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| 1 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 2 | Voltage rise mitigation for solar PV integration at LV grids Studies from PVNET.dk显示文摘Solar energy from photovoltaic(PV)is among the fastest developing renewable energy systems worldwide.Driven by governmental subsidies and technological development,Europe has seen a fast expansion of solar PV in the last few years.Among the installed PV plants,most of them are situated at the distribution systems and bring various operational challenges such as power quality and power flow management.The paper discusses the modelling requirements for PV system integration studies,as well as the possible techniques for voltage rise mitigation at low voltage(LV)grids for increasing PV penetration.Potential solutions are listed and preliminary results are presented. | Guangya YANG Francesco MARRA Miguel JUAMPEREZ Søren Bækhøj KJÆR Seyedmostafa HASHEMI JacobØSTERGAARD Hans Henrik IPSEN Kenn H.B.FREDERIKSEN | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，3： | 5 |
| 3 | Serum uric acid as an independent predictor of mortality in patients with angiographically proven cornonary disease显示文摘 | CHRISTOPH B HANS J R STEFAN B | 2002 | Am J Cardiol2002，89，： | 1 |
| 4 | B io a v a ila b ility andpopulation pharm acokinetics o f voriconazole in lungtransplant recipien ts 显示文摘 | Han K C apitano B B ies R et a l | 2010 | Antimicrob Agents Chemother2010，54，10： | 1 |
| 5 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 6 | Study of high- coercivity sintered NdFeB magnets 显示文摘 | Bai G Gao R W Sun Y Han G B Wang B | 2007 | Journal of Magnetism and Magnetic Materials2007，308，1： | 1 |
| 7 | Analysis of informationflow security in cyber-physical systems显示文摘 | Akella R Tang Han Mcmillin B M | 2010 | International Journalof Critical Infrastructure Protection2010，3，34： | 1 |
| 8 | Phase II clinical trial of XELOX as first line treatment for patients with unresectable or meta- static gastric cancer显示文摘 | Xu R Han B Shi Y | 2007 | J Clin Oncol2007，25，18： | 1 |
| 9 | Simple and mild procedures for synthesis of benzimidazoles using heterogeneous catalyst systems显示文摘 | KIM B H HAN R KIM J S | | 0，，： | 1 |
| 10 | Amylopectin fine structure and rice starch paste breakdown显示文摘 | Han X Z Hamaker B R | | 0，，03： | 1 |
| 11 | Distributed relay selection and pow- er control for muhiuser cooperative communication networks using Stackelberg game显示文摘 | B Wang Z Han K J R Liu | 2009 | IEEE Transactions on Mobile Computing2009，8，7： | 1 |
| 12 | The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain显示文摘 | Pearson R B Dennis P B Han J W | 1995 | EMBO J1995，14，21： | 1 |
| 13 | Colorimetric screening of DNA-binding molecules with gold nanoparticle probes显示文摘 | HAN M S LYTTON-JEAN A K R OH B K | 2006 | Angewandte Chemie-International Edition2006，45，11： | 1 |
| 14 | Chronic gastrointestinal problems and boweldysfunction in patients with spinal cord iniury 显示文摘 | HAN T R KIM J H KWON B S | 1998 | Spinal Cord1998，36，7： | 1 |
| 15 | Identification and characterization of Bphl4, a gene conferring resistance to brown planthopper in rice 显示文摘 | Du B Zhang W Liu B Hu J Wet Z Shi Z He R Zhu L Chen R Han B He G | 2009 | Proceedings of the National Academy of Sciences2009，106，22： | 1 |
| 16 | 查看详情显示文摘 | Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y | | 0，，： | 1 |
| 17 | Gallic acid inhibits the growth of Hela cervical cancer cells via apoptosis and/or necrosis显示文摘 | YOU B R MOON H J HAN Y H | 2010 | Food and Chemical Toxicology2010，48，5： | 1 |
| 18 | Mesoporous aluminosilicates with ordered hexagonal structure,strong acidity,and extraordinary hydrothermal stability at high temperatures显示文摘 | ZHANG Z HAN Y XIAO F QIU S ZHU L WANG R YU Y ZHANG Z ZOU B WANG Y SUN H ZHAO D WEI Y | 2001 | J Am Chem Soc2001，123，21： | 1 |
| 19 | Microbiological safety and quality of commercial Sufu-a Chinese fermented soybean food显示文摘 | HAN B Z BEUMER R R ROMBOUTS F M | 2001 | Food Control2001，，12： | 1 |
| 20 | 查看详情显示文摘 | R Q Ye B Q Han E J Lavernia | | 0，，： | 1 |
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