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| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | The impacts of conservation agriculture on crop yield in China depend on specific practices, crops and cropping regions显示文摘For smooth and wide application of conservation agriculture(CA), remaining uncertainties about its impacts on crop yield need to be reduced. Based on previous field experiments in China, a meta-analysis was performed to quantify the actual impacts of CA practices(NT: no/reduced-tillage only, CTSR: conventional tillage with straw retention, NTSR: NT with straw retention) on crop yields as compared to conventional tillage without straw retention(CT).Although CA practices increased crop yield by 4.6% on average, there were large variations in their impacts. For each CA practice, CTSR and NTSR significantly increased crop yield by 4.9%and 6.3%, respectively, compared to CT. However, no significant effect was found for NT. Among ecological areas, significant positive effects of CA practices were found in areas with an annual precipitation below 600 mm. Similar effects were found in areas with annual mean air temperature above 5 °C. For cropping regions, CA increased crop yield by 6.4% and 5.5%compared to CT in Northwest and South China, respectively, whereas no significant effects were found in the North China and Northeast China regions. Among crops, the positive effects of CA practices were significantly higher in maize(7.5%) and rice(4.1%) than in wheat(2.9%). NT likely decreased wheat yield. Our results indicate that there are great differences in the impacts of CA practices on crop yield, owing to regional variation in climate and crop types. CA will most likely increase maize yield but reduce wheat yield. It is strongly recommended to apply CA with crop straw retention in maize cropping areas and seasons with a warm and dry climate pattern. | Chengyan Zheng Yu Jiang Changqing Chen Yanni Sun Jinfei Feng Aixing Deng Zhenwei Song Weijian Zhang | 2014 | The Crop Journal2014，2，5： | 15 |
| 3 | New quantum matters:Build up versus high pressure tuning显示文摘In this article we briefly review new quantum functional compounds primarily based on our recent works.We will highlight the effects of pressures on both materials synthesis and quantum tuning.The contents include(I)'111'-type iron based superconducting system,(II)pressure induced superconductivity in topological insulators and(III)the new diluted magnetic semiconductors with decoupled spin charge doping. | JIN ChangQing WANG XianCheng LIU QingQing ZHANG SiJia FENG ShaoMin DENG Zheng YU RiCheng ZHU JingLong | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，12： | 11 |
| 4 | GPU-accelerated computing of three-dimensional solar wind background显示文摘High-performance computational models are required to make the real-time or faster than real-time numerical prediction of adverse space weather events and their influence on the geospace environment.The main objective in this article is to explore the application of programmable graphic processing units(GPUs)to the numerical space weather modeling for the study of solar wind background that is a crucial part in the numerical space weather modeling.GPU programming is realized for our Solar-Interplanetary-CESE MHD model(SIP-CESE MHD model)by numerically studying the solar corona/interplanetary solar wind.The global solar wind structures are obtained by the established GPU model with the magnetic field synoptic data as input.Meanwhile,the time-dependent solar surface boundary conditions derived from the method of characteristics and the mass flux limit are incorporated to couple the observation and the three-dimensional(3D)MHD model.The simulated evolution of the global structures for two Carrington rotations 2058 and 2062 is compared with solar observations and solar wind measurements from spacecraft near the Earth.The MHD model is also validated by comparison with the standard potential field source surface(PFSS)model.Comparisons show that the MHD results are in good overall agreement with coronal and interplanetary structures,including the size and distribution of coronal holes,the position and shape of the streamer belts,and the transition of the solar wind speeds and magnetic field polarities. | FENG XueShang ZHONG DingKun XIANG ChangQing ZHANG Yao | 2013 | Science China Earth Sciences2013，56，11： | 7 |
| 5 | Cropping system innovation for coping with climatic warming in China显示文摘China is becoming the largest grain producing and carbon-emitting country in the world,with a steady increase in population and economic development.A review of Chinese experiences in ensuring food self-sufficiency and reducing carbon emission in the agricultural sector can provide a valuable reference for similar countries and regions.According to a comprehensive review of previous publications and recent field observations,China has experienced on average a larger and faster climatic warming trend than the global trend,and there are large uncertainties in precipitation change,which shows a non-significantly increasing trend.Existing evidence shows that the effects of climatic warming on major staple crop production in China could be markedly negative or positive,depending on the specific cropping region,season,and crop.However,historical data analysis and field warming experiments have shown that moderate warming,of less than2.0 °C,could benefit crop production in China overall.During the most recent warming decades,China has made successful adaptations in cropping systems,such as new cultivar breeding,cropping region adjustment,and cropping practice optimization,to exploit the positive rather than to avoid the negative effects of climatic warming on crop growth.All of these successful adaptations have greatly increased crop yield,leading to higher resource use efficiency as well as greatly increased soil organic carbon content with reduced greenhouse gas emissions.Under the warming climate,China has not only achieved great successes in crop production but also realized a large advance in greenhouse gas emission mitigation.Chinese experiences in cropping system innovation for coping with climatic warming demonstrate that food security and climatic warming mitigation can be synergized through policy,knowledge,and technological innovation.With the increasingly critical status of food security and climatic warming,further efforts should be invested in new agricultural policy,knowledge and technology creation,and popularization of climate-smart agriculture,and more financial investments should be made in field infrastructure development to increase cropping system resilience in China. | Aixing Deng Changqing Chen Jinfei Feng Jin chen Weijian Zhang | 2017 | The Crop Journal2017，5，2： | 7 |
| 6 | A comparative study on 3-D solar wind structure observed by Ulysses and MHD simulation显示文摘During Ulysses’ first rapid pole-to-pole transit from September 1994 to June 1995, its observations showed that middle- or high-speed solar winds covered all latitudes except those between ?20° and +20° near the ecliptic plane, where the velocity was 300―450 km/s. At poleward 40°, however, only fast solar winds at the speed of 700―870 km/s were observed. In addition, the transitions from low-speed wind to high-speed wind or vice versa were abrupt. In this paper, the large-scale structure of solar wind observed by Ulysses near solar minimum is simulated by using the three-dimensional numerical MHD model. The model com- bines TVD Lax-Friedrich scheme and MacCormack II scheme and decomposes the calculation region into two re- gions: one from 1 to 22 Rs and the other from 18 Rs to 1 AU. Based on the observations of the solar photospheric magnetic field and an addition of the volumetric heating to MHD equations, the large-scale solar wind structure mentioned above is reproduced by using the three-dimensional MHD model and the numerical results are roughly consistent with Ulysses’ observations. Our simulation shows that the initial magnetic field topology and the addition of volume heating may govern the bimodal structure of solar wind observed by Ulysses and also demonstrates that the three-dimensional MHD numerical model used here is efficient in modeling the large-scale solar wind structure. | FENG Xueshang, XIANG Changqing, ZHONG Dingkun & FAN Quanlin SIGMA Weather Group, Key Laboratory of Space Weather Key Labo- ratory of Geospace Environment and Geodesy, Ministry of Education, Center for Space Science and Applied Research, Chinese Academy of Sciences, Beijing 100080, China | 2005 | Chinese Science Bulletin2005，50，7： | 6 |
| 7 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 8 | 胃食管反流病:内镜评估与治疗方面的革新显示文摘内镜技术的创新为胃食管反流病(GERD)的诊治带来了巨大进步。作为世界上最常见的胃肠疾病之一,GERD一直是内镜介入治疗的前沿。目前,GERD的初步诊断是基于症状和质子泵抑制剂(PPI)初期治疗有效,但这对治疗策略的指导价值有限。然而,内镜检查和病理活检可直接观察和判断食管的异常结构和病理生理损伤;同时,内镜治疗的出现给PPI治疗依从性较差或治疗反应不佳以及不适合行胃底折叠抗反流手术的患者提供了新的治疗选择。本综述对内镜检查和活检在经过恰当的抗反流药物治疗后持续存在GERD相关临床表现的患者中的应用情况进行了概述,并介绍了目前内镜治疗GERD的各项新技术及其优缺点。今后的研究需要对GERD患者进行分层研究,并力图阐明该疾病的主要病理生理机制。 | Sheng Chen Feng Du Changqing Zhong Caifang Liu Xiaoying Wang Yan Chen Gang Wang Xiaopei Gao Lu Zhang Lianyong Li Wei Wu | 2021 | Gastroenterology Report2021，9，5： | 4 |
| 9 | A low dead time vernier delay line TDC implemented in an actel flash-based FPGA显示文摘In this paper,a high precision vernier delay line(VDL) TDC(Time-to-Digital Convertor) in an actel flash-based Field-Programmable-Gate-Arrays A3PE1500 is implemented,achieving a resolution of 16.4-ps root mean square value or 42-ps averaged bin size.The TDC has a dead time of about 200 ns while the dynamic range is 655.36 μs.The double delay lines method is employed to cut the dead time in half to improve its performance.As the bin size of the TDC is dependent on temperature,a compensation algorithm is adopted as temperature drift correction,and the TDC shows satisfying performance in a temperature range from –5℃ to +55℃. | QIN Xi FENG Changqing ZHANG Deliang ZHAO Lei LIU Shubin AN Qi | 2013 | Nuclear Science and Techniques2013，24，4： | 4 |
| 10 | Three Dimensional Simulation of the Steady Solar Wind in Carrington Rotation 1935显示文摘A three-dimensional MHD simulation is conducted to study the steady solar wind in Carrington Rotation (CR) 1935 by using the three-dimensional numerical magnetohydrodynamic (MHD) model introduced by Feng et al The numerical results demonstrate that the neutral current sheet has two peaks and two valleys, which is consistent with the result of PFSS model at Wilcox Solar Observatory (WSO). The obtained proton number density at 2.5 Rs is of the same order of magnitude as the result estimated from K-coronal brightness during the CRs 1733-1742 in 1983 made by Wei et al. The radial velocity profile along heliocentric distance is consistent with that of low solar wind speed deduced by Sheeley and Wang et al. However, it is not able to reproduce the fast-speed flow in coronal holes and slow solar wind in streamers because of oversimplified energy equation adopted in our model. Future efforts must be made to remedy this deficiency. | XIANG Changqing FENG Xueshang YAO Jiusheng | 2006 | 空间科学学报2006，26，1： | 2 |
| 11 | Antioxidan/ constituents in feverfew (Tanacetum parthenium) extract and their chromatographic quantification显示文摘 | WU Changqing CHEN feng WANG xi | 2006 | Food Chemistry2006，96，： | 1 |
| 12 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 13 | Diluted magnetic characteristics of Ni-doped AIN films via ion implantation显示文摘 | Chong ZHAO Qixin WAN Jiangnan DAI Jun ZHANG Feng WU Shuai WANG Hanling LONG Jingwen CHEN Cheng CHEN Changqing CHEN | 2017 | Frontiers of Optoelectronics2017，10，4： | 1 |
| 14 | Study on effects of environmental temperature on dynamic characteristics of Taizhou Yangtze River Bridge显示文摘The dynamic characteristics of three-tower and two-span suspension bridge are analyzed at different global temperatures. An equivalent cable inner force method is proposed to consider temperature effects and to study the effects of environmental temperature on dynamic characteristics of Taizhou Yangtze River Bridge. The result demonstrates that the effects of temperature can not be neglected in static or dynamic analysis of Taizhou Yangtze River Bridge. The relationship between temperature and frequency is negative. The effects of temperature should be taken into account in experimental modal analysis of long-span bridges and damage identification. | Miao Changqing Chen Liang Feng Zhaoxiang | 2011 | Engineering Sciences2011，9，2： | 1 |
| 15 | A novel yeast-binding lectin from hemolymph Cyclina sinensis (Gmelin) and its effects on yeast cells显示文摘 | Changqing Tong Wei Li Liang Kong Chengyu Tan Min Qu Qiao Jin Pavel Lukyanov Xuqiao Feng | 2012 | Process Biochemistry2012，，12： | 1 |
| 16 | The effect of bone marrow mononuclear cells on vascularization and bone regeneration in steroid-induced osteonecrosis of the femoral head显示文摘 | Yuan Sun Yong Feng Changqing Zhang | 2009 | Joint Bone Spine2009，，6： | 1 |
| 17 | The study of temperature effects on steel box girder for Taizhou Bridge显示文摘Using the temperature gradient which was proposed by continuously measuring flat steel box girder of Runyang Bridge, temperature effects of flat steel box girder were studied for Taizhou Bridge. With three temperature gradient models (JTG D60-2004 specification, BS5400 specification and the temperature gradient which was proposed in this paper), the stress of control sections was calculated by finite element program ANSYS. The calculated result indicated that the temperature gradient that was put forward in JTG D60-2004 specification and BS5400 specification for calculating the stress of flat steel box girder was not suitable to apply to flat steel box girder. The temperature gradient on flat steel box girder which was proposed in this paper was reasonable. | Miao Changqing Feng Zhaoxiang Wang Yichun Shi Changhua | 2012 | Engineering Sciences2012，10，3： | 1 |
| 18 | Electronics of BESⅢ TOF monitor system显示文摘 | FENG Changqing LIU Shubin AN Qi | 2010 | Nuclear Science2010，57，2： | 1 |
| 19 | FERONIA receptor kinase pathway suppresses abscisic acid signaling in Arabidopsis by activating ABI2 phosphatase显示文摘 | Feng Yu Lichao Qian Candida Nibau Qiaohong Duan Daniel Kita Kathryn Levasseur Xiaoqian Li Changqing Lu Hui Li Congcong Hou Legong Li Bob B. Buchanan Liangbi Chen Alice Y. Cheung Dongping Li Sheng Luan | 2012 | Proceedings of the National Academy of Sciences2012，，36： | 1 |
| 20 | Conservation of weathered historic sandstone with biomimetic apatite显示文摘The conservation of weathered historic sandstone with apatite was studied.Based on the growth mechanism of bone,calcium and phosphorus were introduced into weathered sandstone and then mineralized at room temperature.The conservation efficiency was investigated by scanning electron microscopy(SEM),energy-dispersive X-ray spectroscopy(EDX),transmission electron microscopy(TEM),selected area electron diffraction(SAED),X-ray diffraction(XRD),and compressive strength,capillary water uptake,water vapor permeability and weather resistance tests.The SEM,EDX,TEM,SAED and XRD results showed that the produced hydroxyapatite could reunite the weathered stone blocks and provide sufficient reinforcement to hold them together.The results of the various tests indicated that the compressive strength and weather resistance of the treated samples was improved significantly.In addition,because of the porous nature of apatite,the water vapor permeability of the treated stone was not affected and its breathability was maintained. | YANG FuWei LIU Yan ZHU YuanCheng LONG ShiJia ZUO GuoFang WANG ChangQing GUO Feng ZHANG BingJian JIANG SiWei | 2012 | Chinese Science Bulletin2012，57，17： | 1 |
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