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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 3 | Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro显示文摘Gastrin and cyclooxygenase-2(COX-2) playimportant roles in the carcinogenesis and progression ofgastric cancer.However,it remains unknown whether the combination of cholecystokinin-2(CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer.Here,we demonstrated that the combination of AG-041R(a CCK-2 receptor antagonist) plus NS-398(a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition,apoptosis induction,down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells.These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone.(C)2008 Elsevier Ireland Ltd.All rights reserved. | Sun, W. H. | 2008 | 南京医科大学学报(自然科学版)2008，28，9： | 30 |
| 4 | The global image of the Moon obtained by the Chang'E-1:Data processing and lunar cartography显示文摘The global lunar image of the first phase of Chinese Lunar Exploration Program is the first image that covered all over the surface of the Moon. It will serve as a critical foundation for succeeding exploration and scientific research. In this paper, the acquisition, characteristics, and data quality of Chang'E-1 CCD image data are described in detail. Also described are the methodology and procedure of data processing. According to rule of planetary cartography, the image data have been processed, geometrically corrected, and then mosaicked and merged in a scale of 1:2.5 million. The results of data processing and charting show that the image data of Chang'E-1 CCD and their geometric precision meet the demand of charting a map in the scale of 1:2.5 million. The relative geometric positioning precision of the global image is better than 240 m, and the absolute geometric positioning precision is slightly better than that of the ULCN2005 and Clementine lunar basemap (V2.0). The plane positioning precision is approximately 100-1500 m. This global image proves to be the best global image of the Moon so far in terms of space coverage, image quality, and positioning precision. | LI ChunLai1, LIU JianJun1, REN Xin1, MOU LingLi1, ZOU YongLiao1, ZHANG HongBo1, Lü Chang1, LIU JianZhong1, ZUO Wei1, SU Yan1, WEN WeiBin1, BIAN Wei1, ZHAO BaoChang2, YANG JianFeng2, ZOU XiaoDuan1, WANG Min1, XU Chun1, KONG DeQing1, WANG XiaoQian1, WANG Fang1, GENG Liang1, ZHANG ZhouBin1, ZHENG Lei1, ZHU XinYing1, LI JunDuo1 & OUYANG ZiYuan11 National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012, China 2 Xi’an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi’an 710119, China | 2010 | Science China Earth Sciences2010，53，8： | 22 |
| 5 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 6 | Laser altimetry data of Chang'E-1 and the global lunar DEM model显示文摘The Laser AltiMeter (LAM), as one of the main payloads of Chang'E-1 probe, is used to measure the topography of the lunar surface. It performed the first measurement at 02:22 on November 28th, 2007. Up to December 4th 2008, the total number of measurements was approximately 9.12 million, covering the whole surface of the Moon. Using the LAM data, we constructed a global lunar Digtal Elevation Model (DEM) with 3 km spatial resolution. The model shows pronounced morphological characteristics, legible and vivid details of the lunar surface. The plane positioning accuracy of the DEM is 445 m (1σ), and the vertical accuracy is 60 m (1σ). From this DEM model, we measured the full range of the altitude difference on the lunar sur-face, which is about 19.807 km. The highest point is 10.629 km high, on a peak between crater Korolev and crater Dirichlet-Jackson at (158.656°W, 5.441°N) and the lowest point is -9.178 km in height, inside crater Antoniadi (172.413°W, 70.368°S) in the South Pole-Aitken Basin. By comparison, the DEM model of Chang'E-1 is better than the USA ULCN2005 in accuracy and resolution and is probably identical to the DEM of Japan SELENE, but the DEM of Chang'E-1 reveals a new lowest point, clearly lower than that of SELENE. | LI ChunLai1, REN Xin1, LIU JianJun1, ZOU XiaoDuan1, MU LingLi1, WANG JianYu2, SHU Rong2, ZOU YongLiao1, ZHANG HongBo1, Lü Chang1, LIU JianZhong1, ZUO Wei1, SU Yan1, WEN WeiBin1, BIAN Wei1, WANG Min1, XU Chun1, KONG DeQing1, WANG XiaoQian1, WANG Fang1, GENG Liang1, ZHANG ZhouBin1, ZHENG Lei1, ZHU XinYing1, LI JunDuo1 & OUYANG ZiYuan1 1 National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012, China 2 Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China | 2010 | Science China Earth Sciences2010，53，11： | 19 |
| 7 | Aminoglycoside-induced and non-syndromic hearing loss is associated with the G7444A mutation in the mitochondrial COI/tRNA (Ser(UCN)) genes in two Chinese families显示文摘 | Zhu Y Qian YP Tang XW Wang JD Yang L Liao ZS Li RH Ji JZ Li ZY Chen JF Choo DI Lu JX Guan MX | 2006 | 中国生物学文摘2006，20，4： | 16 |
| 8 | Finite-time adaptive consensus of a class of multi-agent systems显示文摘Multi-agent systems(MASs) are ubiquitous in natural and artificial systems. This paper aims to establish the finite-time adaptive consensus criterion for a class of MASs with nonlinear dynamics. Traditionally, the finite-time consensus criterion is often established based on the prior information on Lipschitz constants and the eigenvalues of Laplacian matrix. However, it is difficult to acquire the above prior information for most real-world engineering systems. To overcome the above difficulty, this paper develops the finite-time consensus criteria for a class of MASs with nonlinear dynamics via adaptive technique. In detail, we design the finite-time distributed node-based and edge-based adaptive consensus protocols for a class of MASs with fixed and switching topologies. Numerical simulations are also given to validate the proposed finite-time adaptive consensus criterion. | LIU KeXin WU LuLu Lü JinHu ZHU HengHui | 2016 | Science China(Technological Sciences)2016，59，1： | 16 |
| 9 | A 2.8 Ma record of environmental evolution and tectoni events inferred from the Cuoe core in the middle of Tibetan Plateau显示文摘Based on a multi-proxy investigation into the deep core of the Cuoe Lake in the middle of Tibetan Plateau, a 2.8 Ma paleoclimatic and paleoenvironmental evolution is recon- structed. The result of magnetic stratum indicates that the lake basin was formed at about 2.8 MaBP, while the multi-proxy analyses of lithology, grain size, magnetic susceptibility and geo- chemical elements reveal that there have been three major environmental evolution stages and at least two intensive uplifts of the Tibetan Plateau in the lake basin area, i.e. during 2.8—2.5 MaBP, the lake basin came into being as a result of the disaggregation of the planation surface and rapid rising of the Tibetan Plateau. During 2.5—0.8 MaBP, with gradual uplift of the Tibetan Plateau, the environment of this area was more effectively controlled by the climatic cycle of the alternative glacial-interglacial stages. After 0.8 MaBP, the middle part of the Plateau accelerated its uplift and entered cryoshere. | SHEN Ji1,Lü Houyuan2,WANG Sumin1,CHEN Shiyue1,YANG Xiangdong1,WU Yanhong1 & ZHU Zhaoyu3 1.Nanjing Institute of Geography and Limnology,Chinese Academy of Sciences,Nanjing 210008,China 2.Institute of Geology and Geophysics,Chinese Academy of Sciences,Beijing 100029,China 3.Guangzhou Institute of Geochemistry,Chinese Academy of Sciences,Guangzhou 510640,China Correspondence should be addressed to Shen Ji(email: jishen@niglas.ac.cn) | 2004 | Science China Earth Sciences2004，47，11： | 15 |
| 10 | 在血压控制不良的高血压患者中使用数字化干预的家庭和在线血压管理:随机对照试验显示文摘HOME BP试验(The home and online management and evaluation of blood pressure)的目的是评估在初级预防中结合自我监测和自我管理的数字化干预在高血压管理中的作用。研究者纳入英国76个治疗中心经过治疗但血压控制不好(>140/90 mm Hg, 1 mm Hg=0.133 kPa)并能上网的患者622例,进行自动确定主要终点的公开随机对照试验。 | McMa-nus RJ Little P Stuart B Morton K Raftery J Kelly J Bradbury K Zhang J Zhu S Murray E May CR Mair FS Michie S Smith P Band R Ogburn E AllenJ Rice C Nut-tall J Williams B Yardley L 陈嘉睿(译) 叶鹏(审校) | 2021 | 中华高血压杂志2021，29，5： | 15 |
| 11 | Relationship Between Programmed Death-ligand 1 and Clinicopathological Characteristics in Non-small Cell Lung Cancer Patients显示文摘Objective To evaluate the correlation between programmed death-ligand 1(PD-L1)expression in primary lung cancer cells,tumor associated macrophages(TAM)and patients’clinicopathological characteristics.Methods From 2008 to 2010,208 non-small cell lung cancer patients who underwent surgery or CT-guided biopsy were recruited from Huadong Hospital,Fudan University.Immunohistochemistry staining was performed to evaluate the PD-L1 expression in both primary lung cancer cells and CD68 positive TAM.The relationship between PD-L1 expression and the clinical pathology was evaluated usingχ2test.Spearman’s rank correlations were used to determine the correlation between PD-L1 expression in tumor cells and macrophages.Results Positive PD-L1 expression in primary cancer cells was found in 136(65.3%)patients,which were negatively correlated with lymph node metastasis(P=0.009)and smoking history(P=0.036).Besides,TAM with PD-L1 expression(found in 116 patients)was positively associated with smoking history(P=0.034),well-differentiation(P=0.029)and negative lymph node metastasis(P=0.0096).A correlation between PD-L1 expression in primary tumor cells and non-small cell lung cancer associated macrophages was found(r=0.228,P=0.021).Conclusion PD-L1,secreted from TAM,might induce cancer cells apoptosis,and decrease lymph node metastasis. | Yan-yan Chen Liu-bo Wang Hui-li Zhu Xiang-yang Li Yan-ping Zhu Yu-lei Yin Fan-zhen Lü Zi-li Wang Jie-ming Qu | 2013 | Chinese Medical Sciences Journal2013，28，3： | 14 |
| 12 | Effect of metabolic structures and energy requirements on curdlan production by Alcaligenes faecalis显示文摘 | Zheng, ZY Lee, AW Zhan, XB Shi, Z Wang, L Zhu, L Wu, JR Lin, CC | 2007 | 中国生物学文摘2007，21，10： | 13 |
| 13 | Primary scientific results of Chang'E-1 lunar mission显示文摘The strategic plan for the development of the unmanned Chinese Lunar Exploration Program is characterized by three distinct stages: 'orbiting around', 'landing on' and 'returning from' the Moon. The first Chinese lunar probe, Chang'E-1, which was successfully launched on October 24th, 2007 at Xichang Satellite Launch Center, and guided to crash on the Moon on March 1st, 2009, at 52.36°E, 1.50°S, in the north of Mare Fecunditatis, is the first step towards the 'orbiting around' stage. The Chang'E-1 mission lasted 495 days, exceeding the expected life-span by about four months. A total of 1.37 TB raw data was received from Chang'E-1. It was then processed into 4 TB scientific data products at various levels. Many scientific results have been obtained by analyzing these data, including especially the 'global lunar image from the first Chinese lunar explora- tion mission'. All scientific goals of Chang'E-1 have been achieved. It provides much useful materials for further advances of lunar sciences and planetary chemistry. Meanwhile, these results will serve as a firm basis for future Chinese lunar missions. | OUYANG ZiYuan1,2, LI ChunLai1, ZOU YongLiao1, ZHANG HongBo1, Lü Chang1, LIU JianZhong1, LIU JianJun1, ZUO Wei1, SU Yan1, WEN WeiBin1, BIAN Wei1, ZHAO BaoChang3, WANG JianYu4, YANG JianFeng3, CHANG Jin5, WANG HuanYu6, ZHANG XiaoHui7, WANG ShiJin7, WANG Min1, REN Xin1, MU LingLi1, KONG DeQing1, WANG XiaoQian1, WANG Fang1, GENG Liang1, ZHANG ZhouBin1, ZHENG Lei1, ZHU XinYing1, ZHENG YongChun1, LI JunDuo1, ZOU XiaoDuan1, XU Chun1, SHI ShuoBiao1, GAO YiFei1 & GAO GuanNan1 1 National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012, China 2 Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China 3 Xi’an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi’an 710119, China 4 Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China 5 Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210008, China 6 Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China 7 Center for Space Science and Applied Research, Chinese Academy of Sciences, Beijing 100190, China | 2010 | Science China Earth Sciences2010，53，11： | 11 |
| 14 | Modeling of Microstructure Evolution in 22MnB5 Steel during Hot Stamping显示文摘Automobile manufacturers have been increasingly adopting hot-stamped parts for use in newly designed vehicles to improve crash worthiness and fuel efficiency.However,the simulation of hot stamping is rather complex and challenging,and further research still needs to be done on hot stamping hardening mechanism.The microstructure evolution and hardening mechanisms during hot stamping of 22MnB5steel were thoroughly investigated,using information provided in the literatures as well as experimental results.New models were developed to predict the grain growth during heating and the flow stress of a manganese boron steel(22MnB5)with high hardenability by the Gleeble simulation experimental results.The deformed austenite decomposition during stamping and quenching was emphatically quantified based on the transformation thermodynamic and kinetic theories,and the relationship of microstructure to properties was analyzed.The results showed that the optimal process to obtain homogeneous and small lath martensite is heating at 900-950℃for 5min and then quenching at 50℃/s with a pressing time about 8s. | Li-juan ZHU Zheng-wei GU Hong XU Yi L Jiang CHAO | 2014 | Journal of Iron and Steel Research(International)2014，21，2： | 10 |
| 15 | Protective effect of early enteral feeding on postburn impairment of liver function and its mechanism in rats显示文摘AIM To study the protective effect of earlyenteral feeding(EEF)on the postburnimpairment of liver function and its mechanism.METHODS Wistar rats with 30% of total bodysurface area(TBSA)full-thickness burn wereemployed.The effects of EEF on the postburnchanges of gastric intramucosal pH,endotoxinlevels in portal vein,water contents of hepatictissue,blood concentrations of tumor necrosisfactor(TNF-α),plasma activities of alanineaminotransferase(ALT)and asparateaminotransferase(AST),as well as the bloodcontents of total(TB)and direct bilirubin(DB),total protein(TP)and albumin(ALB)wereserially determined within 48h postburn.RESULTS EEF could significantly improvegastric mucosal acidosis,reduce portal veinendotoxin level and water content of hepatictissue,as well as plasma concentrations of TNF-α at all timepoints after severe burns(P<0.01);postburn elevation of the plasma activities ofALT,AST and the contents of TB,DB wereeffectively prevented,whereas the plasmaconcentrations of TP and ALB were markedlyincreased 24 h and 48 h posturn in EEF groupcompared with that of the burn without EEFgroup(P<0.01).CONCLUSION EEF has significant beneficialeffects on the improvement of hepatic function in rats after severe burn,and is probably relatedwith an increase in splanchnic blood flow,reduction of the absorption of gut-originendotoxin and the consequent release ofinflammatory mediators. | Zhu L Yang ZC Li A Cheng DC | 2000 | World Journal of Gastroenterology2000，6，1： | 10 |
| 16 | Use of a Multiplex RT-PCR Assay for Simultaneous Detection of the North American Genotype Porcine Reproductive and Respiratory Syndrome Virus,Swine Influenza Virus and Japanese Encephalitis Virus显示文摘A multiplex reverse transcriptase-polymerase chain reaction(multiplex RT-PCR) assay was developed and subsequently evaluated for its efficacy in the detection of multiple viral infections simultaneously,in swine.Specific primers for each of the 3 RNA viruses,North American genotype porcine reproductive and respiratory syndrome virus,Japanese encephalitis virus,and swine influenza virus,were used in the testing procedure.The assay was shown to be highly sensitive because it could detect as little as 10-5 ng of each of the respective amplicons in a single sample containing a composite of all 3 viruses.The assay was also effective in detecting one or more of the same viruses in various combinations in specimens,including lymph nodes,lungs,spleens,and tonsils,collected from clinically ill pigs and in spleen specimens collected from aborted pig fetuses.The results from the multiplex RT-PCR were confirmed by virus isolation.The relative efficiency(compared to the efficiency of separate assays for each virus) and apparent sensitivity of the multiplex RT-PCR method show that this method has potential for application in routine molecular diagnostic procedures. | CHEN Hong-ying WEI Zhan-yong ZHANG Hong-ying LüXiao-li ZHENG Lan-lan CUI Bao-an LIU Jinpeng ZHU Qian-lei WANG Zi-xin | 2010 | Agricultural Sciences in China2010，9，7： | 10 |
| 17 | Leaf nutrient dynamics and nutrient resorption:a comparison between larch plantations and adjacent secondary forests in Northeast China显示文摘Aims Conversion of secondary forests to pure larch plantations is a common management practice driven by the increasing demand for timber production in Northeast China,resulting in a reduction in soil nutrient availability after a certain number of years following conversion.Nutrient resorption prior to leaf senescence was related to soil fertility,an important nutrient conservation strategy for plants,being especially significant in nutrient-poor habitats.However,the seasonal dynamics of leaf nutrients and nutrient resorption in response to secondary forest conversion to larch plantations is not well understood.Methods A comparative experiment between larch plantations(Larix spp.)and adjacent secondary forests(dominant tree species including Quercus mongolica,Acer mono,Juglans mandshurica and Fraxinus rhynchophylla)was conducted.We examined the variations in leaf nutrient(macronutrients:N,P,K,Ca and Mg;micronutrients:Cu and Zn)concentrations of these tree species during the growing season from May to October in 2013.Nutrient resorption efficiency and proficiency were compared between Larix spp.and the broadleaved species in the secondary forests.Important Findings Results show that the seasonal variation of nutrient concentrations in leaves generally exhibited two trends,one was a downward trend for N,P,K,Cu and Zn,and another was an upward trend for Ca and Mg.The variations in foliar nutrient concentrations were mainly controlled by the developmental stage of leaves rather than by tree species.Resorption of the observed seven elements varied among the five tree species during leaf senescence.Nutrient resorption efficiency varied 6–75%of N,P,K,Mg,Cu and Zn,while Ca was not retranslocated in the senescing leaves of all species,and Mg was not retranslocated in Larix spp.Generally,Larix spp.tended to be more efficient and proficient(higher than 6–30%and 2–271%of nutrient resorption efficiency and resorption proficiency,respectively)in resorbing nutrients than the broadleaved species in the secondary forests,indicating that larch plantations had higher leaf nutrient resorption and thus nutrient use efficiency.Compared with Larix spp.,more nutrients would remain in the leaf litter of the secondary forests,indicating an advantage of secondary forests in sustaining soil fertility.In contrast,the larch plantation would reuse internal nutrients rather than lose nutrients with litter fall and thus produce a positive feedback to soil nutrient availability.In summary,our results suggest that conversion from secondary forests to pure larch plantations would alter nutrient cycling through a plantmediated pathway. | Tao Yan Xiaotao Lü Kai Yang Jiaojun Zhu | 2016 | Journal of Plant Ecology2016，9，2： | 10 |
| 18 | U-Pb zircon geochronology, geochemistry and kinetics of the Huaniushan A-type granite in Northwest China显示文摘The Huaniushan granite is located at the Beishan orogenic belt, northwestern China. At the contact zone between the granite and marble, a hydrothermal Pb-Zn and skarn Au deposit is formed. LA-ICP-MS zircon U-Pb dating yielded a weighted mean 206Pb/238U age of 229.5±2.6 Ma (MSDW=0.93) for the Huaniushan granite, imply-ing its Late Triassic intrusion. Geochemistry analyses show that the Huaniushan granite is enriched in Si, K, Na, and REE, and depleted in Mg and Ca, with contents of SiO2 (70.8% to 74.4%), Na2O+K2O (8.8% to 10.2%), CaO (0.93% to 1.44%), and MgO (0.14% to 0.48%). REE is characterized by obvious negative Eu anomaly. Rb, Th, U, K, Pb, Nb, Zr and Hf elements are rich in the granite while Ba, Sr, P, Ti and Eu are deplete. The granite has a high (Zr+Nb+Ce+Y) abundance and 104 Ga/Al ratios. Petrology, major and trace elements data all indicate that the Hua-niushan granite is A-type granite which intruded in a post-collisional extensional tectonic setting. The magma was dominantly sourced from partial melting of crustal intermediate-felsic igneous rocks. Intensive magmatic activities and Au-Cu-Mo mineralization occurred throughout the Beishan orogenic belt during the period from ca. 240 to 220 Ma. | ZHU Jiang LÜ Xinbiao CAO Xiaofeng MO Yalong CHEN Chao | 2012 | Chinese Journal Of Geochemistry2012，31，1： | 10 |
| 19 | Recovery of alkali and alumina from Bayer red mud by the calcification–carbonation method显示文摘Red mud produced in the Bayer process is a hazardous solid waste because of its high alkalinity; however, it is rich in valuable components such as titanium, iron, and aluminum. In this study, a novel calcification–carbonation method was developed to recover alkali and alumina from Bayer red mud under mild reaction conditions. Batch experiments were performed to evaluate the potential effects of important parameters such as temperature, amount of CaO added, and CO_2 partial pressure on the recovery of alkali and alumina. The results showed that 95.2% alkali and 75.0% alumina were recovered from red mud with decreases in the mass ratios of Na_2 O to Fe_2O_3 and of Al_2O_3 to Fe_2O_3 from 0.42 and 0.89 to 0.02 and 0.22, respectively. The processed red mud with less than 0.5wt% Na_2 O can potentially be used as a construction material. | xiao-feng zhu ting-an zhang yan-xiu wang guo-zhi lü wei-guang zhang | 2016 | International Journal of Minerals,Metallurgy and Materials2016，23，3： | 10 |
| 20 | Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model显示文摘Osteoarthritis(OA) is a degenerative joint disease and a major cause of pain and disability in older adults. We have previously identified epidermal growth factor receptor(EGFR) signaling as an important regulator of cartilage matrix degradation during epiphyseal cartilage development. To study its function in OA progression, we performed surgical destabilization of the medial meniscus(DMM) to induce OA in two mouse models with reduced EGFR activity, one with genetic modification(EgfrWa5/1mice) and the other one with pharmacological inhibition(gefitinib treatment). Histological analyses and scoring at 3 months post-surgery revealed increased cartilage destruction and accelerated OA progression in both mouse models. TUNEL staining demonstrated that EGFR signaling protects chondrocytes from OA-induced apoptosis, which was further confirmed in primary chondrocyte culture. Immunohistochemistry showed increased aggrecan degradation in these mouse models, which coincides with elevated amounts of ADAMTS5 and matrix metalloproteinase 13(MMP13), the principle proteinases responsible for aggrecan degradation, in the articular cartilage after DMM surgery. Furthermore, hypoxia-inducible factor 2a(HIF2a), a critical catabolic transcription factor stimulating MMP13 expression during OA, was also upregulated in mice with reduced EGFR signaling. Taken together, our findings demonstrate a primarily protective role of EGFR during OA progression by regulating chondrocyte survival and cartilage degradation. | Xianrong Zhang Ji Zhu Fei Liu Yumei Li Abhishek Chandra L Scott Levin Frank Beier Motomi Enomoto-Iwamoto Ling Qin | 2014 | Bone Research2014，2，3： | 9 |
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