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| 1 | A novel deletion mutation, c.1296delT in the BCOR gene, is associated with oculo-facio-cardio-dental syndrome显示文摘The purpose of the present study was to analyze the clinical phenotypes of a girl with oculo-facio-cardio-dental(OFCD)syndrome and to identify the potential pathogenic mutation responsible for her disease. The patient underwent detailed clinical examinations and phenotype data were collected over a follow-up period of 9 years. Mutation analysis of the candidate gene BCOR was performed with polymerase chain reaction and Sanger sequencing. BCOR of 60 unrelated normal individuals were also sequenced as a control group. Clinical phenotyping and follow-up study results indicate that this patient had multiple system anomalies including ocular, facial, cardiac, dental, and limb malformations. In addition, papilloma of the choroid plexus was identified, which represents the first report of this phenotype in an OFCD patient. A novel deletion mutation, c.1296 delT in exon4 of the BCOR gene, was identified in this patient and was not found in her parents or in 60 normal unrelated individuals. This deletion was a frameshift mutation and is proposed to encode a premature stop codon, thus producing a truncated protein. Our patient fitted the diagnostic criteria for OFCD syndrome and we report the first papilloma of the choroid plexus in an OFCD patient, expanding the recognized phenotypic spectrum of this disease. Meanwhile, we identified a novel deletion mutation that may cause OFCD syndrome. | Jingshang Zhang Hongyan Jia Jinda Wang Ying Xiong Jing Li Xiaoxia Li Jing Zhao Xiaohui Zhang Qisheng You Guyu Zhu Frank F.Tsai Mark Espina Xiuhua Wan | 2019 | Science China(Life Sciences)2019，62，1： | 6 |
| 2 | Image segmentation algorithm for greenhouse cucumber canopy under various natural lighting conditions显示文摘In this study,machine vision technology was used to capture images of greenhouse cucumber canopy,and image segmentation was implemented under various natural lighting conditions.The images were enhanced by multi-scale retinex with color restore(MSRCR),and the MSRCR images were segmented by four algorithms:normalized difference index(NDI),excess green(ExG),modified excess green(MExG),and modified excess green minus excess red(MExG-ExR).The results indicated that compared with the original images,under various lighting conditions,the average evaluation indexes of brightness,information entropy,average gradient and mean gray value of the MSRCR images were increased by 38.71%,8.04%,4.54%,and 37.81%,respectively,and only the contrast degree decreased by 12.13%.The MExG-ExR segmentation algorithm was used to segment the MSRCR images(fifty images under various lighting conditions in the test and it performed best among the four segmentation algorithms,average overlap ratios and recognition rates of were 99.28%and 98.91%,respectively,while 38.39%and 37.95%respectively for original image.These results indicated that the MExG-ExR segmentation algorithm applied to a MSRCR canopy image produced the most stable results among the four algorithms.By using the MSRCR image enhancement algorithm,the interference of lighting on greenhouse cucumber canopy images was reduced and the foundation for achieving accurate segmentation of a canopy region was laid,which is of great significance for greenhouse cucumber phenotypic parameter measurements. | Sun Guoxiang Li Yongbo Wang Xiaochan Hu Guyue Wang Xuan Zhang Yu | 2016 | International Journal of Agricultural and Biological Engineering2016，9，3： | 4 |
| 3 | TGF-β regulation of microRNA miR-497-5p and ocular lens epithelial cell mesenchymal transition显示文摘The purpose of this study was to investigate the role of a human lens microRNA(miR-497-5p) in regulating epithelialmesenchymal transition(EMT) under the control of transforming growth factor beta(TGF-β). A microRNA array was used to evaluate the microRNA profiles of untreated and TGF-β-treated human lens epithelial cells in culture. This showed that TGF-βtreatment led to the upregulation of 96 microRNAs and downregulation of 39 microRNAs. Thirteen microRNAs were predicted to be involved in the pathogenesis of posterior capsule opacification(PCO). Meanwhile, overexpression of miR-497-5p suppressed cell proliferation and EMT 48 h post-transfection, and inhibition of miR-497-5p accelerated cell proliferation and EMT.Treatment with TGF-β inhibited the expression of miR-497-5p, but not cell proliferation. miR-497-5p was also found to regulate the level of CCNE1 and FGF7, which are reported to be actively involved in EMT. CCNE1 and FGF7 were bona fide targets of miR-497-5p. The results suggest that miR-497-5p participates in the direct regulation of lens epithelial cell EMTand is regulated by TGF-β. miR-497-5p may be a novel target for PCO therapy. | Jinda Wang Jingshang Zhang Ying Xiong Jing Li Xiaoxia Li Jing Zhao Guyu Zhu Hailong He Yusufu Mayinuer Xiuhua Wan | 2020 | Science China(Life Sciences)2020，63，12： | 3 |
| 4 | Microfluidic-enabled ambient-temperature synthesis of ultrasmall bimetallic nanoparticles显示文摘The production of bimetallic nanoparticles with ultrasmall sizes is the constant pursuit in chemistry and materials science because of their promising applications in catalysis,electronics and sensing.Here we report ambient-temperature preparation of bimetallic NPs with tunable size and composition using microfluidic-controlled co-reduction of two metal precursors on silicon surface.Instead of free diffusion of metal ions in bulk system,microfluidic flow could well control the local ions concentration,thus leading to homogenous and controllable reduction rate among different nucleation sites.By controlling precursor concentration,flow rate and reaction time,we rationally design a series of bimetallic NPs including Ag-Cu,Ag-Pd,Cu-Pt,Cu-Pd and Pt-Pd NPs with ultrasmall sizes(~3.0 nm),tight size distributions(relative standard deviation(RSD)<21%),clean surface,and homogenous elemental compositions among particles(standard deviation(SD)of weight ratios<3.5%).This approach provides a facile,green and scalable method toward the synthesis of diverse bimetallic NPs with excellent activity. | Huayi Shi Bin Song Runzhi Chen Qiang Zhang Guyue Hu Jing Li Jinhua Wang Xinyu Meng Houyu Wang Yao He | 2022 | Nano Research2022，15，1： | 2 |
| 5 | Guidance-机器人视觉传感平台显示文摘视觉传感器作为智能机器人的关键技术,可以实现机器人定位、导航和目标跟踪。但是,当前市场上缺乏高性能的机器人视觉传感器平台。本文将介绍一个功能强、效率高的视觉传感平台Guidance,其包含一个中央处理器和多个(五个以上)伺服传感单元,内置的基础功能有:视觉定位、避障、景深图像生成。此外,Guidance配套有完整的SDK文档,可供使用者灵活使用并开发相关的项目,譬如自主导航、目标跟踪、定位和地图构建等。 | guyue zhou lu fang ketan tang honghui zhang kai wang kang yang 刘佰鑫 苏琦 | 2016 | 预应力技术2016，0，3： | 1 |
| 6 | A low-energy ion spectrometer with half-space entrance for three-axis stabilized spacecraft显示文摘A low-energy ion spectrometer(LEIS) for use aboard three-axis stabilized spacecraft has been developed to measure ion energy per charge distribution in three-dimensional space with good energy-, angular-and temporal-resolutions. For the standard top-hat electrostatic analyzer used widely in space plasma detection, three-axis stabilized spacecraft makes it difficult to obtain complete coverage of all possible ion arrival directions. We have designed angular scanning deflectors supplementing to a cylindrically symmetric top-hat electrostatic analyzer to provide a half-space field of view as 360°×90°(–45°–+45°), and fabricated the LEIS flight model for detecting magnetospheric ions in geosynchronous orbit. The performance of this payload has been evaluated in detail by a series of simulation and environmental tests, and the payload has also been calibrated through laboratory experiments using a low-energy ion source. The results show that capabilities of the LEIS payload are in accordance with the requirements of a magnetospheric mission. | HU RenXiang SHAN Xu YUAN GuangYuan WANG ShuWen ZHANG WeiHang QI Wei CAO Zhe LI YiRen CHEN ManMing YANG XiaoPing WANG Bo SHAO SiPei LI Feng ZHONG XiaoQing FAN Dan HAO XinJun FENG ChangQing SU ZhenPeng SHEN ChengLong LI Xin DAI GuYue QIU BingLin PAN ZongHao LIU Kai XU ChunKai LIU ShuBin AN Qi ZHANG TieLong WANG YuMing CHEN XiangJun | 2019 | Science China(Technological Sciences)2019，62，6： | 1 |
| 7 | Synthesis and properties of soluble sulfonated polybenzimidazoles from 3,3'-disulfonate-4,4'-dicarboxylbiphenyl as proton exchange membranes显示文摘 | Kang Sen Zhang Chunjie Xiao Guyu | 2009 | Journal of Membrane Science2009，334，： | 1 |
| 8 | Enterogenic Stenotrophomonas maltophilia migrates to the mammary gland to induce mastitis by activating the calcium-ROS-AMPK-mTOR-autophagy pathway显示文摘Background Mastitis is an inflammatory disease of the mammary gland that has serious economic impacts on the dairy industry and endangers food safety.Our previous study found that the body has a gut/rumen-mammary gland axis and that disturbance of the gut/rumen microbiota could result in‘gastroenterogenic mastitis'.However,the mechanism has not been fully clarified.Recently,we found that long-term feeding of a high-concentrate diet induced mastitis in dairy cows,and the abundance of Stenotrophomonas maltophilia(S.maltophilia)was significantly increased in both the rumen and milk microbiota.Accordingly,we hypothesized that‘gastroenterogenic mastitis'can be induced by the migration of endogenous gut bacteria to the mammary gland.Therefore,this study investigated the mechanism by which enterogenic S.maltophilia induces mastitis.Results First,S.maltophilia was labelled with superfolder GFP and administered to mice via gavage.The results showed that treatment with S.maltophilia promoted the occurrence of mastitis and increased the permeability of the blood-milk barrier,leading to intestinal inflammation and intestinal leakage.Furthermore,tracking of ingested S.maltophilia revealed that S.maltophilia could migrate from the gut to the mammary gland and induce mastitis.Subsequently,mammary gland transcriptome analysis showed that the calcium and AMPK signalling pathways were significantly upregulated in mice treated with S.maltophilia.Then,using mouse mammary epithelial cells(MMECs),we verified that S.maltophilia induces mastitis through activation of the calcium-ROS-AMPK-mTOR-autophagy pathway.Conclusions In conclusion,the results showed that enterogenic S.maltophilia could migrate from the gut to the mammary gland via the gut-mammary axis and activate the calcium-ROS-AMPK-mTOR-autophagy pathway to induce mastitis.Targeting the gut-mammary gland axis may also be an effective method to treat mastitis. | Zhaoqi He Caijun Zhao Yuhong He Zhuoyu Liu Guyue Fan Kun Zhu Yiqi Wang Naisheng Zhang Yunhe Fu Xiaoyu Hu | 2024 | Journal of Animal Science and Biotechnology2024，15，1： | 0 |
| 9 | A case of pulmonary mucormycosis presented with cardiac arrest显示文摘Mucormycosis is an uncommon and opportunistic fungal infection with high mortality. Infections may result from ingestion of contaminated food, inhalation of spores into the respiratory tract or inoculation into disruptedskin.^([1])Pulmonarymucormycosis(PM)is the most common clinical type. | Haijiang Zhou Xuan Qi Jifei Cai Wenxin Liu Chenyu Kang Guyu Zhang Miaomiao Wang Xuefei Xie Chao Liang Lihua Liu Jie Gao Wei Yuan Xue Mei Shubin Guo | 2023 | World Journal of Emergency Medicine2023，14，6： | 0 |
| 10 | OSFPMiner: An Optimal Weighted Traversal Software Patterns Miner Based on Complex Network显示文摘The weighted traversal pattern is important in software system for a better understanding of the internal structure and behavior of software. To mine important patterns of software, a complex network-based Optimal Software Fault Patterns Miner is presented. By analyzing the multiple execution traces of software and the relations among functions, we establish the Weighted Software Execution Dependency Graph model ultimately.The traversal database is generated through depth-first search strategy and the extraction of software path traversals. According to the downward-closure property,a pruning strategy is adopted by Weighted Frequent Candidate Pattern Tree to cut off more unpromising patterns in advance. A set of important patterns is derived without repeated calculation. The experimental results show that the proposed approach has good performance in the number of weighted frequent candidate patterns and time efficiency. | HE Haitao SHAN Chun HE Hongdou ZHAO Guyu ZHANG Yangsen TIAN Xiangmin | 2020 | Chinese Journal of Electronics2020，29，2： | 0 |
| 11 | Modeling of micropipette aspiration and optical tweezers stretching of erythrocytes with or without Malaria parasite显示文摘The erythrocytes play an important role in the human body.The healthy erythrocytes can undergo extremely large deformation while passing through small capillaries.Their infection by Malaria Plasmodium falcipurum(P.f.) will lead to capillary blockage and blood flow obstruction.Many experimental and computational methods have been applied to study the increase in stickiness and decrease in deformability of the Malaria(P.f.) infected erythrocytes.The novelty of this paper lies in the establishment of an multi-component model for investigating mechanical properties of Malaria(P.f.) infected erythrocytes,especially of their enclosed parasites.Finite element method was applied to simulate the erythrocytes' deformation in micropipette aspiration and optical tweezers stretching using the computational software ABAQUS.The comparisons between simulations and experiments were able to quantitatively conclude the effects of stiffness and stickiness of the parasitophorous vacuole membrane on the cells' deformation,which could not be obtained from experiments directly. | Guyue Jiao Ruojing Zhang | 2013 | Theoretical & Applied Mechanics Letters2013，3，3： | 0 |
| 12 | Compositional Prompting Video-language Models to Understand Procedure in Instructional Videos显示文摘Instructional videos are very useful for completing complex daily tasks,which naturally contain abundant clip-narration pairs.Existing works for procedure understanding are keen on pretraining various video-language models with these pairs and then finetuning downstream classifiers and localizers in predetermined category space.These video-language models are proficient at representing short-term actions,basic objects,and their combinations,but they are still far from understanding long-term procedures.In addition,the predetermined procedure category faces the problem of combination disaster and is inherently inapt to unseen procedures.Therefore,we propose a novel compositional prompt learning(CPL)framework to understand long-term procedures by prompting short-term video-language models and reformulating several classical procedure understanding tasks into general video-text matching problems.Specifically,the proposed CPL consists of one visual prompt and three compositional textual prompts(including the action prompt,object prompt,and procedure prompt),which could compositionally distill knowledge from short-term video-language models to facilitate long-term procedure understanding.Besides,the task reformulation enables our CPL to perform well in all zero-shot,few-shot,and fully-supervised settings.Extensive experiments on two widely-used datasets for procedure understanding demonstrate the effectiveness of the proposed approach. | Guyue Hu Bin He Hanwang Zhang | 2023 | Machine Intelligence Research2023，20，2： | 0 |
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