concepts and assembly strategies to utilize dielectric elastomer actuators as powerful platforms for the electro-mechanically controlled 3D assembly.Capabilities of sequential-local loading with desired strain distributions allow access to precisely tailored 3D mesostructures that can be reshaped into distinct geometries,as demonstrated by experimental and theoretical studies of?30 examples.A reconfigurable inductive-capacitive radio-frequency circuit consisting of morphable 3D capacitors serves as an application example. | Wenbo Pang Xu Cheng Haojie Zhao Xiaogang Guo Ziyao Ji Guorui Li Yiming Liang Zhaoguo Xue Honglie Song Fan Zhang Zheng Xu Lei Sang Wen Huang Tiefeng Li Yihui Zhang | 2020 | National Science Review2020，7，2： | 8 |
| 4 | Development of welding technique for petrochemical industry in China显示文摘DevelopmentofweldingtechniqueforpetrochemicalindustryinChina￥LIQinglin(Sino-PetrochemicalCorporation,Beijing(100029)ZHOUZhend... | LI Qinglin (Sino-Petrochemical Corporation, Beijing (100029)ZHOU Zhende and CHEN Ke (Sinopec Yanshan Petrochemical Company, Beijing)ZHEN Guorui and ZHANG Youchuan (The Third Construction Company of Sinopec, Beijing) | 1994 | China Welding1994，3，2： | 7 |
| 5 | Role of C5a-C5aR axis in the development of atherosclerosis显示文摘Complement component 5a(C5a)is a 74 amino acid glycoprotein and an important proinflammatory mediator that is cleaved enzymatically from its precursor,C5,on activation of the complement cascade.C5a is quickly metabolised by carboxypeptidases,forming the less-potent C5a desArg.C5a and C5a desArg interact with their receptors(C5aR and C5L2),which results in a number of effects which are essential to the immune response.C5a has a broad range of biological effects throughout the human body because the widespread expression of C5a receptors throughout the human organs enables C5a and C5a desArg to elicit a broad range of biological effects.Recently,accumulating evidence in humans and experimental animal models shows that the C5a-C5aR axis is involved in the development of atherosclerosis lesions.The absence or blockade of C5aRs greatly reduces the formation of atherosclerotic lesions or wire-injury-induced neointima formation in atherosclerosis-prone mice.Serum C5a level was related to the major adverse cardiovascular events in patients with advanced atherosclerosis and those with drug-eluting stent implantation.Thus,the C5a-C5aR axis may be a significant pathogenic driver of arteriosclerotic vascular disease,making C5a-C5aR inhibition an attractive therapeutic strategy. | AN GuiPeng REN GuoRui AN FengShuang ZHANG Cheng | 2014 | Science China(Life Sciences)2014，57，8： | 6 |
| 6 | Region-based classification by combining MS segmentation and MRF for POLSAR images显示文摘Speckle effects on classification results can be suppressed to some extent by introducing the contextual information.An unsupervised classification algorithm is proposed for polarimetric synthetic aperture radar(POLSAR) images based on the mean shift(MS) segmentation and Markov random field(MRF).First,polarimetric features are exacted by target decomposition for MS segmentation.An initial classification is executed by using the target decomposition and the agglomerative hierarchical clustering algorithm.Thereafter,a classification step based on MRF is performed by using the mean coherence matrices obtained for each segment.Under the MRF framework,the smoothness term is defined according to the distance between neighboring areas.By using POLSAR images acquired by the German Aerospace Centre and National Aeronautics and Space Administration/Jet Propulsion Laboratory,the experimental results confirm that the proposed method has higher accuracy and better regional connectivity than other classification methods. | Bin Zhang Guorui Ma Zhi Zhang Qianqing Qin | 2013 | Journal of Systems Engineering and Electronics2013，24，3： | 5 |
| 7 | Endothelial cells-targeted soluble human Delta-like 4 suppresses both physiological and pathological ocular angiogenesis显示文摘Due to its essential roles in angiogenesis, Notch pathway has emerged as an attractive target for the treatment of pathologic angiogenesis. Although both activation and blockage of Notch signal can impede angiogenesis, activation of Notch signal may be more promising because it was shown that long-term Notch signal blockage resulted in vessel neoplasm. However, an in vivo deliverable Notch ligand with highly efficient Notch-activating capacity has not been developed. Among all the Notch ligands, Delta-like4(Dll4) is specifically involved in angiogenesis. In this study, we generated a novel soluble Notch ligand h D4 R, which consists of the Delta-Serrate-Lag-2 fragment of human Dll4 and an arginine-glycine-aspartate(RGD) motif targeting endothelial cells(ECs). We demonstrated that h D4 R could bind to ECs through its RGD motif and effectively triggered Notch signaling in ECs. Further, we confirmed that h D4 R could suppress angiogenesis in vitro as manifested by network formation assay and sprouting assay. More importantly, h D4 R efficiently repressed neonatal retinal angiogenesis and laser-induced choroidal neovascularization(CNV) as well in vivo. In conclusion, we have developed an in vivo deliverable Notch ligand h D4 R, which suppresses angiogenesis both in vitro and in vivo, thus providing a new approach to tackle excessive angiogenesis relevant disease such as CNV. | YAN XianChun YANG ZiYan CHEN Yan LI Na WANG Li DOU GuoRui LIU Yuan DUAN JuanLi FENG Lei DENG SanMing HAN Hua ZHANG Ping | 2015 | Science China(Life Sciences)2015，58，5： | 5 |
| 8 | Optical characteristics of Ce,Eu:YAG single crystal grown by Czochralski method显示文摘Eu-doped Ce:YAG single crystal(SC) was fabricated by the Czochralski method. The crystal structure,optical and photoelectric property of the constructed w-LED was investigated. The XRD and HRTEM results show that YAG crystal structure has little change when Eu^(3+), Ce^(3+) are doped. Absorption spectra and photoluminescence spectra show that the Ce,Eu:YAG single crystal can effectively absorb the 460 nm blue light to form a broadband emission center at 530 nm, decay curves of the crystal show that the energy transfer between Ce^(3+) and Eu^(3+) is highly suppressed. Compared with commercial Ce:YAG phosphor, Ce,Eu:YAG exhibits better thermal stability. | Jingfeng Zhang Guorui Gu Xiaoxuan Di Weidong Xiang Xiaojuan Liang | 2019 | Journal of Rare Earths2019，37，2： | 4 |
| 9 | Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling显示文摘The link of hedgehog (Hh) signaling activation to human cancer and synthesis of a variety of Hh signaling inhibitors raise great expectation that inhibiting Hh signaling may be effective in human cancer treatment. Cyclopamine (Cyc), an alkaloid from the Veratrum plant, is a specific natural product inhibitor of the Hh pathway that acts by targeting smoothened (SMO) protein. However, its poor solubility, acid sensitivity, and weak potency relative to other Hh antagonists prevent the clinical development of Cyc as a therapeutic agent. Here, we report properties of cyclopamine tartrate salt (CycT) and its activities in Hh signaling-mediated cancer in vitro and in vivo. Unlike Cyc, CycT is water soluble (5-10 mg/mL). The median lethal dose (LD50) of CycT was 62.5 mg/kg body weight compared to 43.5 mg/kg for Cyc, and the plasma half-life (T1/2) of CycT was not significantly different from that of Cyc. We showed that CycT had a higher inhibitory activity for Hh signaling-dependent motor neuron differentiation than did Cyc (IC50 = 50 nmol/L for CycT vs. 300 nmol/L for Cyc). We also tested the antitumor effectiveness of these Hh inhibitors using two mouse models of basal cell carcinomas (K14cre:Ptch1neo/neo and K14cre:SmoM2YFP). After topical application of CycT or Cyc daily for 21 days, we found that all CycT-treated mice had tumor shrinkage and decreased expression of Hh target genes. Taken together, we found that CycT is an effective inhibitor of Hh signaling-mediated carcinogenesis. | Qipeng Fan Dongsheng Gu Miao He Hailan Liu Tao Sheng Guorui Xie Ching-xin Li Xiaoli Zhang Brandon Wainwright Arash Garrossian Massoud Garrossian Dale Gardner Jingwu Xie | 2011 | Chinese Journal of Cancer2011，30，7： | 3 |
| 10 | Effects of Solvent Molecules on the Interlayer Spacing of Graphene Oxide显示文摘Graphene oxide(GO) contains numerous functional groups that facilitate the intercalation of polar solvents. The properties and applications of GO are closely related to its interlayer spacing. We report on the changes in the interlayer spacing of GO after the adsorption of water molecules and the polar organic solvents C_2H_6O_2(EG), C_3H_7NO(DMF), C_5H_9NO(NMP). Experiments were conducted to investigate the variations in the functional groups and structure of GO after solvent adsorption, and they play a vital role in modeling and verifying the results of molecular dynamics simulation. The most stable GO structures are obtained through molecular dynamics simulation. The expansion of the interlayer spacing of GO after the adsorption of monolayer solvent molecules corresponds to the minimum three-dimensional size of the solvent molecules. The spatial arrangement of solvent molecules also contributes to the changes in interlayer spacing. Most adsorbed molecules are oriented parallel to the carbon plane of GO. However, as additional molecules are adsorbed into the interlaminations of GO, the adsorbed molecules are oriented perpendicular to the carbon plane of GO, and a large space forms between two GO interlayers. In addition, the role of large molecules in increasing interlayer spacing becomes more crucial than that of water molecules in the adsorption of binary solvent systems by GO. | Liyan Liu Ruifeng Zhang Ying Liu Haonan Zhu Wei Tan Guorui Zhu Yang Wang | 2018 | Transactions of Tianjin University2018，24，6： | 3 |
| 11 | The Arabidopsis pentatricopeptide repeat protein PDM1 is associated with the intergenic sequence of S11-rpoA for rpoA monocistronic RNA cleavage显示文摘The PDM1 gene encodes a pentatricopeptide repeat protein of the PLS subfamily.It is essential for rpoA polycistronic processing in Arabidopsis.In this study,we performed functional analysis of PDM1 in rpoA monocistronic cleavage and chloroplast development.The pdm1 mutants display an albino lethal phenotype with severe chloroplast development defects.When the construct of PDM1 fused with the GFP gene was introduced into Arabidopsis protoplasts,the GFP signal was exclusively observed in chloroplasts.This shows that PDM1 is localized to chloroplast.In the wild type,the rpoA transcript of about 990 nt is processed.In pdm1,this transcript is absent.However,Western blot showed that the RpoA protein in pdm1 is accumulated at a level approximately 1/3 of the wild type.This suggests that certain other transcripts processed from L23-L2-S19-L22-S3-L16-L14S8-L36-S11-rpoA polycistronic precursor may be used as templates for protein translation.To determine whether PDM1 can bind to the rpoA pre-mRNA,we generated a transgenic Arabidopsis line with PDM1 fused to FLAG tag that was capable of complementing the pdm1-1 mutant phenotype.RNA immunoprecipitation analysis showed that PDM1 is associated with S11-rpoA intergenic sequence.This indicates that PDM1 may bind to the S11-rpoA intergenic region to perform rpoA processing. | YIN QianQian CUI YongLan ZHANG GuoRui ZHANG HongDao WANG XiaoMeng YANG ZhongNan | 2012 | Chinese Science Bulletin2012，57，26： | 2 |
| 12 | ISG20 inhibits bluetongue virus replication显示文摘ISG20 is an interferon-inducible exonuclease that inhibits virus replication.Although ISG20 is thought to degrade viral RNA,the antiviral mechanism and specificity of ISG20 remain unclear.In this study,the antiviral role of ovine ISG20(o ISG20)in bluetongue virus(BTV)infection was investigated.It was found that BTV infection upregulated the transcription of ovine ISG20(o ISG20)in a time-and BTV multiplicity of infection(MOI)-dependent manner.Overexpression of o ISG20 suppressed the production of BTV genome,proteins,and virus titer,whereas the knockdown of o ISG20 increased viral replication.o ISG20 was found to co-localize with BTV proteins VP4,VP5,VP6,and NS2,but only directly interacted with VP4.Exonuclease defective o ISG20 significantly decreased the inhibitory effect on BTV replication.In addition,the interaction of mutant o ISG20 and VP4 was weakened,suggesting that binding to VP4 was associated with the inhibition of BTV replication.The present data characterized the anti-BTV effect of o ISG20,and provides a novel clue for further exploring the inhibition mechanism of double-stranded RNA virus by ISG20. | Di Kang Shandian Gao Zhancheng Tian Guorui Zhang Guiquan Guan Guangyuan Liu Jianxun Luo Junzheng Du Hong Yin | 2022 | Virologica Sinica2022，37，4： | 2 |
| 13 | Research and practice of intelligent coal mine technology systems in China显示文摘This study considered the role of coal as China’s basic energy source and examines the development of the coal industry.We focused on the intelligent development of coal mines,and introduced the“Chinese mode”of intelligent mining in underground coal mines,which uses complete sets of technical equipment to propose classifcation and grading standards.In view of the basic characteristics and technical requirements of intelligent coal mine systems,we established a digital logic model and propose an information entity and knowledge map construction method.This involves an active information push strategy based on a knowledge demand model and an intelligent portfolio modeling and distribution method for collaborative control of coal mines.The top-level architecture of 5G+intelligent coal mine systems combines intelligent applications such as autonomous intelligent mining,human–machine collaborative rapid tunneling,unmanned auxiliary transportation,closed-loop safety control,lean collaborative operation,and intelligent ecology.Progress in intelligent mining technology was described in terms of a dynamic modifed geological model,underground 5G network and positioning technology,intelligent control of the mining height and straightness of the longwall working face,and intelligent mining equipment.The development of intelligent coal mines was analyzed in terms of its imbalances,bottlenecks,and the compatibility of large-scale systems.Implementation ideas for promoting the development of intelligent coal mines were proposed,such as establishing construction standards and technical specifcations,implementing classifcation and grading standards according to mining policy,accelerating key technology research,and building a new management and control model. | Guofa Wang Huaiwei Ren Guorui Zhao Desheng Zhang Zhiguo Wen Lingyu Meng Shixin Gong | 2022 | International Journal of Coal Science & Technology2022，9，2： | 2 |
| 14 | Geochemical and geochronological studies of the Aketas granite from Fuyun County, Xinjiang: the implications of the petrogenesis and tectonic setting显示文摘As the wall rock of the Aketas gold deposit,the Aketas granite is about 45 km away from Fuyun County, Xinjiang Province. The zircon weighted mean U–Pb age of the Aketas granite is 309.0 ± 4.7 Ma, indicating that the Aketas granite was emplaced during the late Carboniferous. The Aketas granite belongs to the High-K calcalkaline series, with Si O2 content from 63.00 to 68.20 %,K2 O content from 3.06 to 4.49 % and Na2 O content from4.14 to 6.02 %. The Alkaline Ratio(AR) of the Aketas granite is high, from 1.89 to 3.47, and is 2.95 on average.The Aketas granite has lowPREE(92.42–122.73 ppm)and highPLREE/PHREE ratios(6.54–11.88). For the trace elements, the Aketas granite is enriched in LILE(Rb,U, Th, K) and incompatible elements, and marked depleted in HFSE(Nb, Ta, P, Ti). The geochemical characteristics of the Aketas granite suggest that it is a typical I-type and volcanic arc granite, and that the crystallization of clinopyroxene and hornblende is notable during the magmatic evolution. In combination with the regional tectonic studies, we propose that the emplacement of the Aketas granite implies the Altai and East Junggar area was still dominated by a subduction system at *309 Ma. | Xiaofeng Wei Xin Zhang Jiuhua Xu Rufu Ding Guorui Zhang Yong Tang | 2015 | Chinese Journal Of Geochemistry2015，34，4： | 1 |
| 15 | Influence of backfilling rate on the stability of the'backfilling bodyimmediate roof'cooperative bearing structure显示文摘To reduce the cost of backfilling coal mining and utilize the underground space of coal mines,a new backfilling mining method with low backfilling rate called constructional backfilling coal mining(CBCM)is proposed.The 'backfilling body-immediate roof' cooperative bearing structure of CBCM is analyzed by establishing the model of the medium thick plate on an elastic foundation.The influence of the backfilling rate on the stability of overlying strata is analyzed by the numerical simulation experiment.The control effect of CBCM is verified by a physic similar simulation test.The economic benefit of CBCM is analyzed.The conclusions are:the deformation characteristics of the immediate roof and critical backfilling spacing in CBCM can be analyzed based on the Hu Haichang’s theory.Exerting the bearing capacity of the immediate roof is beneficial to the stability of the overlying strata.The CBCM has a good control effect on the overburden in Xinyang Mine when the backfilling rate is lower than 25%.The backfilling cost of per ton coal is 37.39 yuan/t when the backfilling rate is 13.7%,with a decrease rate of 56.63%than the full-filling.The research results can provide theoretical support for the application of CBCM in coal mining. | Xianjie Du Guorui Feng Min Zhang Zehua Wang Wenhao Liu | 2022 | International Journal of Mining Science and Technology2022，32，6： | 1 |
| 16 | Diagnosis of ABCB11 gene mutations in children with intrahepatic cholestasisusing high resolution melting analysis and direct sequencing显示文摘 | Guorui Hu Ping He Zhifeng Liu Qian Chen Bixia Zheng Qihua Zhang | 2014 | Molecular Medicine Reports2014，，3： | 1 |
| 17 | Fabrication of Cdl-,ZnS/ TiO2 heterostmctures with enhanced photocatalytic activity 显示文摘 | Yang Guorui Zhang Qian Chang Wei | 2013 | Jo- urnal of Alloys and Compounds2013，580，24： | 1 |
| 18 | An experiment study of the propagation of radio waves in a scaled model of long-wall coal mining tunnels 显示文摘 | Han Guorui Zhang Wenmei Zhang Y P | 2009 | IEEE Antennas and Wireless Propagation Letters2009，8，： | 1 |
| 19 | An Experiment Study of the Propagation of Radio Waves in a Scaled Model of Long-Wall Coal Mining Tunnels显示文摘 | Han Guorui Zhang Wenmei Zhang Y P | 2009 | IEEE Antennas and Wireless PropagationLetters2009，，8： | 1 |
| 20 | High Dynamic Range Compression and Detail Enhancement of Infrared Images in the Gradient Domain 显示文摘 | ZHANG Feifei XIE Wei MA Guorui | 2014 | Infrared Physics & Technology2014，67，11： | 1 |
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