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| 1 | Association of NFKB1 gene polymorphism (rs28362491) with levels of inflammatory biomarkers and susceptibility to diabetic nephropathy in Asian Indians显示文摘AIM To investigate the association of NFKB1 gene-94 ATTG insertion/deletion(rs28362491) polymorphism with inflammatory markers and risk of diabetic nephropathy in Asian Indians.METHODS A total of 300 subjects were recruited(100 each), normoglycemic,(NG); type 2 diabetes mellitus(T2DM) without any complications(DM) and T2 DM with diabetic nephropathy [DM-chronic renal disease(CRD)]. Analysis was carried out by polymerase chain reaction-restriction fragment length polymorphism and ELISA. Pearson's correlation, analysis of variance and logistic regression wereused for statistical analysis.RESULTS The allelic frequencies of-94 ATTG insertion/deletion were 0.655/0.345(NG), 0.62/0.38(DM) and 0.775/0.225(DM-CRD). The-94 ATTG ins allele was associated with significantly increased levels of urinary monocyte chemoattractant protein-1(u MCP-1); u MCP-1(P = 0.026) and plasma tumor necrosis factor-alpha(TNF-α); TNF-α(P = 0.030) and almost doubled the risk of diabetic nephropathy(OR = 1.91, 95%CI: 1.080-3.386, P = 0.025).CONCLUSION-94 ATTG ins/ins polymorphism might be associated with increased risk of developing nephropathy in Asian Indian subjects with diabetes mellitus. | Amar Gautam Stuti Gupta Mohit Mehndiratta Mohini Sharma Kalpana Singh Om P Kalra Sunil Agarwal Jasvinder K Gambhir | 2017 | World Journal of Diabetes2017，8，2： | 4 |
| 2 | Genetic mapping of 66 new microsatellite(SSR)loci in bread wheat显示文摘 | Gupta P K Balyan H S Edwards K J | 2002 | Theor Appl Genet2002，105，： | 2 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Advanced dynamics of rolling elements显示文摘 | Gupta P K | 1984 | Springer-Verlag New York Inc1984，，： | 2 |
| 5 | Primary pediatric mid-brain lymphoma:Report of a rare pediatric tumor in a rare location显示文摘Primary central nervous system lymphoma(PCNSL) is a rare disease in pediatric age group. A thirteen-yearold male child presented with complaints of headache for six months, vomiting and diplopia for three days. Magnetic resonance imaging of the brain showed a single lesion of 1.7 cm × 1.6 cm × 1.6 cm in the mid brain and tectum. He underwent a gross total resection of the tumor. The histopathological evaluation revealed B cell high grade non Hodgkin lymphoma. The patient was treated with High dose methotrexate and cranio spinal radiation. The patient was alive without disease 12 mo after completion of treatment. This case highlights importance of keeping PCNSL as differential in brain stem lesions of pediatric patients also. Radiation and chemotherapy remains the most important treatment for such patients. | Rony Benson Supriya Mallick Suvendu Purkait Vaishali Suri K P Haresh Subhash Gupta Dayanand Sharma Pramod Kumar Julka Goura Kishore Rath | 2016 | World Journal of Clinical Cases2016，4，12： | 2 |
| 6 | Genetic mapping of 66 new microsatellite(SSR) loci in bread wheat显示文摘 | Gupta P K Balyan H S Edwards K J | 2002 | Theor Appl Genet2002，105，： | 1 |
| 7 | Cytogenetic effects of cypermethrin and fenvalerate on the root meristem cells of A Ilium cepa显示文摘 | Chauhan L K S Saxena P N Gupta S K | 1999 | Environ Experi Botany1999，42，3： | 1 |
| 8 | Assessment of the efficiency of various gene promoters via biolistics in leaf and regenerating seed callus of millets,Eleusine coracana and Echinochloa crusgalli显示文摘 | GUPTA P RAGHUVANSHI S TYAGI A K | 2001 | Plant Biotechnol2001，18，： | 1 |
| 9 | Multi-Objective placement of electronic components using evolutionary algorithms显示文摘 | DEB K JAIN P GUPTA N | 2004 | IEEE Transactions on Components and Packaging Technologies2004，27，3： | 1 |
| 10 | Influence of zinc on calcium magnesium, sodium, potassium and phosphorus nutrition of soybeam(Glyeine max) in sodie soils 显示文摘 | Gupta S P Gupta V K | 1984 | Indian Journal of Ecology1984，11，2： | 1 |
| 11 | Composite shaft rotor dynamic analysis using a layer wise theory显示文摘 | SINGH S P GUPTA K | 1996 | Journal of Sound and Vibration1996，191，5： | 1 |
| 12 | Molecular markers and their applications in wheat breeding显示文摘 | P K Gupta R K Varshney P C Sharma B Ramesh | 1999 | Plant Breeding1999，118，： | 1 |
| 13 | Comparative cardiopulmonary effects of xylazine and detomidine in goats显示文摘 | Dilipkumar D Sharma A K Gupta O P | 1998 | Indian Veterinary Journal1998，75，10： | 1 |
| 14 | Molecular markers of glioma: an update on recent progress and perspectives 显示文摘 | Gupta K Salunke P | 2012 | J Cancer Res Clin Oncol2012，138，12： | 1 |
| 15 | Simultaneous visual detection of pulse chirp and temporal asymmetry in ultrashort laser pulses using analysis of unbalanced interferometrie correlation envelope (ICE) functions 显示文摘 | SHARMA A K NAIK P A GUPTA P D | 2007 | Applied Physics B2007，87，4： | 1 |
| 16 | MnO2 decorated graphene nanoribhons with superior permittivity and excel- lent microwave shielding properties 显示文摘 | Gupta T K Singh B P Singh V N | 2014 | J Mater Chem A2014，2，12： | 1 |
| 17 | Comparison of retroperitoneoscopic nephrectomy with open surgery for tuberculo us nonfunctioning kidneys显示文摘 | Hemal A K Gupta N P Kumar R | 2000 | J Urol2000，164，1： | 1 |
| 18 | Single - molecule DNA sequencing technologies for future genomics research 显示文摘 | Gupta P K | 2008 | Trends in Biotechnology2008，26，11： | 1 |
| 19 | A Novel Evolutionary Approach for Load Balanced Clustering Problem for Wireless Sensor Networks显示文摘 | Kuila P Gupta S K Jana P K | 2013 | Swarm and Evolutionary Computation2013，24，12： | 1 |
| 20 | The Cr-Ni-Si(Chromium-Nickel-Silicon)System显示文摘 | Gupta K P | 2006 | Journal of Phase Equilibria and Diffusion2006，27，5： | 1 |
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