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| 1 | Doxorubicin-loaded silicon nanoparticles impregnated into red blood cells featuring bright fluorescence, strong photostability, and lengthened blood residency显示文摘基于唯一的优点荧光灯硅 nanoparticles (SiNPs ) ,长发行量红血房间(RBC ) ,和反癌症药分子(即, doxorubicin (纪录影片)) ,我们开发了使妊娠进 RBC 的多功能的装载纪录影片的 SiNPs。重要地,产生的药交货系统(DDS ) 同时展出了结合的明亮的荧光柔韧的 photostability (即, 24% 损失荧光灯在 25 min 以后的紧张连续激光照耀) 并且显著地变长的血住处(即, t 1/2= 7.31 吗?? | Airui Jiang Bin Song Xiaoyuan Ji Fei Peng Houyu Wang Yuanyuan Su Yao He | 2018 | Nano Research2018，11，4： | 6 |
| 2 | Microfluidic-enabled ambient-temperature synthesis of ultrasmall bimetallic nanoparticles显示文摘The production of bimetallic nanoparticles with ultrasmall sizes is the constant pursuit in chemistry and materials science because of their promising applications in catalysis,electronics and sensing.Here we report ambient-temperature preparation of bimetallic NPs with tunable size and composition using microfluidic-controlled co-reduction of two metal precursors on silicon surface.Instead of free diffusion of metal ions in bulk system,microfluidic flow could well control the local ions concentration,thus leading to homogenous and controllable reduction rate among different nucleation sites.By controlling precursor concentration,flow rate and reaction time,we rationally design a series of bimetallic NPs including Ag-Cu,Ag-Pd,Cu-Pt,Cu-Pd and Pt-Pd NPs with ultrasmall sizes(~3.0 nm),tight size distributions(relative standard deviation(RSD)<21%),clean surface,and homogenous elemental compositions among particles(standard deviation(SD)of weight ratios<3.5%).This approach provides a facile,green and scalable method toward the synthesis of diverse bimetallic NPs with excellent activity. | Huayi Shi Bin Song Runzhi Chen Qiang Zhang Guyue Hu Jing Li Jinhua Wang Xinyu Meng Houyu Wang Yao He | 2022 | Nano Research2022，15，1： | 2 |
| 3 | Highly fluorescent,photostable,and biocompatible silicon theranostic nanoprobes against Staphylococcus aureus infections显示文摘Human health is severely threatened by bacterial infections,which fuel urgent demand for the development of novel theranostic agents that are suitable for diagnosing and combating bacterial infections.To meet this goal,we synthesized a new kind of theranostic probes,made of vancomycin (Van)-modified fluorescent silicon nanoparticles (SiNPs-Van).The new probes feature good selectivity for Gram-positive bacterial infections,favorable fluorescence,strong resistance to photobleaching (e.g.,12%loss of fluorescence intensity during 40min continuous laser excitation in the presence of Staphylococcus aureus (S.aureus)),and good biocompatibility (e.g.,cell viability >95%during 24h treatment).Because of these benefits,the probes were effective at prolonged (i.e.,8-day)fluorescence tracking of S.aureus infections in vivo,thus providing a visible and accurate way to evaluate treatment efficacy.Moreover,the resultant SiNPs-Van with a minimum inhibitory concentration (MIC)of ca.0.5μg/mL exhibited high antibacterial efficiency of 92.5%,superior to that (76.5%)of free Van with higher MIC of ca.1μg/mL. | Xia Zhai Bin Song Binbin Chu Yuanyuan Su Houyu Wang Yao He | 2018 | Nano Research2018，11，12： | 2 |
| 4 | Microwave-assisted continuous flow phytosynthesis of silver nanoparticle/reduced graphene oxide composites and related visible light catalytic performance显示文摘The creation of an environmentally friendly synthesis method for silver nanomaterials(Ag-NPs)is an urgent concern for sustainable nanotechnology development.In the present study,a novel straightforward and green method for the preparation of silver nanoparti-cle/reduced graphene oxide(AgNP/rGO)composites was successfully developed through the combination of phytosynthesis,continuous flow synthesis and microwave-assistance.Oriental persimmon(Diospyros kaki Thunb.)extracts were used as both plant reducing and capping agents for fast online synthesis of AgNP/rGO composites.The experimental param-eters were optimized and the morphologies of the prepared materials were investigated.The characterization results reveal that spherical AgNPs were quickly synthesized and uni-formly dispersed on rGO sheets using the proposed online system.Fourier transform in-frared spectroscopy analysis confirmed that phenols,flavonoids,and other substances in the plant extracts played a decisive role in the synthesis of AgNP/rGO composites.Using sodium borohydride(NaBH4)degradation of p-nitrophenol(4-NP)as a model,the catalytic activity of the prepared AgNP/rGO materials was evaluated.The complete degradation of 4-NP was achieved within 12 min through the use of AgNP/rGO materials,and the compos-ite had a much better catalytic activity than the bare AgNPs and rGO had.Compared with the conventional chemical method,our online method is facile,fast,cost-efficient,and en-vironmentally friendly. | Houyu Wang Chun-Gang Yuan Chenchen Liu Xuelei Duan Qi Guo Yiwen Shen Jingfu Liu Yongsheng Chen | 2022 | Journal of Environmental Sciences2022，34，5： | 2 |
| 5 | Constitutive model models in stability analysis of rock slope 显示文摘 | Yan Zhixin Duan Jian Wang Houyu | 2008 | Journal of Central South University of Technology2008，15，2： | 1 |
| 6 | Constitutive models in stabili- ty analysis of rock slope显示文摘 | Yan Zhixin Duan Jian Wang Houyu | 2008 | Journal of Central South University of Technology2008，15，2： | 1 |
| 7 | Candidate therapeutic agents in a newly established triple wild-typemucosalmelanoma cell line显示文摘Background:Mucosalmelanoma has characteristically distinct genetic features and typically poor prognosis.The lack of representativemucosal melanoma models,especially cell lines,has hindered translational research on this melanoma subtype.In this study,we aimed to establish and provide the biological properties,genomic features and the pharmacological profiles of a mucosal melanoma cell line that would contribute to the understanding and treatment optimization of molecularly-defined mucosal melanoma subtype.Methods:The sample was collected from a 67-year-old mucosal melanoma patient and processed into pieces for the establishment of cell line and patientderived xenograft(PDX)model.The proliferation and tumorigenic property of cancer cells from different passageswere evaluated,andwhole-genome sequencing(WGS)was performed on the original tumor,PDX,established cell line,and the matched blood to confirm the establishment and define the genomic features of this cell line.AmpliconArchitect was conducted to depict the architecture of amplified regions detected by WGS.High-throughput drug screening(HTDS)assay including a total of 103 therapeutic agents was implemented on the established cell line,and selected candidate agents were validated in the corresponding PDX model.Results:A mucosal melanoma cell line,MM9H-1,was established which exhibited robust proliferation and tumorigenicity after more than 100 serial passages.Genomic analysis of MM9H-1,corresponding PDX,and the original tumor showed genetic fidelity across genomes,and MM9H-1 was defined as a triple wild-type(TWT)melanoma subtype lacking well-characterized“driver mutations”.Instead,the amplification of several oncogenes,telomerase reverse transcriptase(TERT),v-Rafmurine sarcoma viral oncogene homolog B1(BRAF),melanocyte Inducing transcription factor(MITF)and INO80 complex ATPase subunit(INO80),via large-scale genomic rearrangement potentially contributed to oncogenesis of MM9H-1.Moreover,HTDS identified proteasome inhibitors,especially bortezomib,as promising therapeutic candidates for MM9H-1,which was verified in the corresponding PDX model in vivo.Conclusions:We established and characterized a new mucosal melanoma cell line,MM9H-1,and defined this cell line as a TWT melanoma subtype lacking well-characterized“driver mutations”.The MM9H-1 cell line could be adopted as a unique model for the preclinical investigation of mucosal melanoma. | Chaoji Shi Ziyue Gu Shengming Xu Houyu Ju Yunteng Wu Yong Han Jiayi Li Chuwen Li Jing Wu Lizhen Wang Jiang Li Guoyu Zhou Weimin Ye Guoxin Ren Zhiyuan Zhang Rong Zhou | 2022 | Cancer Communications2022，42，7： | 1 |
| 8 | Silicon-based nanoprobes cross the blood–brain barrier for photothermal therapy of glioblastoma显示文摘Traditional photothermal agents of indocyanine green(ICG)have poor stability,short circulation time,and poor brain permeability due to the blood–brain barrier(BBB),greatly impairing their therapeutic efficacy in glioblastoma(GBM).Herein,we develop a novel kind of SiNPs-based nanoprobes to bypass the BBB for photothermal therapy of GBM.Typically,the SiNPs-based nanoprobes are composed of the particle itself,the BBB-targeting ligand of glucosamine(G),and the therapeutic agent of ICG.We demonstrate that the as-synthesized nanoprobes could cross the BBB through glucose transporter-1(GLUT1)-mediated transcytosis,followed by accumulation at GBM tissues in mice.Compared with free ICG,G-ICG-SiNPs show stronger stability(for example,the fluorescence intensity of G-ICG-SiNPs loaded with the same dose of ICG decays by 34.6%after 25 days of storage,while the fluorescence intensity of ICG decays by 99.5%under the same conditions).Furthermore,the blood circulation time of G-ICG-SiNPs increases by about 17.3-fold compared with their ICG counterparts.After injection of the therapeutic agents into the GBM-bearing mice,GBM-surface temperature rises to 45.3℃in G-ICG-SiNPs group after 5-min 808 nm irradiation but climbs only to 36.1℃in equivalent ICG group under the identical conditions,indicating the superior photothermal effects of GICG-SiNPs in vivo. | Rong Sun Mingzhu Liu Zhaojian Xu Bin Song Yao He Houyu Wang | 2022 | Nano Research2022，15，8： | 0 |
| 9 | Spatial distribution of bacterial resistance towards antibiotics of rural sanitation system in China and its potential link with diseases incidence显示文摘Chinese government is vigorously promoting toilet renovation in rural areas to reduce the risk of human feces exposure,which would cause infectious diseases,especially antibiotic resistance genes(ARGs)and pathogens.However,the distribution of ARGs in human feces from different regions of China remained ill-defined.It is not yet known how the survival of ARGs after toilet treatment is associated with the regional infection rates.Here,we investigated the prevalence of ARGs in human feces in rural areas of China and their potential relationship with infectious diseases for the first large-scale.The results showed that there were still high ARGs residues in human feces after rural toilet treatment,especially tetM-01 and ermB with average relative abundance as high as 1.21×10^(−1)(Eastern)and 1.56×10^(−1)(Northern),respectively.At a large regional scale,the significant differences in human feces resistomeswere mainly shaped by the toilet types,TN,NH_(3)-N,and the bacterial community.A critical finding was that toilets still cannot effectively decrease the pathogenicity risk in human feces.The significant positive relationship(P<0.05)between infectious diseases and ARGs can infer that ARGs in human feces exposure might be a critical path for enhancing the incidence of diseases,as these ARGs hinder the effectiveness of antibiotics. | Houyu Li Lu Tan Chunxue Zhang Xiaocheng Wei Qiang Wang Qian Li Xiangqun Zheng Yan Xu | 2023 | Journal of Environmental Sciences2023，，5： | 0 |
| 10 | Long-term fundus fluorescence angiography and real-time diagnosis of retinal diseases in non-human primate-animal models显示文摘Fluorescein angiography(FA)is a standard imaging modality for evaluating vascular abnormalities in retina-related diseases,which is recognized as the major cause of vision loss.Long-term and real-time fundus angiography is of great importance in preclinical research,nevertheless remaining big challenges up to present.In this study,we demonstrate that long-term fluorescence imaging of retinal vessels is enabled through a kind of fluorescent nanoagents,which is made of small-sized(hydrodynamic diameter:∼3 nm)silicon nanoparticles(SiNPs)featuring strong fluorescence,robust photostability,lengthened blood residency and negligible toxicity.In particular,the presented SiNPs-based nanoagents are capable of imaging retinal capillaries in∼10 min,which is around 10-fold longer than that(∼1 min)of fluorescein sodium(FS,known as the most widely used contrast agents for FA in clinic).Taking cynomolgus macaques as non-human primate-animal model,we further demonstrate the feasibility of real-time diagnosis of retinal diseases(e.g.,age-related macular degeneration(AMD))through dynamic monitoring of vascular dysfunction. | Miaomiao Tang Lu Zhang Bin Song Xiaoyuan Ji Chenyu Wang Houyu Wang Hua Xu Yuanyuan Su Yao He | 2021 | Nano Research2021，14，11： | 0 |
| 11 | Symmetric or asymmetric glide resistance to twinning disconnection?显示文摘Successive gliding of twinning disconnections(TDs)creates three-dimensional twins in parent crystal and accommodates shear deformation.It is generally recognized that TD is subject to the same Peierls stress as it glides forward or backward because of its dislocation character and the twofold rotation symmetry of the twin plane.Based on atomistic simulations,we demonstrate that the glide of TDs may be subject to a symmetric or asymmetric resistance corresponding to step character,symmetric resistance for A/A type steps but asymmetric resistance for A/B type steps,where A and B represent crystallographic planes in twin and matrix.Furthermore,we experimentally demonstrate that the asymmetric resistance results in asymmetric propagation and growth of twins in Mg alloys. | Mingyu Gong Houyu Ma Kunming Yang Yue Liu Jian-Feng Nie Jian Wang | 2022 | npj Computational Materials2022，，1： | 0 |
| 12 | The in vivo targeted molecular imaging of fluorescent silicon nanoparticles in Caenorhabditis elegans显示文摘 | Yanfeng Zhou Yun Zhang Yiling Zhong Rong Fu Sicong Wu Qin Wang Houyu Wang Yuanyuan Su Huimin Zhang Yao He | 2018 | Nano Research2018，11，5： | 0 |
| 13 | Controllable Synthesis of Silicon-Based Nanohybrids for Reliable Surface-Enhanced Raman Scattering Sensing显示文摘Interface between metallic nanoparticles and dielectric silicon substrate can strongly confine electromagnetic field(EM-field)through its localized surface plasmons,together contributing great surface-enhanced Raman scattering(SERS)enhancement.Typically,silicon-based nanohybrids(metallic nanoparticles in situ grown on silicon substrate)have been widely employed as SERS-active substrates in sensing platforms for the detection of chemical and biological analytes.Silicon-based nanohybrids with surface plasmons allow amplifying Raman signals that associate molecular binding events by several orders of magnitude.Together with interfacial architectures for the specific binding of target analyte on the silicon-based nanohy-brid surface,silicon-based nanohybrid-enhanced Raman scattering represents a promising method for increasing reliability and sensitivity.This re-view affords a presentation to the basics of SERS enhancement of silicon-based nanohybrid,illustrates current advances in controllable synthesis of silicon-based nanohybrid substrates,and outlines current implementations to sensors for reliable detection of ultralow amounts of analytes. | Xing Lu Houyu Wang Yao He | 2022 | Chinese Journal of Chemistry2022，40，6： | 0 |
| 14 | Effects of trifluoromethanesulfonic acid ligand on the Zinc-based catalysts for the acetylene hydration显示文摘Developing an efficient Zn-based catalyst modified with Trifluoromethanesulfonic acid(Tf OH)ligand is extremely desirable for the acetylene hydration reaction.In this paper,with the use of a simple impregnation method,a series of Zn-Tf OH/AC catalysts were synthesized,and the Zn-1.5Tf OH/AC catalyst demonstrated the optimal catalytic performance with 96%acetylene conversion in the hydration of acetylene.The X-ray absorption fine structure(XAFS)spectra of the fresh Zn-1.5Tf OH/AC catalysts demonstrated the establishment of the Zn-O_(4)coordination structure.According to the characterization results,Tf OH ligands effectively inhibited carbon accumulation and Zinc loss,improved acidic sites and the dispersion of active metal,and produced more catalytic active site.Furthermore,the hydration reaction mechanism of Zn-Tf OH/AC catalyst with Zn(OTf)_(2),Tf O-Zn Cl,and Tf O-Zn OH complex configurations was explored by the Density Functional Theory(DFT)method,which showed that the activation barrier increased sequentially TfO-ZnOH | Zhen Chen Fei Zhao Houyu Zhang Qinqin Wang Bin Dai | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 15 | Construction of N-doped carbon frames anchored with Co single atoms and Co nanoparticles as robust electrocatalyst for hydrogen evolution in the entire pH range显示文摘The development of low-cost, efficient, and high atomic economy electrocatalysts for hydrogen evolution reaction(HER) in the entire p H range for sustainable hydrogen production is of great importance but still challenging. Herein, we synthesize a highly dispersed N-doped carbon frames(NCFs) anchored with Co single atoms(SAs) and Co nanoparticles(NPs) catalyst by a doping-adsorption-pyrolysis strategy for electrocatalytic hydrogen evolution. The Co SAs-Co NPs/NCFs catalyst exhibits an excellent HER activity with small overpotential, low Tafel slope, high turnover frequency as well as remarkable stability. It also exhibits a superior HER performance in the entire p H range. Combining with experimental and theoretical calculation, we find that Co SAs with Co-N_(3) coordination structure and Co NPs have a strong interaction for promoting synergistic HER electrocatalytic process. The H_(2)O molecule is easily activated and dissociated on Co NPs, while the generated H^(*) is easily adsorbed on Co SAs for HER, which makes the Co SAs-Co NPs/NCFs catalyst exhibit more suitable H adsorption strength and more conducive to the activation and dissociation of H_(2)O molecules. This work not only proposes a novel idea for constructing coupling catalyst with atomic-level precision, but also provides strong reference for the development of high-efficiency HER electrocatalysts for practical application. | Minmin Wang Min Li Yilin Zhao Naiyou Shi Hui Zhang Yuxue Zhao Yaru Zhang Haoran Zhang Wenhong Wang Kaian Sun Yuan Pan Shoujie Liu Houyu Zhu Wenyue Guo Yanpeng Li Yunqi Liu Chenguang Liu | 2022 | Journal of Energy Chemistry2022，31，4： | 0 |
| 16 | Fluorescent Silicon-based Nanomaterials Imaging Technology in Diseases显示文摘Fluorescence imaging analysis of microscale dynamic process(e.g.,metabolism,mitosis,endocytosis,exocytosis,etc.)is of particular significance to study the related pathogenesis and design the intracellular drug delivery systems.Owing to unique physical,chemical and/or biological properties,silicon(Si)-based nanomaterials have been employed to design and construct different types of nanoprobes for the imaging analysis of diseases.Thus,we herein present an overview of recent advances in fluorescent silicon nanomaterials imaging technology for analyzing and diagnosing diseases.Firstly,we mainly introduce the construction of Si nanomaterials-based bioprobes for long-term fluorescence imaging analysis of cancer-related biological information,such as tumour cells,biomarkers and nanocarriers.Afterwards,we focus on the Si nanomaterials-based imaging technology for monitoring the dynamic process of pathological changes of various ocular diseases(e.g.,ocular angiogenesis,bacterial keratitis,etc.).Then,we outline the construction of Si-based nanoprobes and their applications in simultaneously imaging and treating the bacteria-induced diseases caused by broad-spectrum bacteria-related pathogens.Finally,we further discuss the major challenges and prospects for developing silicon-based fluorescence imaging technology. | CHU Binbin WANG Houyu HE Yao | 2021 | Chemical Research in Chinese Universities2021，37，4： | 0 |
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