|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Endothelial cells-targeted soluble human Delta-like 4 suppresses both physiological and pathological ocular angiogenesis显示文摘Due to its essential roles in angiogenesis, Notch pathway has emerged as an attractive target for the treatment of pathologic angiogenesis. Although both activation and blockage of Notch signal can impede angiogenesis, activation of Notch signal may be more promising because it was shown that long-term Notch signal blockage resulted in vessel neoplasm. However, an in vivo deliverable Notch ligand with highly efficient Notch-activating capacity has not been developed. Among all the Notch ligands, Delta-like4(Dll4) is specifically involved in angiogenesis. In this study, we generated a novel soluble Notch ligand h D4 R, which consists of the Delta-Serrate-Lag-2 fragment of human Dll4 and an arginine-glycine-aspartate(RGD) motif targeting endothelial cells(ECs). We demonstrated that h D4 R could bind to ECs through its RGD motif and effectively triggered Notch signaling in ECs. Further, we confirmed that h D4 R could suppress angiogenesis in vitro as manifested by network formation assay and sprouting assay. More importantly, h D4 R efficiently repressed neonatal retinal angiogenesis and laser-induced choroidal neovascularization(CNV) as well in vivo. In conclusion, we have developed an in vivo deliverable Notch ligand h D4 R, which suppresses angiogenesis both in vitro and in vivo, thus providing a new approach to tackle excessive angiogenesis relevant disease such as CNV. | YAN XianChun YANG ZiYan CHEN Yan LI Na WANG Li DOU GuoRui LIU Yuan DUAN JuanLi FENG Lei DENG SanMing HAN Hua ZHANG Ping | 2015 | Science China(Life Sciences)2015，58，5： | 5 |
| 2 | An experiment study of the propagation of radio waves in a scaled model of long-wall coal mining tunnels 显示文摘 | Han Guorui Zhang Wenmei Zhang Y P | 2009 | IEEE Antennas and Wireless Propagation Letters2009，8，： | 1 |
| 3 | An Experiment Study of the Propagation of Radio Waves in a Scaled Model of Long-Wall Coal Mining Tunnels显示文摘 | Han Guorui Zhang Wenmei Zhang Y P | 2009 | IEEE Antennas and Wireless PropagationLetters2009，，8： | 1 |
| 4 | An experiment study ofthe propagation of radio waves in a scaled model of long-wall coalmining tunnels 显示文摘 | Han Guorui Zhang Wenmei Zhang Y P | 2009 | IEEE Antennas and Wireless PropagationLetters2009，，8： | 1 |
| 5 | An Experiment Study of the Propagation of Radio Waves in a Scaled Model of Long-Wall Coal Mining Tunnels显示文摘 | Han Guorui Zhang Wenmei Zhang Y P | 2009 | IEEE Antennas and Wireless Propagation Letters2009，，8： | 1 |
| 6 | Effect of calcination temperature on the pozzolanic activity of maize straw stem ash treated with portlandite solution显示文摘The effect of calcination temperature on the pozzolanic activity of maize straw stem ash(MSSA)was evaluated.The MSSA samples calcined at temperature values of 500,700,and 850℃ were dissolved in portlandite solution for 6 h,thereby obtaining residual samples.The MSSA and MSSA residual samples were analyzed using Fourier transform infrared spectroscopy,X-ray powder diffraction scanning electron microscopy,and X-ray photoelectron spectroscopy to determine vibration bonds,minerals,microstructures,and Si 2p transformation behavior.The conductivity,pH value,and loss of conductivity with dissolving time of the MSSA-portlandite mixed solution were also determined.The main oxide composition of MSSA was silica and potassium oxide.The dissolution of the Si^(4+) content of MSSA at 500℃ was higher than those of the other calcination temperatures.The conductivity and loss of conductivity of MSSA at 700℃ were higher than those of the other calcination temperatures at a particular dissolving time due to the higher KCl content in MSSA at 700℃.C-S-H was easily identified in MSSA samples using X-ray powder diffraction,and small cubic and nearly spherical particles of C-S-H were found in the MSSA residual samples.In conclusion,the optimum calcination temperature of MSSA having the best pozzolanic activity is 500℃,but excessive agglomeration must be prevented. | Tingye Qi Haochen Wang Guorui Feng Yujiang Zhang Jinwen Bai Yanna Han | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，6： | 0 |
| 7 | Distribution of polychlorinated naphthalenes(PCNs) in the whole blood of typical meat animals显示文摘The concentrations and distribution of polychlorinated naphthalenes(PCNs) in the whole blood of eight typical terrestrial meat animals(chicken, duck, rabbit, pig, cattle, sheep,horse and donkey) consumed daily in our life were investigated. The total concentrations(on a liquid volume basis) of PCNs were in a range from 305 to 987 pg/L. Donkey blood contained the highest PCN concentrations. Mono-CNs were the dominant homolog group,accounting for 38%–71% PCNs. Apart from the mono-CNs and tri-CNs homolog groups, two hepta-CNs(mean: 9.5%) contributed most, followed by tetra-CNs(mean: 6.5%). The congeners CN1, 5/7, 24/14, 27/30, 52/60, 66/67, and 73 were the most abundant congeners or congener groups. The highest toxicity equivalencies(TEQs) were observed in cattle blood(117.4 fg TEQ/L) then chicken blood(117.1 fg TEQ/L). CN73 contributed 65% to total TEQs,followed by CN70(20%) and CN66/67(14%). The dietary intakes of PCNs were also estimated.Chicken meat, which forms the second largest component of meat product consumption in China, contributed most to the total TEQs(61%), followed by beef(27%) and pork(5.9%). The consumption of chicken might pose the highest risk from exposure to PCNs than other types of meat to populations who prefer to eat chicken meat. | Ying Han Wenbin Liu Haifeng Li Rongrong Lei Guorui Liu Lirong Gao Guijin Su | 2018 | Journal of Environmental Sciences2018，30，10： | 0 |
| 8 | LRRC25 plays a key role in all-trans retinoic acid-induced granulocytic differentiation as a novel potential leukocyte differentiation antigen显示文摘 | Weili Liu Ting Li Pingzhang Wang Wanchang Liu Fujun Liu Xiaoning Mo Zhengyang Liu Quansheng Song Ping Lv Guorui Ruan Wenling Han | 2018 | Protein & Cell2018，9，9： | 0 |
| 9 | Energy management strategy based on dynamic programming with durability extension for fuel cell hybrid tramway显示文摘This paper proposes an energy management strategy for a fuel cell(FC)hybrid power system based on dynamic programming and state machine strategy,which takes into account the durability of the FC and the hydrogen consumption of the system.The strategy first uses the principle of dynamic programming to solve the optimal power distribution between the FC and supercapacitor(SC),and then uses the optimization results of dynamic programming to update the threshold values in each state of the finite state machine to realize real-time management of the output power of the FC and SC.An FC/SC hybrid tramway simulation platform is established based on RTLAB real-time simulator.The compared results verify that the proposed EMS can improve the durability of the FC,increase its working time in the high-efficiency range,effectively reduce the hydrogen consumption,and keep the state of charge in an ideal range. | Shiyong Tao Weirong Chen Rui Gan Luoyi Li Guorui Zhang Ying Han Qi Li | 2021 | Railway Engineering Science2021，29，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员