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| 1 | A hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier ocular drug delivery platform显示文摘The objective of this study was to develop a novel hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier(NLC) drug delivery platform. An ophthalmic antiinflammatory drug, baicalin(BN) was chosen as the model drug. BN –NLC was prepared using melt-emulsification combined with ultra-sonication technique. Additionally, a dual pH-and thermo-sensitive hydrogel composed of carboxymethyl chitosan(CMCS) and poloxamer 407(F127) was fabricated by a cross-linking reaction with a nontoxic crosslinker genipin(GP). GP-CMCS/F127 hydrogel was characterized by FTIR, NMR, XRD and SEM. The swelling studies showed GP-CMCS/F127 hydrogel was both pH-and thermo-sensitive. The results of in vitro release suggested BN –NLC gel can prolong the release of baicalin comparing with BN eye drops and BN –NLC. Ex vivo cornea permeation study was evaluated using Franz diffusion cells. The apparent permeability coefficient(Papp) of BN –NLC gel was much higher(4.46-fold) than that of BN eye drops. Through the determination of corneal hydration levels, BN –NLC gel was confirmed that had no significant irritation to cornea. Ex vivo precorneal retention experiments were carried out by a flow-through approach. The results indicated that the NLC-based hydrogel can prolong precorneal residence time. In conclusion, the hybrid NLCbased hydrogel has a promising potential for application in ocular drug delivery. | Yibin Yu Ruoxi Feng Jinyu Li Yuanyuan Wang Yiming Song Guoxin Tan Dandan Liu Wei Liu Xinggang Yang Hao Pan Sanming Li | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，4： | 3 |
| 2 | Taking advantage of glass:capturing and retaining the helium gas on the moon显示文摘Helium-3(3He)is a noble gas that has critical applications in scientific research and promising application potential as clean fusion energy.It is thought that the lunar regolith contains large amounts of helium,but it is challenging to extract because most helium atoms are reserved in defects of crystals or as solid solutions.Here,we find large amounts of helium bubbles in the glassy surface layer of ilmenite particles that were brought back by the Chang’E-5 mission.The special disordered atomic packing structure of glasses should be the critical factor for capturing the noble helium gas.The reserves in bubbles do not require heating to high temperatures to be extracted.Mechanical methods at ambient temperatures can easily break the bubbles.Our results provide insights into the mechanism of helium gathering on the moon and offer guidance on future in situ extraction. | Ao Li Xiao Chen Lijian Song Guoxin Chen Wei Xu Juntao Huo Meng Gao Ming Li Lei Zhang Bingnan Yao Min Ji Yan Zhang Shaofan Zhao Wei Yao Yanhui Liu Jun-Qiang Wang Haiyang Bai Zhigang Zou Mengfei Yang Weihua Wang | 2022 | Materials Futures2022，1，3： | 2 |
| 3 | Application and Development Prospect of Se-rich & High-Ca Organic Fertilizer显示文摘Se is one of trace elements necessary for the human body,and human body could absorb Se via the food. Se intake is insufficient in 2/3 region of China,which seriously affects health of local residents. Therefore,the research of Se-rich fertilizer and the development of Se-rich product become the research focus in food science,medicine and other fields. There are rich marine resources in Beibu Gulf waters of Guangxi,and much carapace organic waste is generated. These carapace waste not only has high Se content but also is composed of a lot of Ca. The preparation of Se-rich & high-Ca fertilizer by these carapace waste not only reaches the target of recycling and environment friendly but also increases the yield of agricultural products,reduces diseases and pests,improves quality,increases the added value of agricultural product,which brings better economic benefit and meets people's demand for healthy food. | Sha Guoxin Huang Wei Liu Yongxian Pan Liping Song Yan Zhang Yu Wang Daobo | 2018 | Meteorological and Environmental Research2018，9，3： | 2 |
| 4 | A novel defivatization method coupled with GC-MS for the simultaneous determination of chlompropanols显示文摘 | CAO Xiujtm SONG Guoxin GAO Yihan | 2009 | Chromatographia2009，70，34： | 1 |
| 5 | A construction of regular cryptogroups显示文摘 | Song Guangtian Liu Guoxin Zhang Jiangang | | 0，，03： | 1 |
| 6 | A construction of cryptogroups显示文摘 | Song Guangtian Liu Guoxin Zhang Jiangang | | 0，，： | 1 |
| 7 | Rapid Detection and Quantification by GC–MS of Camellia Seed Oil Adulterated with Soybean Oil显示文摘 | Jia Xie Tianshun Liu Yingxin Yu Guoxin Song Yaoming Hu | 2013 | Journal of the American Oil Chemists’ Society2013，，5： | 1 |
| 8 | Headspace Solid-phase Microextraction - Gas Chromatographic - MassSpectrometric analysis of the Essential Oils of two traditional Chinese Medicines, Angelica pubescens and Angelica sinensis显示文摘 | Guoxin Song | 2004 | Chromatographia2004，59，： | 1 |
| 9 | Simultaneous A- nalysis of Organophosphorus Pesticides in Water by Mag- netic Solid-Phase Extraction Coupled with GC - MS 显示文摘 | Jia Xie Tianshun Liu Guoxin Song | 2013 | Chromatogr2013，76，9： | 1 |
| 10 | Application of HS-SPME and GC-MS to characterization of volatile compounds emitted from Osmanthus flowers显示文摘 | DENG Chunhui SONG Guoxin HU Yaoming | 2004 | Ann Chim2004，94，12： | 1 |
| 11 | Comparison of essential oil composition of Artemisia argyi leaves at different collection times by headspace solid-phase microextraction and gas chromatography-mass spectrometry显示文摘 | Zheng Xiaohua Deng Chunhui Song Guoxin | 2004 | Chromatographia2004，59，11： | 1 |
| 12 | Rapid determm' ation of volatile compounds emitted from Chimonanthus praecox flowers by HS-SPME-GC-MS显示文摘 | DENG Chunhui SONG Guoxin HU Yaoming | 2004 | Zeitschrift Pdr Naturforschung C2004，59，910： | 1 |
| 13 | Application of HSSPME and GC-MS to characterization of volatile compounds emitted from osmanthus flowers显示文摘 | DENG Chunhui SONG Guoxin HU Yaoming | 2004 | Annalidi Chimical2004，94，12： | 1 |
| 14 | Determining organic compounds in coking wastewater by SPME-GC /MS显示文摘The solid-phase microextraction (SPME) combined with gas chromatography/mass spectrometry (GC/MS) was used to determine and analyze organic pollutants in coking wastewater.Based on the fact that the main compounds in the wastewater were organics, some key parameters of the SPME were optimized.The method has good linearity (its correlation coefficients>0.99) in the range determined,its relative standard deviations (RSD) are less than 15%,and its recovery is from 87.9% to 128.1% with the lowest quantification limit of 5 μg/L.This method has been used to measure 15 organic pollutants in wastewater from a certain coking plant.The results show that compared with the conventional method,it can save an hour in pretreatment time.It is a fast,low-cost,accurate,simple and efficient analytical method indeed. | SONG Guoxin ZHU Chunyan XIA Jianzhong HOU Wenjie | 2013 | Baosteel Technical Research2013，7，1： | 1 |
| 15 | Compari- son of essential oil composition of Artemisia argi leaves at differ- ent collection times by headspace solid-phase microextraction and gas chromatography-mass spectrometry显示文摘 | Zheng Xiaohua Deng Chunhui Song Guoxin | 2004 | Chromatograph- ia2004，59，6： | 1 |
| 16 | Rapid Detection and Quantification by GC–MS of Camellia Seed Oil Adulterated with Soybean Oil显示文摘 | Jia Xie Tianshun Liu Yingxin Yu Guoxin Song Yaoming Hu | 2013 | Journal of the American Oil Chemists’ Society2013，，5： | 1 |
| 17 | Determination of the Food Colorant Chrysoidine, in Fish by GC-MS显示文摘 | Wang Xiang Song Guoxin Wu Weiping | 2008 | Chromatographia2008，68，： | 1 |
| 18 | Simultaneous Analysis of Organophosphorus Pesticides in Water by Magnetic Solid-Phase Extraction Coupled with GC–MS显示文摘 | Jia Xie Tianshun Liu Guoxin Song Yaoming Hu Chunhui Deng | 2013 | Chromatographia2013，，9： | 1 |
| 19 | Comparison of headspace solid-phase microextraction with solvent extrac- tion for the analysis of the volatile constituents of leaf twig of Chinese arborvitae 显示文摘 | Guoxin Song Chunhui Deng Dan Wu | 2003 | Chromatographia2003，58，： | 1 |
| 20 | Determination of the Food Colorant Chrysoidine in Fish by GC-MS 显示文摘 | Xiang Wang Guoxin Song Weiping Wu | 2008 | Chroma- tographia2008，68，78： | 1 |
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