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| 1 | Relationship between vitamin D and IL-23,IL-17 and macrophage chemoattractant protein-1 as markers of fibrosis in hepatitis C virus Egyptians显示文摘AIM:To assess vitamin D in hepatitis C patients and its relationship to interleukin (IL)-23, IL-17, and macrophage chemoattractant protein-1 (MCP-1). METHODS:The study was conducted on 50 Egyptian hepatitis C virus (HCV) genotype number IV-infected patients and 25 ageand gender-matched healthy subjects. Venous blood samples were obtained. Samples were allowed to clot and sera were separated by centrifugation and stored at -20 ℃. A 25 hydroxy vitamin D assay was carried out using solid phase RIA. A 1,25 dihydroxy vitamin D assay was carried out using a commercial kit purchased from Incstar Corporation. IL-17 and -23 and MCP-1 were assayed by an enzyme immunoassay. Quantitative and qualitative polymerase chain reaction for HCV virus were done by TaqMan technology. Only HCV genotype IV-infected subjectswere included in the study. The mean ± SD were determined, a t-test for comparison of means of different parameters was used. Correlation analysis was done using Pearson's correlation. Differences among different groups were determined using the Kruskal-Wallis test. RESULTS:The mean vitamin D level in HCV patients (groupⅠ) was 15 ± 5.2 ng/mL while in control (group Ⅱ) was 39.7 ± 10.8. For active vitamin D in groupⅠas 16.6 ± 4.8 ng/mL while in group Ⅱ was 41.9 ± 7.9. IL-23 was 154 ± 97.8 in group Ⅰ and 6.7 ± 2.17 in group Ⅱ. IL-17 was 70.7 ± 72.5 in cases and 1.2 ± 0.4 in control. MCP-1 was 1582 ± 794.4 in group Ⅰand 216.1 ± 5.38 in group Ⅱ. Vitamin D deficiency affected 72% of HCV-infected patients and 0% of the control group. Vitamin D insufficiency existed in 28% of HCV-in-fected patients and 12% of the control group. One hundred percent of the cirrhotic patients and 40% of non cirrhotic HCV-infected patients had vitamin D deficiency. IL-23, IL-17, and MCP-1 were markedly increased in HCV-infected patients in comparison to controls.A significant negative correlation between vitamin D and IL-17 and-23 and MCP-1 was detected. HCV-infected males and females showed no differences with respect to viral load, vitamin D levels, IL-17, IL-23 and MCP-1. The viral load was negatively correlated with vitamin D and active vitamin D (P = 0.0001 and P = 0.001, respectively), while positively correlated with IL-23, IL-17, and MCP-1. We classified the patients according to sonar findings into four groups. Group Ⅰa with bright hepatomegaly and included 14 patients. Group Ⅰb with perihepatic fibrosis and included 11 patients. Group Ⅰc with liver cirrhosis and included 11 patients. Group Ⅰd with he patocellular carcinoma (HCC) and included 14 patients. Vitamin D and active vitamin D were shown to be lower in cirrhotic patients and much lower in patients with HCC, and this difference was highly significant (P = 0.0001). IL-17 and-23 and MCP-1 were higher in advanced liver disease) and the differences were highly significant (P = 0.0001).CONCLUSION:Whether the deficiency of vitamin D is related to HCV-induced chronic liver disease or predisposing factor for higher viral load is a matter of debate. | Noha M El Husseiny Hala M Fahmy Waleed A Mohamed Hisham H Amin | 2012 | World Journal of Hepatology2012，4，8： | 12 |
| 2 | Drainage vs. non-drainage after cholecystectomy for acute cholecystitis:a retrospective study显示文摘Many surgeons practice prophylactic drainage after cholecystectomy without reliable evidence,this study was conducted to answer the question whether to drain or not to drain after cholecystectomy for acute calculous cholecystitis.A retrospective review of all patients who had cholecystectomy for acute cholecystitis in Aseer Central Hospital,Abha,Saudi Arabia,was conducted from April 2010 to April 2012.Data were extracted from hospital case files.Preoperative data included clinical presentation,routine investigations and liver function tests.Operative data included excessive adhesions,bleeding,bile leak,and drain insertion.Complicated cases such as pericholecystic collections,mucocele and empyema were also reported.Patients who needed therapeutic drainage were excluded.Postoperative data included hospital stay,volume of drained fluid,time of drain removal,and drain site problems.The study included 103 patients allocated into two groups;group A(n = 38) for patients with operative drain insertion and group B(n = 65) for patients without drain insertion.The number of patients with preoperative diagnosis of acute non-complicated cholecystitis was significantly greater in group B(80%) than group A(36.8%)(P < 0.001).Operative time was significantly longer in group A.All patients who were converted from laparoscopic to open cholecystectomy were in group A.Multivariate analysis revealed that hospital stay was significantly(P < 0.001) longer in patients with preoperative complications.There was no added benefit for prophylactic drain insertion after cholecystectomy for acute calculous cholecystitis in non-complicated or in complicated cases. | Mohammed A Bawahab Walid M Abd El Maksoud Saeed A Alsareii Fahad S Al Amri Hala F Ali Abdul Rahman Nimeri Abdul Rahman M Al Amri Adel A Assiri Mohammed I Abdul Aziz | 2014 | The Journal of Biomedical Research2014，28，3： | 3 |
| 3 | Small-scale deceit:deception as a marker of two-,three-,and four-year-olds' early theories of mind显示文摘 | Fritz A S Hala S | 1989 | Child Development1989，，6： | 1 |
| 4 | Learning and memory impairment in adult rats due to sever zinc deficiency lactation 显示文摘 | Halas E S Eberhardt M J Diers A | 1983 | Physiol Behav1983，30，3： | 1 |
| 5 | Fledgling theories of mind:Deception asa marker of three - year - oldsr understanding of false belief 显示文摘 | Hala S Chandler M Fritz A S | 1991 | ChildDevelopment1991，62，： | 1 |
| 6 | Malondialdehyde and coenzyme Q10 in platelets and serum in type 2 diabetes mellitus: correlation with glycemic control显示文摘 | Eman A El-ghoroury Hala M Raslan Ehsan A Badawy Gamila S El-Saaid Mervat H Agybi Ibrahem Siam Sohair I Salem | 2009 | Blood Coagulation & Fibrinolysis2009，，4： | 1 |
| 7 | Small-scale deceit: deception as a marker of two - , three - , and four - year - olds' early theories of mind显示文摘 | CHANDLER M FRrIZ A S HALA S | 1989 | Child Development1989，60，6： | 1 |
| 8 | Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy 显示文摘 | Gobin A M Lee M H Halas N J | 2007 | Nano Lett2007，7，7： | 1 |
| 9 | Suppressive effects of anti-inflammatory agents on human endothelial cell activatory agents on human endothelial cell activation and induction of heat shock proteins显示文摘 | AMBERGE A HALA M SAURWEIN-TEISSL M | 1999 | Mol Med1999，5，： | 1 |
| 10 | Double versus single autotransplantation in multiple myeloma; a single center experience of 100 patients显示文摘 | Putkonen M Rauhala A hala M | 2005 | Haematologica2005，90，： | 1 |
| 11 | QT dispersion and myocardial viability in patients after acute myocardial infarction 显示文摘 | KOSMALA W PRZEWLOCKA-KOSMALA M HALA - A B | 2004 | Int J Cardiol2004，94，2： | 1 |
| 12 | COMP acts as a catalyst in collagen fibrillogenesis显示文摘 | Hala'sz K Kassner A Morgelin M | 2007 | J Biol Chem2007，282，31： | 1 |
| 13 | Small scale deceit: deception as a marker of 2 , 3-, and 4 year-olds' early theories of mind显示文摘 | Chandler M J Fritz A S Hala S M | 1989 | Child Development1989，60，6： | 1 |
| 14 | Cognitive impairment after cerebrovascular stroke: Relationship to vascular risk factors 显示文摘 | Eman M Khedr Sherifa A Hamed Hala K El - Shereef | 2009 | Neuropsychiatr Dis Treat2009，5，： | 1 |
| 15 | Mutation in Wnt10A is associated with an autosomal recessive ectodermal dysplasia:The odonto-onycho-dermal dysplasia 显示文摘 | LYNN A ELIANE C HALA M B | 2007 | Am J Hum Genet2007，81，4： | 1 |
| 16 | On Some Routh-Hurwitz Conditions for Fractional Order Differential Equations and Their Applications in Lorenz, Rossler, Chua and Chen Systems显示文摘 | Ahmed E E1-Sayed A M A E1-Saka Hala A A | 2006 | Physics Letters A2006，358，： | 1 |
| 17 | The 'recycling trap': a generalized explanation of discharge runaway in high-pow- er impulse magnetron sputtering 显示文摘 | Anders A Capek J Hala M | 2012 | Journal of Physics D: Applied Physics2012，45，01： | 1 |
| 18 | Suppressive effects of anti-inflammatory agents on human endothelial cell activation and induction of heat shock proteins显示文摘 | Amberger A Hala M Saurwein-Teissl M | 1999 | Mol Med1999，5，2： | 1 |
| 19 | effect of high gamma dose on the PADC properties显示文摘 | ABU-JARAD F HALA A M FARHAT M | 1997 | Radiation Measurements1997，28，： | 1 |
| 20 | Small scale deceit: Deception as a marker of 2-, 3- and 4-year-olds' early theories of mind 显示文摘 | Chandler M J Fritz A S Hala S M | 1989 | Child Development1989，60，： | 1 |
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