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| 1 | In situ simultaneous determination of trace elements,U-Pb and Lu-Hf isotopes in zircon and baddeleyite显示文摘This paper describes a combined method of simultaneously measuring U-Pb and Lu-Hf isotopes as well as trace elements in Phalaborwa baddeleyite and 91500, GJ-1, TEMORA-1 and SK10-2 zircons by means of Neptune MC-ICPMS and Agilent Q-ICPMS connected to a 193 nm excimer laser ablation system. Material ablated by laser was carried in different proportions into Q-ICPMS for U-Pb isotopic and trace elemental and MC-ICPMS for Lu-Hf isotopic compositions. Experiments indicate that different proportions of ablated material for the Q-ICPMS and MC-ICPMS (6:4, 5:5 and 4:6 respectively) do not show any bias for the zircon/baddeleyite U-Pb age, Lu-Hf isotope and trace elemental compositions within ana-lytical errors. Using 40―60 μm spot size, the obtained U-Pb ages of Phalaborwa baddeleyite, 91500, GJ-1, TEMORA and SK10-2 zircons are 2065±15 (2σ, n=20), 1063±6 (2σ, n=19), 613±6 (2σ, n=20), 416±5 (2σ, n=20) and 32.6±0.5 (2σ, n=20) Ma, respectively. The 176Hf/177Hf ratios are 0.281231±24 (2SD, n=20), 0.282310±35 (2SD, n=19), 0.282028±34 (2SD, n=20), 0.282687±34 (2SD, n=20) and 0.282752±53 (2SD, n=20), respectively. The obtained trace elemental compositions are identical to the reference values. Therefore, this kind of technique makes it possible to simultaneously obtain the U-Pb age, Lu-Hf iso-topes and trace elemental compositions of zircon and baddeleyite, which could be an important tool in solving problems in earth sciences. | XIE LieWen ZHANG YanBin ZHANG HuiHuang SUN JingFeng WU FuYuan | 2008 | Chinese Science Bulletin2008，53，10： | 97 |
| 2 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 3 | Effect of Cyclocarya paliurus polysaccharides on streptozotocin-induced diabetic nephropathy in rats显示文摘OBJEVTIVE:To investigate the efficacy of Cyclocarya paliurus(C.paliurus)polysaccharides on streptozotocin-induced diabetic nephropathy in rats.METHODS:Rats were divided into 6 groups,including group of normal control,group of diabetic control,group of metformin treatment,low-dose group of C.paliurus polysaccharides treatment,middle-dose group of C.paliurus polysaccharides treatment and high-dose group of C.paliurus polysaccharides treatment.Histological analysis of kidney was analyzed using hematoxilin and eosin.Levels of blood glucose,creatinine,urea,uric acid were determined by spectrophotometry.Anti-oxidative enzymes were measured by real-time polymerase chain reaction(PCR)and enzyme-linked immunosorbent assay(ELISA).Advanced glycation end products(AGEs)and transforming growth factor-β1(TGF-β1)level was measured by ELISA.RESULTS:Abnormal changes were observed in the group of diabetic control characterized by atrophy of the renal glomeruli with hypercellularity,congestion of glomerular tufts,dilation of the renal spaces,and degeneration of renal tubule.Compared with that of normal group,blood glucose,creatinine,urea,uric acid level was significantly increased in the group of diabetic control.Superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase level was significantly decreased,but AGEs and TGF-β1 level was significantly increased.By contrast,administration of C.paliurus polysaccharides and metformin could reverse the above-mentioned results of the group of diabetic control,especially in the high-dose group of C.paliurus polysaccharides.CONCLUSION:Our findings suggest that C.paliurus polysaccharides may play a protecting role for nephropathy of diabetic rats by lowering glucose,creatinine,urea,uric acid level,enhancing the antioxidative ability,and reducing AGEs and TGF-β1 expression. | Xia Xichao Mao Dongxue Dai Hongmei Wu Xi Zhang Zuyuan Wang Huaying Zhou Wenwen Dong Yanmei Wang Mengqi Li Yuan Shao Xiangyang Ouyang Jingfeng | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 9 |
| 4 | Velvet antler polypeptide is able to induce differentiation of neural stem cells towards neurons in vitro显示文摘OBJECTIVE: To investigate the neural differentiation capacity of water extraction of velvet antler.METHODS: Velvet antler(Cervus Nippon Temminck) polypeptide(VAP) was used to differentiate neural stem cells(NSCs) towards neurons in the study. Firstly, we obtain the polypeptides of VAP by water extraction. Secondly, we observed the morphology, assayed the factors in the media by enzyme-linked immunosorbent assay, and detected the special neural molecules by immuno fl uorescence staining. NSCs were cultured on the cell climbing film. After neuronal differentiation, differentiated NSCs were mounted for immunocytochemistry with immunofluorescence technique.RESULTS: The differentiating cells look like neuron,some special factors, such as Glial cell line-derived neurotrophic factor, nerve growth factor, in the media can be detected while differentiated neuron-like cells can express the special neural molecules.CONCLUSION: Differentiation of NSCs towards neurons can be induced by velvet antler polypeptide. | Zhang Lihong Zhuang Zhihong Sun Yanan Ma Shuhua Yang Weifeng Lei Hongtao Zuo Junling Ouyang Jingfeng Wang Yi | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 8 |
| 5 | Micro-arc oxidation of magnesium alloys:A review显示文摘Magnesium(Mg)and its alloys present great potential to be extensively applied in different applications.However,the relatively poor resistance to corrosion and wear significantly restricts their applications in practice.As one of strategies of surface treatment,micro-arc oxidation(MAO)process attracts a lot of attention,since it does not use neither expensive equipment,nor complicated manipulation.This review systematically discusses MAO mechanism and some typical models,which still need to be further developed to provide a better understanding and guide for future researchers.Subsequently,main influencing factors of MAO process are analyzed in detail.Further,some popular applications of MAO coatings are respectively reviewed,including biomedical application,decoration,thermal control,corrosion and wear resistance,and industrial applications in practice.The existing issues and future perspectives are finally discussed to further accelerate extensive applications of Mg alloys. | Wenhui Yao Liang Wu Jingfeng Wang Bin Jiang Dingfei Zhang Maria Serdechnova Tatsiana Shulha Carsten Blawert Mikhail L.Zheludkevich Fusheng Pan | 2022 | Journal of Materials Science & Technology2022，，23： | 8 |
| 6 | Seismic Sedimentology Interpretation Method of Meandering Fluvial Reservoir:From Model to Real Data显示文摘Reservoir architecture of meandering river deposition is complex and traditional seismic facies interpretation method cannot characterize it when layer thickness is under seismic vertical resolution.In this study,a seismic sedimentology interpretation method and workflow for point bar characterization is built.Firstly,the influences of seismic frequency and sandstone thickness on seismic reflection are analyzed by outcrop detection with ground penetrating radar(GPR) and seismic forward modeling.It is found that(1) sandstone thickness can influence seismic reflection of point bar architecture.With the increasing of sandstone thickness from 1/4 wavelength(λ) to λ/2,seismic reflection geometries various from ambiguous reflection,'V' type reflection to 'X' type reflection;(2) seismic frequency can influence reservoirs' seismic reflection geometry.Seismic events follow inclined lateral aggradation surfaces,which is isochronic depositional boundaries,in high frequency seismic data while the events extend along lithologic surfaces,which are level,in low frequency data.Secondly,strata slice interpretation method for thin layer depositional characterization is discussed with seismic forward modeling.Lastly,a method and workflow based on the above study is built which includes seismic frequency analysis,90 o phasing,stratal slicing and integrated interpretation of slice and seismic profile.This method is used in real data study in Tiger shoal,the Gulf of Mexico.Two episodes of meandering fluvial deposition is recognized in the study layer.Sandstone of the lower unit,which is formed in low base level stage,distributes limited.Sandstone distribution dimension and channel sinuosity become larger in the upper layer,which is high base level deposition. | Tao Zhang Xianguo Zhang Chengyan Lin Jingfeng Yu Shouxiu Zhang | 2015 | Journal of Earth Science2015，26，4： | 8 |
| 7 | Processes of coastal ecosystem carbon sequestration and approaches for increasing carbon sink显示文摘The oceans are the largest carbon pools on Earth, and play the role of a 'buffer' in climate change. Blue carbon, the carbon(mainly organic carbon) captured by marine ecosystems, is one of the important mechanisms of marine carbon storage.Blue carbon was initially recognized only in the form of visible coastal plant carbon sequestration. In fact, microorganisms(phytoplankton, bacteria, archaea, viruses, and protozoa), which did not receive much attention in the past, account for more than 90% of the total marine biomass and are the main contributors to blue carbon. Chinese coastal seas, equivalent to 1/3 of China's total land area, have a huge carbon sink potential needing urgently research and development. In this paper, we focus on the processes and mechanisms of coastal ocean's carbon sequestration and the approaches for increasing that sequestration. We discuss the structures of coastal ecosystems, the processes of carbon cycle, and the mechanisms of carbon sequestration. Using the evolution of coastal ocean's carbon sinks in sedimentary records over geologic times, we also discuss the possible effects of natural processes and anthropogenic activities on marine carbon sinks. Finally, we discuss the prospect of using carbon sequestration engineering for increasing coastal ocean's carbon storage capacity. | ZHANG Yao ZHAO MeiXun CUI Qiu FAN Wei QI JiaGuo CHEN Ying ZHANG YongYu GAO KunShan FAN JingFeng WANG GuangYi YAN ChongLing LU HaoLiang LUO YaWei ZHANG ZiLian ZHENG Qiang XIAO Wei JIAO NianZhi | 2017 | Science China Earth Sciences2017，60，5： | 6 |
| 8 | The temporal and spatial fluctuation of the groundwater level along the Tarim Desert Highway显示文摘In this work, a groundwater monitor section along the Tarim Desert Highway was set up, and the groundwater level data were recorded. The temporal and spatial fluctuations of the groundwater level were analyzed based on the groundwater level measurements, hydrologic data, the groundwater/surface water interconversion theory and the groundwater dynamics. The spatial distribution of groundwater is mostly affected by sand dune height and landform variation. The four primary temporal influence factors of groundwater level can be ordered in decreasing significance as: shelterbelt pumping > vertical leakage > river flow change > runoff replenishment. The runoff replenishment has the biggest influence range, and the shelterbelt pumping has the smallest influence range. The groundwater level fluctuates annually in a natural pattern. | FAN JingLong XU XinWen LEI JaQiang ZHAO JingFeng LI ShengYu WANG HaiFeng ZHANG JianGuo ZHOU HongWei | 2008 | Chinese Science Bulletin2008，53，S2： | 6 |
| 9 | Efficacy of Bushenjianpi prescription on autoimmune premature ovarian failure in mice显示文摘OBJECTIVE: To assess the efficacy of Bushenjianpi prescription(BSJPP), a formula from Traditional Chinese Medicine, on a mouse model of autoimmune premature ovarian failure(POF) induced by mouse zona pellucida(ZP3) and to investigate the mechanisms underlying the action.METHODS: After randomization, POF was induced in the model mice by immunization with ZP3. One week later, mice received low(8.1 mg/kg), moderate(16.2 mg/kg) and high(32.4 mg/kg) doses of BSJPP by gastrogavage once daily for 90 days. Premarin(0.03 mg/kg) served as the positive group. Serum samples were collected 1 week after the last dose and stored at-20 ℃ for analysis. After cervical dislocation, the uterus and ovaries were collected aseptically for evaluation by histological assessment, scanning electron microscopy, immunohistochemical staining, and Western blot and reverse transcription-polymerase chain reaction analyses.RESULTS: Serum E2 levels in POF model mice were decreased, whereas follicle-stimulating hormone(FSH) and luteinizing hormone(LH) levels were dramatically increased. Serum levels of E2,LH and FSH were reduced in POF model mice treated with BSJPP(moderate and high doses) and premarin. Anti-bone morphogenetic protein 15(BMP-15) and connexin 43(Cx43) were repressed in autoimmune POF model mice, whereas high expression was observed in control mice and those treated with BSJPP(moderate and high doses)and premarin.CONCLUSION: BSJPP is effective in treating ZP3-induced POF in mice and the increase in the expression of BMP-15 and Cx43 may be implicated in the mechanism underpinning the action. | Feng Guilin Lin Meijiao Zhou Xiaolin Zhang Lihong Li Jing Ouyang Jingfeng | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 6 |
| 10 | Development of integrated two-stage thermoelectric generators for large temperature difference显示文摘Multi-stage thermoelectric(TE) modules can withstand a large temperature difference and can be used to obtain a high conversion efficiency. In this study, two-stage PbTe/Bi2Te3 TE modules were developed with an enhanced efficiency through a comprehensive study of device structure design, module fabrication, and performance evaluation. PbTe-based AgPbmSbTem+2(abbreviated as LAST) is a typically high ZT material, while the corresponding TE module was rarely reported so far. How to utilize LAST to fabricate high efficiency TE modules therefore remains a central problem. Finite element simulation indicates that the temperature stability of the two-stage module for LAST is better than that of two-segmented module. Compared to Cu,Ni, and Ni-Fe alloys, Co-Fe alloy is an effective metallization layer for PbTe due to its low contact resistance and thin diffusion layer. By sintering a slice of Cu on TE legs, pure tinfoil can be used as a common welding method for mid-temperature TE modules. A maximum efficiency(ηmax) of 9.5% was achieved in the range of 303 to 923 K in an optimized PbTe/Bi2Te3 based two-stage module, which was almost twice that of a commercial TE module. | PEI Jun LI LiangLiang LIU DaWei ZHANG BoPing XIAO Yu LI JingFeng | 2019 | Science China(Technological Sciences)2019，62，9： | 6 |
| 11 | China's sizeable and uncertain carbon sink: a perspective from GOSAT显示文摘Despite the agreement that China’s terrestrial ecosystems can provide a carbon sink and offset carbon dioxide(CO2)emissions from fossil fuels,the magnitude and spatial distribution of the sink remain uncertain.Accurate quantification of the carbon sequestration capacity of China’s terrestrial ecosystems has profound scientific and policy implications.Here,we report on the magnitude and patterns of China’s terrestrial carbon sink using the global monthly CO2flux data product from the Greenhouse gases Observing SATellite(GOSAT),the world’s first satellite dedicated to global greenhouse gas observation.We use the first year’s data from GOSAT(June 2009–May2010)that are currently available to assess China’s biospheric carbon fluxes.Our results show that China’s terrestrial ecosystems provide a carbon sink of-0.21 Pg C a-1.The consumption of fossil fuels in China leads to carbon dioxide emissions of 1.90 Pg C a-1into the atmosphere,approximately 11.1%of which is offset by China’s terrestrial ecosystems.China’s terrestrial ecosystems play a significant role in offsetting fossil fuel emissions and slowing down the buildup of CO2in the atmosphere.Our analysis based on GOSAT data offers a new perspective on the magnitude and distribution of China’s carbon sink.Our results show that China’s terrestrial ecosystems provide a sizeable and uncertain carbon sink,and further research is needed to reduce the uncertainty in its magnitude and distribution. | Li Zhang Jingfeng Xiao Li Li Liping Lei Jing Li | 2014 | Chinese Science Bulletin2014，59，14： | 5 |
| 12 | MHC polymorphism and disease-resistance to Edwardsiella tarda in six turbot(Scophthalmus maximus) families显示文摘This study examined genetic variation in the major histocompatibility complex(MHC) Class II B gene in turbot(Scophthalmus maximus) by virulent bacterial pathogen challenge.One hundred fry from each of six families were infected with Edwardsiella tarda by intraperitoneal injection.Family mortality ranged from 28.0% to 83.3%.Complete exon 2 and intron 1 sequences of MHC Class II B genes were amplified from five survivor and five non-survivor individuals per family using the clone-sequence method.Thirty-seven sequences from 60 individuals revealed 37 different alleles,25 of which were unique to this study.The 25 unique alleles belonged to 16 major allele types.Nine alleles were used to examine the association between alleles and resistance/susceptibility to disease.Five alleles were present in an individual,suggesting a minimum of three loci or copies of the turbot MHC Class II B gene.The rate of non-synonymous substitution(d N) was 2.30 and 1.58 times higher than synonymous substitution(d S) in the peptide-binding regions(PBR) and non-PBR in whole families,respectively,which suggested balancing selection on exon 2 of the MHC Class II B gene in turbot.One allele,Scma-DBB1*02,was significantly more prevalent in survivor stock than in non-survivor stock(P=0.001).Therefore,this allele might be associated with resistance to bacteria.A second allele,Scma-DBB1*10,was significantly more prevalent in non-survivor stock(P=0.021),and is likely associated with susceptibility to bacteria. | DU Min CHEN SongLin LIU YanHong NIU BaoZhen YANG JingFeng ZHANG Bo | 2012 | Chinese Science Bulletin2012，57，25： | 5 |
| 13 | An improved neural network model for prediction of mechanical properties of magnesium alloys显示文摘An improved neural network model was developed for prediction of mechanical properties in the de-sign and development of new types of magnesium alloys by refining the types of input variables and using a more reasonable algorithm. The results showed that the improved model apparently decreased the prediction errors, and raised the accuracy of the prediction results. Better preprocessing parame-ters were found to be [0.15, 0.90] for the tensile strength, [0.1, 0.9] for the yield strength, and [0.15, 0.90] for the elongation. When the above parameters were used, the relativity for predicition of strength was bigger than 0.95. By using improved ANN analysis, more reasonable process parameters and compo- sition could be obtained in some magnesium alloys without addition of strontoum. | TANG AiTao LIU Bin PAN FuSheng ZHANG Jing PENG Jian WANG JingFeng | 2009 | Science China(Technological Sciences)2009，52，1： | 5 |
| 14 | Nutrient maximums related to low oxygen concentrations in the southern Canada Basin显示文摘The phenomenon of nutrient maximums at 70~200 m occurred only in the region of the Canada Basin among the world oceans. The prevailing hypothesis was that the direct injection of the low-temperature high-nutrient brines from the Chukchi Sea shelf (<50 m) in winter provided the nutrient maximums. However, we found that there are five problems in the direct injection process. Formerly Jin et al. considered that the formation of nutrient maximums can be a process of locally long-term regeneration. Here we propose a regeneration-mixture process. Data of temperature, salinity, oxygen and nutrients were collected at three stations in the southern Canada Basin during the summer 1999 cruise. We identified the cores of the surface, near-surface, potential temperature maximum waters and Arctic Bottom Water by the diagrams and vertical profiles of salinity, potential temperature, oxygen and nutrients. The historical 129I data indicated that the surface and near-surface waters were Pacific-origin, but the waters below the potential temperature maximum core depth was Atlantic-origin. Along with the correlation of nutrient maximums and very low oxygen contents in the near-surface water, we hypothesize that, the putative organic matter was decomposed to inorganic nutrients; and the Pacific water was mixed with the Atlantic water in the transition zone. The idea of the regeneration-mixture process agrees with the historical observations of no apparent seasonal changes, the smooth nutrient profiles, the lowest saturation of CaCO3 above 400 m, low rate of CFC-11 ventilation and 3H-3He ages of 8~18 a around the nutrient maximum depths. | JIN Ming-ming SHI Jiuxin LU Yong CHEN Jianfang GAO Guoping WU Jingfeng ZHANG Haisheng | 2005 | Acta Oceanologica Sinica2005，24，6： | 5 |
| 15 | Total body irradiation of donors can alter the course of tolerance and induce acute rejection in a spontaneous tolerance rat liver transplantation model显示文摘Liver transplantation is an established therapy for end-stage liver diseases. Graft rejection occurs unless the recipient receives immunosuppression after transplantation. This study aimed to explore the mechanism of acute rejection of liver allografts in rats pre-treated with total body irradiation to eliminate passenger lymphocytes and to define the role of CD4 + CD25 + regulatory T cells in the induction of immunotolerance in the recipient. Male Lewis rats were used as donors and male DA rats were recipients. Rats were randomly assigned to the following four groups: control group, homogeneity liver transplantation group, idio-immunotolerance group and acute rejection group. After transplantation, the survival time of each group, serum alanine aminotransferase, total bilirubin levels, number of Foxp3 + CD4 + CD25 + regulatory T cells, expression of glucocorticoid-induced tumor necrosis factor receptor on T cell subgroups, histopathology of the hepatic graft and spleen cytotoxic T lymphocyte lytic activity were measured. In the acute rejection group, where donors were preconditioned with total body irradiation before liver transplantation, all recipients died between day 17 and day 21. On day 14, serum alanine aminotransferase increased signifi- cantly to (459.2±76.9) U L -1 , total bilirubin increased to (124.1±33.7) μmol L -1 (P<0.05) and the ratio of Foxp3 + CD4 + CD25 + regulatory T cells decreased significantly to 1.50%±0.50% (P<0.05) compared with the other groups. Analysis of the T cell subpopulations in the acute rejection group varied from the other groups. Histological analysis showed typical changes of acute rejection in the acute rejection group only. Preconditioning of the donors with total body irradiation eliminated passenger lymphocytes of the liver graft, and thus affected the course of tolerance and induced acute rejection after liver transplantation. | ZHANG YeWei ZHAO HeWei BO Lin YANG YinXue LU Xiang SUN JingFeng WEN JianFei HE Xia YIN GuoWen | 2012 | Science China(Life Sciences)2012，55，9： | 4 |
| 16 | Optical characteristics of Ce,Eu:YAG single crystal grown by Czochralski method显示文摘Eu-doped Ce:YAG single crystal(SC) was fabricated by the Czochralski method. The crystal structure,optical and photoelectric property of the constructed w-LED was investigated. The XRD and HRTEM results show that YAG crystal structure has little change when Eu^(3+), Ce^(3+) are doped. Absorption spectra and photoluminescence spectra show that the Ce,Eu:YAG single crystal can effectively absorb the 460 nm blue light to form a broadband emission center at 530 nm, decay curves of the crystal show that the energy transfer between Ce^(3+) and Eu^(3+) is highly suppressed. Compared with commercial Ce:YAG phosphor, Ce,Eu:YAG exhibits better thermal stability. | Jingfeng Zhang Guorui Gu Xiaoxuan Di Weidong Xiang Xiaojuan Liang | 2019 | Journal of Rare Earths2019，37，2： | 4 |
| 17 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 18 | High-temperature Electric Properties of Polycrystalline La-doped CaMnO_3 Ceramics显示文摘Polycrystalline La-doped CaMnO3 ceramics have been prepared by a solid-state sintering method.Analysis of microstructure and phase composition indicates that the addition of La can prohibit the further growth of grain,and no impurity phase appears.The results revealed that the La doping can lead to a large change of the activation energy(from 0.22 to 0.02 eV),and thus result in a marked increase in electric conductivity of 2-4 orders of magnitude.The power factor can reach about 1.5×10-4 W·m-1·K-2 in a wide temperature range,which potentially make them attractive for n-type high-temperature thermoelectric materials. | Jinle Lan Yuanhua Lin Ao Mei Cewen Nan Yong Liu Boping Zhang Jingfeng Li | 2009 | Journal of Materials Science & Technology2009，25，4： | 3 |
| 19 | A CRISPR/Cas12a-empowered surface plasmon resonance platform for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2显示文摘The outbreak of the COVID-19 pandemic was partially due to the challenge of identifying asymptomatic and presymptomatic carriers of the virus,and thus highlights a strong motivation for diagnostics with high sensitivity that can be rapidly deployed.On the other hand,several concerning SARS-CoV-2 variants,including Omicron,are required to be identified as soon as the samples are identified as‘positive’.Unfortunately,a traditional PCR test does not allow their specific identification.Herein,for the first time,we have developed MOPCS(Methodologies of Photonic CRISPR Sensing),which combines an optical sensing technology-surface plasmon resonance(SPR)with the‘gene scissors’clustered regularly interspaced short palindromic repeat(CRISPR)technique to achieve both high sensitivity and specificity when it comes to measurement of viral variants.MOPCS is a low-cost,CRISPR/Cas12a-systemempowered SPR gene-detecting platform that can analyze viral RNA,without the need for amplification,within 38 min from sample input to results output,and achieve a limit of detection of 15 fM.MOPCS achieves a highly sensitive analysis of SARS-CoV-2,and mutations appear in variants B.1.617.2(Delta),B.1.1.529(Omicron)and BA.1(a subtype of Omicron).This platform was also used to analyze some recently collected patient samples from a local outbreak in China,identified by the Centers for Disease Control and Prevention.This innovative CRISPR-empowered SPR platform will further contribute to the fast,sensitive and accurate detection of target nucleic acid sequences with single-base mutations. | Zhi Chen Jingfeng Li Tianzhong Li Taojian Fan Changle Meng Chaozhou Li Jianlong Kang Luxiao Chai Yabin Hao Yuxuan Tang Omar AAl-Hartomy Swelm Wageh Abdullah GAl-Sehemi Zhiguang Luo Jiangtian Yu Yonghong Shao Defa Li Shuai Feng William J.Liu Yaqing He Xiaopeng Ma Zhongjian Xie Han Zhang | 2022 | National Science Review2022，9，8： | 3 |
| 20 | Influence of Ni interlayer on interfacial microstructure and mechanical properties of Ti-6Al-4V/AZ91D bimetals fabricated by a solid–liquid compound casting process显示文摘The solid–liquid compound casting of Mg-AZ91D and Ti-TC4 alloys was developed by using pure Ni electro-deposited coating.The pouring temperatures of 660℃,690℃,720℃and 750℃were chosen to investigated the effects of casting temperatures on microstructural evolution,properties,and fracture behaviors of Ni-coated TC4/AZ91D bimetals by the solid–liquid compound casting(SLCC).The scanning electron microscopy(SEM)and the energy dispersive spectroscopy(EDS)results showed that the interfacial zone mainly composed of nickel,Mg_(2)Ni and Mg-Al-Ni in the bimetals cast at 660℃.As the pouring temperature was increased to 750℃,the width of the interface zone,which mainly composed ofδ(Mg),Mg_(2)Ni,Mg-Al-Ni,Mg_(3)TiNi_(2) and Al_(3)Ni,gradually increased.The microhardness tests showed that the micro-hardness of the interface zone was smaller than that of TC4 substrate but larger than that of the cast AZ91D matrix.At the pouring temperature of 720℃,the Ni-coated TC4/AZ91D bimetals had the most typical homogeneous interface,which had granular Mg-Al-Ni ternary phase but no ribbon-like Al3Ni binary phase,and achieved the highest shear strength of 97.35MPa.Meanwhile,further fracture behavior analysis showed that most fracture failure of Ni-coated TC4/AZ91D bimetals occurred at the Mg_(2)Ni+δ(Mg)eutectic structure and Al_(3)Ni hard intermetallic. | Fulin Wen Jianhua Zhao Miaowang Yuan Jingfeng Wang Dengzhi Zheng Jinyong Zhang Ke He Jingjing Shangguan Yu Guo | 2021 | Journal of Magnesium and Alloys2021，9，4： | 3 |
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