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| 1 | miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges显示文摘心血管的疾病(CVD ) 在世界上是病态和死亡的领先的原因。尽管可观的进步在 CVD 的诊断,治疗和预后被取得了,仍然有批评需要让新奇诊断 biomarkers 和新治疗学的干预减少这疾病的发生。最近,正在增加证据那传播 miRNAs (miRNAs ) ,即内长的、稳定的、搁浅单人赛的、短、非编码的 RNA,能为 CVD 被用作诊断 biomarkers。而且, miRNAs 为几心血管的混乱代表潜在的新奇治疗学的目标。在这评论我们提供几 CVD 的效果的概述;包括心失败,尖锐心肌的梗塞,心律不齐和肺的高血压;在传播 miRNAs 的层次上。另外, miRNA 的使用也作为治疗学的目标被讨论,以及质问并且在他们在 CVD 的诊断的使用的建议。 | Shan-shan ZHOU Jing-peng JIN Ji-qun WANG Zhi-guo ZHANG Jonathan H FREEDMAN Yang ZHENG Lu CAI | 2018 | Acta Pharmacologica Sinica2018，39，7： | 31 |
| 2 | 甲状腺乳头状癌诊断与鉴别的可靠标记物显示文摘目的寻找更好的标记物,用于甲状腺乳头状癌的诊断与鉴别。方法以甲状腺乳头状癌(PTC)为研究组,以甲状腺滤泡状腺瘤(FA)和良性乳头状病变(BPL)作对照组。经自制组织芯片和免疫组化技术,对Twist、Galectin-3、HBME-1、p14ARF和TPO进行标记,并与CK19对比实验。结果6种指标阳性表达率依次为:PTC组100.0%、95.6%、80.0%、28.9%、15.6%和78.0%;FA组0.0、11.1%、6.7%、75.6%、88.9%和0.0;BPL组7.0%、7.5%、2.5%、77.5%、100.0%和0.0。PTC组与FA和BPL组比较差异均有显著性(P<0.05)。6种指标的灵敏度、特异度、准确度分别为100.0%、95.6%、80.0%、71.1%、84.4%、78.0;96.4%、90.1%、95.3%、76.5%、94.1%、100.0%和97.7%、92.3%、90.0%、74.6%、90.8%、91.9%。结论在PTC中6种指标阳性表达率最高的为Twist,其次为Galectin-3,因此临床病理工作中标记Twist和Galectin-3鉴别PTC与FA或BPL有实用意义。Twist的灵敏度和准确度最高,CK19特异度最高。因此该2种指标联合使用对于PTC的鉴别诊断最可靠。 | 何春年 Lili H Jin Q CH 陈士超 赵焕芬 翟金萍 | 2007 | 临床与实验病理学杂志2007，23，6： | 14 |
| 3 | Glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide dual receptor agonist DA-CH5 is superior to exendin-4 in protecting neurons in the 6-hydroxydopamine rat Parkinson model显示文摘Patients with Parkinson's disease(PD) have impaired insulin signaling in the brain. Incretin hormones, including glucagon-like peptide-1(GLP-1) and glucose-dependent insulinotropic polypeptide(GIP), can re-sensitize insulin signaling. In a recent phase II clinical trial, the first GLP-1 mimic, exendin-4, has shown reliable curative effect in patients with PD. DA-CH5 is a novel GLP-1/GIP receptor unimolecular coagonist with a novel peptide sequence added to cross the blood-brain barrier. Here we showed that both exendin-4 and DA-CH5 protected against 6-hydroxydopamine(6-OHDA) cytotoxicity, inhibited apoptosis, improved mitogenesis and induced autophagy flux in SH-SY5Y cells via activation of the insulin receptor substrate-1(IRS-1)/alpha serine/threonine-protein kinase(Akt)/c AMP response element-binding protein(CREB) pathway. We also found that DA-CH5(10 nmol/kg) daily intraperitoneal administration for 30 days post-lesion alleviated motor dysfunction in rats and prevented stereotactic unilateral administration of 6-OHDA induced dopaminergic neurons loss in the substantia nigra pars compacta. However, DA-CH5 showed curative effects in reducing the levels of α-synuclein and the levels of pro-inflammatory cytokines(tumor necrosis factor-α, interleukin-1β). It was also more effective than exendin-4 in inhibiting apoptotic process and protecting mitochondrial functions. In addition, insulin resistance was largely alleviated and the expression of autophagy-related proteins was upregulated in PD model rats after DA-CH5 treatment. These results in this study indicate DA-CH5 plays a therapeutic role in the 6-OHDAunilaterally lesioned PD rat model and is superior to GLP-1 analogue exendin-4. The study was approved by the Animal Ethics Committee of Shanxi Medical University of China. | Ling-Yu Zhang Qian-Qian Jin Christian Hölscher Lin Li | 2021 | Neural Regeneration Research2021，16，8： | 10 |
| 4 | Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short-term outcomes of an open-label randomised controlled trial显示文摘 | Sung-Bum Kang Ji Won Park Seung-Yong Jeong Byung Ho Nam Hyo Seong Choi Duck-Woo Kim Seok-Byung Lim Taek-Gu Lee Dae Yong Kim Jae-Sung Kim Hee Jin Chang Hye-Seung Lee Sun Young Kim Kyung Hae Jung Yong Sang Hong Jee Hyun Kim Dae Kyung Sohn Dae-Hyun Kim Jae H | 2010 | Lancet Oncology2010，，7： | 5 |
| 5 | Inhibition of the G9a/GLP histone methyltransferase complex modulates anxiety-related behavior in mice显示文摘Epigenetic 基因规定畸形包括精神分裂症和消沉在各种各样的 neuropsychiatric 混乱,以及在心情和焦虑的规定被含有。另外, epigenetic 机制涉及精神病学的药的行动。当前的 anxiolytic 药有新药的重要缺点,和开发被保证。二蛋白质, G9a (也作为 EHMT2 或 KMT1C 知道) 并且 GLP (象 G9a 一样蛋白质,也作为 EHMT1 或 KMT1D 知道) ,它甲醇化物离氨酸 9 histone H3 (H3K9 ) ,能正在答应 anxiolytic 目标。G9a 的出生后的基因大美人减少焦虑相关的行为,与由过去常对待焦虑(amitriptyline, imipramine 和 paroxetine ) 的一些药的 G9a 层次的减小一致。相反地,在有 GLP haplodeficiency 的老鼠有增加的像焦虑的行为。我们寻求了决定是否 G9a/GLP, UNC0642 和 A-366 的二个药理学禁止者,将有类似的效果到基因 G9a/GLP 不足。当予成年老鼠以时,我们发现有任何一个化合物的 G9a/GLP 抑制减少了像焦虑的行为,与在大脑的减少的 H3K9 methylation 一起。相反,到这些的暴露从胚胎的白天加重(E9.5 ) 9.5 增加了像焦虑的行为直到出生并且减少在成人生活的社会相互作用,当 H3K9 methylation 在在成年老鼠的大脑的正常层次时。这些调查结果增强 G9a/GLP 在大脑开发的不同阶段在像焦虑的行为上有不同效果的基因证据,并且建议指向这条 histone methyltransferase 小径能为开发新 anxiolytic 药是有用的。这些数据也建议在 utero 的抗抑郁剂暴露能在成人生活有否定效果,并且这些效果的进一步的调查被保证。 | Dong-yao WANG Joel KOSOWAN James SAMSOM Laura LEUNG Kai-lai ZHANG Ying-xiang LI Yan XIONG Jian JIN Arturas PETRONIS Gabriel OH Albert H C WONG | 2018 | Acta Pharmacologica Sinica2018，39，5： | 4 |
| 6 | Shoot and root traits in drought tolerant maize(Zea mays L.) hybrids显示文摘This study aimed to investigate the differences in shoot and root traits, and water use and water use efficiency(WUE) in drought tolerant(DT) maize(Zea mays L.) hybrids under full and deficit irrigated conditions. A two-year greenhouse study was conducted with four hybrids(one conventional hybrid, 33D53AM, two commercial DT hybrids, P1151 AM, N75H, and an experimental hybrid, Exp HB) grown under two water regimes(I_(100) and I_(50), referring to 100 and 50% of evapotranspiration requirements). Under water stress, the hybids P1151 AM, N75, and Exp HB showed more drought tolerance and had either greater shoot dry weight or less dry weight reduction than the conventional hybrid(33 D53 AM). However, these three hybrids responded to water stress using different mechanisms. Compared with the conventional hybrid, the two commercial DT hybrids(P1151 AM and N75H) had a smaller leaf area, shoot dry weight, and root system per plant. As a result, these hybrids used less water but had a higher WUE compared with the conventional hybrid. In contrast, the experimental hybrid(ExpHB) produced more shoot biomass by silking stage at both irrigation levels than all other hybrids, but it had relatively lower WUE. The hybrids demonstrated different drought response mechanisms that may require different irrigation management strategies. More investigation and validation are needed under field conditions and in different soil types. | ZHAO Jin XUE Qing-wu Kirk E Jessup HOU Xiao-bo HAO Bao-zhen Thomas H Marek XU Wen-wei Steven R Evett Susan A O'Shaughnessy David K Brauer | 2018 | Journal of Integrative Agriculture2018，17，5： | 3 |
| 7 | Core-shell structured mesoporous silica:a new immobilized strategy for rhodium catalyzed asymmetric transfer hydrogenation显示文摘 | ZHANG H JIN R YAO H | | 0，，63： | 2 |
| 8 | Single Nucleotide Polymorphism rs10919543 in FCGR2A/ FCGR3A Region Confers Susceptibility to Takayasu Arteritis in Chinese Population显示文摘 | Fang Qin Hu Wang Lei Song Xi-Li Lu Li-Rui Yang Er-Peng Liang Wei Wang Yu-Bao Zou Jin Bian Hai-Ying Wu Xian-Liang Zhou Ru-Tai Hui H ui--Min Zhang Xiong-Jing Jiang | 2016 | Chinese Medical Journal2016，，7： | 2 |
| 9 | Thousandfold change in resistivity and magnetoresistance La-Ca-Mn-O film 显示文摘 | Jin S Tiefel T H McCormack M | 1994 | Science1994，264，： | 2 |
| 10 | Multiple network fusion using fuzzy logic 显示文摘 | SUNG B C JIN H K | 1995 | IEEE Trans on Neural Networks1995，6，2： | 2 |
| 11 | Biosorption removal of cadmium from aqueous solution by using pretreated fungal biomass cultured from starch waste water显示文摘 | Yin P H Yu Q M Jin B | 1999 | Wat Res1999，33，8： | 2 |
| 12 | Thousandfold change in resistivity in magnetoresistive La-Ca-Mn-O films 显示文摘 | Jin S Tiefel T H McCormack M | 1994 | Science1994，264，： | 2 |
| 13 | Metallothionein 2A expression is associated with cell proliferation in breast cancer显示文摘 | Jin R Chow V T Tan P H | 2002 | Carcinogenesis2002，23，1： | 2 |
| 14 | Renal dysfunction and its relative factors in metabolic syndrome显示文摘 | Jin Y H Zhu Z M Zhao Z G | 2003 | Am J Hypertens2003，16，5： | 2 |
| 15 | Design and fabrication of a micro wankel engine using MEMS technology 显示文摘 | Lee C H Jiang K C Jin P | 2004 | Microelectronic Engineering2004，，： | 1 |
| 16 | Vulnerability to unidirectional conduction block and reentry in rabbit left ventricular wedge preparation: effect of stimulation sequence and location 显示文摘 | Chen XZ Zhang H Jin YB | 2009 | Chinese J Physiol2009，52，： | 1 |
| 17 | Modern seismic methods in engineering investigation at a nuclear power plant site显示文摘 | Zhao Y G Jin H X Wang C F | 1996 | Scientia Geologica Sinica1996，5，4： | 1 |
| 18 | Optimal control of a tethered subsatellite of three degrees of freedom显示文摘 | Jin D P Hu H Y | 2006 | Nonlinear Dynamics2006，46，12： | 1 |
| 19 | Cyclosporin a inhibits flow-mediated activation of endothelial nitric-oxide synthase by altering cholesterol content in caveolae 显示文摘 | Lungu AO Jin ZG Yamawaki H | 2004 | J Biol Chem2004，279，48： | 1 |
| 20 | Trishear kinematic modeling of extensional fault-propagation folding显示文摘 | Guohai Jin Groshong Jr R H | 2006 | Journal of Structural Geology2006，28，1： | 1 |
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