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| 1 | Ultrafast hydrogen bond dynamics of liquid water revealed by terahertz-induced transient birefringence显示文摘The fundamental properties of water molecules,such as their molecular polarizability,have not yet been clarified.The hydrogen bond network is generally considered to play an important role in the thermodynamic properties of water.The terahertz(THz)Kerr effect technique,as a novel tool,is expected to be useful in exploring the low-frequency molecular dynamics of liquid water.Here,we use an intense and ultrabroadband THz pulse(peak electric field strength of 14.9 MV/cm,centre frequency of 3.9 THz,and bandwidth of 1–10 THz)to resonantly excite intermolecular modes of liquid water.Bipolar THz field-induced transient birefringence signals are observed in a free-flowing water film.We propose a hydrogen bond harmonic oscillator model associated with the dielectric susceptibility and combine it with the Lorentz dynamic equation to investigate the intermolecular structure and dynamics of liquid water.We mainly decompose the bipolar signals into a positive signal caused by hydrogen bond stretching vibration and a negative signal caused by hydrogen bond bending vibration,indicating that the polarizability perturbation of water presents competing contributions under bending and stretching conditions.A Kerr coefficient equation related to the intermolecular modes of water is established.The ultrafast intermolecular hydrogen bond dynamics of water revealed by an ultrabroadband THz pump pulse can provide further insights into the transient structure of liquid water corresponding to the pertinent modes. | Hang Zhao Yong Tan Liangliang Zhang Rui Zhang Mostafa Shalaby Cunlin Zhang Yuejin Zhao Xi-Cheng Zhang | 2020 | Light(Science & Applications)2020，9，1： | 10 |
| 2 | The biological effect of recombinant humanized collagen on damaged skin induced by UV-photoaging:An in vivo study显示文摘The application of medical devices to repair skin damage is clinically accepted and natural polymer enjoys an important role in this field,such as collagen or hyaluronic acid,etc.However,the biosafety and efficacy of these implants are still challenged.In this study,a skin damage animal model was prepared by UV-photoaging and recombinant humanized type Ⅲ collagen(rhCol Ⅲ)was applied as a bioactive material to implant in vivo to study its biological effect,comparing with saline and uncrosslinked hyaluronic acid(HA).Animal skin conditions were non-invasively and dynamically monitored during the 8 weeks experiment.Histological observation,specific gene expression and other molecular biological methods were applied by the end of the animal experiment.The results indicated that rhCol Ⅲ could alleviate the skin photoaging caused by UV radiation,including reduce the thickening of epidermis and dermis,increase the secretion of Collagen Ⅰ(Col Ⅰ)and Collagen Ⅲ(Col Ⅲ)and remodel of extracellular matrix(ECM).Although the cell-material interaction and mechanism need more investigation,the effect of rhCol Ⅲ on damaged skin was discussed from influence on cells,reconstruction of ECM,and stimulus of small biological molecules based on current results.In conclusion,our findings provided rigorous biosafety information of rhCol Ⅲ and approved its potential in skin repair and regeneration.Although enormous efforts still need to be made to achieve successful translation from bench to clinic,the recombinant humanized collagen showed superiorities from both safety and efficacy aspects. | Jing Wang He Qiu Yang Xu Yongli Gao Peijie Tan Rui Zhao Zhanhong Liu Yajun Tang Xiangdong Zhu Chongyun Bao Hang Wang Hai Lin Xingdong Zhang | 2022 | Bioactive Materials2022，7，5： | 7 |
| 3 | Cell sheet formation enhances the therapeutic effects of human umbilical cord mesenchymal stem cells on myocardial infarction as a bioactive material显示文摘Stem cell-based therapy has been used to treat ischaemic heart diseases for two decades.However,optimal cell types and transplantation methods remain unclear.This study evaluated the therapeutic effects of human umbilical cord mesenchymal stem cell(hUCMSC)sheet on myocardial infarction(MI).Methods:hUCMSCs expressing luciferase were generated by lentiviral transduction for in vivo bio-luminescent imaging tracking of cells.We applied a temperature-responsive cell culture surface-based method to form the hUCMSC sheet.Cell retention was evaluated using an in vivo bio-luminescent imaging tracking system.Unbiased transcriptional profiling of infarcted hearts and further immunohistochemical assessment of monocyte and macrophage subtypes were used to determine the mechanisms underlying the therapeutic effects of the hUCMSC sheet.Echocardiography and pathological analyses of heart sections were performed to evaluate cardiac function,angiogenesis and left ventricular remodelling.Results:When transplanted to the infarcted mouse hearts,hUCMSC sheet significantly improved the retention and survival compared with cell suspension.At the early stage of MI,hUCMSC sheet modulated inflammation by decreasing Mcp1-positive monocytes and CD68-positive macrophages and increasing Cx3cr1-positive non-classical macrophages,preserving the cardiomyocytes from acute injury.Moreover,the extracellular matrix produced by hUCMSC sheet then served as bioactive scaffold for the host cells to graft and generate new epicardial tissue,providing mechanical support and routes for revascularsation.These effects of hUCMSC sheet treatment significantly improved the cardiac function at days 7 and 28 post-MI.Conclusions:hUCMSC sheet formation dramatically improved the biological functions of hUCMSCs,mitigating adverse post-MI remodelling by modulating the inflammatory response and providing bioactive scaffold upon transplantation into the heart.Translational perspective:Due to its excellent availability as well as superior local cellular retention and survival,allogenic transplantation of hUCMSC sheets can more effectively acquire the biological functions of hUCMSCs,such as modulating inflammation and enhancing angiogenesis.Moreover,the hUCMSC sheet method allows the transfer of an intact extracellular matrix without introducing exogenous or synthetic biomaterial,further improving its clinical applicability. | Rui Guo Feng Wan Masatoshi Morimatsu Qing Xu Tian Feng Hang Yang Yichen Gong Shuhong Ma Yun Chang Siyao Zhang Youxu Jiang Heqing Wang Dehua Chang Hongjia Zhang Yunpeng Ling Feng Lan | 2021 | Bioactive Materials2021，6，9： | 6 |
| 4 | Prevention of surgical site infection under different ventilation systems in operating room environment显示文摘Biological particles in the operating room(OR)air environment can cause surgical site infections(SSIs).Various ventilation systems have been employed in ORs to ensure an ultraclean environment.However,the effect of different ventilation systems on the control of bacteria-carrying particles(BCPs)released from the surgical staff during surgery is unclear.In this study,the performance of four different ventilation systems(vertical laminar airflow ventilation(VLAF),horizontal laminar airflow ventilation(HLAP),differential vertical airflow ventilation(DVAF),and temperature-controlled airflow ventilation(TAF))used in an OR was evaluated and compared based on the spatial BCP concentration.The airflow field in the OR was solved by the Renormalization Group(RNG)k-e turbulence model,and the BCP phase was calculated by Lagrangian particle tracking(LPT)and the discrete random walk(DRW)model.It was found that the TAF system was the most effective ventilation system among the four ventilation systems for ensuring air cleanliness in the operating area.This study also indicated that air cleanliness in the operating area depended not only on the airflow rate of the ventilation system but also on the airflow distribution,which was greatly affected by obstacles such as surgical lamps and surgical staff. | Zhijian Liu Haiyang Liu Hang Yin Rui Rong Guoqing Cao Qihong Deng | 2021 | Frontiers of Environmental Science & Engineering2021，15，3： | 5 |
| 5 | A novel design of 3D carbon host for stable lithium metal anode显示文摘Rational design of porous conductive hosts with high electrical conductivity,large surface area,and adequate interior space is desirable to suppressing dendritic lithium growth and accommodating large volume change of lithium metal anode during the Li plating/stripping process.However,due to the conductive nature of the conductive hosts,Li is easily deposited directly on the top of the hosts,which hinders it from fully functioning.To circumvent the issue,in this study,we designed a novel porous carbon host with a gradient-pore-size structure based on one-dimensional(1D)carbon with different diameters.With this kind of host,stable cycling with high and stable Coulombic efficiency of~98%is achieved at 0.5 mA cm^(−2) with an areal capacity of 1 mAh cm^(−2) over 320 cycles.In contrast,the normal three-dimensional(3D)carbon nanotube host presents a moss-like Li morphology with wildly fluctuating Coulombic efficiency after 100 cycles.The results reveal that the unique gradient-pore-size structure of the 3D conductive host greatly improves the performance of lithium metal batteries. | Hang Liu Jie Di Ping Wang Rui Gao Han Tian Pengfei Ren Qingxi Yuan Wanxia Huang Ruiping Liu Qiang Liu Ming Feng | 2022 | Carbon Energy2022，4，4： | 5 |
| 6 | 临床的 MDCT 上的食道的有鳞的房间癌的对比改进的量的测量显示文摘 AIM:To investigate contrast-enhanced computed tomography(CECT)for discriminating esophageal squamous cell carcinoma(ESCC)from normal esophagus and evaluating outcomes within tumors after chemoradiotherapy(CRT).METHODS:Sixty-four patients with surgical ESCC served as group A,and underwent thoracic contrastenhanced scan with 16-section multidetector row CT 1 wk before surgery.Thirty-five patients with advanced ESCC receiving 4-wk CRT and showing response to CRT served as group B,and underwent CT scans similar with group A 4 wk after completion of CRT.In group A,differences in CT attenuation values(in HU)between the preoperative ESCC and background normal esophageal wall(delta CT1),or between different background normal esophageal walls(delta CT2)were compared.Furthermore,delta CT1 between group A and B was also compared.RESULTS:In group A,mean delta CT1 was higher than delta CT2(23.86±10.59 HU vs 6.24±3.06 HU,P<0.05).When a delta CT1 of 10.025 HU was employed at a cut-off value to discriminate ESCC from normal esophagus,a sensitivity of 89.1%and specificity of 90.6%were achieved.Mean delta CT1 was lower in group B than in group A(9.25±10.86 vs 23.86 ±10.59,P<0.05),and a delta CT1 of 15.45 HU was obtained at a cut-off value to assess the CRT changes with a sensitivity of 76.6%and specificity of 77.1%.CONCLUSION:CECT might be a clinical technique for discriminating ESCC from normal esophagus,and evaluating outcome in the tumors treated with CRT. | Rui Li Tian-Wu Chen Li-Ying Wang Li Zhou Hang Li Xiao-Li Chen Chun-Ping Li Xiao-Ming Zhang Ru-Hui Xiao | 2012 | World Journal of Radiology2012，4，4： | 3 |
| 7 | Observation of specific ion effects in humus aggregation process显示文摘Specific ion effects play a vital role in a variety of colloidal and interfacial processes.However,few studies have reported the specific ion effects in the humus aggregation process,which strongly influence the transport and fate of environmental pollutants.In this study,soil humus colloids were prepared and characterized,and the specific ion effects on humus aggregation in electrolyte solutions were investigated at a variety of concentrations and pH values using dynamic light scattering methods.Activation energy(ΔE),which is known to reflect the dynamics and stability of a colloidal system,was used to quantitatively characterize the specific ion effects.The results showed that given ΔE value of 2.48×10^(3) J mol^(-1) at pH 3.0,the electrolyte concentrations were 91.6,58.2,3.8,and 0.8 mmol L^(-1) for Na^(+),K^(+),Mg^(2+),and Ca_(2+),respectively,thus indicating significant specific ion effects in the humus aggregation process.Most importantly,decreasing the electrolyte concentrations increased the differences in the ΔE value between two cation species with the same valence(i.e.,ΔE_(Na)-ΔE_(K) and ΔE_(Mg)-ΔE_(Ca)),while increasing the pH increased the magnitude of ΔE_(Mg)-ΔE_(Ca).However,the classic Derjaguin,Landau,Verwey,and Overbeek(DLVO)theory and the double layer theory,as well as the currently widely used ionic hydration and dispersion effects,failed to predict the experimentally observed increase in the specific ion effects with decreasing electrolyte concentrations in a quantitative sense.These results have implications for the necessity of involving specific ion effects for a better understanding of humus aggregation and interactions in aqueous and soil systems. | Rui TIAN Xinmin LIU Xiaodan GAO Rui LI Hang LI | 2021 | Pedosphere2021，31，5： | 3 |
| 8 | Molecular basis of CONSTANS oligomerization in FLOWERING LOCUS T activation显示文摘The transcription factor CONSTANS(CO)integrates day-length information to induce the expression of florigen FLOWERING LOCUS T(FT)in Arabidopsis.We recently reported that the C-terminal CCT domain of CO forms a complex with NUCLEAR FACTOR-YB/YC to recognize multiple cis-elements in the FT promoter,and the N-terminal tandem B-box domains form a homomultimeric assembly.However,the mechanism and biological function of CO multimerization remained unclear.Here,we report that CO takes on a head-to-tail oligomeric configuration via its B-boxes to mediate FT activation in long days.The crystal structure of B-boxesCOreveals a closely connected tandem B-box fold forming a continuous head-to-tail assembly through unique CDHH zinc fingers.Mutating the key residues involved in CO oligomerization resulted in a non-functional CO,as evidenced by the inability to rescue co mutants.By contrast,a transgene encoding a human p53-derived tetrameric peptide in place of the B-boxesCOrescued co mutant,emphasizing the essential role of BboxesCO-mediated oligomerization.Furthermore,we found that the four TGTG-bearing cis-elements in FT proximal promoter are required for FT activation in long days.Our results suggest that CO forms a multimer to bind to the four TGTG motifs in the FT promoter to mediate FT activation. | Xiaolin Zeng Xinchen Lv Rui Liu Hang He Shiqi Liang Lixian Chen Fan Zhang Liu Chen Yuehui He Jiamu Du | 2022 | Journal of Integrative Plant Biology2022，64，3： | 2 |
| 9 | Recent progress about 2D metal dichalcogenides: Synthesis and application in photodetectors显示文摘In recent years, two-dimensional (2D) layered metal dichalcogenides (MDCs) have received enormous attention on account of their excellent optoelectronic properties. Especially, various MDCs can be constructed into vertical/lateral heterostructures with many novel optical and electrical properties, exhibiting great potential for the application in photodetectors. Therefore, the batch production of 2D MDCs and their heterostructures is crucial for the practical application. Recently, the vapour phase methods have been proved to be dependable for growing large-scale MDCs and related heterostructures with high quality. In this paper, we summarize the latest progress about the synthesis of 2D MDCs and their heterostructures by vapour phase methods. Particular focus is paid to the control of influence factors during the vapour phase growth process. Furthermore, the application of MDCs and their heterostructures in photodetectors with outstanding performance is also outlined. Finally, the challenges and prospects for the future application are presented. | Yongfeng Pei Rui Chen Hang Xu Dong He Changzhong Jiang Wenqing Li Xiangheng Xiao | 2021 | Nano Research2021，14，6： | 2 |
| 10 | The transcription factors TLR1 and TLR2 negatively regulate trichome density and artemisinin levels in Artemisia annua显示文摘The important antimalarial drug artemisinin is biosynthesized and stored in Artemisia annua glandular trichomes and the artemisinin content correlates with trichome density;however,the factors affecting trichome development are largely unknown.Here,we demonstrate that the A.annua R2R3 MYB transcription factor TrichomeLess Regulator 1(TLR1)negatively regulates trichome development.In A.annua,TLR1 overexpression lines had 44.7%–64.0%lower trichome density and 11.5%–49.4%lower artemisinin contents and TLR1-RNAi lines had 33%–93.3%higher trichome density and 32.2%–84.0%higher artemisinin contents compared with non-transgenic controls.TLR1 also negatively regulates the expression of anthocyanin biosynthetic pathway genes in A.annua.When heterologously expressed in Arabidopsis thaliana,TLR1 interacts with GLABROUS3a,positive regulator of trichome development,and represses trichome development.Yeast two-hybrid and pull-down assays indicated that TLR1 interacts with the WUSCHEL homeobox(WOX)protein AaWOX1,which interacts with the LEAFY-like transcription factor TLR2.TLR2 overexpression in Arabidopsis and A.annua showed that TLR2 reduces trichome development by reducing gibberellin levels.Furthermore,artemisinin contents were 19%–43%lower in TLR2-overexpressing A.annua plants compared to controls.These data indicate that TLR1 and TLR2 negatively regulate trichome density by lowering gibberellin levels and may enable approaches to enhance artemisinin yields. | Zongyou Lv JinXing Li Shi Qiu Fei Qi Hang Su Qitao Bu Rui Jiang Kexuan Tang Lei Zhang Wansheng Chen | 2022 | Journal of Integrative Plant Biology2022，64，6： | 2 |
| 11 | A Novel Porcine Model of Septic Shock Induced by Acute Respiratory Distress Syndrome due to Methicillin-resistant Staphylococcus aureus显示文摘 | Shuo Wang Jun-Yu Wang Tao Wang Chen-Chen Hang Rui Shao Chun-Sheng Li | 2017 | Chinese Medical Journal2017，，10： | 2 |
| 12 | Unraveling the size distributions of surface properties for purple soil and yellow soil显示文摘Soils contain diverse colloidal particles whose properties are pertinent to ecological and human health, whereas few investigations systematically analyze the surface properties of these particles. The objective of this study was to elucidate the surface properties of particles within targeted size ranges(i.e. > 10, 1–10, 0.5–1, 0.2–0.5 and < 0.2 μm) for a purple soil(Entisol) and a yellow soil(Ultisol) using the combined determination method. The mineralogy of corresponding particle-size fractions was determined by X-ray diffraction.We found that up to 80% of the specific surface area and 85% of the surface charge of the entire soil came from colloidal-sized particles(< 1 μm), and almost half of the specific surface area and surface charge came from the smallest particles(< 0.2 μm). Vermiculite,illite, montmorillonite and mica dominated in the colloidal-sized particles, of which the smallest particles had the highest proportion of vermiculite and montmorillonite. For a given size fraction, the purple soil had a larger specific surface area, stronger electrostatic field, and higher surface charge than the yellow soil due to differences in mineralogy.Likewise, the differences in surface properties among the various particle-size fractions can also be ascribed to mineralogy. Our results indicated that soil surface properties were essentially determined by the colloidal-sized particles, and the < 0.2 μm nanoparticles made the largest contribution to soil properties. The composition of clay minerals within the diverse particle-size fractions could fully explain the size distributions of surface properties. | Ying Tang Hang Li Xinmin Liu Hualing Zhu Rui Tian | 2015 | Journal of Environmental Sciences2015，27，6： | 2 |
| 13 | Preparation of phospholipid-based polycarbonate urethanes for potential applications of blood-contacting implants显示文摘Polyurethanes are widely used in interventional devices due to the excellent physicochemical property.However,non-specific adhesion and severe inflammatory response of ordinary polyurethanes may lead to severe complications of intravenous devices.Herein,a novel phospholipid-based polycarbonate urethanes(PCUs)were developed via two-step solution polymerization by direct synthesis based on functional raw materials.Furthermore,PCUs were coated on biomedical metal sheets to construct biomimetic anti-fouling surface.The results of stress–strain curves exhibited excellent tensile properties of PCUs films.Differential scanning calorimetry results indicated that the microphase separation of such PCUs polymers could be well regulated by adjusting the formulation of chain extender,leading to different biological response.In vitro blood compatibility tests including bovine serum albumin adsorption,fibrinogen adsorption and denaturation,platelet adhesion and whole-blood experiment showed superior performance in inhibition non-specific adhesion of PCUs samples.Endothelial cells and smooth muscle cells culture tests further revealed a good anti-cell adhesion ability.Finally,animal experiments including ex vivo blood circulation and subcutaneous inflammation animal experiments indicated a strong ability in anti-thrombosis and histocompatibility.These results high light the strong anti-adhesion property of phospholipid-based PCUs films,which may be applied to the blood-contacting implants such as intravenous catheter or antithrombotic surface in the future. | Peichuang Li Wanhao Cai Xin Li Kebing Wang Lei Zhou Tianxue You Rui Wang Hang Chen Yuancong Zhao Jin Wang Nan Huang | 2020 | Regenerative Biomaterials2020，7，5： | 1 |
| 14 | Fatty acid composition of Camellia oleifera oil 显示文摘 | MA Jinlin YE Hang RUI Yukui | 2010 | Journal of Consumer Protection and Food Safety2010，6，： | 1 |
| 15 | Generalized Poisson—Boltzmann Equation Taking into Account Ionic Interaction and Steric Effects显示文摘 | Liu Xin-Min Li Hang Li Rui Tian Rui Xu Chen-Yang | 2012 | Communications in Theoretical Physics2012，，3： | 1 |
| 16 | Targeting of DICE1 tumor suppressor by Epstein–Barr virus‐encoded miR‐BART3* microRNA in nasopharyngeal carcinoma显示文摘 | Ting Lei Kit‐San Yuen Rui Xu Sai Wah Tsao Honglin Chen Mengfeng Li Kin‐Hang Kok Dong‐Yan Jin | 2013 | Int J Cancer2013，，1： | 1 |
| 17 | Research into the electrical property variation of un-doped CdTe and ZnTe crystals grown under Te-rich conditions 显示文摘 | XU Ya-dong LIU Hang HE Yi-hui YANG Rui LUO Lin JIE Wan-qi | 2014 | Journalof Alloys and Compounds2014，612，： | 1 |
| 18 | Fatty acid composition of Camellia oleifera oil显示文摘 | MA Jin-lin YE Hang RUI Yu-kui | 2011 | J Verbrauch Lebensm2011，6，1： | 1 |
| 19 | Fatty acid composition of Camellia oleifera oil显示文摘 | MA Jin-lin YE Hang RUI Yu kui | 2011 | Journal Ftr Verbrauch erschutz Und Lebensmittelsicherheit2011，6，1： | 1 |
| 20 | Fatty acid composition of Camellia oleifera oil显示文摘 | Jinlin Ma Hang Ye Yukui Rui | 2011 | J Verbr Lebensm2011，，6： | 1 |
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